Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0386 | 0.1332 | 0.1332 |
Echinococcus multilocularis | sodium and chloride dependent glycine | 0.0386 | 0.1332 | 0.1233 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0386 | 0.1332 | 0.1332 |
Echinococcus granulosus | sodium and chloride dependent glycine | 0.0386 | 0.1332 | 0.1233 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0386 | 0.1332 | 0.1233 |
Loa Loa (eye worm) | hypothetical protein | 0.0176 | 0.0369 | 0.026 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0569 | 0.2171 | 0.6991 |
Trichomonas vaginalis | hypothetical protein | 0.0762 | 0.3057 | 1 |
Schistosoma mansoni | sodium-dependent neurotransmitter transporter | 0.0386 | 0.1332 | 0.1332 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.012 | 0.0112 | 0.0112 |
Echinococcus granulosus | uncharacterized sodium dependent transporter | 0.0386 | 0.1332 | 0.1233 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0176 | 0.0369 | 0.026 |
Chlamydia trachomatis | enoyl-acyl-carrier protein reductase | 0.0762 | 0.3057 | 1 |
Schistosoma mansoni | sodium/chloride dependent neurotransmitter transporter | 0.0386 | 0.1332 | 0.1332 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.012 | 0.0112 | 0.0112 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0665 | 0.2612 | 0.2612 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0386 | 0.1332 | 0.1332 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.012 | 0.0112 | 0.0112 |
Echinococcus multilocularis | sodium:chloride dependent neurotransmitter | 0.0386 | 0.1332 | 0.1233 |
Echinococcus granulosus | sodium:chloride dependent neurotransmitter | 0.0386 | 0.1332 | 0.1233 |
Schistosoma mansoni | sodium-dependent neurotransmitter transporter | 0.0386 | 0.1332 | 0.1332 |
Loa Loa (eye worm) | norepinephrine transporter | 0.2273 | 1 | 1 |
Echinococcus multilocularis | serotonin transporter | 0.2273 | 1 | 1 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0386 | 0.1332 | 0.1332 |
Mycobacterium ulcerans | enoyl-(acyl carrier protein) reductase | 0.0762 | 0.3057 | 0.5 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0176 | 0.0369 | 0.0369 |
Loa Loa (eye worm) | hypothetical protein | 0.2273 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0386 | 0.1332 | 0.1233 |
Brugia malayi | Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog | 0.0176 | 0.0369 | 0.026 |
Loa Loa (eye worm) | hypothetical protein | 0.0386 | 0.1332 | 0.1233 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0176 | 0.0369 | 0.026 |
Toxoplasma gondii | enoyl-acyl carrier reductase ENR | 0.0762 | 0.3057 | 1 |
Mycobacterium tuberculosis | NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) | 0.0762 | 0.3057 | 0.5 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0609 | 0.2355 | 0.2268 |
Schistosoma mansoni | sodium/chloride dependent neurotransmitter transporter | 0.0386 | 0.1332 | 0.1332 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0176 | 0.0369 | 0.0369 |
Loa Loa (eye worm) | hypothetical protein | 0.0386 | 0.1332 | 0.1233 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0386 | 0.1332 | 0.1233 |
Brugia malayi | hypothetical protein | 0.0386 | 0.1332 | 0.1233 |
Onchocerca volvulus | 0.2273 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0386 | 0.1332 | 0.1233 |
Plasmodium vivax | enoyl-acyl carrier protein reductase | 0.0762 | 0.3057 | 1 |
Loa Loa (eye worm) | Sodium:neurotransmitter symporter family protein | 0.0386 | 0.1332 | 0.1233 |
Echinococcus granulosus | sodium and chloride dependent glycine | 0.0386 | 0.1332 | 0.1233 |
Wolbachia endosymbiont of Brugia malayi | enoyl-ACP reductase | 0.0762 | 0.3057 | 0.5 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.2273 | 1 | 1 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.2273 | 1 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0665 | 0.2612 | 0.2612 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0609 | 0.2355 | 0.2268 |
Echinococcus granulosus | sodium dependent neurotransmitter transporter | 0.0386 | 0.1332 | 0.1233 |
Echinococcus multilocularis | voltage gated potassium channel | 0.0176 | 0.0369 | 0.026 |
Loa Loa (eye worm) | hypothetical protein | 0.2273 | 1 | 1 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0609 | 0.2355 | 0.2268 |
Loa Loa (eye worm) | hypothetical protein | 0.0386 | 0.1332 | 0.1233 |
Echinococcus granulosus | uncharacterized sodium dependent transporter | 0.0386 | 0.1332 | 0.1233 |
Schistosoma mansoni | voltage-gated potassium channel | 0.012 | 0.0112 | 0.0112 |
Loa Loa (eye worm) | serotonin transporter b | 0.2273 | 1 | 1 |
Schistosoma mansoni | sodium-dependent amino acid transporter | 0.0386 | 0.1332 | 0.1332 |
Loa Loa (eye worm) | hypothetical protein | 0.0386 | 0.1332 | 0.1233 |
Mycobacterium leprae | NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) | 0.0762 | 0.3057 | 0.5 |
Schistosoma mansoni | hyperpolarization activated cyclic nucleotide-gated potassium channel | 0.012 | 0.0112 | 0.0112 |
Loa Loa (eye worm) | hypothetical protein | 0.0528 | 0.1986 | 0.1895 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.2273 | 1 | 0.5 |
Echinococcus multilocularis | sodium and chloride dependent glycine | 0.0386 | 0.1332 | 0.1233 |
Echinococcus granulosus | voltage gated potassium channel | 0.0176 | 0.0369 | 0.026 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0609 | 0.2355 | 0.2268 |
Schistosoma mansoni | sodium-dependent neurotransmitter transporter | 0.0386 | 0.1332 | 0.1332 |
Loa Loa (eye worm) | Sodium:neurotransmitter symporter family protein | 0.0386 | 0.1332 | 0.1233 |
Plasmodium falciparum | enoyl-acyl carrier reductase | 0.0762 | 0.3057 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0386 | 0.1332 | 0.1233 |
Brugia malayi | Sodium:neurotransmitter symporter family protein 1, putative | 0.0386 | 0.1332 | 0.1233 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0386 | 0.1332 | 0.1233 |
Echinococcus multilocularis | sodium dependent neurotransmitter transporter | 0.0386 | 0.1332 | 0.1233 |
Loa Loa (eye worm) | hypothetical protein | 0.2273 | 1 | 1 |
Schistosoma mansoni | sodium/chloride dependent neurotransmitter transporter | 0.0386 | 0.1332 | 0.1332 |
Echinococcus multilocularis | uncharacterized sodium dependent transporter | 0.0386 | 0.1332 | 0.1233 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.2273 | 1 | 1 |
Echinococcus granulosus | serotonin transporter | 0.2273 | 1 | 1 |
Schistosoma mansoni | hyperpolarization activated cyclic nucleotide-gated potassium channel | 0.012 | 0.0112 | 0.0112 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0569 | 0.2171 | 0.6991 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.