Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | snurportin 1 | 0.0303 | 0.072 | 0.072 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0032 | 0.0032 |
Trichomonas vaginalis | importin beta-1, putative | 0.0023 | 0.0005 | 1 |
Echinococcus granulosus | snurportin 1 | 0.0303 | 0.072 | 0.072 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0028 | 0.0018 | 0.0018 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0028 | 0.0018 | 0.0018 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0018 | 0.0018 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0049 | 0.0072 | 0.0072 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0165 | 0.0368 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0165 | 0.0368 | 0.0368 |
Chlamydia trachomatis | Ssodium-dependent amino acid transporter | 0.0028 | 0.0018 | 0.5 |
Echinococcus granulosus | sodium dependent neurotransmitter transporter | 0.0028 | 0.0018 | 0.0018 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0028 | 0.0018 | 0.0018 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0028 | 0.0019 | 0.0046 |
Plasmodium falciparum | transporter, putative | 0.0028 | 0.0018 | 0.9541 |
Onchocerca volvulus | 0.0165 | 0.0368 | 0.0351 | |
Loa Loa (eye worm) | vesicular acetylcholine transporter unc-17 | 0.3935 | 1 | 1 |
Echinococcus multilocularis | vesicular acetylcholine transporter | 0.3935 | 1 | 1 |
Schistosoma mansoni | sodium/chloride dependent neurotransmitter transporter | 0.0028 | 0.0018 | 0.0018 |
Echinococcus multilocularis | uncharacterized sodium dependent transporter | 0.0028 | 0.0018 | 0.0018 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0018 | 0.0018 |
Loa Loa (eye worm) | Sodium:neurotransmitter symporter family protein | 0.0028 | 0.0018 | 0.0018 |
Echinococcus granulosus | geminin | 0.0167 | 0.0373 | 0.0373 |
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.0303 | 0.072 | 0.072 |
Loa Loa (eye worm) | serotonin transporter b | 0.0165 | 0.0368 | 0.0368 |
Echinococcus granulosus | uncharacterized sodium dependent transporter | 0.0028 | 0.0018 | 0.0018 |
Echinococcus multilocularis | sodium dependent neurotransmitter transporter | 0.0028 | 0.0018 | 0.0018 |
Onchocerca volvulus | Vesicular acetylcholine transporter homolog | 0.3935 | 1 | 1 |
Leishmania major | importin beta-1 subunit, putative | 0.0023 | 0.0005 | 0.0013 |
Brugia malayi | Importin beta-1 subunit | 0.0028 | 0.0019 | 0.0019 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0072 | 0.0072 |
Toxoplasma gondii | Sodium:neurotransmitter symporter family protein | 0.0028 | 0.0018 | 0.9541 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.0165 | 0.0368 | 0.0368 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0028 | 0.0019 | 0.0046 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.1664 | 0.4198 | 1 |
Schistosoma mansoni | sodium-dependent neurotransmitter transporter | 0.0028 | 0.0018 | 0.0018 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0028 | 0.0018 | 0.0018 |
Schistosoma mansoni | hypothetical protein | 0.0303 | 0.072 | 0.072 |
Brugia malayi | RNA, U transporter 1 | 0.0081 | 0.0153 | 0.0153 |
Echinococcus granulosus | sodium and chloride dependent glycine | 0.0028 | 0.0018 | 0.0018 |
Schistosoma mansoni | sodium-dependent amino acid transporter | 0.0028 | 0.0018 | 0.0018 |
Echinococcus granulosus | vesicular acetylcholine transporter | 0.3935 | 1 | 1 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0028 | 0.0018 | 0.0018 |
Schistosoma mansoni | importin beta-1 | 0.0028 | 0.0019 | 0.0019 |
Echinococcus granulosus | sodium and chloride dependent glycine | 0.0028 | 0.0018 | 0.0018 |
Schistosoma mansoni | vesicular acetylcholine transporter | 0.3935 | 1 | 1 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0165 | 0.0368 | 0.0368 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0023 | 0.0005 | 1 |
Loa Loa (eye worm) | norepinephrine transporter | 0.0165 | 0.0368 | 0.0368 |
Schistosoma mansoni | sodium/chloride dependent neurotransmitter transporter | 0.0028 | 0.0018 | 0.0018 |
Echinococcus multilocularis | sodium:chloride dependent neurotransmitter | 0.0028 | 0.0018 | 0.0018 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0018 | 0.0018 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.0072 | 0.0072 |
Echinococcus granulosus | sodium:chloride dependent neurotransmitter | 0.0028 | 0.0018 | 0.0018 |
Brugia malayi | Sodium:neurotransmitter symporter family protein 1, putative | 0.0028 | 0.0018 | 0.0018 |
Giardia lamblia | GTP-binding nuclear protein RAN/TC4 | 0.0021 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0019 | 0.0019 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0018 | 0.0018 |
Schistosoma mansoni | sodium-dependent neurotransmitter transporter | 0.0028 | 0.0018 | 0.0018 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0028 | 0.0018 | 0.0018 |
Echinococcus granulosus | importin subunit beta 1 | 0.0028 | 0.0019 | 0.0019 |
Plasmodium falciparum | importin beta, putative | 0.0028 | 0.0019 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0851 | 0.212 | 0.212 |
Toxoplasma gondii | hypothetical protein | 0.0028 | 0.0018 | 0.9541 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0028 | 0.0018 | 0.0018 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.0072 | 0.0072 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0018 | 0.0018 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0018 | 0.0018 |
Brugia malayi | ERG2 and Sigma1 receptor like protein | 0.1664 | 0.4198 | 0.4198 |
Trypanosoma cruzi | importin beta-1 subunit, putative | 0.0023 | 0.0005 | 0.0013 |
Toxoplasma gondii | HEAT repeat-containing protein | 0.0028 | 0.0019 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0165 | 0.0368 | 0.0368 |
Leishmania major | C-8 sterol isomerase-like protein | 0.1664 | 0.4198 | 1 |
Echinococcus multilocularis | importin subunit beta 1 | 0.0028 | 0.0019 | 0.0019 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.1664 | 0.4198 | 1 |
Schistosoma mansoni | sodium-dependent neurotransmitter transporter | 0.0028 | 0.0018 | 0.0018 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0165 | 0.0368 | 0.0368 |
Loa Loa (eye worm) | hypothetical protein | 0.0165 | 0.0368 | 0.0368 |
Plasmodium vivax | importin-beta 2, putative | 0.0028 | 0.0019 | 1 |
Brugia malayi | hypothetical protein | 0.0028 | 0.0018 | 0.0018 |
Toxoplasma gondii | Sodium:neurotransmitter symporter family protein | 0.0028 | 0.0018 | 0.9541 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0165 | 0.0368 | 0.0368 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0023 | 0.0005 | 1 |
Echinococcus granulosus | uncharacterized sodium dependent transporter | 0.0028 | 0.0018 | 0.0018 |
Echinococcus multilocularis | sodium and chloride dependent glycine | 0.0028 | 0.0018 | 0.0018 |
Echinococcus multilocularis | sodium and chloride dependent glycine | 0.0028 | 0.0018 | 0.0018 |
Schistosoma mansoni | hypothetical protein | 0.0167 | 0.0373 | 0.0373 |
Schistosoma mansoni | hypothetical protein | 0.0167 | 0.0373 | 0.0373 |
Echinococcus multilocularis | serotonin transporter | 0.0165 | 0.0368 | 0.0368 |
Loa Loa (eye worm) | hypothetical protein | 0.1664 | 0.4198 | 0.4198 |
Entamoeba histolytica | hypothetical protein | 0.0023 | 0.0005 | 1 |
Schistosoma mansoni | sodium/chloride dependent neurotransmitter transporter | 0.0028 | 0.0018 | 0.0018 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0018 | 0.0018 |
Toxoplasma gondii | Sodium:neurotransmitter symporter family protein | 0.0028 | 0.0018 | 0.9541 |
Loa Loa (eye worm) | Sodium:neurotransmitter symporter family protein | 0.0028 | 0.0018 | 0.0018 |
Plasmodium falciparum | amino acid transporter, putative | 0.0028 | 0.0018 | 0.9541 |
Toxoplasma gondii | hypothetical protein | 0.0028 | 0.0018 | 0.9541 |
Plasmodium vivax | hypothetical protein, conserved | 0.0028 | 0.0018 | 0.9541 |
Echinococcus multilocularis | geminin | 0.0167 | 0.0373 | 0.0373 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0034 | 0.0032 | 0.0032 |
Echinococcus granulosus | serotonin transporter | 0.0165 | 0.0368 | 0.0368 |
Plasmodium vivax | amine transporter, putative | 0.0028 | 0.0018 | 0.9541 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0032 | 0.0032 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.