Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0093 | 0.2979 | 0.2979 |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.4014 | 0.4014 |
Brugia malayi | beta-lactamase family protein | 0.0035 | 0.0039 | 0.0039 |
Giardia lamblia | Histone acetyltransferase GCN5 | 0.0038 | 0.019 | 0.5 |
Echinococcus multilocularis | geminin | 0.017 | 0.6908 | 0.6896 |
Schistosoma mansoni | hypothetical protein | 0.0064 | 0.1487 | 0.2152 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0039 | 0.0039 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0061 | 0.136 | 0.1968 |
Loa Loa (eye worm) | matrixin family protein | 0.007 | 0.1804 | 0.1804 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0041 | 0.0365 | 0.0328 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0224 | 0.9619 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0061 | 0.136 | 1 |
Onchocerca volvulus | Matrilysin homolog | 0.0064 | 0.1511 | 0.1511 |
Loa Loa (eye worm) | acetyltransferase | 0.0141 | 0.5417 | 0.5417 |
Loa Loa (eye worm) | lipase | 0.0231 | 1 | 1 |
Schistosoma mansoni | subfamily M12A unassigned peptidase (M12 family) | 0.0118 | 0.4257 | 0.6163 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0093 | 0.2979 | 0.2979 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0039 | 0.0039 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0061 | 0.136 | 1 |
Onchocerca volvulus | 0.0035 | 0.0039 | 0.0039 | |
Loa Loa (eye worm) | hypothetical protein | 0.0123 | 0.4513 | 0.4513 |
Schistosoma mansoni | hypothetical protein | 0.017 | 0.6908 | 1 |
Echinococcus multilocularis | sn1 specific diacylglycerol lipase beta | 0.0231 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0039 | 0.0039 |
Loa Loa (eye worm) | hypothetical protein | 0.0093 | 0.2979 | 0.2979 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0039 | 0.0039 |
Echinococcus granulosus | geminin | 0.017 | 0.6908 | 0.6896 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0039 | 0.0039 |
Mycobacterium tuberculosis | Probable peptidoglycan hydrolase | 0.0035 | 0.0046 | 0.0007 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-B | 0.0041 | 0.0365 | 0.2474 |
Loa Loa (eye worm) | matrixin family protein | 0.0064 | 0.1511 | 0.1511 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0703 | 0.0703 |
Entamoeba histolytica | acetyltransferase, GNAT family | 0.0038 | 0.019 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.1487 | 0.1487 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0041 | 0.0365 | 0.0328 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0084 | 0.2515 | 0.2486 |
Trichomonas vaginalis | cat eye syndrome critical region protein 2, cscr2, putative | 0.0041 | 0.0365 | 0.0328 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0061 | 0.136 | 0.1326 |
Brugia malayi | Hemopexin family protein | 0.0041 | 0.0338 | 0.0338 |
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | 0.0105 | 0.3588 | 0.3563 |
Echinococcus granulosus | sn1 specific diacylglycerol lipase beta | 0.0231 | 1 | 1 |
Loa Loa (eye worm) | bone morphogenetic protein 1b | 0.0118 | 0.4257 | 0.4257 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0231 | 1 | 1 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0035 | 0.0039 | 0.0056 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.0141 | 0.5417 | 0.54 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0064 | 0.1511 | 0.1511 |
Brugia malayi | acetyltransferase, GNAT family protein | 0.0141 | 0.5417 | 0.5417 |
Loa Loa (eye worm) | multiple epidermal growth factor-like domains 6 | 0.0038 | 0.0195 | 0.0195 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.0338 | 0.049 |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.0038 | 0.0195 | 0.1183 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0035 | 0.0039 | 0.0039 |
Plasmodium falciparum | histone acetyltransferase GCN5 | 0.0038 | 0.019 | 0.5 |
Echinococcus multilocularis | fibrillin 1 | 0.0038 | 0.0195 | 0.0157 |
Brugia malayi | beta-lactamase family protein | 0.0035 | 0.0039 | 0.0039 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0093 | 0.2979 | 0.2979 |
Leishmania major | hypothetical protein, conserved | 0.0231 | 1 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0061 | 0.136 | 0.1968 |
Trypanosoma brucei | lipase domain protein, putative | 0.0231 | 1 | 1 |
Onchocerca volvulus | Huntingtin homolog | 0.0123 | 0.4513 | 0.4513 |
Echinococcus multilocularis | Tolloid protein 1 | 0.0118 | 0.4257 | 0.4235 |
Brugia malayi | Matrixin family protein | 0.007 | 0.1804 | 0.1804 |
Echinococcus granulosus | laminin | 0.0038 | 0.0195 | 0.0157 |
Echinococcus multilocularis | laminin | 0.0038 | 0.0195 | 0.0157 |
Onchocerca volvulus | 0.0035 | 0.0039 | 0.0039 | |
Loa Loa (eye worm) | AStacin protease | 0.0074 | 0.201 | 0.201 |
Brugia malayi | beta-lactamase | 0.0035 | 0.0039 | 0.0039 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0084 | 0.2515 | 0.364 |
Onchocerca volvulus | 0.0041 | 0.0338 | 0.0338 | |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.0038 | 0.0195 | 0.1183 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0061 | 0.136 | 0.1326 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0061 | 0.136 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0195 | 0.0195 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0039 | 0.0039 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0137 | 0.5217 | 0.5198 |
Schistosoma mansoni | hypothetical protein | 0.017 | 0.6908 | 1 |
Brugia malayi | Fibulin-1 precursor | 0.0038 | 0.0195 | 0.0195 |
Loa Loa (eye worm) | beta-lactamase | 0.0035 | 0.0039 | 0.0039 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0035 | 0.0039 | 0.0056 |
Onchocerca volvulus | Huntingtin homolog | 0.0123 | 0.4513 | 0.4513 |
Onchocerca volvulus | 0.0231 | 1 | 1 | |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0084 | 0.2515 | 0.364 |
Trypanosoma brucei | lipase domain protein, putative | 0.0231 | 1 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0084 | 0.2515 | 0.2515 |
Onchocerca volvulus | 0.0035 | 0.0039 | 0.0039 | |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0084 | 0.2515 | 0.2486 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0231 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0046 | 0.0046 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0038 | 0.0195 | 0.0195 |
Loa Loa (eye worm) | hypothetical protein | 0.0123 | 0.4513 | 0.4513 |
Echinococcus granulosus | Tolloid protein 1 | 0.0118 | 0.4257 | 0.4235 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0084 | 0.2515 | 0.2486 |
Mycobacterium ulcerans | hydrolase | 0.0035 | 0.0046 | 0.0052 |
Trichomonas vaginalis | lipase containing protein, putative | 0.0231 | 1 | 1 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0061 | 0.136 | 0.1379 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0035 | 0.0039 | 0.0039 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0084 | 0.2515 | 0.2515 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0084 | 0.2515 | 0.364 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0061 | 0.136 | 0.1326 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0064 | 0.1487 | 0.1487 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-A | 0.0041 | 0.0365 | 0.2474 |
Brugia malayi | hypothetical protein | 0.0123 | 0.4513 | 0.4513 |
Brugia malayi | Matrix metalloprotease, N-terminal domain containing protein | 0.0035 | 0.0046 | 0.0046 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0061 | 0.136 | 1 |
Mycobacterium leprae | PROBABLE HYDROLASE | 0.0035 | 0.0046 | 1 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.0141 | 0.5417 | 0.7842 |
Trichomonas vaginalis | lipase containing protein, putative | 0.0231 | 1 | 1 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.0105 | 0.3588 | 0.3563 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0084 | 0.2515 | 0.2486 |
Plasmodium vivax | histone acetyltransferase GCN5, putative | 0.0041 | 0.0365 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.