TDR Targets

Basic information

Technical information

TDR Targets ID: 873544
Name: N-(3-methylphenyl)-4-[(4-methylpiperidin-1-yl )methyl]piperidine-1-carboxamide
MW: 329.48 | Formula: C20H31N3O
H donors: 1 H acceptors: 1 LogP: 3.54 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: CC1CCN(CC1)CC1CCN(CC1)C(=O)Nc1cccc(c1)C
InChi: 1S/C20H31N3O/c1-16-6-10-22(11-7-16)15-18-8-12-23(13-9-18)20(24)21-19-5-3-4-17(2)14-19/h3-5,14,16,18H,6-13,15H2,1-2H3,(H,21,24)
InChiKey: ORLVIYKLSNOJRZ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-(3-methylphenyl)-4-[(4-methyl-1-piperidyl)methyl]piperidine-1-carboxamide
N-(3-methylphenyl)-4-[(4-methyl-1-piperidinyl)methyl]-1-piperidinecarboxamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	laminin	0.0038	0.0195	0.0157
Brugia malayi	Matrixin family protein	0.007	0.1804	0.1804
Echinococcus multilocularis	laminin	0.0038	0.0195	0.0157
Leishmania major	hypothetical protein, conserved	0.0231	1	1
Trypanosoma brucei	lipase domain protein, putative	0.0231	1	1
Schistosoma mansoni	aldehyde dehydrogenase	0.0061	0.136	0.1968
Onchocerca volvulus	Huntingtin homolog	0.0123	0.4513	0.4513
Echinococcus multilocularis	Tolloid protein 1	0.0118	0.4257	0.4235
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0084	0.2515	0.364
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0061	0.136	0.1326
Toxoplasma gondii	calcium binding egf domain-containing protein	0.0038	0.0195	0.1183
Onchocerca volvulus		0.0041	0.0338	0.0338
Loa Loa (eye worm)	AStacin protease	0.0074	0.201	0.201
Onchocerca volvulus		0.0035	0.0039	0.0039
Brugia malayi	beta-lactamase	0.0035	0.0039	0.0039
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0137	0.5217	0.5198
Brugia malayi	Fibulin-1 precursor	0.0038	0.0195	0.0195
Schistosoma mansoni	hypothetical protein	0.017	0.6908	1
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0039	0.0039
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0195	0.0195
Toxoplasma gondii	aldehyde dehydrogenase	0.0061	0.136	1
Trypanosoma brucei	lipase domain protein, putative	0.0231	1	1
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0084	0.2515	0.2515
Trypanosoma cruzi	hypothetical protein, conserved	0.0231	1	1
Onchocerca volvulus		0.0035	0.0039	0.0039
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0084	0.2515	0.2486
Loa Loa (eye worm)	beta-lactamase	0.0035	0.0039	0.0039
Onchocerca volvulus	Huntingtin homolog	0.0123	0.4513	0.4513
Onchocerca volvulus		0.0231	1	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0084	0.2515	0.364
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0035	0.0039	0.0056
Brugia malayi	Calcium binding EGF domain containing protein	0.0038	0.0195	0.0195
Loa Loa (eye worm)	hypothetical protein	0.0123	0.4513	0.4513
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0084	0.2515	0.2486
Echinococcus granulosus	Tolloid protein 1	0.0118	0.4257	0.4235
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0046	0.0046
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0084	0.2515	0.2515
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0035	0.0039	0.0039
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0061	0.136	0.1379
Mycobacterium ulcerans	hydrolase	0.0035	0.0046	0.0052
Trichomonas vaginalis	lipase containing protein, putative	0.0231	1	1
Brugia malayi	hypothetical protein	0.0123	0.4513	0.4513
Brugia malayi	Matrix metalloprotease, N-terminal domain containing protein	0.0035	0.0046	0.0046
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0061	0.136	0.1326
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0084	0.2515	0.364
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.0041	0.0365	0.2474
Brugia malayi	latrophilin 2 splice variant baaae	0.0064	0.1487	0.1487
Trichomonas vaginalis	lipase containing protein, putative	0.0231	1	1
Echinococcus multilocularis	matrix metallopeptidase 7 (M10 family)	0.0105	0.3588	0.3563
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.0141	0.5417	0.7842
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0041	0.0365	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0084	0.2515	0.2486
Mycobacterium leprae	PROBABLE HYDROLASE	0.0035	0.0046	1
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0061	0.136	1
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0039	0.0039
Schistosoma mansoni	aldehyde dehydrogenase	0.0061	0.136	0.1968
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0093	0.2979	0.2979
Schistosoma mansoni	hypothetical protein	0.0064	0.1487	0.2152
Brugia malayi	beta-lactamase family protein	0.0035	0.0039	0.0039
Giardia lamblia	Histone acetyltransferase GCN5	0.0038	0.019	0.5
Echinococcus multilocularis	geminin	0.017	0.6908	0.6896
Loa Loa (eye worm)	hypothetical protein	0.0113	0.4014	0.4014
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0061	0.136	1
Loa Loa (eye worm)	matrixin family protein	0.007	0.1804	0.1804
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0224	0.9619	1
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0041	0.0365	0.0328
Onchocerca volvulus	Matrilysin homolog	0.0064	0.1511	0.1511
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0061	0.136	1
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0093	0.2979	0.2979
Loa Loa (eye worm)	acetyltransferase	0.0141	0.5417	0.5417
Schistosoma mansoni	subfamily M12A unassigned peptidase (M12 family)	0.0118	0.4257	0.6163
Loa Loa (eye worm)	lipase	0.0231	1	1
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0039	0.0039
Echinococcus granulosus	geminin	0.017	0.6908	0.6896
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0039	0.0039
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0039	0.0039
Schistosoma mansoni	hypothetical protein	0.017	0.6908	1
Onchocerca volvulus		0.0035	0.0039	0.0039
Loa Loa (eye worm)	hypothetical protein	0.0123	0.4513	0.4513
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0039	0.0039
Loa Loa (eye worm)	hypothetical protein	0.0093	0.2979	0.2979
Echinococcus multilocularis	sn1 specific diacylglycerol lipase beta	0.0231	1	1
Loa Loa (eye worm)	hypothetical protein	0.0064	0.1487	0.1487
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0041	0.0365	0.0328
Entamoeba histolytica	acetyltransferase, GNAT family	0.0038	0.019	0.5
Brugia malayi	Hemopexin family protein	0.0041	0.0338	0.0338
Echinococcus granulosus	matrix metallopeptidase 7 M10 family	0.0105	0.3588	0.3563
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0061	0.136	0.1326
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	0.0041	0.0365	0.0328
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0084	0.2515	0.2486
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.0041	0.0365	0.2474
Mycobacterium tuberculosis	Probable peptidoglycan hydrolase	0.0035	0.0046	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0703	0.0703
Loa Loa (eye worm)	matrixin family protein	0.0064	0.1511	0.1511
Trypanosoma cruzi	hypothetical protein, conserved	0.0231	1	1
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.0141	0.5417	0.54
Onchocerca volvulus	Matrix metalloproteinase homolog	0.0064	0.1511	0.1511
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0035	0.0039	0.0056
Loa Loa (eye worm)	bone morphogenetic protein 1b	0.0118	0.4257	0.4257
Echinococcus granulosus	sn1 specific diacylglycerol lipase beta	0.0231	1	1
Toxoplasma gondii	calcium binding egf domain-containing protein	0.0038	0.0195	0.1183
Schistosoma mansoni	hypothetical protein	0.0041	0.0338	0.049
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0035	0.0039	0.0039
Loa Loa (eye worm)	multiple epidermal growth factor-like domains 6	0.0038	0.0195	0.0195
Brugia malayi	acetyltransferase, GNAT family protein	0.0141	0.5417	0.5417
Echinococcus multilocularis	fibrillin 1	0.0038	0.0195	0.0157
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0093	0.2979	0.2979
Brugia malayi	beta-lactamase family protein	0.0035	0.0039	0.0039
Plasmodium falciparum	histone acetyltransferase GCN5	0.0038	0.019	0.5

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 873544