TDR Targets

Basic information

Technical information

TDR Targets ID: 874330
Name: N-butyl-1-[[1-(cyclopropanecarbonyl)-2-methyl -2,3-dihydroindol-5-yl]sulfonyl]-N-methylpipe ridine-4-carboxamide
MW: 461.617 | Formula: C24H35N3O4S
H donors: 0 H acceptors: 4 LogP: 2.56 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: CCCCN(C(=O)C1CCN(CC1)S(=O)(=O)c1ccc2c(c1)CC(N2C(=O)C1CC1)C)C
InChi: 1S/C24H35N3O4S/c1-4-5-12-25(3)23(28)19-10-13-26(14-11-19)32(30,31)21-8-9-22-20(16-21)15-17(2)27(22)24(29)18-6-7-18/h8-9,16-19H,4-7,10-15H2,1-3H3
InChiKey: UXNHOMOLEYZBMT-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-butyl-1-[1-(cyclopropanecarbonyl)-2-methyl-indolin-5-yl]sulfonyl-N-methyl-piperidine-4-carboxamide
N-butyl-1-[[1-(cyclopropyl-oxomethyl)-2-methyl-5-indolinyl]sulfonyl]-N-methyl-4-piperidinecarboxamide
N-butyl-1-[1-(cyclopropanecarbonyl)-2-methyl-indolin-5-yl]sulfonyl-N-methyl-isonipecotamide
N-butyl-1-[(1-cyclopropylcarbonyl-2-methyl-2,3-dihydroindol-5-yl)sulfonyl]-N-methyl-piperidine-4-carboxamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	hypothetical protein	0.0416	0.1131	0.1131
Schistosoma mansoni	hypothetical protein	0.0416	0.1131	0.1131
Loa Loa (eye worm)	hypothetical protein	0.0336	0.0686	0.0686
Brugia malayi	Chymotrypsin-like protease CTRL-1 precursor	0.0336	0.0686	0.0814
Schistosoma mansoni	carbonic anhydrase	0.0442	0.1276	0.1276
Echinococcus granulosus	carbonic anhydrase II	0.0761	0.305	0.305
Loa Loa (eye worm)	hypothetical protein	0.0416	0.1131	0.1131
Onchocerca volvulus		0.0336	0.0686	0.0814
Loa Loa (eye worm)	hypothetical protein	0.0336	0.0686	0.0686
Echinococcus multilocularis	carbonic anhydrase	0.0442	0.1276	0.1276
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0442	0.1276	0.1515
Loa Loa (eye worm)	hypothetical protein	0.1091	0.4891	0.4891
Loa Loa (eye worm)	notch protein	0.0416	0.1131	0.1131
Loa Loa (eye worm)	hypothetical protein	0.1091	0.4891	0.4891
Echinococcus multilocularis	fibropellin Ia	0.0416	0.1131	0.1131
Echinococcus multilocularis	laminin	0.1091	0.4891	0.4891
Loa Loa (eye worm)	hypothetical protein	0.0442	0.1276	0.1276
Schistosoma mansoni	aminopeptidase PILS (M01 family)	0.0336	0.0686	0.0686
Brugia malayi	GCC2 and GCC3 family protein	0.0416	0.1131	0.1342
Brugia malayi	EGF-like domain containing protein	0.0416	0.1131	0.1342
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0336	0.0686	0.0686
Echinococcus multilocularis	neurogenic locus notch protein 4	0.0416	0.1131	0.1131
Brugia malayi	Muscle positioning protein 4	0.0416	0.1131	0.1342
Loa Loa (eye worm)	hypothetical protein	0.0613	0.2226	0.2226
Loa Loa (eye worm)	hypothetical protein	0.0336	0.0686	0.0686
Brugia malayi	Fibulin-1 precursor	0.1091	0.4891	0.5806
Echinococcus multilocularis	protein jagged 1	0.0416	0.1131	0.1131
Plasmodium vivax	cysteine repeat modular protein 1, putative	0.0213	0	0.5
Echinococcus multilocularis	neurogenic locus notch protein	0.0416	0.1131	0.1131
Loa Loa (eye worm)	hypothetical protein	0.0336	0.0686	0.0686
Echinococcus granulosus	carbonic anhydrase	0.0442	0.1276	0.1276
Schistosoma mansoni	cercarial elastase (S01 family)	0.0336	0.0686	0.0686
Echinococcus multilocularis	carbonic anhydrase II	0.0761	0.305	0.305
Trypanosoma cruzi	carbonic anhydrase-like protein, putative	0.0761	0.305	1
Onchocerca volvulus		0.0416	0.1131	0.1342
Echinococcus granulosus	carbonic anhydrase	0.0442	0.1276	0.1276
Trypanosoma cruzi	carbonic anhydrase-like protein, putative	0.0761	0.305	1
Onchocerca volvulus	Neurogenic locus notch homolog	0.0416	0.1131	0.1342
Echinococcus granulosus	delta-like protein 1	0.0416	0.1131	0.1131
Schistosoma mansoni	notch	0.0416	0.1131	0.1131
Loa Loa (eye worm)	Notch2	0.0416	0.1131	0.1131
Onchocerca volvulus		0.0416	0.1131	0.1342
Echinococcus multilocularis	carbonic anhydrase	0.0442	0.1276	0.1276
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0336	0.0686	0.0686
Schistosoma mansoni	cercarial elastase (S01 family)	0.0336	0.0686	0.0686
Schistosoma mansoni	cercarial elastase (S01 family)	0.0336	0.0686	0.0686
Echinococcus multilocularis	protein jagged 2	0.0416	0.1131	0.1131
Schistosoma mansoni	notch	0.0416	0.1131	0.1131
Loa Loa (eye worm)	hypothetical protein	0.0416	0.1131	0.1131
Loa Loa (eye worm)	low-density lipoprotein receptor repeat class B containing protein	0.1091	0.4891	0.4891
Onchocerca volvulus	Slit protein homolog	0.0416	0.1131	0.1342
Loa Loa (eye worm)	eukaryotic-type carbonic anhydrase	0.0442	0.1276	0.1276
Schistosoma mansoni	notch	0.0416	0.1131	0.1131
Loa Loa (eye worm)	hypothetical protein	0.1091	0.4891	0.4891
Schistosoma mansoni	cercarial elastase (S01 family)	0.0336	0.0686	0.0686
Onchocerca volvulus		0.0336	0.0686	0.0814
Brugia malayi	Calcium binding EGF domain containing protein	0.1091	0.4891	0.5806
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0336	0.0686	0.0686
Schistosoma mansoni	hypothetical protein	0.0416	0.1131	0.1131
Loa Loa (eye worm)	carbonic anhydrase 3	0.0761	0.305	0.305
Schistosoma mansoni	cercarial elastase (S01 family)	0.0336	0.0686	0.0686
Echinococcus granulosus	neurogenic locus notch protein 4	0.0416	0.1131	0.1131
Echinococcus granulosus	neurogenic locus notch protein	0.0416	0.1131	0.1131
Brugia malayi	Low-density lipoprotein receptor repeat class B containing protein	0.1091	0.4891	0.5806
Loa Loa (eye worm)	hypothetical protein	0.0416	0.1131	0.1131
Echinococcus granulosus	carbonic anhydrase	0.0442	0.1276	0.1276
Loa Loa (eye worm)	hypothetical protein	0.0416	0.1131	0.1131
Loa Loa (eye worm)	hypothetical protein	0.0416	0.1131	0.1131
Onchocerca volvulus	Putative cubilin	0.0416	0.1131	0.1342
Loa Loa (eye worm)	hypothetical protein	0.1091	0.4891	0.4891
Schistosoma mansoni	cercarial elastase (S01 family)	0.0336	0.0686	0.0686
Echinococcus granulosus	neurogenic locus protein delta	0.0416	0.1131	0.1131
Brugia malayi	EGF-like domain containing protein	0.0416	0.1131	0.1342
Loa Loa (eye worm)	hypothetical protein	0.0416	0.1131	0.1131
Brugia malayi	EGF-like domain containing protein	0.0416	0.1131	0.1342
Brugia malayi	notch-like transmembrane receptor	0.0416	0.1131	0.1342
Brugia malayi	Trypsin family protein	0.0336	0.0686	0.0814
Echinococcus multilocularis	carbonic anhydrase	0.0442	0.1276	0.1276
Onchocerca volvulus		0.0336	0.0686	0.0814
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0761	0.305	0.3621
Echinococcus multilocularis	neurogenic locus protein delta	0.0416	0.1131	0.1131
Brugia malayi	Transmembrane cell adhesion receptor mua-3 precursor, putative	0.0416	0.1131	0.1342
Schistosoma mansoni	hypothetical protein	0.0416	0.1131	0.1131
Toxoplasma gondii	calcium binding egf domain-containing protein	0.1091	0.4891	1
Echinococcus multilocularis	neurogenic locus protein delta	0.0416	0.1131	0.1131
Echinococcus multilocularis	subfamily S1A unassigned peptidase (S01 family)	0.0336	0.0686	0.0686
Loa Loa (eye worm)	hypothetical protein	0.0416	0.1131	0.1131
Brugia malayi	Calcium binding EGF domain containing protein	0.0416	0.1131	0.1342
Echinococcus multilocularis	neurogenic locus notch protein	0.0416	0.1131	0.1131
Toxoplasma gondii	calcium binding egf domain-containing protein	0.1091	0.4891	1
Schistosoma mansoni	carbonic anhydrase II (carbonate dehydratase II)	0.0761	0.305	0.305
Leishmania major	carbonic anhydrase-like protein	0.0761	0.305	1
Brugia malayi	EGF-like domain containing protein	0.0416	0.1131	0.1342
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.1725	0.8424	0.8424
Brugia malayi	EGF-like domain containing protein	0.0416	0.1131	0.1342
Echinococcus multilocularis	small conductance calcium activated potassium	0.2008	1	1
Schistosoma mansoni	septate junction protein	0.0416	0.1131	0.1131
Schistosoma mansoni	hypothetical protein	0.2008	1	1
Schistosoma mansoni	cercarial elastase (S01 family)	0.0336	0.0686	0.0686
Schistosoma mansoni	subfamily M12A unassigned peptidase (M12 family)	0.1091	0.4891	0.4891
Giardia lamblia	High cysteine protein	0.0416	0.1131	0.5
Loa Loa (eye worm)	hypothetical protein	0.0416	0.1131	0.1131
Loa Loa (eye worm)	hypothetical protein	0.2008	1	1
Schistosoma mansoni	hypothetical protein	0.0336	0.0686	0.0686
Schistosoma mansoni	notch	0.0416	0.1131	0.1131
Brugia malayi	Trypsin family protein	0.0336	0.0686	0.0814
Echinococcus multilocularis	Peptidase S1 S6, chymotrypsin Hap	0.0336	0.0686	0.0686
Toxoplasma gondii	EGF family domain-containing protein	0.0416	0.1131	0.2312
Schistosoma mansoni	cercarial elastase (S01 family)	0.0336	0.0686	0.0686
Loa Loa (eye worm)	multiple epidermal growth factor-like domains 6	0.1091	0.4891	0.4891
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0336	0.0686	0.0686
Plasmodium falciparum	carbonic anhydrase	0.0442	0.1276	1
Echinococcus multilocularis	protein jagged 1	0.0416	0.1131	0.1131
Schistosoma mansoni	cercarial elastase (S01 family)	0.0336	0.0686	0.0686
Loa Loa (eye worm)	hypothetical protein	0.0683	0.2616	0.2616
Echinococcus multilocularis	Mastin	0.0336	0.0686	0.0686
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0442	0.1276	0.1515
Onchocerca volvulus		0.0416	0.1131	0.1342
Loa Loa (eye worm)	hypothetical protein	0.0416	0.1131	0.1131
Schistosoma mansoni	notch	0.0416	0.1131	0.1131
Echinococcus granulosus	protein jagged 1	0.0416	0.1131	0.1131
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.1725	0.8424	0.8424
Brugia malayi	Cadherin domain containing protein	0.0416	0.1131	0.1342
Trypanosoma brucei	carbonic anhydrase-like protein	0.0761	0.305	0.5
Loa Loa (eye worm)	hypothetical protein	0.0913	0.3897	0.3897
Schistosoma mansoni	cercarial elastase (S01 family)	0.0336	0.0686	0.0686
Echinococcus granulosus	glycoprotein Antigen 5	0.0336	0.0686	0.0686
Echinococcus granulosus	slit 2 protein	0.0416	0.1131	0.1131
Schistosoma mansoni	laminin gamma-3 chain	0.0416	0.1131	0.1131
Brugia malayi	Carbonic anhydrase like protein 2 precursor	0.0442	0.1276	0.1515
Echinococcus granulosus	neurogenic locus notch protein	0.0416	0.1131	0.1131
Echinococcus granulosus	Tolloid protein 1	0.1091	0.4891	0.4891
Loa Loa (eye worm)	bone morphogenetic protein 1b	0.1091	0.4891	0.4891
Echinococcus granulosus	notch	0.0416	0.1131	0.1131
Loa Loa (eye worm)	hypothetical protein	0.0646	0.241	0.241
Loa Loa (eye worm)	hypothetical protein	0.0416	0.1131	0.1131
Loa Loa (eye worm)	eukaryotic-type carbonic anhydrase	0.0761	0.305	0.305
Schistosoma mansoni	cell polarity protein	0.0416	0.1131	0.1131
Schistosoma mansoni	egf-like domain protein	0.1091	0.4891	0.4891
Loa Loa (eye worm)	hypothetical protein	0.0416	0.1131	0.1131
Echinococcus multilocularis	neural cadherin	0.0416	0.1131	0.1131
Onchocerca volvulus		0.1389	0.655	0.7775
Schistosoma mansoni	slit	0.0416	0.1131	0.1131
Loa Loa (eye worm)	hypothetical protein	0.0416	0.1131	0.1131
Echinococcus multilocularis	transmembrane protease serine 3	0.0336	0.0686	0.0686
Loa Loa (eye worm)	hypothetical protein	0.0416	0.1131	0.1131
Loa Loa (eye worm)	hypothetical protein	0.0416	0.1131	0.1131
Loa Loa (eye worm)	hypothetical protein	0.1091	0.4891	0.4891
Schistosoma mansoni	Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)]	0.0416	0.1131	0.1131
Brugia malayi	EGF-like domain containing protein	0.0416	0.1131	0.1342
Loa Loa (eye worm)	hypothetical protein	0.0416	0.1131	0.1131
Onchocerca volvulus		0.0336	0.0686	0.0814
Loa Loa (eye worm)	hypothetical protein	0.0416	0.1131	0.1131
Onchocerca volvulus		0.0336	0.0686	0.0814
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0442	0.1276	0.1515
Echinococcus granulosus	enteropeptidase	0.0336	0.0686	0.0686
Echinococcus granulosus	subfamily S1A unassigned peptidase S01 family	0.0336	0.0686	0.0686
Mycobacterium ulcerans	hypothetical protein	0.0336	0.0686	0.5
Loa Loa (eye worm)	hypothetical protein	0.0416	0.1131	0.1131
Echinococcus granulosus	laminin	0.1091	0.4891	0.4891
Echinococcus multilocularis	glycoprotein Antigen 5	0.0336	0.0686	0.0686
Echinococcus multilocularis	fat cadherin tumor suppressor	0.0416	0.1131	0.1131
Schistosoma mansoni	calcium-activated potassium channel	0.1296	0.6031	0.6031
Echinococcus granulosus	neural cadherin	0.0416	0.1131	0.1131
Echinococcus multilocularis	slit 2 protein	0.0416	0.1131	0.1131
Echinococcus granulosus	fibropellin Ia	0.0416	0.1131	0.1131
Toxoplasma gondii	PAN domain-containing protein	0.0653	0.2447	0.5003
Brugia malayi	Trypsin family protein	0.0336	0.0686	0.0814
Loa Loa (eye worm)	trypsin family protein	0.0336	0.0686	0.0686
Echinococcus granulosus	protein jagged 1	0.0416	0.1131	0.1131
Loa Loa (eye worm)	hypothetical protein	0.0416	0.1131	0.1131
Echinococcus multilocularis	notch	0.0416	0.1131	0.1131
Loa Loa (eye worm)	hypothetical protein	0.1725	0.8424	0.8424
Loa Loa (eye worm)	hypothetical protein	0.0336	0.0686	0.0686
Schistosoma mansoni	carbonic anhydrase-related	0.0442	0.1276	0.1276
Onchocerca volvulus	Neurogenic locus notch protein homolog	0.0416	0.1131	0.1342
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0336	0.0686	0.0686
Echinococcus granulosus	transmembrane protease serine 3	0.0336	0.0686	0.0686
Onchocerca volvulus	Arrow homolog	0.1091	0.4891	0.5806
Brugia malayi	Calcium binding EGF domain containing protein	0.0416	0.1131	0.1342
Toxoplasma gondii	PAN domain-containing protein	0.0653	0.2447	0.5003
Echinococcus granulosus	Mastin	0.0336	0.0686	0.0686
Echinococcus granulosus	protein jagged 2	0.0416	0.1131	0.1131
Schistosoma mansoni	hypothetical protein	0.0442	0.1276	0.1276
Brugia malayi	Putative carbonic anhydrase 5 precursor	0.0761	0.305	0.3621
Loa Loa (eye worm)	hypothetical protein	0.0416	0.1131	0.1131
Echinococcus multilocularis	enteropeptidase	0.0336	0.0686	0.0686
Schistosoma mansoni	carbonic anhydrase II (carbonate dehydratase II)	0.0761	0.305	0.305
Brugia malayi	Calcium binding EGF domain containing protein	0.0416	0.1131	0.1342
Schistosoma mansoni	hypothetical protein	0.0336	0.0686	0.0686
Echinococcus multilocularis	Tolloid protein 1	0.1091	0.4891	0.4891
Loa Loa (eye worm)	hypothetical protein	0.0416	0.1131	0.1131
Toxoplasma gondii	hypothetical protein	0.0442	0.1276	0.2609
Echinococcus granulosus	Peptidase S1 S6 chymotrypsin Hap	0.0336	0.0686	0.0686
Loa Loa (eye worm)	hypothetical protein	0.0442	0.1276	0.1276
Loa Loa (eye worm)	hypothetical protein	0.0416	0.1131	0.1131
Schistosoma mansoni	notch	0.0416	0.1131	0.1131
Schistosoma mansoni	cercarial elastase (S01 family)	0.0336	0.0686	0.0686
Schistosoma mansoni	hypothetical protein	0.0416	0.1131	0.1131
Onchocerca volvulus		0.0416	0.1131	0.1342
Brugia malayi	Trypsin-like protease protein 5	0.0336	0.0686	0.0814
Brugia malayi	Trypsin family protein	0.1725	0.8424	1
Schistosoma mansoni	carbonic anhydrase-related	0.0442	0.1276	0.1276
Schistosoma mansoni	hypothetical protein	0.0416	0.1131	0.1131
Echinococcus granulosus	protein jagged 2	0.0416	0.1131	0.1131
Onchocerca volvulus		0.0416	0.1131	0.1342
Onchocerca volvulus		0.1725	0.8424	1
Brugia malayi	Cadherin domain containing protein	0.0416	0.1131	0.1342
Schistosoma mansoni	calcium-activated potassium channel	0.2008	1	1
Loa Loa (eye worm)	hypothetical protein	0.1725	0.8424	0.8424
Brugia malayi	hypothetical protein	0.0336	0.0686	0.0814
Schistosoma mansoni	hypothetical protein	0.0416	0.1131	0.1131
Brugia malayi	Delta serrate ligand family protein	0.0416	0.1131	0.1342
Schistosoma mansoni	carbonic anhydrase-related	0.0442	0.1276	0.1276
Echinococcus multilocularis	fibrillin 1	0.1091	0.4891	0.4891
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0979	0.4267	0.4267
Brugia malayi	Carbonic anhydrase like protein 2 precursor	0.0442	0.1276	0.1515
Brugia malayi	EGF-like domain containing protein	0.0416	0.1131	0.1342
Loa Loa (eye worm)	hypothetical protein	0.0416	0.1131	0.1131

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 874330