TDR Targets

Basic information

Technical information

TDR Targets ID: 875803
Name: ethyl 4-(2-morpholin-4-ylethylamino)-8-(trifl uoromethyl)quinoline-3-carboxylate
MW: 397.391 | Formula: C19H22F3N3O3
H donors: 1 H acceptors: 2 LogP: 3.49 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: CCOC(=O)c1cnc2c(c1NCCN1CCOCC1)cccc2C(F)(F)F
InChi: 1S/C19H22F3N3O3/c1-2-28-18(26)14-12-24-17-13(4-3-5-15(17)19(20,21)22)16(14)23-6-7-25-8-10-27-11-9-25/h3-5,12H,2,6-11H2,1H3,(H,23,24)
InChiKey: JHPRJSYWCQJWEK-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

ethyl 4-(2-morpholinoethylamino)-8-(trifluoromethyl)quinoline-3-carboxylate
4-(2-morpholinoethylamino)-8-(trifluoromethyl)-3-quinolinecarboxylic acid ethyl ester
4-(2-morpholinoethylamino)-8-(trifluoromethyl)quinoline-3-carboxylic acid ethyl ester

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0211	0.0521
Trichomonas vaginalis	penicillin-binding protein, putative	0.0079	0.062	0.2354
Brugia malayi	hypothetical protein	0.0038	0.0211	0.0573
Echinococcus granulosus	neuropeptide receptor A26	0.0038	0.0211	0.0191
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0038	0.0211	0.0191
Brugia malayi	Niemann-Pick C1 protein precursor	0.0101	0.0834	0.2266
Schistosoma mansoni	hypothetical protein	0.0038	0.0211	0.0191
Trypanosoma cruzi	hypothetical protein, conserved	0.0079	0.062	1
Brugia malayi	Dopamine receptor	0.0038	0.0211	0.0573
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.002	0.003	0.001
Echinococcus multilocularis	serotonin receptor	0.0038	0.0211	0.0191
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.002	0.003	0.001
Echinococcus multilocularis	neuropeptide Y receptor	0.0038	0.0211	0.0191
Loa Loa (eye worm)	hypothetical protein	0.0079	0.062	0.1638
Echinococcus multilocularis	g-protein coupled receptor	0.0038	0.0211	0.0191
Echinococcus granulosus	neuropeptide Y receptor	0.0038	0.0211	0.0191
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.002	0.003	0.001
Brugia malayi	hypothetical protein	0.0038	0.0211	0.0573
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.002	0.003	0.001
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0211	0.0521
Schistosoma mansoni	hypothetical protein	0.0038	0.0211	0.0191
Echinococcus granulosus	rhodopsin orphan GPCR	0.0038	0.0211	0.0191
Echinococcus granulosus	Niemann Pick C1 protein	0.0144	0.1265	0.1247
Trichomonas vaginalis	conserved hypothetical protein	0.0043	0.0261	0.0946
Brugia malayi	ImpB/MucB/SamB family protein	0.0019	0.002	0.0055
Schistosoma mansoni	thyroid hormone receptor	0.002	0.003	0.001
Trichomonas vaginalis	penicillin-binding protein, putative	0.0079	0.062	0.2354
Schistosoma mansoni	biogenic amine receptor	0.0038	0.0211	0.0191
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.002	0.003	0.001
Brugia malayi	hypothetical protein	0.0038	0.0211	0.0573
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0038	0.0211	0.0521
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0038	0.0211	0.0191
Onchocerca volvulus		0.0038	0.0211	0.0786
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0038	0.0211	0.0191
Onchocerca volvulus		0.0038	0.0211	0.0786
Loa Loa (eye worm)	hypothetical protein	0.002	0.003	0.0027
Trichomonas vaginalis	set domain proteins, putative	0.0251	0.2331	0.9068
Loa Loa (eye worm)	hypothetical protein	0.0294	0.2755	0.7469
Schistosoma mansoni	RAR-like nuclear receptor	0.002	0.003	0.001
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0211	0.0521
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0038	0.0211	0.0191
Onchocerca volvulus		0.0038	0.0211	0.0786
Brugia malayi	neuropeptide F receptor	0.0038	0.0211	0.0573
Echinococcus multilocularis	sterol regulatory element binding protein	0.0043	0.0261	0.0242
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0038	0.0211	0.0191
Echinococcus multilocularis	Niemann Pick C1 protein	0.0144	0.1265	0.1247
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0101	0.0834	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0227	0.2094	0.2078
Schistosoma mansoni	neuropeptide receptor	0.0038	0.0211	0.0191
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0079	0.062	0.1236
Brugia malayi	Serotonin receptor	0.0038	0.0211	0.0573
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.002	0.003	0.001
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0033	0.0155	0.0135
Loa Loa (eye worm)	hypothetical protein	0.007	0.0532	0.1397
Mycobacterium ulcerans	glutaminase	0.0275	0.2569	1
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.002	0.003	0.0082
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0038	0.0211	0.0191
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0211	0.0521
Echinococcus multilocularis	geminin	0.1022	1	1
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.002	0.003	0.001
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0507	0.4874	1
Brugia malayi	Serotonin receptor	0.0038	0.0211	0.0573
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.002	0.003	0.0082
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0211	0.0521
Echinococcus multilocularis	G protein coupled receptor 139	0.0038	0.0211	0.0191
Echinococcus granulosus	g protein coupled receptor	0.0038	0.0211	0.0191
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0038	0.0211	0.0191
Onchocerca volvulus		0.0038	0.0211	0.0786
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.002	0.003	0.0027
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.002	0.003	0.0082
Onchocerca volvulus		0.0038	0.0211	0.0786
Echinococcus granulosus	orexin receptor type 2	0.0038	0.0211	0.0191
Onchocerca volvulus		0.0038	0.0211	0.0786
Brugia malayi	glutaminase DH11.1	0.0275	0.2569	0.6976
Brugia malayi	hypothetical protein	0.0088	0.0706	0.1916
Schistosoma mansoni	hypothetical protein	0.0042	0.0246	0.0226
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0211	0.0521
Brugia malayi	Melatonin receptor type 1A	0.0038	0.0211	0.0573
Loa Loa (eye worm)	beta-lactamase	0.0079	0.062	0.1638
Brugia malayi	G protein-coupled receptor F59B2.13	0.0038	0.0211	0.0573
Echinococcus multilocularis	orexin receptor type 2	0.0038	0.0211	0.0191
Echinococcus multilocularis	g protein coupled receptor	0.0038	0.0211	0.0191
Echinococcus granulosus	fmrfamide receptor	0.0038	0.0211	0.0191
Schistosoma mansoni	coup transcription factor	0.002	0.003	0.001
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.003	0.0134	0.0114
Schistosoma mansoni	growth hormone secretagogue receptor	0.0038	0.0211	0.0191
Brugia malayi	beta-lactamase	0.0079	0.062	0.1684
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.002	0.003	0.0082
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0038	0.0211	0.0573
Mycobacterium leprae	conserved hypothetical protein	0.0079	0.062	0.5
Loa Loa (eye worm)	hypothetical protein	0.002	0.003	0.0027
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0227	0.2094	0.2078
Echinococcus multilocularis	serotonin receptor	0.0038	0.0211	0.0191
Schistosoma mansoni	hypothetical protein	0.0033	0.0155	0.0135
Echinococcus granulosus	neuropeptides capa receptor	0.0038	0.0211	0.0191
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0227	0.2094	0.5687
Echinococcus multilocularis	dro:myosuppressin receptor	0.0038	0.0211	0.0191
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0146	0.0343
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0038	0.0211	0.0191
Trypanosoma brucei	PAB1-binding protein , putative	0.0026	0.0093	0.1211
Schistosoma mansoni	biogenic amine receptor	0.0038	0.0211	0.0191
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0211	0.0521
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.002	0.003	0.001
Onchocerca volvulus		0.0038	0.0211	0.0786
Brugia malayi	hypothetical protein	0.0038	0.0211	0.0573
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0227	0.2094	0.2078
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0211	0.0521
Echinococcus multilocularis	ecdysone induced protein 78C	0.002	0.003	0.001
Echinococcus granulosus	FTZ F1 alpha	0.002	0.003	0.001
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0038	0.0211	0.0573
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.002	0.003	0.001
Brugia malayi	photoreceptor-specific nuclear receptor	0.002	0.003	0.0082
Echinococcus granulosus	neuropeptide s receptor	0.0038	0.0211	0.0191
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0032	0.0146	0.0126
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.002	0.003	0.0027
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0211	0.0521
Onchocerca volvulus		0.0038	0.0211	0.0786
Schistosoma mansoni	hypothetical protein	0.0038	0.0211	0.0191
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0079	0.062	0.1236
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0211	0.0521
Echinococcus multilocularis	Niemann Pick C1 protein	0.0101	0.0834	0.0816
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0038	0.0211	0.0191
Brugia malayi	hypothetical protein	0.0038	0.0211	0.0573
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0032	0.0146	0.0126
Brugia malayi	putative neuropeptide receptor	0.0038	0.0211	0.0573
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0038	0.0211	0.0191
Onchocerca volvulus		0.0038	0.0211	0.0786
Schistosoma mansoni	amine GPCR	0.0038	0.0211	0.0191
Schistosoma mansoni	nuclear hormone receptor	0.002	0.003	0.001
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.002	0.003	0.0082
Brugia malayi	G-protein coupled receptor	0.0038	0.0211	0.0573
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0033	0.0155	0.0135
Echinococcus multilocularis	protein dispatched 1	0.0049	0.0322	0.0303
Echinococcus granulosus	Protein patched homolog 1	0.0043	0.0261	0.0242
Echinococcus granulosus	beta LACTamase domain containing family member	0.0079	0.062	0.0601
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.002	0.003	0.0082
Echinococcus multilocularis	thyroid hormone receptor alpha	0.002	0.003	0.001
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0038	0.0211	0.0191
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0211	0.0521
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0102	0.085	0.0831
Brugia malayi	Dopamine receptor protein 2	0.0038	0.0211	0.0573
Onchocerca volvulus		0.0038	0.0211	0.0786
Trypanosoma cruzi	PAB1-binding protein , putative	0.0026	0.0093	0.1211
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.002	0.003	0.0027
Echinococcus granulosus	hypothetical protein	0.0038	0.0211	0.0191
Echinococcus granulosus	tm gpcr rhodopsin	0.0038	0.0211	0.0191
Schistosoma mansoni	hypothetical protein	0.0038	0.0211	0.0191
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0038	0.0211	0.0786
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0038	0.0211	0.0573
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0038	0.0211	0.0191
Brugia malayi	Latrophilin receptor protein 2	0.0033	0.0155	0.0422
Schistosoma mansoni	amine GPCR	0.0038	0.0211	0.0191
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0227	0.2094	0.5663
Loa Loa (eye worm)	steroid hormone receptor	0.002	0.003	0.0027
Schistosoma mansoni	adenoreceptor	0.0038	0.0211	0.0191
Brugia malayi	hypothetical protein	0.0038	0.0211	0.0573
Echinococcus granulosus	histone lysine methyltransferase setb	0.0032	0.0146	0.0126
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.002	0.003	0.001
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0211	0.0521
Trypanosoma brucei	hypothetical protein, conserved	0.0079	0.062	1
Echinococcus granulosus	sex peptide receptor	0.0038	0.0211	0.0191
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0038	0.0211	0.0191
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0807	0.7861	0.7857
Echinococcus granulosus	neuropeptide receptor	0.0038	0.0211	0.0191
Echinococcus granulosus	neuropeptide FF receptor 2	0.0038	0.0211	0.0191
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.002	0.003	0.0082
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0032	0.0146	0.0126
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0038	0.0211	0.0573
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0032	0.0146	0.1003
Schistosoma mansoni	amine GPCR	0.0038	0.0211	0.0191
Echinococcus granulosus	allatostatin A receptor	0.0038	0.0211	0.0191
Brugia malayi	hypothetical protein	0.0038	0.0211	0.0573
Loa Loa (eye worm)	glutaminase	0.0275	0.2569	0.696
Echinococcus multilocularis	fmrfamide receptor	0.0038	0.0211	0.0191
Loa Loa (eye worm)	hypothetical protein	0.002	0.003	0.0027
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0211	0.0521
Echinococcus granulosus	7TM GPCR rhodopsin	0.0038	0.0211	0.0191
Schistosoma mansoni	neuropeptide f receptor 76f	0.0038	0.0211	0.0191
Onchocerca volvulus		0.0251	0.2331	1
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0038	0.0211	0.0191
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0038	0.0211	0.0191
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0038	0.0211	0.0191
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0032	0.0146	0.0126
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.002	0.003	0.001
Loa Loa (eye worm)	STE/STE20/TAO protein kinase	0.0387	0.3682	1
Trichomonas vaginalis	D-aminoacylase, putative	0.0079	0.062	0.2354
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0038	0.0211	0.0191
Schistosoma mansoni	patched 1	0.0043	0.0261	0.0242
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0706	0.1872
Loa Loa (eye worm)	hypothetical protein	0.0103	0.0856	0.2283
Echinococcus granulosus	tm gpcr rhodopsin	0.0038	0.0211	0.0191
Echinococcus granulosus	biogenic amine 5HT receptor	0.0038	0.0211	0.0191
Plasmodium falciparum	ataxin-2 like protein, putative	0.0026	0.0093	0.5
Mycobacterium tuberculosis	Probable esterase LipL	0.0079	0.062	0.1236
Schistosoma mansoni	histamine h1 receptor	0.0038	0.0211	0.0191
Leishmania major	hypothetical protein, conserved	0.0026	0.0093	0.1211
Plasmodium vivax	hypothetical protein, conserved	0.0079	0.062	1
Onchocerca volvulus		0.0038	0.0211	0.0786
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0033	0.0155	0.0422
Schistosoma mansoni	hypothetical protein	0.0033	0.0155	0.0135
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0211	0.0521
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0033	0.0155	0.0135
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0211	0.0521
Echinococcus multilocularis	g protein coupled receptor	0.0038	0.0211	0.0191
Echinococcus granulosus	neuropeptides capa receptor	0.0038	0.0211	0.0191
Brugia malayi	hypothetical protein	0.0026	0.0093	0.0252
Echinococcus granulosus	ecdysone induced protein 78C	0.002	0.003	0.001
Onchocerca volvulus		0.0038	0.0211	0.0786
Onchocerca volvulus		0.0038	0.0211	0.0786
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0038	0.0211	0.0191
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.002	0.003	0.0082
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0038	0.0211	0.0191
Schistosoma mansoni	neuropeptide receptor	0.0038	0.0211	0.0191
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0038	0.0211	0.0521
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0038	0.0211	0.0191
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0038	0.0211	0.0191
Schistosoma mansoni	hypothetical protein	0.0042	0.0246	0.0226
Echinococcus granulosus	rhodopsin orphan GPCR	0.0038	0.0211	0.0191
Echinococcus granulosus	muscleblind protein	0.0294	0.2755	0.274
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0211	0.0521
Loa Loa (eye worm)	melatonin receptor type 1A	0.0038	0.0211	0.0521
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0211	0.0521
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.002	0.003	0.0082
Onchocerca volvulus		0.0079	0.062	0.2564
Echinococcus multilocularis	protein patched	0.0043	0.0261	0.0242
Loa Loa (eye worm)	hypothetical protein	0.002	0.003	0.0027
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0155	0.0368
Brugia malayi	nuclear receptor NHR-88	0.002	0.003	0.0082
Echinococcus multilocularis	FTZ F1 alpha	0.002	0.003	0.001
Brugia malayi	putative neuropeptide receptor NPR1	0.0038	0.0211	0.0573
Brugia malayi	Steroid receptor seven-up type 2	0.002	0.003	0.0082
Echinococcus multilocularis	neuropeptide s receptor	0.0038	0.0211	0.0191
Onchocerca volvulus		0.0038	0.0211	0.0786
Echinococcus granulosus	G protein coupled receptor 139	0.0038	0.0211	0.0191
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0211	0.0521
Schistosoma mansoni	glutaminase	0.0275	0.2569	0.2553
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.002	0.003	0.0082
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0211	0.0521
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.002	0.003	0.001
Brugia malayi	larval opioid receptor	0.0038	0.0211	0.0573
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0227	0.2094	0.2078
Echinococcus granulosus	7tm_1 domain containing protein	0.0038	0.0211	0.0191
Onchocerca volvulus		0.0038	0.0211	0.0786
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.002	0.003	0.0082
Loa Loa (eye worm)	hypothetical protein	0.0079	0.062	0.1638
Mycobacterium tuberculosis	Conserved protein	0.0079	0.062	0.1236
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0211	0.0521
Echinococcus granulosus	GPCR family 2	0.0033	0.0155	0.0135
Schistosoma mansoni	hypothetical protein	0.1022	1	1
Trichomonas vaginalis	D-aminoacylase, putative	0.0079	0.062	0.2354
Trichomonas vaginalis	esterase, putative	0.0079	0.062	0.2354
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0211	0.0521
Schistosoma mansoni	hypothetical protein	0.1022	1	1
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0033	0.0155	0.0135
Echinococcus granulosus	g protein coupled receptor	0.0038	0.0211	0.0191
Schistosoma mansoni	opsin-like receptor	0.0038	0.0211	0.0191
Echinococcus multilocularis	somatostatin receptor	0.0038	0.0211	0.0191
Brugia malayi	hypothetical protein	0.0038	0.0211	0.0573
Brugia malayi	steroid hormone receptor	0.002	0.003	0.0082
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0038	0.0211	0.0191
Brugia malayi	nuclear hormone receptor	0.002	0.003	0.0082
Schistosoma mansoni	neuropeptide receptor	0.0038	0.0211	0.0191
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0032	0.0146	0.0126
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.002	0.003	0.0082
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0211	0.0521
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0211	0.0521
Giardia lamblia	DINP protein human, muc B family	0.0019	0.002	0.5
Schistosoma mansoni	hypothetical protein	0.0033	0.0155	0.0135
Loa Loa (eye worm)	G-protein coupled receptor	0.0038	0.0211	0.0521
Echinococcus granulosus	rhodopsin orphan GPCR	0.0038	0.0211	0.0191
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0038	0.0211	0.0191
Echinococcus multilocularis	fmrfamide receptor	0.0038	0.0211	0.0191
Echinococcus granulosus	serotonin receptor	0.0038	0.0211	0.0191
Schistosoma mansoni	biogenic amine receptor	0.0038	0.0211	0.0191
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0038	0.0211	0.0521
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.002	0.003	0.0027
Echinococcus granulosus	rhodopsin orphan GPCR	0.0038	0.0211	0.0191
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0038	0.0211	0.0191
Echinococcus granulosus	rhodopsin orphan GPCR	0.0038	0.0211	0.0191
Echinococcus granulosus	biogenic amine 5HT receptor	0.0038	0.0211	0.0191
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0079	0.062	0.1236
Loa Loa (eye worm)	TYRA-2 protein	0.0038	0.0211	0.0521
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0211	0.0521
Schistosoma mansoni	amine GPCR	0.0038	0.0211	0.0191
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.002	0.003	0.0082
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0103	0.0856	0.2283
Brugia malayi	CHE-14 protein	0.0043	0.0261	0.071
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0038	0.0211	0.0191
Schistosoma mansoni	neuropeptide receptor	0.0038	0.0211	0.0191
Echinococcus multilocularis	neuropeptide receptor A26	0.0038	0.0211	0.0191
Brugia malayi	Pre-SET motif family protein	0.0032	0.0146	0.0396
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0211	0.0521
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0211	0.0521
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0038	0.0211	0.0191
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0038	0.0211	0.0191
Brugia malayi	ecdysteroid receptor	0.002	0.003	0.0082
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0211	0.0521
Loa Loa (eye worm)	hypothetical protein	0.0294	0.2755	0.7469
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0227	0.2094	0.2078
Schistosoma mansoni	eyes absent homolog	0.0088	0.0706	0.0687
Loa Loa (eye worm)	hypothetical protein	0.002	0.003	0.0027
Schistosoma mansoni	steroid hormone receptor ad4bp	0.002	0.003	0.001
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0358	0.0923
Loa Loa (eye worm)	hypothetical protein	0.002	0.003	0.0027
Toxoplasma gondii	ABC1 family protein	0.0079	0.062	1
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.002	0.003	0.001
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0038	0.0211	0.0191
Mycobacterium tuberculosis	Probable lipase LipD	0.0079	0.062	0.1236
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0038	0.0211	0.0191
Echinococcus multilocularis	allatostatin A receptor	0.0038	0.0211	0.0191
Leishmania major	hypothetical protein, conserved	0.0079	0.062	1
Loa Loa (eye worm)	G-protein coupled receptor	0.0038	0.0211	0.0521
Schistosoma mansoni	opsin-like receptor	0.0038	0.0211	0.0191
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.002	0.003	0.001
Schistosoma mansoni	hypothetical protein	0.0042	0.0246	0.0226
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0211	0.0521
Schistosoma mansoni	neuropeptide F-like receptor	0.0038	0.0211	0.0191
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0032	0.0146	0.0126
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0227	0.2094	0.2078
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0038	0.0211	0.0191
Schistosoma mansoni	opsin-like receptor	0.0038	0.0211	0.0191
Brugia malayi	G-protein coupled receptor	0.0038	0.0211	0.0573
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.002	0.003	0.0027
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0038	0.0211	0.0521
Echinococcus granulosus	neuropeptide receptor	0.0038	0.0211	0.0191
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0038	0.0211	0.0191
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0038	0.0211	0.0573
Mycobacterium ulcerans	esterase/lipase LipP	0.0079	0.062	0.2354
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0038	0.0211	0.0191
Echinococcus granulosus	rhodopsin orphan GPCR	0.0038	0.0211	0.0191
Onchocerca volvulus		0.0038	0.0211	0.0786
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0038	0.0211	0.0191
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0103	0.0856	0.2326
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0706	0.1872
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0103	0.0856	0.2326
Echinococcus multilocularis	neuropeptide receptor	0.0038	0.0211	0.0191
Brugia malayi	beta-lactamase family protein	0.0079	0.062	0.1684
Trichomonas vaginalis	D-aminoacylase, putative	0.0079	0.062	0.2354
Mycobacterium tuberculosis	Conserved protein	0.0079	0.062	0.1236
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0211	0.0521
Loa Loa (eye worm)	hypothetical protein	0.0079	0.062	0.1638
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0038	0.0211	0.0191
Loa Loa (eye worm)	hypothetical protein	0.0079	0.062	0.1638
Mycobacterium tuberculosis	Conserved protein	0.0079	0.062	0.1236
Echinococcus granulosus	Niemann Pick C1 protein	0.0101	0.0834	0.0816
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0038	0.0211	0.0191
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0079	0.062	0.1684
Onchocerca volvulus		0.0032	0.0146	0.0503
Mycobacterium tuberculosis	Probable hydrolase	0.0079	0.062	0.1236
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.002	0.003	0.001
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0038	0.0211	0.0191
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0038	0.0211	0.0191
Echinococcus granulosus	expressed conserved protein	0.0095	0.0774	0.0755
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0038	0.0211	0.0573
Mycobacterium ulcerans	lipase LipD	0.0079	0.062	0.2354
Echinococcus multilocularis	g protein coupled receptor	0.0038	0.0211	0.0191
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0211	0.0521
Echinococcus granulosus	rhodopsin orphan GPCR	0.0038	0.0211	0.0191
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0038	0.0211	0.0191
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0038	0.0211	0.0191
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0038	0.0211	0.0191
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.002	0.003	0.001
Echinococcus multilocularis	muscleblind protein	0.0294	0.2755	0.274
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0211	0.0521
Brugia malayi	hypothetical protein	0.0038	0.0211	0.0573
Loa Loa (eye worm)	hypothetical protein	0.0079	0.062	0.1638
Schistosoma mansoni	hypothetical protein	0.007	0.0532	0.0513
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0079	0.062	0.0601
Echinococcus multilocularis	GPCR, family 2	0.0033	0.0155	0.0135
Loa Loa (eye worm)	hypothetical protein	0.002	0.003	0.0027
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.002	0.003	0.0027
Brugia malayi	AKH receptor	0.0038	0.0211	0.0573
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0038	0.0211	0.0191
Echinococcus multilocularis	serine:threonine protein kinase TAO1	0.0387	0.3682	0.3669
Schistosoma mansoni	amine GPCR	0.0038	0.0211	0.0191
Brugia malayi	Nuclear hormone receptor-like 1	0.002	0.003	0.0082
Trypanosoma cruzi	PAB1-binding protein , putative	0.0026	0.0093	0.1211
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0211	0.0521
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0227	0.2094	0.2078
Brugia malayi	GnHR receptor homolog	0.0038	0.0211	0.0573
Onchocerca volvulus		0.0079	0.062	0.2564
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.002	0.003	0.0027
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0038	0.0211	0.0191
Loa Loa (eye worm)	neuropeptide F receptor	0.0038	0.0211	0.0521
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0211	0.0521
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0079	0.062	0.0601
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0211	0.0521
Brugia malayi	Serine/threonine-protein kinase SULU	0.0387	0.3682	1
Echinococcus multilocularis	neuropeptide receptor	0.0038	0.0211	0.0191
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0038	0.0211	0.0191
Schistosoma mansoni	hypothetical protein	0.0042	0.0246	0.0226
Brugia malayi	follicle stimulating hormone receptor	0.0038	0.0211	0.0573
Echinococcus granulosus	somatostatin receptor	0.0038	0.0211	0.0191
Echinococcus multilocularis	neuropeptides capa receptor	0.0038	0.0211	0.0191
Loa Loa (eye worm)	glutaminase 2	0.0275	0.2569	0.696
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0211	0.0521
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0038	0.0211	0.0191
Schistosoma mansoni	hypothetical protein	0.0033	0.0155	0.0135
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0079	0.062	0.2354
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0038	0.0211	0.0191
Loa Loa (eye worm)	hypothetical protein	0.0079	0.062	0.1638
Echinococcus granulosus	tm gpcr rhodopsin	0.0038	0.0211	0.0191
Echinococcus granulosus	g protein coupled receptor	0.0038	0.0211	0.0191
Onchocerca volvulus		0.0038	0.0211	0.0786
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0038	0.0211	0.0191
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0038	0.0211	0.0191
Brugia malayi	G protein-coupled receptor	0.0038	0.0211	0.0573
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0038	0.0211	0.0191
Echinococcus granulosus	serine:threonine protein kinase TAO1	0.0387	0.3682	0.3669
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0211	0.0521
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0211	0.0521
Brugia malayi	hypothetical protein	0.0387	0.3682	1
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0079	0.062	0.1638
Plasmodium falciparum	ataxin-2 like protein, putative	0.0026	0.0093	0.5
Brugia malayi	hypothetical protein	0.0038	0.0211	0.0573
Brugia malayi	ORL1-like opioid receptor	0.0038	0.0211	0.0573
Brugia malayi	Dopamine receptor protein 1	0.0038	0.0211	0.0573
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0038	0.0211	0.0191
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0211	0.0521
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0033	0.0155	0.0368
Loa Loa (eye worm)	neuropeptide F receptor	0.0038	0.0211	0.0521
Mycobacterium ulcerans	beta-lactamase	0.0079	0.062	0.2354
Echinococcus multilocularis	muscleblind protein 1	0.0294	0.2755	0.274
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0211	0.0521
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0211	0.0521
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0261	0.0658
Brugia malayi	ImpB/MucB/SamB family protein	0.0019	0.002	0.0055
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0211	0.0521
Schistosoma mansoni	myosin xvIII	0.0038	0.0211	0.0191
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0038	0.0211	0.0191
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0038	0.0211	0.0191
Echinococcus multilocularis	sex peptide receptor	0.0038	0.0211	0.0191
Mycobacterium ulcerans	hypothetical protein	0.0079	0.062	0.2354
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0038	0.0211	0.0191
Mycobacterium tuberculosis	Probable lipase LipE	0.0079	0.062	0.1236
Echinococcus granulosus	g-protein coupled receptor	0.0038	0.0211	0.0191
Schistosoma mansoni	retinoic acid receptor RXR	0.002	0.003	0.001
Loa Loa (eye worm)	hypothetical protein	0.0101	0.0834	0.2223
Onchocerca volvulus		0.0079	0.062	0.2564
Brugia malayi	latrophilin 2 splice variant baaae	0.007	0.0532	0.1444
Loa Loa (eye worm)	hypothetical protein	0.002	0.003	0.0027
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0211	0.0521
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0038	0.0211	0.0191
Brugia malayi	Pre-SET motif family protein	0.0221	0.2028	0.5507
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0221	0.2028	0.5482
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0093	0.0198
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0038	0.0211	0.0191
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.002	0.003	0.001
Schistosoma mansoni	serine/threonine protein kinase	0.0387	0.3682	0.3669
Brugia malayi	beta-lactamase family protein	0.0079	0.062	0.1684
Brugia malayi	Muscleblind-like protein	0.0294	0.2755	0.7483
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0038	0.0211	0.0786
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.002	0.003	0.001
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0038	0.0211	0.0191
Trichomonas vaginalis	glutaminase, putative	0.0275	0.2569	1
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0211	0.0521
Trypanosoma cruzi	hypothetical protein, conserved	0.0079	0.062	1
Schistosoma mansoni	neuropeptide F-like receptor	0.0038	0.0211	0.0191
Echinococcus multilocularis	expressed conserved protein	0.0095	0.0774	0.0755
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0038	0.0211	0.0191
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0211	0.0521
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0038	0.0211	0.0191
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0043	0.0261	0.0658
Schistosoma mansoni	thyroid hormone receptor	0.002	0.003	0.001
Plasmodium vivax	SET domain protein, putative	0.0032	0.0146	0.1003
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0038	0.0211	0.0521
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0079	0.062	0.0601
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.002	0.003	0.001
Brugia malayi	RE15519p	0.0038	0.0211	0.0573
Echinococcus granulosus	neuropeptide Y receptor	0.0038	0.0211	0.0191
Echinococcus multilocularis	neuropeptides capa receptor	0.0038	0.0211	0.0191
Brugia malayi	neuropeptide F receptor	0.0038	0.0211	0.0573
Echinococcus granulosus	sterol regulatory element binding protein	0.0043	0.0261	0.0242
Echinococcus granulosus	dro:myosuppressin receptor	0.0038	0.0211	0.0191
Mycobacterium leprae	Probable lipase LipE	0.0079	0.062	0.5
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0038	0.0211	0.0191
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0211	0.0521
Echinococcus multilocularis	neuropeptide Y receptor	0.0038	0.0211	0.0191
Brugia malayi	sulfakinin receptor protein	0.0038	0.0211	0.0573

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 875803