Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | thioredoxin reductase, putative | 0.0098 | 0.0318 | 0.5 |
Trichomonas vaginalis | C-MYB, putative | 0.0049 | 0.0072 | 0.9763 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0052 | 0.0083 | 0.0774 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.004 | 0.0022 | 0.2001 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0222 | 0.0956 | 0.1313 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.004 | 0.0022 | 0.0208 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0247 | 0.1082 | 0.0249 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.004 | 0.0022 | 0.0078 |
Schistosoma mansoni | hypothetical protein | 0.035 | 0.1604 | 1 |
Entamoeba histolytica | myb-like DNA-binding domain containing protein | 0.0049 | 0.0072 | 1 |
Entamoeba histolytica | myb-like DNA-binding domain containing protein | 0.0049 | 0.0072 | 1 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.004 | 0.0022 | 0.0199 |
Brugia malayi | TAR-binding protein | 0.0066 | 0.0155 | 0.1436 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0098 | 0.0318 | 0.2951 |
Trichomonas vaginalis | pc-MYB2, putative | 0.0049 | 0.0072 | 0.9763 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0098 | 0.0318 | 0.1931 |
Trichomonas vaginalis | r2r3-MYB transcription factor, putative | 0.005 | 0.0073 | 1 |
Brugia malayi | Thioredoxin reductase | 0.0098 | 0.0318 | 0.2951 |
Trichomonas vaginalis | MYB3r3, putative | 0.0049 | 0.0072 | 0.9763 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.0155 | 0.0964 |
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.004 | 0.0022 | 0.014 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0066 | 0.0155 | 0.1436 |
Brugia malayi | MH2 domain containing protein | 0.0246 | 0.1077 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0066 | 0.0155 | 0.0907 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.004 | 0.0022 | 0.0199 |
Echinococcus granulosus | dna polymerase eta | 0.0066 | 0.0156 | 0.0916 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0052 | 0.0083 | 0.0774 |
Schistosoma mansoni | hypothetical protein | 0.035 | 0.1604 | 1 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0222 | 0.0956 | 0.1313 |
Brugia malayi | glutathione reductase | 0.0098 | 0.0318 | 0.2951 |
Schistosoma mansoni | hypothetical protein | 0.0037 | 0.001 | 0.0063 |
Mycobacterium ulcerans | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | 0.1994 | 1 | 1 |
Schistosoma mansoni | DNA polymerase eta | 0.0066 | 0.0156 | 0.0973 |
Mycobacterium tuberculosis | Probable reductase | 0.0222 | 0.0956 | 0.1313 |
Trichomonas vaginalis | r2r3-MYB transcription factor, putative | 0.0049 | 0.0072 | 0.9763 |
Schistosoma mansoni | ATP synthase F0 subunit 6 | 0.0217 | 0.0928 | 0.5785 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0222 | 0.0956 | 0.1313 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0098 | 0.0318 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0052 | 0.0083 | 0.0774 |
Trichomonas vaginalis | r2r3-MYB transcription factor, putative | 0.0049 | 0.0072 | 0.9763 |
Loa Loa (eye worm) | RNA binding protein | 0.0066 | 0.0155 | 0.1436 |
Trypanosoma brucei | trypanothione reductase | 0.0098 | 0.0318 | 1 |
Entamoeba histolytica | myb-like DNA-binding domain containing protein | 0.0049 | 0.0072 | 1 |
Mycobacterium leprae | probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS | 0.0562 | 0.269 | 0.2841 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0083 | 0.0774 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0247 | 0.1082 | 0.1491 |
Plasmodium falciparum | thioredoxin reductase | 0.0098 | 0.0318 | 0.5 |
Leishmania major | DNA polymerase kappa, putative,DNA polymerase IV, putative | 0.004 | 0.0022 | 0.0199 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.0155 | 0.0964 |
Echinococcus multilocularis | tar DNA binding protein | 0.0066 | 0.0155 | 0.0907 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.0155 | 0.0964 |
Toxoplasma gondii | shikimate dehydrogenase substrate binding domain-containing protein | 0.0562 | 0.269 | 1 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0222 | 0.0956 | 0.1313 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.004 | 0.0022 | 0.0078 |
Echinococcus multilocularis | dna polymerase kappa | 0.004 | 0.0022 | 0.0078 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0246 | 0.1077 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0156 | 0.1449 |
Echinococcus multilocularis | dna polymerase eta | 0.0066 | 0.0156 | 0.0916 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.004 | 0.0022 | 0.014 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0037 | 0.001 | 0.0063 |
Entamoeba histolytica | myb-like DNA-binding domain containing protein | 0.0049 | 0.0072 | 1 |
Plasmodium vivax | glutathione reductase, putative | 0.0098 | 0.0318 | 0.5 |
Leishmania major | DNA polymerase eta, putative | 0.0066 | 0.0156 | 0.4633 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0066 | 0.0155 | 0.1436 |
Trichomonas vaginalis | MYB, putative | 0.005 | 0.0073 | 1 |
Plasmodium falciparum | glutathione reductase | 0.0098 | 0.0318 | 0.5 |
Mycobacterium leprae | PROBABLE NADH DEHYDROGENASE NDH | 0.0222 | 0.0956 | 0.0045 |
Trichomonas vaginalis | r2r3-MYB transcription factor, putative | 0.0049 | 0.0072 | 0.9763 |
Giardia lamblia | Myb 1-like protein | 0.005 | 0.0073 | 1 |
Brugia malayi | RNA binding protein | 0.0066 | 0.0155 | 0.1436 |
Trichomonas vaginalis | MYB72, putative | 0.0049 | 0.0072 | 0.9763 |
Echinococcus granulosus | geminin | 0.035 | 0.1604 | 1 |
Mycobacterium tuberculosis | Probable ATP synthase a chain AtpB (protein 6) | 0.0217 | 0.0928 | 0.1274 |
Leishmania major | DNA polymerase kappa, putative | 0.004 | 0.0022 | 0.0199 |
Trichomonas vaginalis | r2r3-MYB transcription factor, putative | 0.0049 | 0.0072 | 0.9763 |
Echinococcus granulosus | dna polymerase kappa | 0.004 | 0.0022 | 0.0078 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0246 | 0.1077 | 1 |
Trichomonas vaginalis | r2r3-MYB transcription factor, putative | 0.0049 | 0.0072 | 0.9763 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0066 | 0.0156 | 0.1449 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0098 | 0.0318 | 0.1931 |
Entamoeba histolytica | myb-like DNA-binding domain containing protein | 0.0049 | 0.0072 | 1 |
Mycobacterium leprae | PROBABLE UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE MURA | 0.1432 | 0.713 | 1 |
Leishmania major | trypanothione reductase | 0.0098 | 0.0318 | 1 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0066 | 0.0156 | 0.4524 |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.004 | 0.0022 | 0.0208 |
Trichomonas vaginalis | pc-MYB2, putative | 0.0049 | 0.0072 | 0.9763 |
Loa Loa (eye worm) | glutathione reductase | 0.0098 | 0.0318 | 0.2951 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.0155 | 0.0964 |
Toxoplasma gondii | Myb family DNA-binding domain-containing protein | 0.005 | 0.0073 | 0.0212 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.004 | 0.0022 | 0.0199 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0098 | 0.0318 | 0.0416 |
Trichomonas vaginalis | r2r3-MYB transcription factor, putative | 0.0049 | 0.0072 | 0.9763 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0222 | 0.0956 | 0.1313 |
Toxoplasma gondii | thioredoxin reductase | 0.0098 | 0.0318 | 0.1128 |
Trichomonas vaginalis | C-MYB, putative | 0.0049 | 0.0072 | 0.9763 |
Treponema pallidum | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | 0.1994 | 1 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.0155 | 0.0964 |
Mycobacterium tuberculosis | Probable UDP-N-acetylglucosamine 1-carboxyvinyltransferase MurA | 0.1432 | 0.713 | 1 |
Wolbachia endosymbiont of Brugia malayi | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | 0.1994 | 1 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0066 | 0.0155 | 0.1436 |
Mycobacterium ulcerans | 3-phosphoshikimate 1-carboxyvinyltransferase | 0.0562 | 0.269 | 0.2673 |
Trichomonas vaginalis | r2r3-MYB transcription factor, putative | 0.005 | 0.0073 | 1 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0247 | 0.1082 | 0.1491 |
Echinococcus multilocularis | geminin | 0.035 | 0.1604 | 1 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.004 | 0.0022 | 0.0199 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0066 | 0.0156 | 0.4633 |
Mycobacterium ulcerans | F0F1 ATP synthase subunit A | 0.0217 | 0.0928 | 0.0908 |
Brugia malayi | hypothetical protein | 0.0037 | 0.001 | 0.0093 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0247 | 0.1082 | 0.1491 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.