Detailed information for compound 893325

Basic information

Technical information
  • TDR Targets ID: 893325
  • Name: (5E)-5-[(3-hydroxyphenyl)methylidene]-1-(4-me thylphenyl)-1,3-diazinane-2,4,6-trione
  • MW: 322.315 | Formula: C18H14N2O4
  • H donors: 2 H acceptors: 4 LogP: 2.71 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc(cc1)N1C(=O)NC(=O)C(=Cc2cccc(c2)O)C1=O
  • InChi: 1S/C18H14N2O4/c1-11-5-7-13(8-6-11)20-17(23)15(16(22)19-18(20)24)10-12-3-2-4-14(21)9-12/h2-10,21H,1H3,(H,19,22,24)/b15-10+
  • InChiKey: OMNOSRRMISICIS-XNTDXEJSSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 5-[(3-hydroxyphenyl)methylidene]-1-(4-methylphenyl)-1,3-diazinane-2,4,6-trione
  • 5-[(3-hydroxyphenyl)methylene]-1-(4-methylphenyl)hexahydropyrimidine-2,4,6-trione
  • (5E)-5-[(3-hydroxyphenyl)methylene]-1-(4-methylphenyl)hexahydropyrimidine-2,4,6-trione
  • 5-(3-hydroxybenzylidene)-1-(4-methylphenyl)barbituric acid
  • (5E)-5-(3-hydroxybenzylidene)-1-(4-methylphenyl)barbituric acid
  • ZINC00179625

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0193 0.3672 1
Echinococcus granulosus flap endonuclease 1 0.0028 0.0315 0.0264
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0333 0.0461
Loa Loa (eye worm) hypothetical protein 0.0029 0.0333 0.0333
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0193 0.3672 0.9151
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0333 0.0461
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0029 0.0333 0.14
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0193 0.3672 0.9151
Echinococcus granulosus solute carrier family 22 0.0029 0.0333 0.0311
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0209 0.3993 1
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0037 0.0489 0.325
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0089 0.1551 0.2099
Loa Loa (eye worm) hypothetical protein 0.0104 0.1856 0.1856
Echinococcus granulosus Sugar transporter ERD6 protein 0.0029 0.0333 0.0311
Leishmania major protein kinase, putative 0.0032 0.0395 0.2132
Trypanosoma brucei glucose transporter, putative 0.0065 0.1055 1
Trichomonas vaginalis glucose transporter, putative 0.0029 0.0333 0.0461
Loa Loa (eye worm) hypothetical protein 0.0193 0.3672 0.3672
Brugia malayi Major Facilitator Superfamily protein 0.0029 0.0333 0.0341
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0193 0.3672 0.9151
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0193 0.3672 0.5162
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0193 0.3672 0.5162
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0193 0.3672 0.9151
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0193 0.3672 0.9151
Echinococcus multilocularis glycine receptor subunit beta 0.0193 0.3672 0.9151
Loa Loa (eye worm) hypothetical protein 0.0029 0.0333 0.0333
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0193 0.3672 0.9151
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0193 0.3672 0.5162
Loa Loa (eye worm) hypothetical protein 0.0032 0.0381 0.0381
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0333 0.0461
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0333 0.0461
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0193 0.3672 0.5162
Loa Loa (eye worm) hypothetical protein 0.0268 0.5206 0.5206
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0193 0.3672 0.9151
Schistosoma mansoni protein kinase 0.0032 0.0395 0.0474
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0089 0.1551 0.2099
Brugia malayi Cam kinase protein 1 0.0032 0.0395 0.0429
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0297 0.0093
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0037 0.0489 0.325
Loa Loa (eye worm) hypothetical protein 0.0028 0.0297 0.0297
Plasmodium falciparum calcium-dependent protein kinase 2 0.0032 0.0395 0.0207
Loa Loa (eye worm) major facilitator superfamily transporter 0.0029 0.0333 0.0333
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0333 0.0461
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0089 0.1551 0.2099
Schistosoma mansoni sugar transporter 0.0029 0.0333 0.0311
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0171 0.3219 0.3464
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0193 0.3672 0.5162
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0193 0.3672 0.3672
Onchocerca volvulus 0.0089 0.1551 0.3647
Echinococcus granulosus General substrate transporter 0.0179 0.3394 0.8415
Trypanosoma cruzi glucose transporter, putative 0.0029 0.0333 0.14
Brugia malayi Sugar transporter family protein 0.0029 0.0333 0.0341
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0395 0.0474
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0029 0.0333 1
Plasmodium falciparum hexose transporter 0.0209 0.3993 0.4356
Brugia malayi hypothetical protein 0.0029 0.0333 0.0341
Toxoplasma gondii facilitative glucose transporter GT1 0.0209 0.3993 0.6732
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0333 0.0461
Loa Loa (eye worm) hypothetical protein 0.0089 0.1551 0.1551
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0032 0.0395 0.0395
Loa Loa (eye worm) hypothetical protein 0.0029 0.0333 0.0333
Echinococcus multilocularis nAChR subunit 0.0193 0.3672 0.9151
Giardia lamblia Flap structure-specific endonuclease 0.0028 0.0315 0.601
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0193 0.3672 0.9151
Toxoplasma gondii sugar transporter ST1 0.0029 0.0333 0.0209
Entamoeba histolytica hypothetical protein 0.0104 0.1856 1
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0193 0.3672 0.9151
Brugia malayi hypothetical protein 0.0039 0.0537 0.0635
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0068 0.1133 0.1133
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0333 0.0461
Trichomonas vaginalis flap endonuclease-1, putative 0.0028 0.0315 0.0414
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0104 0.1856 0.2539
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0209 0.3993 1
Echinococcus multilocularis General substrate transporter 0.0179 0.3394 0.8415
Loa Loa (eye worm) hypothetical protein 0.0089 0.1551 0.1551
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0037 0.0489 0.325
Entamoeba histolytica hypothetical protein 0.0039 0.0537 0.1958
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0089 0.1551 0.3535
Trypanosoma brucei THT1 - hexose transporter, putative 0.0065 0.1055 1
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0028 0.0315 0.1186
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0032 0.0381 0.0438
Onchocerca volvulus 0.0193 0.3672 1
Echinococcus multilocularis solute carrier family 22 0.0029 0.0333 0.0311
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0028 0.0315 0.1186
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0193 0.3672 0.9151
Schistosoma mansoni glucose transport protein 0.0209 0.3993 1
Loa Loa (eye worm) hypothetical protein 0.0193 0.3672 0.3672
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0028 0.0315 0.1186
Schistosoma mansoni nAChR subunit 0.0193 0.3672 0.9151
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0193 0.3672 0.5162
Brugia malayi Major Facilitator Superfamily protein 0.0029 0.0333 0.0341
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0209 0.3993 1
Plasmodium vivax CDK-related protein kinase 6, putative 0.0448 0.8886 1
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0193 0.3672 0.5162
Trypanosoma cruzi hexose transporter, putative 0.0065 0.1055 1
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0333 0.0461
Leishmania major glucose transporter, lmgt1 0.0065 0.1055 1
Echinococcus multilocularis synaptic vesicle 2 protein 0.0029 0.0333 0.0311
Brugia malayi Cation transporter family protein 0.0193 0.3672 0.5162
Schistosoma mansoni tar DNA-binding protein 0.0068 0.1133 0.2427
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0032 0.0381 0.0438
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0193 0.3672 0.5162
Loa Loa (eye worm) LGC-31 protein 0.0193 0.3672 0.3672
Trypanosoma cruzi hexose transporter, putative 0.0029 0.0333 0.14
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0209 0.3993 1
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0209 0.3993 1
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0032 0.0395 0.0207
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0333 0.0461
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0333 0.0461
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0039 0.0537 0.085
Schistosoma mansoni protein kinase 0.0032 0.0395 0.0474
Loa Loa (eye worm) hypothetical protein 0.0104 0.1856 0.1856
Loa Loa (eye worm) ACC-1 protein 0.0193 0.3672 0.3672
Schistosoma mansoni sugar transporter 0.0029 0.0333 0.0311
Loa Loa (eye worm) hypothetical protein 0.0029 0.0333 0.0333
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0032 0.0395 0.0207
Chlamydia trachomatis lysine--tRNA ligase 0.0024 0.0216 0.5
Schistosoma mansoni nAChR subunit 0.0089 0.1551 0.3535
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0193 0.3672 0.3672
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0209 0.3993 1
Echinococcus granulosus glycine receptor subunit alpha 1 0.0193 0.3672 0.9151
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0333 0.0461
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0032 0.0381 0.041
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0333 0.0461
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0333 0.0461
Brugia malayi hypothetical protein 0.0029 0.0333 0.0341
Trichomonas vaginalis conserved hypothetical protein 0.0209 0.3993 1
Brugia malayi excitatory GABA receptor EXP-1A 0.0193 0.3672 0.5162
Loa Loa (eye worm) hypothetical protein 0.0193 0.3672 0.3672
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0039 0.0537 0.085
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0089 0.1551 0.3535
Schistosoma mansoni acetylcholine receptor-related 0.0089 0.1551 0.3535
Trypanosoma brucei glucose transporter 1E 0.0065 0.1055 1
Loa Loa (eye worm) hypothetical protein 0.0089 0.1551 0.1551
Trypanosoma brucei glucose transporter, putative 0.0065 0.1055 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0297 0.0964
Echinococcus granulosus tar DNA binding protein 0.0068 0.1133 0.2427
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0029 0.0333 0.0136
Loa Loa (eye worm) hypothetical protein 0.0193 0.3672 0.3672
Loa Loa (eye worm) hypothetical protein 0.0026 0.026 0.026
Plasmodium vivax calcium-dependent protein kinase, putative 0.0032 0.0395 0.0207
Loa Loa (eye worm) flap endonuclease-1 0.0028 0.0315 0.0315
Brugia malayi Cation transporter family protein 0.0193 0.3672 0.5162
Echinococcus multilocularis tar DNA binding protein 0.0068 0.1133 0.2427
Toxoplasma gondii transporter, major facilitator family protein 0.0029 0.0333 0.0209
Trypanosoma brucei glucose transporter, putative 0.0065 0.1055 1
Loa Loa (eye worm) hypothetical protein 0.0089 0.1551 0.1551
Loa Loa (eye worm) hypothetical protein 0.0193 0.3672 0.3672
Loa Loa (eye worm) hypothetical protein 0.0032 0.0395 0.0395
Loa Loa (eye worm) hypothetical protein 0.0029 0.0333 0.0333
Brugia malayi Sugar transporter family protein 0.0029 0.0333 0.0341
Loa Loa (eye worm) acetylcholine receptor protein 0.0089 0.1551 0.1551
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0032 0.0381 1
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0193 0.3672 0.9151
Entamoeba histolytica Flap nuclease, putative 0.0028 0.0315 0.0607
Loa Loa (eye worm) hypothetical protein 0.0193 0.3672 0.3672
Trypanosoma brucei glucose transporter, putative 0.0065 0.1055 1
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0032 0.0395 0.0395
Echinococcus multilocularis solute carrier family 22 0.0029 0.0333 0.0311
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0028 0.0315 0.0177
Loa Loa (eye worm) sugar transporter 0.0029 0.0333 0.0333
Loa Loa (eye worm) hypothetical protein 0.0104 0.1856 0.1856
Loa Loa (eye worm) hypothetical protein 0.0104 0.1856 0.1856
Loa Loa (eye worm) hypothetical protein 0.0104 0.1856 0.1856
Plasmodium vivax ataxin-2 like protein, putative 0.0028 0.0297 0.0093
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0333 0.0461
Echinococcus granulosus solute carrier family 22 0.0029 0.0333 0.0311
Echinococcus multilocularis flap endonuclease 1 0.0028 0.0315 0.0264
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0333 0.0461
Toxoplasma gondii sugar transporter ST2 0.0029 0.0333 0.0209
Trichomonas vaginalis CAMK family protein kinase 0.0032 0.0395 0.0621
Loa Loa (eye worm) hypothetical protein 0.0193 0.3672 0.3672
Loa Loa (eye worm) cytochrome P450 family protein 0.0028 0.0312 0.0312
Echinococcus multilocularis glycine receptor subunit beta 0.0193 0.3672 0.9151
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0089 0.1551 0.2099
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0297 0.0964
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0193 0.3672 0.5162
Loa Loa (eye worm) hypothetical protein 0.0104 0.1856 0.1856
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0029 0.0333 0.0311
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0193 0.3672 0.5162
Echinococcus granulosus glycine receptor subunit alpha 1 0.0193 0.3672 0.9151
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0089 0.1551 0.2099
Echinococcus granulosus glycine receptor subunit beta 0.0193 0.3672 0.9151
Schistosoma mansoni sugar transporter 0.0029 0.0333 0.0311
Brugia malayi Sugar transporter family protein 0.0209 0.3993 0.5625
Loa Loa (eye worm) hypothetical protein 0.0193 0.3672 0.3672
Loa Loa (eye worm) hypothetical protein 0.0089 0.1551 0.1551
Loa Loa (eye worm) hypothetical protein 0.0104 0.1856 0.1856
Onchocerca volvulus 0.0193 0.3672 1
Entamoeba histolytica hypothetical protein 0.0039 0.0537 0.1958
Loa Loa (eye worm) hypothetical protein 0.0089 0.1551 0.1551
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0333 0.0461
Loa Loa (eye worm) hypothetical protein 0.0089 0.1551 0.1551
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0395 0.0474
Leishmania major glucose transporter, lmgt3 0.0065 0.1055 1
Schistosoma mansoni nAChR subunit 0.0193 0.3672 0.9151
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0032 0.0395 0.032
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0032 0.0381 0.041
Brugia malayi hypothetical protein 0.0089 0.1551 0.2099
Plasmodium falciparum calcium-dependent protein kinase 5 0.0032 0.0395 0.0207
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0032 0.0381 0.0586
Onchocerca volvulus 0.0104 0.1856 0.456
Trichomonas vaginalis glucose transporter, putative 0.0065 0.1055 0.2343
Loa Loa (eye worm) hypothetical protein 0.0029 0.0333 0.0333
Entamoeba histolytica protein kinase, putative 0.0032 0.0395 0.1091
Schistosoma mansoni protein kinase 0.0032 0.0395 0.0474
Brugia malayi Cytochrome P450 family protein 0.0028 0.0312 0.031
Brugia malayi hypothetical protein 0.0089 0.1551 0.2099
Schistosoma mansoni hypothetical protein 0.0039 0.0537 0.085
Echinococcus granulosus nAChR subunit 0.0193 0.3672 0.9151
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0193 0.3672 0.3672
Trypanosoma brucei glucose transporter, putative 0.0065 0.1055 1
Entamoeba histolytica protein kinase, putative 0.0032 0.0395 0.1091
Echinococcus multilocularis nAChR subunit 0.0104 0.1856 0.4342
Echinococcus granulosus calcium dependent protein kinase 0.003 0.0354 0.0366
Brugia malayi major facilitator superfamily protein 0.0029 0.0333 0.0341
Giardia lamblia Prolyl-tRNA synthetase 0.0032 0.0381 1
Loa Loa (eye worm) hypothetical protein 0.0104 0.1856 0.1856
Mycobacterium ulcerans integral membrane transport protein 0.0029 0.0333 1
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0333 0.0461
Brugia malayi TAR-binding protein 0.0068 0.1133 0.1495
Echinococcus granulosus glycine receptor subunit beta 0.0193 0.3672 0.9151
Schistosoma mansoni nAChR subunit 0.0193 0.3672 0.9151
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0193 0.3672 0.5162
Brugia malayi Major Facilitator Superfamily protein 0.0029 0.0333 0.0341
Plasmodium vivax proline--tRNA ligase, putative 0.0037 0.0489 0.0315
Plasmodium falciparum calcium-dependent protein kinase 3 0.0032 0.0395 0.0207
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0193 0.3672 0.5162
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0171 0.3219 0.5352
Schistosoma mansoni tar DNA-binding protein 0.0068 0.1133 0.2427
Trypanosoma cruzi hexose transporter, putative 0.0065 0.1055 1
Brugia malayi hypothetical protein 0.0029 0.0333 0.0341
Loa Loa (eye worm) hypothetical protein 0.0032 0.0381 0.0381
Loa Loa (eye worm) hypothetical protein 0.0089 0.1551 0.1551
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0089 0.1551 0.1551
Giardia lamblia Hexose transporter 0.0029 0.0333 0.7094
Trichomonas vaginalis glucose transporter, putative 0.0065 0.1055 0.2343
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0297 0.0093
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0193 0.3672 0.9151
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0032 0.0395 0.0207
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0032 0.0381 0.101
Toxoplasma gondii sugar transporter ST3 0.0029 0.0333 0.0209
Schistosoma mansoni sugar transporter 0.0029 0.0333 0.0311
Onchocerca volvulus 0.0193 0.3672 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0333 0.0333
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0104 0.1856 0.4342
Plasmodium falciparum mitogen-activated protein kinase 2 0.0171 0.3219 0.3464
Plasmodium vivax sugar transporter, putative 0.0029 0.0333 0.0136
Brugia malayi Flap endonuclease-1 0.0028 0.0315 0.0315
Echinococcus granulosus nAChR subunit 0.0104 0.1856 0.4342
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0193 0.3672 0.5162
Echinococcus multilocularis calcium dependent protein kinase 0.003 0.0354 0.0366
Schistosoma mansoni nAChR subunit 0.0193 0.3672 0.9151
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0193 0.3672 0.9151
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0333 0.0461
Loa Loa (eye worm) hypothetical protein 0.0089 0.1551 0.1551
Schistosoma mansoni glucose transporter 0.0029 0.0333 0.0311
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0032 0.0381 0.0438
Loa Loa (eye worm) sugar transporter 0.0209 0.3993 0.3993
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0193 0.3672 0.9151
Trypanosoma brucei glucose transporter, putative 0.0065 0.1055 1
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0032 0.0395 0.0474
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0024 0.0216 0.3046
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0395 0.0474
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0333 0.0461
Schistosoma mansoni neurotransmitter gated ion channel 0.0089 0.1551 0.3535
Loa Loa (eye worm) hypothetical protein 0.0029 0.0333 0.0333
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0193 0.3672 0.9151
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0032 0.0395 0.032
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0104 0.1856 0.2539
Loa Loa (eye worm) hypothetical protein 0.0193 0.3672 0.3672
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0193 0.3672 0.3672
Loa Loa (eye worm) ACC-1 protein 0.0193 0.3672 0.3672
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.1055 0.2343
Loa Loa (eye worm) hypothetical protein 0.0357 0.7022 0.7022
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0333 0.0461
Trichomonas vaginalis myo-inositol transporter, putative 0.0029 0.0333 0.0461
Echinococcus multilocularis solute carrier family 22 0.0029 0.0333 0.0311
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0193 0.3672 0.9151
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0333 0.0461
Brugia malayi hypothetical protein 0.0089 0.1551 0.2099
Schistosoma mansoni serine/threonine protein kinase 0.0032 0.0395 0.0474
Loa Loa (eye worm) hypothetical protein 0.0029 0.0333 0.0333
Brugia malayi RNA recognition motif domain containing protein 0.0068 0.1133 0.1495
Loa Loa (eye worm) hypothetical protein 0.0089 0.1551 0.1551
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0032 0.0395 0.032
Brugia malayi lysyl-tRNA synthetase 0.0024 0.0216 0.0171
Loa Loa (eye worm) hypothetical protein 0.0193 0.3672 0.3672
Loa Loa (eye worm) hypothetical protein 0.0193 0.3672 0.3672
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0333 0.0461
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0357 0.7022 1
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0333 0.0461
Brugia malayi RNA binding protein 0.0068 0.1133 0.1495
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0032 0.0395 0.2132
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0193 0.3672 0.9151
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0193 0.3672 0.5162
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0029 0.0333 1
Schistosoma mansoni nAChR subunit 0.0193 0.3672 0.9151
Toxoplasma gondii protein kinase, putative 0.0298 0.5826 1
Brugia malayi hypothetical protein 0.0089 0.1551 0.2099
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0209 0.3993 1
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0193 0.3672 0.3672
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0089 0.1551 0.1551
Loa Loa (eye worm) hypothetical protein 0.0089 0.1551 0.1551
Trypanosoma cruzi sugar transporter, putative 0.0029 0.0333 0.14
Trichomonas vaginalis sugar transporter, putative 0.0065 0.1055 0.2343
Schistosoma mansoni neurotransmitter gated ion channel 0.0104 0.1856 0.4342
Leishmania major hypothetical protein, conserved 0.0028 0.0297 0.0964
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0333 0.0461
Echinococcus multilocularis solute carrier family 22 0.0029 0.0333 0.0311
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0089 0.1551 0.3535
Onchocerca volvulus 0.0104 0.1856 0.456
Trypanosoma brucei glucose transporter, putative 0.0065 0.1055 1
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0333 0.0461
Mycobacterium ulcerans sugar transporter 0.0029 0.0333 1
Loa Loa (eye worm) major facilitator superfamily transporter 0.0029 0.0333 0.0333
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0333 0.0461
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0209 0.3993 1
Trichomonas vaginalis sugar transporter, putative 0.0065 0.1055 0.2343
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0333 0.0461
Onchocerca volvulus 0.0089 0.1551 0.3647
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0333 0.0461
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0029 0.0333 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0333 0.0333
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0193 0.3672 0.9151
Loa Loa (eye worm) hypothetical protein 0.0193 0.3672 0.3672
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0193 0.3672 0.9151
Schistosoma mansoni flap endonuclease-1 0.0026 0.0259 0.0116
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0104 0.1856 0.2539
Brugia malayi hypothetical protein 0.0028 0.0297 0.0288
Trypanosoma brucei THT1 - hexose transporter, putative 0.0065 0.1055 1
Loa Loa (eye worm) TAR-binding protein 0.0068 0.1133 0.1133
Schistosoma mansoni neurotransmitter gated ion channel 0.0089 0.1551 0.3535
Toxoplasma gondii LsmAD domain-containing protein 0.0028 0.0297 0.0144
Loa Loa (eye worm) hypothetical protein 0.0193 0.3672 0.3672
Schistosoma mansoni nAChR subunit 0.0193 0.3672 0.9151
Onchocerca volvulus 0.0089 0.1551 0.3647
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0029 0.0333 0.5
Plasmodium falciparum calcium-dependent protein kinase 1 0.0032 0.0395 0.0207
Schistosoma mansoni tar DNA-binding protein 0.0068 0.1133 0.2427
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0333 0.0461
Schistosoma mansoni tar DNA-binding protein 0.0068 0.1133 0.2427
Schistosoma mansoni nAChR subunit 0.0193 0.3672 0.9151
Loa Loa (eye worm) hypothetical protein 0.0089 0.1551 0.1551
Schistosoma mansoni tar DNA-binding protein 0.0068 0.1133 0.2427
Brugia malayi Cation transporter family protein 0.0193 0.3672 0.5162
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0333 0.0461
Entamoeba histolytica hypothetical protein 0.0039 0.0537 0.1958
Leishmania major myo-inositol/proton symporter (MIT) 0.0029 0.0333 0.14
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0333 0.0461
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0333 0.0461
Loa Loa (eye worm) GABA receptor subunit 0.0104 0.1856 0.1856
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0333 0.0461
Plasmodium falciparum calcium-dependent protein kinase 4 0.0032 0.0395 0.0207
Plasmodium falciparum proline--tRNA ligase 0.0037 0.0489 0.0315
Loa Loa (eye worm) hypothetical protein 0.0193 0.3672 0.3672
Loa Loa (eye worm) hypothetical protein 0.0089 0.1551 0.1551
Schistosoma mansoni nAChR subunit 0.0089 0.1551 0.3535
Echinococcus granulosus solute carrier family 22 0.0029 0.0333 0.0311
Loa Loa (eye worm) RNA binding protein 0.0068 0.1133 0.1133
Onchocerca volvulus 0.0193 0.3672 1
Trypanosoma brucei THT1 - hexose transporter, putative 0.0065 0.1055 1
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0193 0.3672 0.3672
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0395 0.0474
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0024 0.0216 0.0155
Trypanosoma brucei PAB1-binding protein , putative 0.0028 0.0297 0.0964
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0104 0.1856 0.2539
Loa Loa (eye worm) hypothetical protein 0.0193 0.3672 0.3672
Plasmodium vivax flap endonuclease 1, putative 0.0028 0.0315 0.0115
Onchocerca volvulus 0.0193 0.3672 1
Trichomonas vaginalis sugar transporter, putative 0.0065 0.1055 0.2343
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0193 0.3672 0.9151
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0193 0.3672 0.9151
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0193 0.3672 0.5162
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0333 0.0461
Brugia malayi hypothetical protein 0.0089 0.1551 0.2099
Loa Loa (eye worm) hypothetical protein 0.0029 0.0333 0.0333
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0029 0.0333 1
Leishmania major hypothetical protein, conserved 0.0029 0.0333 0.14
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0193 0.3672 0.9151
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0089 0.1551 0.3535
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0333 0.0461
Trypanosoma brucei sugar transporter, putative 0.0029 0.0333 0.14
Trypanosoma cruzi hexose transporter, putative 0.0035 0.0456 0.2867
Echinococcus granulosus glycine receptor subunit alpha 1 0.0193 0.3672 0.9151
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0032 0.0381 0.0438
Onchocerca volvulus Putative nachr subunit 0.0193 0.3672 1
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0333 0.0461
Loa Loa (eye worm) hypothetical protein 0.0193 0.3672 0.3672
Plasmodium vivax hexose transporter 0.0209 0.3993 0.4356
Loa Loa (eye worm) hypothetical protein 0.0029 0.0333 0.0333
Loa Loa (eye worm) hypothetical protein 0.0029 0.0333 0.0333
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0089 0.1551 0.2099
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0037 0.0489 0.325
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0029 0.0333 0.0311
Trypanosoma brucei glucose transporter 2A 0.0065 0.1055 1
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0333 0.0461
Echinococcus granulosus synaptic vesicle 2 protein 0.0029 0.0333 0.0311
Schistosoma mansoni transcription factor LCR-F1 0.0039 0.0537 0.085
Trichomonas vaginalis sugar transport protein, putative 0.0029 0.0333 0.0461
Trypanosoma cruzi hexose transporter 0.0065 0.1055 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0216 0.0216
Brugia malayi major facilitator superfamily protein 0.0029 0.0333 0.0341
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0089 0.1551 0.3535
Loa Loa (eye worm) hypothetical protein 0.0089 0.1551 0.1551
Plasmodium falciparum protein kinase 7 0.0298 0.5826 0.6471
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.1055 0.2343
Echinococcus granulosus solute carrier family 22 0.0029 0.0333 0.0311
Loa Loa (eye worm) hypothetical protein 0.0089 0.1551 0.1551
Schistosoma mansoni glucose transport protein 0.0209 0.3993 1
Giardia lamblia Sugar-proton symporter 0.0029 0.0333 0.7094
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0333 0.0461
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0032 0.0395 0.0429
Leishmania major glucose transporter/membrane transporter D2, putative 0.0065 0.1055 1
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0395 0.0474
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0037 0.0489 0.325
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0333 0.0461
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0395 0.0474
Loa Loa (eye worm) hypothetical protein 0.0029 0.0333 0.0333
Loa Loa (eye worm) hypothetical protein 0.0193 0.3672 0.3672
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0104 0.1856 0.4342
Entamoeba histolytica hypothetical protein 0.0039 0.0537 0.1958
Plasmodium falciparum flap endonuclease 1 0.0028 0.0315 0.0115
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0037 0.0489 0.0486
Schistosoma mansoni glucose transport protein 0.0209 0.3993 1
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0395 0.0474
Schistosoma mansoni acetylcholine receptor subunit beta 0.0089 0.1551 0.3535
Plasmodium falciparum protein kinase 6 0.0448 0.8886 1
Leishmania major glucose transporter, lmgt2 0.0065 0.1055 1
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0333 0.0461
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0193 0.3672 0.9151
Trypanosoma brucei glucose transporter, putative 0.0065 0.1055 1
Trypanosoma cruzi hexose transporter, putative 0.0065 0.1055 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0333 0.0333
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0193 0.3672 0.9151
Schistosoma mansoni hypothetical protein 0.0209 0.3993 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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