Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.001 | 0.0174 | 0.2128 |
Schistosoma mansoni | DNA helicase recq1 | 0.0009 | 0.0132 | 0.0861 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0174 | 0.0263 |
Onchocerca volvulus | 0.0028 | 0.0724 | 0.0724 | |
Plasmodium vivax | SET domain protein, putative | 0.0031 | 0.0818 | 0.2184 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0013 | 0.0269 | 0.3288 |
Schistosoma mansoni | thyroid hormone receptor | 0.001 | 0.0174 | 0.1137 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0005 | 0.0019 | 0.0026 |
Giardia lamblia | Telomerase catalytic subunit | 0.0087 | 0.2618 | 1 |
Brugia malayi | Pre-SET motif family protein | 0.0214 | 0.6632 | 0.9178 |
Plasmodium vivax | telomerase reverse transcriptase, putative | 0.0087 | 0.2618 | 1 |
Echinococcus multilocularis | ATP dependent DNA helicase Q5 | 0.0009 | 0.0132 | 0.1611 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.001 | 0.0174 | 0.1137 |
Loa Loa (eye worm) | hypothetical protein | 0.0005 | 0.0019 | 0.0028 |
Brugia malayi | hypothetical protein | 0.0005 | 0.0019 | 0.0026 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0269 | 0.0406 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.0087 | 0.2618 | 1 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.001 | 0.0174 | 0.1137 |
Echinococcus multilocularis | ATP dependent DNA helicase Q1 | 0.0009 | 0.0132 | 0.1611 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.001 | 0.0174 | 0.0174 |
Brugia malayi | nuclear receptor NHR-88 | 0.001 | 0.0174 | 0.0241 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0174 | 0.0263 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.001 | 0.0174 | 0.0241 |
Brugia malayi | Pre-SET motif family protein | 0.0031 | 0.0818 | 0.1132 |
Echinococcus granulosus | ATP dependent DNA helicase Q1 | 0.0009 | 0.0132 | 0.1611 |
Echinococcus granulosus | intermediate filament protein | 0.0028 | 0.0724 | 0.885 |
Onchocerca volvulus | Bile acid receptor homolog | 0.001 | 0.0174 | 0.0174 |
Trichomonas vaginalis | DNA helicase recq1, putative | 0.0022 | 0.054 | 0.0441 |
Loa Loa (eye worm) | steroid hormone receptor | 0.001 | 0.0174 | 0.0263 |
Trichomonas vaginalis | DNA helicase recq, putative | 0.0022 | 0.054 | 0.0441 |
Loa Loa (eye worm) | hypothetical protein | 0.0005 | 0.0019 | 0.0028 |
Schistosoma mansoni | intermediate filament proteins | 0.0028 | 0.0724 | 0.4728 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.001 | 0.0174 | 0.0241 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0015 | 0.0316 | 0.0437 |
Plasmodium falciparum | telomerase reverse transcriptase | 0.0087 | 0.2618 | 1 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.001 | 0.0174 | 0.2128 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.001 | 0.0174 | 0.0241 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0005 | 0.0019 | 0.0228 |
Brugia malayi | Bloom's syndrome protein homolog | 0.0022 | 0.054 | 0.0748 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.001 | 0.0174 | 0.0263 |
Trypanosoma brucei | telomerase reverse transcriptase | 0.0087 | 0.2618 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0174 | 0.0263 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0031 | 0.0818 | 0.5343 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.001 | 0.0174 | 0.2128 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0174 | 0.0263 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.001 | 0.0174 | 0.0241 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.001 | 0.0174 | 0.0241 |
Loa Loa (eye worm) | ATP-dependent DNA helicase | 0.0009 | 0.0132 | 0.0199 |
Schistosoma mansoni | DNA helicase recq5 | 0.0009 | 0.0132 | 0.0861 |
Leishmania major | telomerase reverse transcriptase, putative | 0.0087 | 0.2618 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.001 | 0.0174 | 0.0241 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0174 | 0.0263 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.001 | 0.0174 | 0.2128 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.001 | 0.0174 | 0.0263 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.001 | 0.0174 | 0.0263 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.0087 | 0.2618 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.001 | 0.0174 | 0.0241 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0031 | 0.0818 | 1 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.001 | 0.0174 | 0.2128 |
Echinococcus multilocularis | lamin dm0 | 0.0028 | 0.0724 | 0.885 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.001 | 0.0174 | 0.0241 |
Plasmodium falciparum | ADP-dependent DNA helicase RecQ | 0.0019 | 0.0456 | 0.1304 |
Brugia malayi | nuclear receptor RXR | 0.0005 | 0.0019 | 0.0026 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0818 | 0.1234 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0031 | 0.0818 | 0.5343 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0005 | 0.0019 | 0.0026 |
Entamoeba histolytica | recQ family helicase, putative | 0.0012 | 0.0216 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.001 | 0.0174 | 0.1137 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0005 | 0.0019 | 0.0028 |
Onchocerca volvulus | 0.0028 | 0.0724 | 0.0724 | |
Echinococcus granulosus | lamin | 0.0028 | 0.0724 | 0.885 |
Brugia malayi | ATP-dependent DNA helicase, RecQ family protein | 0.0009 | 0.0132 | 0.0182 |
Toxoplasma gondii | RNA-directed DNA polymerase | 0.0087 | 0.2618 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0005 | 0.0019 | 0.0122 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0174 | 0.0263 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.001 | 0.0174 | 0.2128 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0253 | 0.0381 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.001 | 0.0174 | 0.0241 |
Loa Loa (eye worm) | RecQ helicase | 0.0022 | 0.054 | 0.0815 |
Brugia malayi | steroid hormone receptor | 0.001 | 0.0174 | 0.0241 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.001 | 0.0174 | 0.2128 |
Onchocerca volvulus | 0.0031 | 0.0818 | 0.0818 | |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.001 | 0.0174 | 0.1137 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.001 | 0.0174 | 0.2128 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.0132 | 0.0199 |
Trichomonas vaginalis | set domain proteins, putative | 0.0244 | 0.757 | 1 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.001 | 0.0174 | 0.2128 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0031 | 0.0818 | 1 |
Onchocerca volvulus | 0.0244 | 0.757 | 0.757 | |
Echinococcus granulosus | ATP dependent DNA helicase Q5 | 0.0009 | 0.0132 | 0.1611 |
Brugia malayi | Telomerase reverse transcriptase | 0.0233 | 0.7226 | 1 |
Brugia malayi | ATP-dependent DNA helicase, RecQ family protein | 0.0009 | 0.0132 | 0.0182 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0214 | 0.6632 | 1 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.001 | 0.0174 | 0.1137 |
Echinococcus multilocularis | musashi | 0.0028 | 0.0724 | 0.885 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0031 | 0.0818 | 0.5343 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.001 | 0.0174 | 0.0241 |
Echinococcus granulosus | bloom syndrome protein | 0.0022 | 0.054 | 0.6606 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0005 | 0.0019 | 0.0122 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.001 | 0.0174 | 0.0241 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.001 | 0.0174 | 0.0241 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0031 | 0.0818 | 0.276 |
Loa Loa (eye worm) | hypothetical protein | 0.0005 | 0.0019 | 0.0028 |
Brugia malayi | ecdysteroid receptor | 0.001 | 0.0174 | 0.0241 |
Echinococcus multilocularis | bloom syndrome protein | 0.0022 | 0.054 | 0.6606 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0253 | 0.0381 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.001 | 0.0174 | 0.2128 |
Brugia malayi | hypothetical protein | 0.0005 | 0.0019 | 0.0026 |
Echinococcus multilocularis | FTZ F1 alpha | 0.001 | 0.0174 | 0.2128 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0009 | 0.0132 | 0.00000000052618 |
Loa Loa (eye worm) | hypothetical protein | 0.0005 | 0.0019 | 0.0028 |
Schistosoma mansoni | thyroid hormone receptor | 0.001 | 0.0174 | 0.1137 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0031 | 0.0818 | 0.5343 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.001 | 0.0174 | 0.2128 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0015 | 0.031 | 0.0715 |
Brugia malayi | nuclear hormone receptor | 0.001 | 0.0174 | 0.0241 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.001 | 0.0174 | 0.0263 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0724 | 0.1092 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0005 | 0.0019 | 0.0228 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0028 | 0.0724 | 0.1092 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0028 | 0.0724 | 0.1002 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.003 | 0.0782 | 0.9562 |
Onchocerca volvulus | 0.001 | 0.0174 | 0.0174 | |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.001 | 0.0174 | 0.2128 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.001 | 0.0174 | 0.1137 |
Schistosoma mansoni | lamin | 0.0028 | 0.0724 | 0.4728 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.001 | 0.0174 | 0.2128 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.001 | 0.0174 | 0.2128 |
Echinococcus granulosus | FTZ F1 alpha | 0.001 | 0.0174 | 0.2128 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0174 | 0.0263 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.001 | 0.0174 | 0.0263 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.001 | 0.0174 | 0.1137 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.001 | 0.0174 | 0.1137 |
Loa Loa (eye worm) | hypothetical protein | 0.0005 | 0.0019 | 0.0028 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.001 | 0.0174 | 0.0241 |
Schistosoma mansoni | nuclear hormone receptor | 0.001 | 0.0174 | 0.1137 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0174 | 0.0263 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0708 | 0.1067 |
Schistosoma mansoni | lamin | 0.0028 | 0.0724 | 0.4728 |
Echinococcus multilocularis | lamin | 0.0028 | 0.0724 | 0.885 |
Schistosoma mansoni | blooms syndrome DNA helicase | 0.0017 | 0.0394 | 0.2573 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.001 | 0.0174 | 0.2128 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.001 | 0.0174 | 0.2128 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0031 | 0.0818 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.04 | 0.0602 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.001 | 0.0174 | 0.0241 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0015 | 0.0316 | 0.0476 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.001 | 0.0174 | 0.0263 |
Schistosoma mansoni | hypothetical protein | 0.0053 | 0.1531 | 1 |
Echinococcus granulosus | lamin dm0 | 0.0028 | 0.0724 | 0.885 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.001 | 0.0174 | 0.0241 |
Loa Loa (eye worm) | intermediate filament protein | 0.0028 | 0.0724 | 0.1092 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.001 | 0.0174 | 0.0263 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.001 | 0.0174 | 0.0174 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.001 | 0.0174 | 0.0241 |
Brugia malayi | intermediate filament protein | 0.0028 | 0.0724 | 0.1002 |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0013 | 0.0269 | 0.3288 |
Schistosoma mansoni | coup transcription factor | 0.001 | 0.0174 | 0.1137 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.001 | 0.0174 | 0.1137 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.