Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | Sodium:neurotransmitter symporter family protein | 0.0033 | 0 | 0.5 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0405 | 0.631 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0197 | 0.2781 | 0.4407 |
Echinococcus granulosus | serotonin transporter | 0.0197 | 0.2781 | 0.4407 |
Loa Loa (eye worm) | hypothetical protein | 0.0405 | 0.631 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0033 | 0 | 0.5 |
Toxoplasma gondii | Sodium:neurotransmitter symporter family protein | 0.0033 | 0 | 0.5 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0081 | 0.0804 | 0.5 |
Echinococcus granulosus | biogenic amine 5HT receptor | 0.0405 | 0.631 | 1 |
Loa Loa (eye worm) | serotonin transporter b | 0.0197 | 0.2781 | 0.4407 |
Toxoplasma gondii | hypothetical protein | 0.0033 | 0 | 0.5 |
Mycobacterium ulcerans | beta-ketoacyl synthase-like protein | 0.0622 | 1 | 0.5 |
Echinococcus multilocularis | serotonin transporter | 0.0197 | 0.2781 | 0.4407 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0081 | 0.0804 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | 3-oxoacyl-ACP synthase | 0.0622 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0197 | 0.2781 | 0.4407 |
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.0622 | 1 | 0.5 |
Plasmodium falciparum | beta-ketoacyl-ACP synthase III | 0.0622 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0405 | 0.631 | 1 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0197 | 0.2781 | 0.4407 |
Loa Loa (eye worm) | norepinephrine transporter | 0.0197 | 0.2781 | 0.4407 |
Loa Loa (eye worm) | hypothetical protein | 0.0197 | 0.2781 | 0.4407 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0081 | 0.0804 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0175 | 0.2408 | 0.3817 |
Plasmodium vivax | beta-ketoacyl-acyl carrier protein synthase III precursor, putative | 0.0622 | 1 | 1 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0081 | 0.0804 | 0.5 |
Mycobacterium tuberculosis | 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) | 0.0622 | 1 | 0.5 |
Toxoplasma gondii | Sodium:neurotransmitter symporter family protein | 0.0033 | 0 | 0.5 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0197 | 0.2781 | 0.4407 |
Echinococcus multilocularis | serotonin receptor | 0.0405 | 0.631 | 1 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0197 | 0.2781 | 1 |
Echinococcus multilocularis | serotonin receptor | 0.0405 | 0.631 | 1 |
Onchocerca volvulus | 0.0197 | 0.2781 | 1 | |
Onchocerca volvulus | Bile acid receptor homolog | 0.0175 | 0.2408 | 0.8661 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0081 | 0.0804 | 0.5 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.0197 | 0.2781 | 0.4407 |
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.0622 | 1 | 0.5 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0197 | 0.2781 | 0.5 |
Brugia malayi | ecdysteroid receptor | 0.0175 | 0.2408 | 0.8661 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.