Detailed information for compound 896032

Basic information

Technical information
  • TDR Targets ID: 896032
  • Name: methyl 2-[1,3-dimethyl-5-(3-methylphenyl)-2,4 -dioxopyrrolo[4,3-d]pyrimidin-6-yl]benzoate
  • MW: 403.431 | Formula: C23H21N3O4
  • H donors: 0 H acceptors: 3 LogP: 3.09 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC(=O)c1ccccc1n1cc2c(c1c1cccc(c1)C)c(=O)n(c(=O)n2C)C
  • InChi: 1S/C23H21N3O4/c1-14-8-7-9-15(12-14)20-19-18(24(2)23(29)25(3)21(19)27)13-26(20)17-11-6-5-10-16(17)22(28)30-4/h5-13H,1-4H3
  • InChiKey: MRFDXHZXNHMGQV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • methyl 2-[1,3-dimethyl-5-(3-methylphenyl)-2,4-dioxo-pyrrolo[4,3-d]pyrimidin-6-yl]benzoate
  • 2-[1,3-dimethyl-5-(3-methylphenyl)-2,4-dioxo-6-pyrrolo[4,3-d]pyrimidinyl]benzoic acid methyl ester
  • 2-[2,4-diketo-1,3-dimethyl-5-(3-methylphenyl)pyrrolo[4,3-d]pyrimidin-6-yl]benzoic acid methyl ester
  • D077-0102
  • NCGC00115642-01
  • ZINC04623146
  • A3820/0162217

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Homo sapiens mechanistic target of rapamycin (serine/threonine kinase) Starlite/ChEMBL No references
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Candida albicans similar to internal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) protein/phosphatidylinositol kinases involved in n Get druggable targets OG5_127212 All targets in OG5_127212
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma brucei gambiense phosphatidylinositol 3 kinase, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania infantum target of rapamycin (TOR) kinase 2, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma congolense Phosphatidylinositol 3-kinase tor2 Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania mexicana phosphatidylinositol 3-kinase (tor2)-like protein Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus multilocularis FKBP12 rapamycin complex associated protein Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania mexicana phosphatidylinositol 3 kinase, putative Get druggable targets OG5_127212 All targets in OG5_127212
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania major target of rapamycin (TOR) kinase 1, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma brucei gambiense phosphatidylinositol 3-kinase tor, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma congolense Phosphatidylinositol 3-kinase tor1 Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma japonicum ko:K07203 FKBP12-rapamycin complex-associated protein, putative Get druggable targets OG5_127212 All targets in OG5_127212
Giardia lamblia GTOR Get druggable targets OG5_127212 All targets in OG5_127212
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma japonicum FKBP12-rapamycin complex-associated protein, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans frameshifted from upsteam TOR2 CDS (CaP19.9461) Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans similar to N terminal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) putative protein/phosphatidylinositol kinases in Get druggable targets OG5_127212 All targets in OG5_127212
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans similar to internal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) protein/phosphatidylinositol kinases involved in n Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania braziliensis target of rapamycin (TOR) kinase 2, putative Get druggable targets OG5_127212 All targets in OG5_127212
Neospora caninum Phosphatidylinositol 3-kinase tor2, related Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania donovani Phosphatidylinositol 3-kinase tor1 Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans frameshifted from upstream TOR2 CDS (CaP19.1905) Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Toxoplasma gondii target of rapamycin (TOR), putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma brucei phosphatidylinositol 4-kinase, putative Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma japonicum FKBP12-rapamycin complex-associated protein, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein Get druggable targets OG5_127212 All targets in OG5_127212
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania major target of rapamycin (TOR) kinase 2, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Echinococcus granulosus FKBP12 rapamycin complex associated protein Get druggable targets OG5_127212 All targets in OG5_127212
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Leishmania infantum target of rapamycin (TOR) kinase 1, putative Get druggable targets OG5_127212 All targets in OG5_127212
Loa Loa (eye worm) phosphatidylinositol 3 Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans similar to N terminal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) putative protein/phosphatidylinositol kinases in Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania donovani Phosphatidylinositol 3-kinase tor2 Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma japonicum FKBP12-rapamycin complex-associated protein, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0155 0.0724 1
Onchocerca volvulus 0.0286 0.1398 0.1302
Entamoeba histolytica prolyl oligopeptidase family protein 0.0155 0.0724 1
Entamoeba histolytica hypothetical protein, conserved 0.0155 0.0724 1
Plasmodium vivax hypothetical protein, conserved 0.0155 0.0724 1
Trypanosoma brucei prolyl oligopeptidase, putative 0.0155 0.0724 0.214
Echinococcus granulosus prolyl endopeptidase 0.0155 0.0724 0.0706
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0155 0.0724 0.5175
Brugia malayi Pre-SET motif family protein 0.0251 0.1219 0.1203
Loa Loa (eye worm) hypothetical protein 0.0155 0.0724 0.0706
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.0155 0.0724 0.5
Loa Loa (eye worm) prolyl oligopeptidase 0.1956 1 1
Trypanosoma cruzi hypothetical protein, conserved 0.0155 0.0724 0.214
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.0658 0.3312 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0019 0.0134
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0076 0.0541
Plasmodium falciparum peptidase, putative 0.0155 0.0724 0.5
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.0155 0.0724 0.214
Toxoplasma gondii acylaminoacyl-peptidase, putative 0.0155 0.0724 0.1914
Toxoplasma gondii prolyl endopeptidase 0.0155 0.0724 0.1914
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0092 0.0658
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0076 0.0543
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0092 0.0658
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0054 0.0204 0.0564
Brugia malayi prolyl oligopeptidase family protein 0.0155 0.0724 0.0706
Echinococcus multilocularis prolyl endopeptidase 0.0155 0.0724 0.0706
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.009 0.0646
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0133 0.095
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0054 0.0204 0.0186
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0111 0.0092
Entamoeba histolytica prolyl oligopeptidase family protein 0.0155 0.0724 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0112 0.0805
Brugia malayi MH2 domain containing protein 0.0144 0.0667 0.065
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0147 0.1054
Trichomonas vaginalis Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase 0.0155 0.0724 0.5175
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0133 0.095
Trypanosoma brucei prolyl endopeptidase 0.0155 0.0724 0.214
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0054 0.0204 0.0186
Giardia lamblia Alanyl dipeptidyl peptidase 0.0155 0.0724 1
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0155 0.0724 0.5
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.1956 1 1
Giardia lamblia Alanyl dipeptidyl peptidase 0.0155 0.0724 1
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.1956 1 1
Schistosoma mansoni acylaminoacyl-peptidase (S09 family) 0.0155 0.0724 0.0706
Echinococcus multilocularis acylamino acid releasing enzyme 0.0155 0.0724 0.0706
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0054 0.0204 0.0186
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0155 0.0724 1
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0054 0.0204 0.0564
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0155 0.0724 0.214
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0104 0.0085
Trypanosoma brucei Alpha/beta hydrolase domain-containing protein 0.0155 0.0724 0.214
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.1956 1 1
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.0658 0.3312 1
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.1956 1 1
Brugia malayi hypothetical protein 0.0503 0.2514 0.25
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0133 0.095
Brugia malayi prolyl oligopeptidase family protein 0.0658 0.3312 0.33
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0019 0.0134
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.009 0.0646
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0147 0.1054
Echinococcus granulosus acylamino acid releasing enzyme 0.0155 0.0724 0.0706
Brugia malayi prolyl oligopeptidase family protein 0.0155 0.0724 0.0706
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0106 0.0761
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0076 0.0541
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.0204 0.1463
Trypanosoma cruzi oligopeptidase b 0.0155 0.0724 0.214
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0023 0.0041 0.0068
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.0164 0.117
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0251 0.1219 0.1203
Trichomonas vaginalis set domain proteins, putative 0.0286 0.1398 1
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.0658 0.3312 1
Toxoplasma gondii hypothetical protein 0.0155 0.0724 0.1914
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0019 0.0134
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0092 0.0658
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.0658 0.3312 1
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0026 0.0057 0.0117
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0133 0.095
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0036 0.0111 0.0092
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0155 0.0724 0.0706
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0054 0.0204 0.0564
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.0204 0.1463
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0155 0.0724 0.214
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0076 0.0541
Brugia malayi Pre-SET motif family protein 0.0036 0.0111 0.0092
Loa Loa (eye worm) hypothetical protein 0.0155 0.0724 0.0706
Loa Loa (eye worm) phosphatidylinositol 3 0.0054 0.0204 0.0186
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.0111 0.0092
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0147 0.1054
Trichomonas vaginalis conserved hypothetical protein 0.0155 0.0724 0.5175
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.0658 0.3312 0.33
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0076 0.0543
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0076 0.0543
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0147 0.1054
Echinococcus multilocularis Dipeptidyl peptidase 9 0.0658 0.3312 0.33
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0043 0.0148 0.0391
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0155 0.0724 0.0706
Entamoeba histolytica prolyl oligopeptidase family protein 0.0155 0.0724 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0111 0.0092
Trypanosoma cruzi oligopeptidase b 0.0155 0.0724 0.214
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0054 0.0204 0.0186
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.0658 0.3312 1
Trypanosoma cruzi target of rapamycin kinase 3 0.0043 0.0148 0.0391
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.0204 0.1463
Loa Loa (eye worm) hypothetical protein 0.0036 0.0111 0.0092
Leishmania major oligopeptidase b 0.0155 0.0724 0.214
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.0667 0.065
Loa Loa (eye worm) prolyl oligopeptidase 0.0155 0.0724 0.0706
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0043 0.0148 0.0391
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0054 0.0204 0.0564
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0133 0.095
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0019 0.0134
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0076 0.0543
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0155 0.0724 0.214
Trypanosoma brucei oligopeptidase b 0.0155 0.0724 0.214
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0155 0.0724 0.214
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0155 0.0724 0.0706
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0111 0.0092
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.0111 0.0092
Brugia malayi prolyl oligopeptidase family protein 0.0155 0.0724 0.0706
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0019 0.0134
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.0658 0.3312 1
Trypanosoma cruzi hypothetical protein, conserved 0.0155 0.0724 0.214
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0133 0.095
Echinococcus granulosus Dipeptidyl peptidase 9 0.0658 0.3312 0.33
Loa Loa (eye worm) hypothetical protein 0.0503 0.2514 0.25
Toxoplasma gondii target of rapamycin (TOR), putative 0.004 0.0133 0.0069
Mycobacterium tuberculosis Probable peptidase 0.0155 0.0724 0.5
Trypanosoma cruzi prolyl endopeptidase 0.0155 0.0724 0.214
Onchocerca volvulus Prolyl endopeptidase homolog 0.0155 0.0724 0.062
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0111 0.0092
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.0155 0.0724 0.5
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0054 0.0204 0.0564
Loa Loa (eye worm) hypothetical protein 0.0155 0.0724 0.0706
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.0667 0.065
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0147 0.1054
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0133 0.095
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0054 0.0204 0.0564

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 2.6122 uM PUBCHEM_BIOASSAY: IN Cell qHTS Assay for Inhibitors of the mTORC1 Signaling Pathway in MEF (Tsc2-/-, p53-/-) Cells: Sytravon. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2660, AID2666, AID2667, AID2668, AID2681, AID493208] ChEMBL. No reference
Potency (functional) 5.2119 uM PUBCHEM_BIOASSAY: Acumen qHTS Assay for Inhibitors of the mTORC1 Signaling Pathway in MEF (Tsc2-/-, p53-/-) Cells: Sytravon. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2660, AID2666, AID2667, AID2668, AID2681, AID504465] ChEMBL. No reference
Potency (functional) 7.9433 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 7.9433 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53 Null Cells at the Nonpermissive Temperature. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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