Detailed information for compound 896921

Basic information

Technical information
  • TDR Targets ID: 896921
  • Name: 2-ethylsulfanylethyl 4-(2-chloro-6-fluorophen yl)-1,6-dimethyl-2-oxo-3,4-dihydropyrimidine- 5-carboxylate
  • MW: 386.869 | Formula: C17H20ClFN2O3S
  • H donors: 1 H acceptors: 2 LogP: 2.94 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCSCCOC(=O)C1=C(C)N(C)C(=O)NC1c1c(F)cccc1Cl
  • InChi: 1S/C17H20ClFN2O3S/c1-4-25-9-8-24-16(22)13-10(2)21(3)17(23)20-15(13)14-11(18)6-5-7-12(14)19/h5-7,15H,4,8-9H2,1-3H3,(H,20,23)
  • InChiKey: BFBAOEQJOXZRKE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-ethylsulfanylethyl 4-(2-chloro-6-fluoro-phenyl)-1,6-dimethyl-2-oxo-3,4-dihydropyrimidine-5-carboxylate
  • 4-(2-chloro-6-fluorophenyl)-1,6-dimethyl-2-oxo-3,4-dihydropyrimidine-5-carboxylic acid 2-(ethylthio)ethyl ester
  • 4-(2-chloro-6-fluoro-phenyl)-2-keto-1,6-dimethyl-3,4-dihydropyrimidine-5-carboxylic acid 2-(ethylthio)ethyl ester
  • A3095/0131021

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0035 0.0043 0.0018
Brugia malayi Probable ClpP-like protease 0.0089 0.0826 0.0803
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0035 0.0043 0.0018
Loa Loa (eye worm) hypothetical protein 0.0112 0.1162 0.1139
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0035 0.0043 0.0018
Schistosoma mansoni hypothetical protein 0.0198 0.2433 0.2414
Schistosoma mansoni hypothetical protein 0.0198 0.2433 0.2414
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0035 0.0043 0.0018
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0035 0.0043 0.0018
Echinococcus granulosus Receptor type tyrosine protein phosphatase O 0.0035 0.0043 0.0018
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0061 0.0414 0.0794
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0035 0.0043 0.0018
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0035 0.0043 0.0018
Schistosoma mansoni receptor protein tyrosine phosphatase r (pcptp1) 0.0035 0.0043 0.0018
Brugia malayi latrophilin 2 splice variant baaae 0.0076 0.0644 0.062
Schistosoma mansoni pcd6 interacting protein-related 0.0035 0.0043 0.0018
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0035 0.0043 0.0018
Schistosoma mansoni hypothetical protein 0.0035 0.0043 0.0018
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0035 0.0043 0.0018
Onchocerca volvulus 0.0035 0.0043 0.0802
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0035 0.0043 0.0018
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0035 0.0043 0.0018
Schistosoma mansoni receptor protein tyrosine phosphatase n (ia2) 0.0035 0.0043 0.0018
Onchocerca volvulus 0.0035 0.0043 0.0802
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0353 0.4708 1
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0089 0.0826 0.0803
Loa Loa (eye worm) hypothetical protein 0.0035 0.0043 0.0018
Onchocerca volvulus 0.0035 0.0043 0.0802
Echinococcus multilocularis hypothetical protein 0.0035 0.0043 0.0018
Schistosoma mansoni hypothetical protein 0.0035 0.0043 0.0018
Onchocerca volvulus 0.0035 0.0043 0.0802
Schistosoma mansoni non-receptor protein-tyrosine phosphatase 0.0035 0.0043 0.0018
Echinococcus multilocularis geminin 0.0198 0.2433 0.2414
Onchocerca volvulus 0.0035 0.0043 0.0802
Brugia malayi Protein-tyrosine phosphatase 0.0035 0.0043 0.0018
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0089 0.0826 1
Brugia malayi hypothetical protein 0.0035 0.0043 0.0018
Loa Loa (eye worm) hypothetical protein 0.0035 0.0043 0.0018
Loa Loa (eye worm) protein tyrosine phosphatase 0.0035 0.0043 0.0018
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0035 0.0043 0.0018
Echinococcus multilocularis receptor type tyrosine protein phosphatase H 0.0035 0.0043 0.0018
Loa Loa (eye worm) hypothetical protein 0.0035 0.0043 0.0018
Brugia malayi jmjC domain containing protein 0.0041 0.0131 0.0106
Loa Loa (eye worm) hypothetical protein 0.0035 0.0043 0.0018
Onchocerca volvulus 0.0035 0.0043 0.0802
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0035 0.0043 0.0018
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0035 0.0043 0.0018
Echinococcus multilocularis chromobox protein 1 0.0081 0.0721 0.0697
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0035 0.0043 0.0018
Echinococcus granulosus jumonji domain containing protein 0.0047 0.0222 0.0196
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0035 0.0043 0.0018
Loa Loa (eye worm) dual specificity protein phosphatase CDC14B 0.0035 0.0043 0.0018
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0035 0.0043 0.0018
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0035 0.0043 0.0018
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0035 0.0043 0.0018
Loa Loa (eye worm) hypothetical protein 0.0035 0.0043 0.0018
Echinococcus granulosus Receptor type tyrosine protein phosphatase O 0.0035 0.0043 0.0018
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0196 0.2714
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0035 0.0043 0.0018
Schistosoma mansoni chromobox protein 0.0081 0.0721 0.0697
Echinococcus multilocularis jumonji domain containing protein 0.0047 0.0222 0.0196
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0035 0.0043 0.0018
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0035 0.0043 0.0018
Echinococcus granulosus chromobox protein 1 0.0081 0.0721 0.0697
Onchocerca volvulus 4.1 G protein, putative homolog 0.0035 0.0043 0.0802
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0112 0.1164 0.1141
Brugia malayi Protein-tyrosine phosphatase 0.0035 0.0043 0.0018
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0035 0.0043 0.0018
Loa Loa (eye worm) hypothetical protein 0.0035 0.0043 0.0018
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0035 0.0043 0.0018
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0035 0.0043 0.0018
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0035 0.0043 0.5
Loa Loa (eye worm) hypothetical protein 0.0035 0.0043 0.0018
Trichomonas vaginalis chromobox protein, putative 0.0049 0.0247 0.3419
Brugia malayi chromobox protein homolog 3 0.0046 0.0196 0.017
Onchocerca volvulus 0.0035 0.0043 0.0802
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0035 0.0043 0.0018
Loa Loa (eye worm) hypothetical protein 0.0035 0.0043 0.0018
Onchocerca volvulus 0.0035 0.0043 0.0802
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0035 0.0043 0.0018
Onchocerca volvulus 0.0035 0.0043 0.0802
Loa Loa (eye worm) jmjC domain-containing protein 0.0041 0.0131 0.0106
Onchocerca volvulus 0.0035 0.0043 0.0802
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0089 0.0826 1
Brugia malayi hypothetical protein 0.0035 0.0043 0.0018
Loa Loa (eye worm) hypothetical protein 0.0046 0.0196 0.017
Loa Loa (eye worm) hypothetical protein 0.0035 0.0043 0.0018
Loa Loa (eye worm) transcription factor SMAD2 0.0128 0.1397 0.1374
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.005 0.0254 0.0452
Loa Loa (eye worm) heterochromatin protein 1 0.0081 0.0721 0.0697
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0714 1 1
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0035 0.0043 0.0018
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0035 0.0043 0.0018
Brugia malayi MH2 domain containing protein 0.0128 0.1397 0.1374
Trichomonas vaginalis pten, drome, putative 0.0035 0.0043 0.0603
Onchocerca volvulus 0.0035 0.0043 0.0802
Onchocerca volvulus 0.0035 0.0043 0.0802
Schistosoma mansoni protein tyrosine phosphatase 0.0035 0.0043 0.0018
Echinococcus multilocularis protein tyrosine phosphatase n9 0.0035 0.0043 0.0018
Trypanosoma brucei DNA polymerase beta thumb, putative 0.005 0.0254 0.0452
Brugia malayi hypothetical protein 0.0035 0.0043 0.0018
Brugia malayi jmjC domain containing protein 0.0112 0.1164 0.1141
Brugia malayi Dual specificity protein phosphatase CDC14B 0.0035 0.0043 0.0018
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0035 0.0043 0.0018
Loa Loa (eye worm) hypothetical protein 0.0035 0.0043 0.0018
Trichomonas vaginalis chromobox protein, putative 0.0081 0.0721 1
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0035 0.0043 0.0018
Loa Loa (eye worm) hypothetical protein 0.0035 0.0043 0.0018
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0035 0.0043 0.0018
Schistosoma mansoni protein-tyrosine phosphatase non-receptor type nt5 0.0035 0.0043 0.0018
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0035 0.0043 0.0018
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0167 0.1978 0.4148
Onchocerca volvulus 0.0035 0.0043 0.0802
Trichomonas vaginalis chromobox protein, putative 0.0081 0.0721 1
Leishmania major mitochondrial DNA polymerase beta 0.0353 0.4708 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0043 0.0018
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0035 0.0043 0.0018
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0035 0.0043 0.0018
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0167 0.1978 0.4148
Echinococcus multilocularis peptidase Clp (S14 family) 0.0058 0.0378 0.0353
Loa Loa (eye worm) hypothetical protein 0.0035 0.0043 0.0018
Brugia malayi protein-tyrosine phosphatase Lar-like precursor, putative 0.0035 0.0043 0.0018
Loa Loa (eye worm) hypothetical protein 0.0036 0.0051 0.0025
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0035 0.0043 0.0018
Loa Loa (eye worm) jmjC domain-containing protein 0.007 0.0558 0.0534
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0035 0.0043 0.0018
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0035 0.0043 0.0018
Schistosoma mansoni protein tyrosine phosphatase 0.0035 0.0043 0.0018
Brugia malayi hypothetical protein 0.0035 0.0043 0.0018
Onchocerca volvulus 0.0035 0.0043 0.0802
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0035 0.0043 0.0018
Onchocerca volvulus 0.0035 0.0043 0.0802
Loa Loa (eye worm) hypothetical protein 0.0035 0.0043 0.0018
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0035 0.0043 0.0018
Onchocerca volvulus 0.0035 0.0043 0.0802
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0035 0.0043 0.0018
Schistosoma mansoni receptor protein tyrosine phosphatase 0.0035 0.0043 0.0018
Loa Loa (eye worm) hypothetical protein 0.0035 0.0043 0.0018
Schistosoma mansoni jumonji/arid domain-containing protein 0.0041 0.0131 0.0106
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0035 0.0043 0.0018
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.0035 0.0043 0.0018
Schistosoma mansoni receptor protein tyrosine phosphatase n (ia2) 0.0035 0.0043 0.0018
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0035 0.0043 0.0018
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0035 0.0043 0.5
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0046 0.0196 0.7695
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0035 0.0043 0.0018
Brugia malayi Protein-tyrosine phosphatase 1 0.0035 0.0043 0.0018
Onchocerca volvulus 0.0035 0.0043 0.0802
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0035 0.0043 0.0018
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0035 0.0043 0.0018
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0035 0.0043 0.0018
Brugia malayi Calcitonin receptor-like protein seb-1 0.0112 0.1162 0.1139
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0196 0.2714
Onchocerca volvulus 0.0036 0.0051 0.1137
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0035 0.0043 0.0018
Echinococcus granulosus chromobox protein 1 0.0081 0.0721 0.0697
Echinococcus multilocularis lysine specific demethylase 5A 0.0041 0.0131 0.0106
Loa Loa (eye worm) protein-tyrosine phosphatase 1 0.0035 0.0043 0.0018
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0035 0.0043 0.0018
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.0528 0.7267 0.726
Brugia malayi Latrophilin receptor protein 2 0.0035 0.0043 0.0018
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0035 0.0043 0.0018
Mycobacterium tuberculosis Conserved hypothetical protein 0.0186 0.2255 1
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.0035 0.0043 0.0018
Brugia malayi Heterochromatin protein 1 0.0081 0.0721 0.0697
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0035 0.0043 0.0018
Loa Loa (eye worm) hypothetical protein 0.0035 0.0043 0.0018
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0035 0.0043 0.0018
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0035 0.0043 0.0018
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0089 0.0826 0.5
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0035 0.0043 0.0018
Entamoeba histolytica Pten 3-phosphoinositide phosphatase, putative 0.0035 0.0043 0.5
Schistosoma mansoni chromobox protein 0.0081 0.0721 0.0697
Trichomonas vaginalis chromobox protein, putative 0.0049 0.0247 0.3419
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0089 0.0826 1
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0035 0.0043 0.0018
Loa Loa (eye worm) hypothetical protein 0.0035 0.0043 0.0018
Loa Loa (eye worm) hypothetical protein 0.0035 0.0043 0.0018
Echinococcus granulosus lysine specific demethylase 5A 0.0041 0.0131 0.0106
Loa Loa (eye worm) hypothetical protein 0.0035 0.0043 0.0018
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0089 0.0826 0.5
Onchocerca volvulus 0.0035 0.0043 0.0802
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0049 0.0247 1
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.0035 0.0043 0.0018
Schistosoma mansoni hypothetical protein 0.0035 0.0043 0.0018
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0035 0.0043 0.0018
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0035 0.0043 0.0018
Onchocerca volvulus 0.0035 0.0043 0.0802
Echinococcus granulosus geminin 0.0198 0.2433 0.2414
Brugia malayi hypothetical protein 0.0035 0.0043 0.0018
Giardia lamblia Protein tyrosine phosphatase 0.0035 0.0043 1
Schistosoma mansoni rgs-gaip interacting protein gipc 0.0035 0.0043 0.0018
Loa Loa (eye worm) hypothetical protein 0.0035 0.0043 0.0018
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0035 0.0043 0.0018
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0089 0.0826 1
Loa Loa (eye worm) protein-tyrosine-phosphatase 0.0035 0.0043 0.0018
Schistosoma mansoni hypothetical protein 0.0035 0.0043 0.0018
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0112 0.1164 0.1141
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0035 0.0043 0.0018
Loa Loa (eye worm) hypothetical protein 0.0035 0.0043 0.0018
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.005 0.0254 0.0452
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0167 0.1978 0.4148
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0035 0.0043 0.0018
Echinococcus multilocularis 0.0035 0.0043 0.0018
Echinococcus multilocularis chromobox protein 1 0.0081 0.0721 0.0697
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0035 0.0043 0.0018
Loa Loa (eye worm) hypothetical protein 0.0076 0.0644 0.062
Loa Loa (eye worm) MH2 domain-containing protein 0.0128 0.1397 0.1374
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0089 0.0826 1
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0035 0.0043 0.0018
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0035 0.0043 0.0018
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.005 0.0254 0.0452
Schistosoma mansoni peptidase Clp (S14 family) 0.0089 0.0826 0.0803
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0528 0.7267 0.726
Loa Loa (eye worm) hypothetical protein 0.0035 0.0043 0.0018
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0035 0.0043 0.0018
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0035 0.0043 0.0018
Onchocerca volvulus 0.0035 0.0043 0.0802
Schistosoma mansoni hypothetical protein 0.0076 0.0644 0.062
Toxoplasma gondii hypothetical protein 0.0057 0.0361 0.4192
Echinococcus granulosus peptidase Clp S14 family 0.0058 0.0378 0.0353
Loa Loa (eye worm) hypothetical protein 0.0035 0.0043 0.0018
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0035 0.0043 0.0018
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0035 0.0043 0.0018
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0035 0.0043 0.0018
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.0035 0.0043 0.0018
Loa Loa (eye worm) hypothetical protein 0.0035 0.0043 0.0018
Onchocerca volvulus 0.0035 0.0043 0.0802
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0035 0.0043 0.0018
Onchocerca volvulus 0.0035 0.0043 0.0802
Loa Loa (eye worm) hypothetical protein 0.0035 0.0043 0.0018
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.0035 0.0043 0.0018
Schistosoma mansoni jumonji/arid domain-containing protein 0.0041 0.0131 0.0106
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0035 0.0043 0.0018
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0112 0.1162 0.1139
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0035 0.0043 0.0018
Echinococcus granulosus protein tyrosine phosphatase n9 0.0035 0.0043 0.0018
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0035 0.0043 0.0018
Loa Loa (eye worm) latrophilin receptor protein 2 0.0035 0.0043 0.0018
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0528 0.7267 0.726
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0089 0.0826 0.0803
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0089 0.0826 0.5
Loa Loa (eye worm) hypothetical protein 0.0035 0.0043 0.0018
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0089 0.0826 0.5
Echinococcus multilocularis GPCR, family 2 0.0035 0.0043 0.0018
Loa Loa (eye worm) hypothetical protein 0.0089 0.0826 0.0803
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0112 0.1162 0.1139
Schistosoma mansoni jumonji domain containing protein 0.0089 0.0827 0.0804
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0714 1 1
Loa Loa (eye worm) hypothetical protein 0.0058 0.0383 0.0358
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0714 1 1
Schistosoma mansoni protein tyrosine phosphatase non-receptor type nt1 0.0714 1 1
Echinococcus granulosus GPCR family 2 0.0035 0.0043 0.0018
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0353 0.4708 1
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0035 0.0043 0.0018
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0035 0.0043 0.0018
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0353 0.4708 1
Schistosoma mansoni protein tyrosine phosphatase 0.0035 0.0043 0.0018
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0035 0.0043 0.0018
Onchocerca volvulus 0.0035 0.0043 0.0802
Schistosoma mansoni protein-tyrosine phosphatase n9 0.0035 0.0043 0.0018
Mycobacterium ulcerans hypothetical protein 0.0186 0.2255 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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