Detailed information for compound 897348

Basic information

Technical information
  • TDR Targets ID: 897348
  • Name: 2-(4-chlorophenoxy)-N-[(3,5-dibromo-2-methoxy phenyl)methylideneamino]acetamide
  • MW: 476.547 | Formula: C16H13Br2ClN2O3
  • H donors: 1 H acceptors: 1 LogP: 4.85 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1c(C=NNC(=O)COc2ccc(cc2)Cl)cc(cc1Br)Br
  • InChi: 1S/C16H13Br2ClN2O3/c1-23-16-10(6-11(17)7-14(16)18)8-20-21-15(22)9-24-13-4-2-12(19)3-5-13/h2-8H,9H2,1H3,(H,21,22)/b20-8+
  • InChiKey: QQVZBJRQINRSSV-DNTJNYDQSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-(4-chlorophenoxy)-N-[(3,5-dibromo-2-methoxy-phenyl)methyleneamino]acetamide
  • 2-(4-chlorophenoxy)-N-[(3,5-dibromo-2-methoxyphenyl)methyleneamino]acetamide
  • 2-(4-chlorophenoxy)-N-[(3,5-dibromo-2-methoxy-benzylidene)amino]acetamide
  • 2-(4-chlorophenoxy)-N-[(3,5-dibromo-2-methoxy-phenyl)methylideneamino]ethanamide
  • A0763/0035691

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi hypothetical protein 0.0449 0.6764 1
Schistosoma mansoni lamin 0.0071 0.0619 0.3217
Loa Loa (eye worm) hypothetical protein 0.0449 0.6764 1
Echinococcus multilocularis lamin dm0 0.0071 0.0619 0.06
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0302 0.4381 1
Echinococcus granulosus tar DNA binding protein 0.007 0.0596 0.0852
Loa Loa (eye worm) phosphotyrosine protein phosphatase 0.0302 0.4381 0.6477
Brugia malayi Low molecular weight phosphotyrosine protein phosphatase containing protein 0.0302 0.4381 0.6433
Brugia malayi jmjC domain containing protein 0.0048 0.0245 0.0243
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0038 0.0083 0.0122
Schistosoma mansoni survival motor neuron protein 0.0092 0.0952 0.5376
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0124 0.1484 0.2169
Loa Loa (eye worm) inositol-1 0.0041 0.0124 0.0183
Mycobacterium ulcerans phosphotyrosine protein phosphatase PtpA 0.0302 0.4381 1
Entamoeba histolytica hypothetical protein 0.0068 0.0574 0.1058
Echinococcus granulosus tumor protein p63 0.0345 0.5067 0.7484
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0093 0.0979 0.201
Schistosoma mansoni cellular tumor antigen P53 0.005 0.0283 0.1037
Loa Loa (eye worm) transcription factor SMAD2 0.0098 0.105 0.1553
Echinococcus granulosus lamin dm0 0.0071 0.0619 0.0887
Loa Loa (eye worm) MH2 domain-containing protein 0.0098 0.105 0.1553
Schistosoma mansoni jumonji domain containing protein 0.0048 0.0245 0.0789
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0068 0.0574 0.0554
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0124 0.1484 0.2193
Loa Loa (eye worm) RNA binding protein 0.007 0.0596 0.0881
Echinococcus multilocularis lamin 0.0071 0.0619 0.06
Echinococcus multilocularis inositol monophosphatase 1 0.0041 0.0124 0.0103
Schistosoma mansoni tar DNA-binding protein 0.007 0.0596 0.3063
Leishmania major hypothetical protein, conserved 0.0093 0.0979 1
Entamoeba histolytica hypothetical protein 0.0068 0.0574 0.1058
Echinococcus multilocularis geminin 0.0135 0.1665 0.1647
Loa Loa (eye worm) hypothetical protein 0.0098 0.1055 0.156
Echinococcus multilocularis survival motor neuron protein 1 0.0449 0.6764 0.6757
Brugia malayi hypothetical protein 0.0098 0.1055 0.1456
Mycobacterium tuberculosis Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) 0.0209 0.2865 1
Brugia malayi TAR-binding protein 0.007 0.0596 0.0768
Brugia malayi hypothetical protein 0.0068 0.0574 0.0735
Onchocerca volvulus 0.0092 0.0952 0.1632
Schistosoma mansoni tar DNA-binding protein 0.007 0.0596 0.3063
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0124 0.1484 0.2169
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0302 0.4381 1
Loa Loa (eye worm) hypothetical protein 0.005 0.0283 0.0419
Brugia malayi RNA recognition motif domain containing protein 0.007 0.0596 0.0768
Onchocerca volvulus 0.0302 0.4381 1
Brugia malayi Inositol-1 0.0041 0.0124 0.0061
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0302 0.4381 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0124 0.1484 0.8823
Schistosoma mansoni jumonji/arid domain-containing protein 0.0048 0.0245 0.0789
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0048 0.0245 0.0224
Schistosoma mansoni hypothetical protein 0.0092 0.0952 0.5376
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0302 0.4381 1
Loa Loa (eye worm) intermediate filament protein 0.0071 0.0619 0.0916
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0048 0.0245 0.0332
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0041 0.0124 0.5
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0068 0.0574 0.082
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0124 0.1484 0.2097
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0092 0.0952 0.1302
Brugia malayi RNA binding protein 0.007 0.0596 0.0768
Loa Loa (eye worm) hypothetical protein 0.0071 0.0619 0.0916
Echinococcus multilocularis tumor protein p63 0.0345 0.5067 0.5057
Schistosoma mansoni transcription factor LCR-F1 0.0068 0.0574 0.2922
Loa Loa (eye worm) pigment dispersing factor receptor c 0.004 0.0111 0.0164
Brugia malayi intermediate filament protein 0.0071 0.0619 0.0804
Giardia lamblia Low molecular weight protein-tyrosine-phosphatase 0.0302 0.4381 0.5
Brugia malayi jmjC domain containing protein 0.0048 0.0245 0.0243
Brugia malayi MH2 domain containing protein 0.0098 0.105 0.1449
Brugia malayi Intermediate filament tail domain containing protein 0.0071 0.0619 0.0804
Onchocerca volvulus 0.0071 0.0619 0.082
Echinococcus granulosus intermediate filament protein 0.0071 0.0619 0.0887
Echinococcus granulosus lamin 0.0071 0.0619 0.0887
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0036 0.0054 0.5
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0302 0.4381 1
Trypanosoma cruzi hypothetical protein, conserved 0.0093 0.0979 1
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0041 0.0124 0.5
Trypanosoma brucei low molecular weight protein tyrosine phosphatase, putative 0.0093 0.0979 1
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0302 0.4381 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.007 0.0596 0.0881
Schistosoma mansoni hypothetical protein 0.0135 0.1665 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.004 0.0111 0.0042
Onchocerca volvulus Huntingtin homolog 0.0098 0.1055 0.1883
Echinococcus granulosus survival motor neuron protein 1 0.0449 0.6764 1
Echinococcus multilocularis musashi 0.0071 0.0619 0.06
Trypanosoma cruzi hypothetical protein, conserved 0.0093 0.0979 1
Schistosoma mansoni hypothetical protein 0.0135 0.1665 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0124 0.1484 0.1465
Echinococcus granulosus geminin 0.0135 0.1665 0.2438
Schistosoma mansoni tar DNA-binding protein 0.007 0.0596 0.3063
Schistosoma mansoni intermediate filament proteins 0.0071 0.0619 0.3217
Entamoeba histolytica hypothetical protein 0.0068 0.0574 0.1058
Onchocerca volvulus 0.0071 0.0619 0.082
Loa Loa (eye worm) hypothetical protein 0.0098 0.1055 0.156
Brugia malayi Calcitonin receptor-like protein seb-1 0.004 0.0111 0.0042
Schistosoma mansoni hypothetical protein 0.0068 0.0574 0.2922
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0124 0.1484 0.8823
Loa Loa (eye worm) hypothetical protein 0.0034 0.0021 0.0031
Schistosoma mansoni tar DNA-binding protein 0.007 0.0596 0.3063
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0093 0.0979 0.201
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0071 0.0619 0.0916
Loa Loa (eye worm) TAR-binding protein 0.007 0.0596 0.0881
Echinococcus multilocularis lysine specific demethylase 5A 0.0048 0.0245 0.0224
Schistosoma mansoni tar DNA-binding protein 0.007 0.0596 0.3063
Loa Loa (eye worm) hypothetical protein 0.004 0.0111 0.0164
Loa Loa (eye worm) hypothetical protein 0.007 0.0598 0.0884
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0124 0.1484 0.8823
Echinococcus granulosus lysine specific demethylase 5A 0.0048 0.0245 0.0332
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0124 0.1484 0.1465
Loa Loa (eye worm) jmjC domain-containing protein 0.0048 0.0245 0.0362
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0302 0.4381 1
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0302 0.4381 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0048 0.0245 0.0789
Entamoeba histolytica hypothetical protein 0.0068 0.0574 0.1058
Echinococcus multilocularis tar DNA binding protein 0.007 0.0596 0.0576
Echinococcus granulosus inositol monophosphatase 1 0.0041 0.0124 0.0152
Schistosoma mansoni lamin 0.0071 0.0619 0.3217
Onchocerca volvulus Huntingtin homolog 0.0098 0.1055 0.1883

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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