Detailed information for compound 903333

Basic information

Technical information
  • TDR Targets ID: 903333
  • Name: [6-[[5-(cyclopropanecarbonylamino)-1,3,4-thia diazol-2-yl]sulfanylmethyl]-4-oxopyran-3-yl] 2-propylpentanoate
  • MW: 451.56 | Formula: C20H25N3O5S2
  • H donors: 1 H acceptors: 5 LogP: 3.69 Rotable bonds: 13
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCC(C(=O)Oc1coc(cc1=O)CSc1nnc(s1)NC(=O)C1CC1)CCC
  • InChi: 1S/C20H25N3O5S2/c1-3-5-13(6-4-2)18(26)28-16-10-27-14(9-15(16)24)11-29-20-23-22-19(30-20)21-17(25)12-7-8-12/h9-10,12-13H,3-8,11H2,1-2H3,(H,21,22,25)
  • InChiKey: LOCCDLSNAIIADN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [6-[[5-(cyclopropanecarbonylamino)-1,3,4-thiadiazol-2-yl]sulfanylmethyl]-4-oxo-pyran-3-yl] 2-propylpentanoate
  • 2-propylpentanoic acid [6-[[[5-[(cyclopropyl-oxomethyl)amino]-1,3,4-thiadiazol-2-yl]thio]methyl]-4-oxo-3-pyranyl] ester
  • 2-propylvaleric acid [6-[[[5-(cyclopropanecarbonylamino)-1,3,4-thiadiazol-2-yl]thio]methyl]-4-keto-pyran-3-yl] ester
  • [6-[[5-(cyclopropylcarbonylamino)-1,3,4-thiadiazol-2-yl]sulfanylmethyl]-4-oxo-pyran-3-yl] 2-propylpentanoate

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0022 0.009 0.009
Onchocerca volvulus 0.0033 0.0219 0.0901
Plasmodium vivax acyl-CoA synthetase, putative 0.0017 0.0036 0.0044
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0064 0.0574 0.0676
Leishmania major phosphoinositide-specific phospholipase C, putative 0.0017 0.0037 0.0053
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0054 0.0462 0.2386
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0104 1
Onchocerca volvulus 0.0033 0.0219 0.0901
Loa Loa (eye worm) hypothetical protein 0.0022 0.009 0.0466
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0022 0.009 0.0377
Onchocerca volvulus 0.0181 0.1935 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.0022 0.009 0.009
Onchocerca volvulus 0.0033 0.0219 0.0901
Schistosoma mansoni coup transcription factor 0.0022 0.009 0.0067
Toxoplasma gondii casein kinase ii regulatory subunit protein 0.0071 0.0661 0.1869
Trichomonas vaginalis casein kinase II beta chain, putative 0.0071 0.0661 1
Brugia malayi ecdysteroid receptor 0.0022 0.009 0.0377
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.0033 0.0173
Echinococcus multilocularis ecdysone induced protein 78C 0.0022 0.009 0.009
Trichomonas vaginalis casein kinase II beta chain, putative 0.0071 0.0661 1
Trichomonas vaginalis casein kinase II beta chain, putative 0.0071 0.0661 1
Onchocerca volvulus Bile acid receptor homolog 0.0022 0.009 0.0219
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0175 0.0818
Echinococcus multilocularis musashi 0.0029 0.0175 0.0175
Onchocerca volvulus 0.0022 0.009 0.0219
Echinococcus granulosus GPCR family 2 0.0017 0.0035 0.0041
Trichomonas vaginalis casein kinase II beta chain, putative 0.0071 0.0661 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0104 0.0536
Echinococcus multilocularis 1 phosphatidylinositol 4,5 bisphosphate 0.0018 0.0049 0.0049
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0018 0.0093
Loa Loa (eye worm) PAN domain-containing protein 0.0033 0.0219 0.1131
Echinococcus granulosus 1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-4 0.0018 0.0049 0.0058
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0022 0.009 0.0466
Schistosoma mansoni RAR-like nuclear receptor 0.0022 0.009 0.0067
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.009 0.0377
Brugia malayi PAN domain containing protein 0.0033 0.0219 0.1048
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.009 0.0377
Schistosoma mansoni jumonji/arid domain-containing protein 0.0064 0.0574 0.064
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0181 0.1935 1
Onchocerca volvulus 0.0033 0.0219 0.0901
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0022 0.009 0.0377
Brugia malayi Calcitonin receptor-like protein seb-1 0.0054 0.0462 0.2314
Brugia malayi PAN domain containing protein 0.0033 0.0219 0.1048
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0017 0.0035 0.0041
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0104 0.0447
Loa Loa (eye worm) hypothetical protein 0.0018 0.0049 0.0252
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0104 0.1118
Loa Loa (eye worm) hypothetical protein 0.0022 0.009 0.0466
Loa Loa (eye worm) hypothetical protein 0.0017 0.0035 0.0179
Brugia malayi nuclear receptor NHR-88 0.0022 0.009 0.0377
Brugia malayi Latrophilin receptor protein 2 0.0017 0.0035 0.0087
Loa Loa (eye worm) hypothetical protein 0.0051 0.0428 0.2209
Brugia malayi PAN domain containing protein 0.0033 0.0219 0.1048
Echinococcus granulosus ecdysone induced protein 78C 0.0022 0.009 0.0106
Onchocerca volvulus 0.0033 0.0219 0.0901
Brugia malayi Steroid receptor seven-up type 2 0.0022 0.009 0.0377
Loa Loa (eye worm) hypothetical protein 0.0037 0.0264 0.1364
Trichomonas vaginalis casein kinase II beta chain, putative 0.0071 0.0661 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0169 0.0872
Onchocerca volvulus 0.0033 0.0219 0.0901
Onchocerca volvulus 0.0051 0.0428 0.2008
Schistosoma mansoni casein kinase II beta subunit 0.0071 0.0661 0.0743
Echinococcus multilocularis JmjC domain containing protein 4 0.0017 0.0033 0.0033
Loa Loa (eye worm) Csnk2b protein 0.0071 0.0661 0.3417
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0104 0.0445
Plasmodium vivax phospholipase C-like, putative 0.0017 0.0037 0.0053
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0022 0.009 0.0106
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0126 0.1298 0.6707
Echinococcus multilocularis GPCR, family 2 0.0017 0.0035 0.0035
Toxoplasma gondii ck2 beta subunit 0.0071 0.0661 0.1869
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0022 0.009 0.0466
Loa Loa (eye worm) hypothetical protein 0.0022 0.009 0.0466
Brugia malayi jmjC domain containing protein 0.0017 0.0033 0.0081
Brugia malayi Variant SH3 domain containing protein 0.0126 0.1298 0.6676
Loa Loa (eye worm) hypothetical protein 0.0029 0.0175 0.0904
Trichomonas vaginalis casein kinase II beta chain, putative 0.0071 0.0661 1
Toxoplasma gondii phosphoinositide phospholipase PIPLC 0.0018 0.0049 0.0046
Toxoplasma gondii hypothetical protein 0.0033 0.0219 0.0552
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0022 0.009 0.0106
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0104 0.0447
Toxoplasma gondii kringle domain-containing protein 0.0051 0.0428 0.1174
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0104 1
Echinococcus granulosus intermediate filament protein 0.0029 0.0175 0.0206
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0104 0.1118
Toxoplasma gondii PAN domain-containing protein 0.0306 0.3392 1
Brugia malayi PAN domain containing protein 0.0033 0.0219 0.1048
Leishmania major hypothetical protein, conserved 0.0051 0.0428 0.6278
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0022 0.009 0.009
Loa Loa (eye worm) hypothetical protein 0.0017 0.0037 0.019
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0017 0.0033 0.0039
Trichomonas vaginalis casein kinase II beta chain, putative 0.0071 0.0661 1
Trypanosoma cruzi Casein kinase II subunit beta, putative 0.0071 0.0661 1
Loa Loa (eye worm) PAN domain-containing protein 0.0033 0.0219 0.1131
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0022 0.009 0.009
Schistosoma mansoni lamin 0.0029 0.0175 0.0167
Schistosoma mansoni retinoic acid receptor RXR 0.0022 0.009 0.0067
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0104 1
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0175 0.0904
Loa Loa (eye worm) hypothetical protein 0.0022 0.009 0.0466
Trichomonas vaginalis casein kinase II beta chain, putative 0.0071 0.0661 1
Echinococcus granulosus phd:f box containing protein 0.0017 0.0033 0.0039
Loa Loa (eye worm) hypothetical protein 0.0017 0.0033 0.0173
Brugia malayi Csnk2b protein 0.0071 0.0661 0.3355
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0022 0.009 0.0106
Toxoplasma gondii PAN domain-containing protein 0.0033 0.0219 0.0552
Echinococcus multilocularis casein kinase ii subunit beta 0.0071 0.0661 0.0661
Loa Loa (eye worm) ShTK domain-containing protein 0.0181 0.1935 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0033 0.0173
Brugia malayi Phosphatidylinositol-specific phospholipase C, X domain containing protein 0.0018 0.0049 0.0161
Echinococcus multilocularis microtubule associated protein 2 0.0745 0.8486 0.8486
Schistosoma mansoni hypothetical protein 0.0017 0.0035 0.0001
Brugia malayi PAN domain containing protein 0.0033 0.0219 0.1048
Echinococcus granulosus FTZ F1 alpha 0.0022 0.009 0.0106
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0022 0.009 0.0067
Echinococcus multilocularis jumonji domain containing 1A 0.0017 0.0033 0.0033
Echinococcus granulosus microtubule associated protein 2 0.0745 0.8486 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.0035 0.0087
Trichomonas vaginalis casein kinase II beta chain, putative 0.0071 0.0661 1
Plasmodium vivax casein kinase II beta chain, putative 0.0071 0.0661 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0022 0.009 0.0067
Onchocerca volvulus 0.0181 0.1935 1
Brugia malayi PAN domain containing protein 0.0033 0.0219 0.1048
Toxoplasma gondii PAN domain-containing protein 0.0033 0.0219 0.0552
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0104 1
Giardia lamblia Casein kinase II beta chain 0.0071 0.0661 1
Schistosoma mansoni jumonji domain containing protein 0.0064 0.0574 0.064
Loa Loa (eye worm) hypothetical protein 0.0018 0.0049 0.0252
Brugia malayi intermediate filament protein 0.0029 0.0175 0.0818
Plasmodium falciparum casein kinase II beta chain 0.0071 0.0661 1
Onchocerca volvulus 0.0033 0.0219 0.0901
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.009 0.0377
Echinococcus granulosus casein kinase ii subunit beta 0.0071 0.0661 0.0779
Leishmania major phosphatidylinositol-specific phospholipase-like protein 0.0017 0.0037 0.0053
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0104 0.0445
Brugia malayi Kringle domain containing protein 0.0051 0.0428 0.2136
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0181 0.1935 1
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0022 0.009 0.0219
Brugia malayi Protein kinase domain containing protein 0.0051 0.0428 0.2136
Echinococcus multilocularis FTZ F1 alpha 0.0022 0.009 0.009
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0017 0.0036 0.5
Toxoplasma gondii hypothetical protein 0.0033 0.0219 0.0552
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.009 0.0377
Echinococcus granulosus lamin 0.0029 0.0175 0.0206
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0022 0.009 0.0067
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.009 0.009
Schistosoma mansoni hypothetical protein 0.0017 0.0035 0.0001
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0017 0.0033 0.0033
Trypanosoma cruzi phosphoinositide-specific phospholipase C, putative 0.0018 0.0049 0.0245
Schistosoma mansoni lamin 0.0029 0.0175 0.0167
Brugia malayi Common central domain of tyrosinase family protein 0.0181 0.1935 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.009 0.0106
Onchocerca volvulus 0.0181 0.1935 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0017 0.0035 0.0035
Brugia malayi PAN domain containing protein 0.0033 0.0219 0.1048
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0104 0.0447
Onchocerca volvulus 0.0033 0.0219 0.0901
Trypanosoma brucei phosphoinositide-specific phospholipase C 0.0018 0.0049 0.0245
Mycobacterium ulcerans hypothetical protein 0.0023 0.0104 1
Brugia malayi ShTK domain containing protein 0.0181 0.1935 1
Echinococcus granulosus jumonji domain containing 1A 0.0017 0.0033 0.0039
Trichomonas vaginalis casein kinase II beta chain, putative 0.0071 0.0661 1
Schistosoma mansoni nuclear hormone receptor 0.0022 0.009 0.0067
Loa Loa (eye worm) hypothetical protein 0.0022 0.009 0.0466
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.009 0.0377
Brugia malayi Hypothetical tyrosinase-like protein F21C3.2 in chromosome I 0.0181 0.1935 1
Leishmania major phospholipase c-like protein 0.0018 0.0049 0.0245
Loa Loa (eye worm) hypothetical protein 0.0017 0.0036 0.0187
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0051 0.0428 0.6278
Leishmania major protein kinase ck2 regulatory subunit, putative 0.0071 0.0661 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0104 0.1118
Trichomonas vaginalis casein kinase II beta chain, putative 0.0071 0.0661 1
Schistosoma mansoni phospholipase C beta 0.0017 0.0037 0.0004
Brugia malayi latrophilin 2 splice variant baaae 0.0037 0.0264 0.1283
Onchocerca volvulus Casein kinase II subunit beta homolog 0.0071 0.0661 0.3246
Toxoplasma gondii microneme protein MIC4 0.0033 0.0219 0.0552
Toxoplasma gondii PAN domain-containing protein 0.0033 0.0219 0.0552
Loa Loa (eye worm) hypothetical protein 0.0181 0.1935 1
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0104 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0017 0.0035 0.0035
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0104 1
Brugia malayi PAN domain containing protein 0.0033 0.0219 0.1048
Schistosoma mansoni hypothetical protein 0.0051 0.0428 0.0466
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0022 0.009 0.0377
Loa Loa (eye worm) hypothetical protein 0.0022 0.009 0.0466
Schistosoma mansoni tyrosinase precursor 0.0181 0.1935 0.225
Loa Loa (eye worm) hypothetical protein 0.0023 0.0104 0.0536
Trypanosoma brucei Casein kinase II subunit beta, putative 0.0071 0.0661 1
Loa Loa (eye worm) phosphatidylinositol-specific phospholipase C 0.0018 0.0049 0.0252
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0064 0.0574 0.0574
Echinococcus granulosus lamin dm0 0.0029 0.0175 0.0206
Toxoplasma gondii 1,3(4)-beta-glucanase 0.0033 0.0219 0.0552
Echinococcus multilocularis lamin dm0 0.0029 0.0175 0.0175
Brugia malayi jmjC domain containing protein 0.0017 0.0033 0.0081
Schistosoma mansoni microtubule-associated protein tau 0.0745 0.8486 1
Brugia malayi 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 4 0.0017 0.0037 0.0098
Onchocerca volvulus 0.0033 0.0219 0.0901
Toxoplasma gondii microneme protein MIC17C 0.0033 0.0219 0.0552
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0022 0.009 0.0466
Loa Loa (eye worm) hypothetical protein 0.0017 0.0033 0.0173
Echinococcus multilocularis lysine specific demethylase 5A 0.0064 0.0574 0.0574
Loa Loa (eye worm) ShTK domain-containing protein 0.0181 0.1935 1
Loa Loa (eye worm) Plcb4 protein 0.0017 0.0037 0.019
Echinococcus multilocularis lysine specific demethylase 6a 0.0017 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.0023 0.0104 0.0536
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.009 0.0377
Loa Loa (eye worm) hypothetical protein 0.0017 0.0036 0.0187
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0022 0.009 0.009
Onchocerca volvulus 0.0033 0.0219 0.0901
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0022 0.009 0.0067
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0022 0.009 0.0377
Onchocerca volvulus 0.0029 0.0175 0.0668
Brugia malayi Phosphatidylinositol-specific phospholipase C, X domain containing protein 0.0017 0.0037 0.0098
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0022 0.009 0.0106
Loa Loa (eye worm) steroid hormone receptor 0.0022 0.009 0.0466
Schistosoma mansoni jumonji/arid domain-containing protein 0.0064 0.0574 0.064
Plasmodium falciparum phosphoinositide-specific phospholipase C 0.0017 0.0037 0.0053
Echinococcus multilocularis tissue type plasminogen activator 0.0051 0.0428 0.0428
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0022 0.009 0.0466
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.009 0.009
Schistosoma mansoni hypothetical protein 0.0017 0.0035 0.0001
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0104 1
Schistosoma mansoni tyrosinase precursor 0.0181 0.1935 0.225
Loa Loa (eye worm) hypothetical protein 0.0033 0.0219 0.1131
Loa Loa (eye worm) hypothetical protein 0.0017 0.0036 0.0187
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0071 0.0661 1
Brugia malayi PAN domain containing protein 0.0033 0.0219 0.1048
Loa Loa (eye worm) tyrosinase 1 0.0181 0.1935 1
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0175 0.0904
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0022 0.009 0.0466
Brugia malayi nuclear hormone receptor 0.0022 0.009 0.0377
Onchocerca volvulus 0.0029 0.0175 0.0668
Schistosoma mansoni intermediate filament proteins 0.0029 0.0175 0.0167
Loa Loa (eye worm) hypothetical protein 0.0181 0.1935 1
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0104 0.5
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0104 0.0445
Toxoplasma gondii microneme protein, putative 0.0033 0.0219 0.0552
Loa Loa (eye worm) hypothetical protein 0.0054 0.0462 0.2386
Brugia malayi jmjC domain containing protein 0.0017 0.0033 0.0081
Trichomonas vaginalis casein kinase II beta chain, putative 0.0071 0.0661 1
Trichomonas vaginalis casein kinase II beta chain, putative 0.0071 0.0661 1
Loa Loa (eye worm) PAN domain-containing protein 0.0033 0.0219 0.1131
Onchocerca volvulus 0.0181 0.1935 1
Schistosoma mansoni hypothetical protein 0.0037 0.0264 0.0273
Echinococcus multilocularis lamin 0.0029 0.0175 0.0175
Schistosoma mansoni steroid hormone receptor ad4bp 0.0022 0.009 0.0067
Trichomonas vaginalis casein kinase II beta chain, putative 0.0071 0.0661 1
Echinococcus granulosus lysine specific demethylase 6a 0.0017 0.0033 0.0039
Echinococcus granulosus lysine specific demethylase 5A 0.0064 0.0574 0.0676
Loa Loa (eye worm) hypothetical protein 0.0017 0.0036 0.0187
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0022 0.009 0.0377
Loa Loa (eye worm) hypothetical protein 0.0033 0.0219 0.1131
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.009 0.0106
Loa Loa (eye worm) hypothetical protein 0.0033 0.0219 0.1131
Loa Loa (eye worm) jmjC domain-containing protein 0.0064 0.0574 0.2966
Onchocerca volvulus 0.0033 0.0219 0.0901
Schistosoma mansoni thyroid hormone receptor 0.0022 0.009 0.0067
Schistosoma mansoni hypothetical protein 0.0017 0.0035 0.0001
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.0033 0.0173
Brugia malayi jmjC domain containing protein 0.0017 0.0033 0.0081
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0054 0.0462 0.2314
Toxoplasma gondii microneme protein MIC17B 0.0033 0.0219 0.0552
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.0035 0.0041
Brugia malayi PAN domain containing protein 0.0033 0.0219 0.1048
Schistosoma mansoni thyroid hormone receptor 0.0022 0.009 0.0067
Onchocerca volvulus 0.0023 0.0104 0.0291
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0022 0.009 0.0106
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0022 0.009 0.0466
Plasmodium falciparum acyl-CoA synthetase 0.0017 0.0036 0.0044
Brugia malayi jmjC domain containing protein 0.0064 0.0574 0.29
Echinococcus multilocularis phd:f box containing protein 0.0017 0.0033 0.0033
Brugia malayi jmjC domain containing protein 0.0064 0.0574 0.29
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0022 0.009 0.0377
Plasmodium falciparum casein kinase II beta chain 0.0071 0.0661 1
Loa Loa (eye worm) casein kinase II 0.0021 0.0078 0.0402
Plasmodium falciparum cysteine repeat modular protein 1 0.0051 0.0428 0.6278
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0022 0.009 0.0377
Loa Loa (eye worm) TK/ROR protein kinase 0.0051 0.0428 0.2209
Toxoplasma gondii PAN domain-containing protein 0.0306 0.3392 1
Trypanosoma cruzi hypothetical protein, conserved 0.0051 0.0428 0.6278
Loa Loa (eye worm) hypothetical protein 0.0022 0.009 0.0466
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0071 0.0661 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.0035 0.0179
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0104 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.0033 0.0173
Loa Loa (eye worm) hypothetical protein 0.0033 0.0219 0.1131
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0022 0.009 0.0466
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.0036 0.139
Onchocerca volvulus Protein ultraspiracle homolog 0.0022 0.009 0.0219
Brugia malayi steroid hormone receptor 0.0022 0.009 0.0377
Toxoplasma gondii subtilisin SUB12 0.0033 0.0219 0.0552
Loa Loa (eye worm) PAN domain-containing protein 0.0033 0.0219 0.1131
Brugia malayi casein kinase II, putaitve 0.0021 0.0078 0.0312
Loa Loa (eye worm) hypothetical protein 0.0033 0.0219 0.1131
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0071 0.0661 1
Echinococcus granulosus tissue type plasminogen activator 0.0051 0.0428 0.0504
Loa Loa (eye worm) hypothetical protein 0.0022 0.009 0.0466
Loa Loa (eye worm) hypothetical protein 0.0017 0.0036 0.0187
Trichomonas vaginalis casein kinase II beta chain, putative 0.0071 0.0661 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0022 0.009 0.0067
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0181 0.1935 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0104 1
Brugia malayi photoreceptor-specific nuclear receptor 0.0022 0.009 0.0377
Onchocerca volvulus Casein kinase II subunit beta homolog 0.0071 0.0661 0.3246
Toxoplasma gondii microneme protein MIC17A 0.0033 0.0219 0.0552
Loa Loa (eye worm) hypothetical protein 0.0033 0.0219 0.1131
Toxoplasma gondii PAN/Apple domain-containing protein 0.0033 0.0219 0.0552
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.009 0.0377
Trypanosoma cruzi Casein kinase II subunit beta, putative 0.0071 0.0661 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0022 0.009 0.0067
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0104 0.5
Loa Loa (eye worm) hypothetical protein 0.0033 0.0219 0.1131
Plasmodium vivax casein kinase II beta chain, putative 0.0071 0.0661 1
Loa Loa (eye worm) PAN domain-containing protein 0.0033 0.0219 0.1131
Toxoplasma gondii PAN domain-containing protein 0.0033 0.0219 0.0552
Echinococcus granulosus JmjC domain containing protein 4 0.0017 0.0033 0.0039

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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