TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 439.483 | Formula: C23H26FN5O3
H donors: 2 H acceptors: 3 LogP: 1.81 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: CCOC(=O)C1=C(CN2CCN(CC2)c2ccccn2)NC(=O)NC1c1ccc(cc1)F
InChi: 1S/C23H26FN5O3/c1-2-32-22(30)20-18(26-23(31)27-21(20)16-6-8-17(24)9-7-16)15-28-11-13-29(14-12-28)19-5-3-4-10-25-19/h3-10,21H,2,11-15H2,1H3,(H2,26,27,31)
InChiKey: ODKPJTUHZMCARU-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0248	0.2205	0.2205
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0233	0.0233
Trichomonas vaginalis	CAMK family protein kinase	0.0047	0.0121	0.0253
Schistosoma mansoni	neuropeptide receptor	0.0248	0.2205	0.2205
Schistosoma mansoni	opsin-like receptor	0.0248	0.2205	0.2205
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0248	0.2205	1
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0248	0.2205	0.2205
Brugia malayi	Papain family cysteine protease containing protein	0.011	0.0774	0.0774
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0349	0.3253	1
Loa Loa (eye worm)	hypothetical protein	0.0248	0.2205	0.2205
Leishmania major	cathepsin L-like protease	0.0187	0.1567	0.4654
Echinococcus granulosus	neuropeptides capa receptor	0.0248	0.2205	0.2205
Loa Loa (eye worm)	neuropeptide F receptor	0.0248	0.2205	0.2205
Giardia lamblia	Kinase, PLK	0.0096	0.0623	0.1293
Trichomonas vaginalis	CAMK family protein kinase	0.0096	0.0623	0.1816
Echinococcus granulosus	chromobox protein 1	0.0071	0.0362	0.0362
Leishmania major	cathepsin L-like protease	0.0187	0.1567	0.4654
Schistosoma mansoni	transcription factor LCR-F1	0.0037	0.0007	0.0007
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0248	0.2205	0.2205
Loa Loa (eye worm)	hypothetical protein	0.0248	0.2205	0.2205
Plasmodium vivax	vivapain-2	0.0187	0.1567	1
Echinococcus multilocularis	jumonji domain containing protein	0.0041	0.0056	0.0056
Echinococcus granulosus	dna polymerase eta	0.0045	0.01	0.01
Onchocerca volvulus		0.0248	0.2205	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0058	0.0233	0.0233
Entamoeba histolytica	cysteine protease, putative	0.0058	0.0233	0.1444
Brugia malayi	neuropeptide F receptor	0.0248	0.2205	0.2205
Echinococcus granulosus	biogenic amine 5HT receptor	0.0248	0.2205	0.2205
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0248	0.2205	0.2205
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0248	0.2205	0.2205
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0058	0.0233	0.06
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0248	0.2205	0.2205
Onchocerca volvulus		0.0248	0.2205	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0058	0.0233	0.06
Echinococcus multilocularis	geminin	0.0172	0.1413	0.1413
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0248	0.2205	0.2205
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0058	0.0233	0.06
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0999	1	1
Plasmodium vivax	serine-repeat antigen 5 (SERA)	0.0058	0.0233	0.0451
Echinococcus multilocularis	g protein coupled receptor	0.0248	0.2205	0.2205
Trichomonas vaginalis	CAMK family protein kinase	0.0047	0.0121	0.0253
Leishmania major	cathepsin L-like protease	0.0187	0.1567	0.4654
Echinococcus granulosus	hypothetical protein	0.0248	0.2205	0.2205
Loa Loa (eye worm)	hypothetical protein	0.0248	0.2205	0.2205
Onchocerca volvulus		0.0187	0.1567	0.7054
Onchocerca volvulus		0.0248	0.2205	1
Loa Loa (eye worm)	hypothetical protein	0.0135	0.1026	0.1026
Loa Loa (eye worm)	hypothetical protein	0.0248	0.2205	0.2205
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0248	0.2205	0.2205
Trichomonas vaginalis	conserved hypothetical protein	0.0058	0.0233	0.06
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0349	0.3253	0.3185
Loa Loa (eye worm)	hypothetical protein	0.0248	0.2205	0.2205
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0058	0.0233	0.06
Loa Loa (eye worm)	hypothetical protein	0.0248	0.2205	0.2205
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0058	0.0233	0.0233
Brugia malayi	hypothetical protein	0.0248	0.2205	0.2205
Loa Loa (eye worm)	hypothetical protein	0.0248	0.2205	0.2205
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0248	0.2205	0.2205
Echinococcus granulosus	neuropeptide Y receptor	0.0248	0.2205	0.2205
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0248	0.2205	0.2205
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0248	0.2205	0.2205
Brugia malayi	jmjC domain containing protein	0.0097	0.0634	0.0634
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0248	0.2205	0.2205
Entamoeba histolytica	cysteine protease, putative	0.011	0.0774	0.4913
Echinococcus multilocularis	cathepsin b	0.0999	1	1
Trypanosoma brucei	polo-like protein kinase	0.0096	0.0623	0.1659
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0058	0.0233	0.06
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0187	0.1567	0.1567
Echinococcus granulosus	tm gpcr rhodopsin	0.0248	0.2205	0.2205
Echinococcus multilocularis	neuropeptides capa receptor	0.0248	0.2205	0.2205
Onchocerca volvulus		0.0248	0.2205	1
Schistosoma mansoni	hypothetical protein	0.0248	0.2205	0.2205
Giardia lamblia	Cathepsin B precursor	0.0349	0.3253	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0248	0.2205	0.2205
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0233	0.0233
Echinococcus multilocularis	somatostatin receptor	0.0248	0.2205	0.2205
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0248	0.2205	0.2205
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or H-like cysteine peptidase	0.0058	0.0233	0.06
Trichomonas vaginalis	CAMK family protein kinase	0.0096	0.0623	0.1816
Entamoeba histolytica	cysteine protease, putative	0.011	0.0774	0.4913
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0248	0.2205	0.2205
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0187	0.1567	0.4654
Leishmania major	cathepsin L-like protease	0.0187	0.1567	0.4654
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0248	0.2205	0.2205
Brugia malayi	hypothetical protein	0.0248	0.2205	0.2205
Brugia malayi	AKH receptor	0.0248	0.2205	0.2205
Echinococcus multilocularis	allatostatin A receptor	0.0248	0.2205	0.2205
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.011	0.0774	0.0681
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0058	0.0233	0.0233
Onchocerca volvulus		0.0248	0.2205	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0187	0.1567	0.4654
Brugia malayi	Cathepsin L-like precursor	0.0135	0.1026	0.1026
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.011	0.0774	0.2137
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0248	0.2205	0.2205
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0233	0.0233
Entamoeba histolytica	cysteine protease, putative	0.0058	0.0233	0.1444
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0248	0.2205	0.2205
Entamoeba histolytica	cysteine protease, putative	0.011	0.0774	0.4913
Schistosoma mansoni	adenoreceptor	0.0248	0.2205	0.2205
Echinococcus multilocularis	neuropeptide Y receptor	0.0248	0.2205	0.2205
Onchocerca volvulus		0.0248	0.2205	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0058	0.0233	0.0233
Onchocerca volvulus		0.0135	0.1026	0.4555
Plasmodium vivax	serine-repeat antigen (SERA)	0.0058	0.0233	0.0451
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0248	0.2205	0.2205
Leishmania major	cathepsin L-like protease	0.0187	0.1567	0.4654
Leishmania major	cathepsin L-like protease	0.0187	0.1567	0.4654
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.011	0.0774	0.0774
Loa Loa (eye worm)	hypothetical protein	0.004	0.004	0.004
Loa Loa (eye worm)	hypothetical protein	0.0248	0.2205	0.2205
Echinococcus granulosus	somatostatin receptor	0.0248	0.2205	0.2205
Brugia malayi	cathepsin L precursor	0.0058	0.0233	0.0233
Trichomonas vaginalis	CAMK family protein kinase	0.0096	0.0623	0.1816
Echinococcus multilocularis	fmrfamide receptor	0.0248	0.2205	0.2205
Entamoeba histolytica	cysteine proteinase, putative	0.0187	0.1567	1
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0058	0.0233	0.0233
Trypanosoma cruzi	cruzipain precursor, putative	0.0187	0.1567	0.1482
Echinococcus multilocularis	chromobox protein 1	0.0071	0.0362	0.0362
Trichomonas vaginalis	conserved hypothetical protein	0.0058	0.0233	0.06
Leishmania major	cysteine peptidase A (CPA)	0.0187	0.1567	0.4654
Brugia malayi	cathepsin L-like cysteine proteinase	0.0058	0.0233	0.0233
Onchocerca volvulus		0.0248	0.2205	1
Loa Loa (eye worm)	hypothetical protein	0.0248	0.2205	0.2205
Echinococcus granulosus	orexin receptor type 2	0.0248	0.2205	0.2205
Brugia malayi	Dopamine receptor	0.0248	0.2205	0.2205
Entamoeba histolytica	cysteine protease, putative	0.011	0.0774	0.4913
Schistosoma mansoni	neuropeptide receptor	0.0248	0.2205	0.2205
Loa Loa (eye worm)	jmjC domain-containing protein	0.0061	0.0262	0.0262
Onchocerca volvulus		0.0058	0.0233	0.089
Schistosoma mansoni	hypothetical protein	0.0248	0.2205	0.2205
Brugia malayi	Cathepsin L-like precursor	0.0187	0.1567	0.1567
Onchocerca volvulus		0.0248	0.2205	1
Brugia malayi	Papain family cysteine protease containing protein	0.011	0.0774	0.0774
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0187	0.1567	0.4754
Brugia malayi	chromobox protein homolog 3	0.004	0.004	0.004
Loa Loa (eye worm)	hypothetical protein	0.0248	0.2205	0.2205
Schistosoma mansoni	biogenic amine receptor	0.0248	0.2205	0.2205
Echinococcus multilocularis	neuropeptide receptor	0.0248	0.2205	0.2205
Loa Loa (eye worm)	hypothetical protein	0.0248	0.2205	0.2205
Schistosoma mansoni	opsin-like receptor	0.0248	0.2205	0.2205
Entamoeba histolytica	cysteine proteinase, putative	0.0187	0.1567	1
Echinococcus multilocularis	neuropeptide s receptor	0.0248	0.2205	0.2205
Echinococcus multilocularis	cathepsin L	0.0058	0.0233	0.0233
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0248	0.2205	0.2205
Onchocerca volvulus		0.0248	0.2205	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0187	0.1567	0.4654
Trichomonas vaginalis	chromobox protein, putative	0.0071	0.0362	0.1003
Brugia malayi	G protein-coupled receptor F59B2.13	0.0248	0.2205	0.2205
Echinococcus granulosus	dro:myosuppressin receptor	0.0248	0.2205	0.2205
Echinococcus granulosus	biogenic amine 5HT receptor	0.0248	0.2205	0.2205
Echinococcus granulosus	tm gpcr rhodopsin	0.0248	0.2205	0.2205
Plasmodium vivax	unspecified product	0.0058	0.0233	0.0451
Schistosoma mansoni	histamine h1 receptor	0.0248	0.2205	0.2205
Onchocerca volvulus		0.0248	0.2205	1
Echinococcus multilocularis	neuropeptide Y receptor	0.0248	0.2205	0.2205
Brugia malayi	Dopamine receptor protein 1	0.0248	0.2205	0.2205
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0187	0.1567	0.4754
Plasmodium vivax	serine-repeat antigen 2 (SERA)	0.0058	0.0233	0.0451
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0187	0.1567	0.4754
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0052	0.017	0.017
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0248	0.2205	0.2205
Echinococcus granulosus	rhodopsin orphan GPCR	0.0248	0.2205	0.2205
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0187	0.1567	0.4654
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0135	0.1026	0.307
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0187	0.1567	0.4754
Loa Loa (eye worm)	hypothetical protein	0.0248	0.2205	0.2205
Plasmodium vivax	unspecified product	0.011	0.0774	0.4322
Schistosoma mansoni	hypothetical protein	0.0248	0.2205	0.2205
Trypanosoma cruzi	cysteine peptidase, putative	0.011	0.0774	0.0681
Brugia malayi	GnHR receptor homolog	0.0248	0.2205	0.2205
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0058	0.0233	0.0233
Brugia malayi	G protein-coupled receptor	0.0248	0.2205	0.2205
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0058	0.0233	0.1444
Schistosoma mansoni	cathepsin F (C01 family)	0.0135	0.1026	0.1026
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0058	0.0233	0.06
Schistosoma mansoni	myosin xvIII	0.0248	0.2205	0.2205
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0187	0.1567	0.4754
Entamoeba histolytica	cysteine protease, putative	0.0058	0.0233	0.1444
Loa Loa (eye worm)	hypothetical protein	0.0248	0.2205	0.2205
Entamoeba histolytica	cysteine proteinase, putative	0.011	0.0774	0.4913
Onchocerca volvulus		0.0187	0.1567	0.7054
Entamoeba histolytica	cysteine protease, putative	0.0058	0.0233	0.1444
Brugia malayi	Cathepsin L-like precursor	0.0187	0.1567	0.1567
Echinococcus granulosus	cathepsin b	0.0999	1	1
Onchocerca volvulus	Serine\/threonine kinase homolog	0.0096	0.0623	0.2694
Echinococcus granulosus	rhodopsin orphan GPCR	0.0248	0.2205	0.2205
Echinococcus multilocularis	serotonin receptor	0.0248	0.2205	0.2205
Loa Loa (eye worm)	hypothetical protein	0.0187	0.1567	0.1567
Echinococcus granulosus	cysteine protease	0.011	0.0774	0.0774
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0187	0.1567	0.4754
Entamoeba histolytica	cysteine proteinase, putative	0.011	0.0774	0.4913
Brugia malayi	Cathepsin L-like precursor	0.0187	0.1567	0.1567
Echinococcus granulosus	fmrfamide receptor	0.0248	0.2205	0.2205
Echinococcus granulosus	7TM GPCR rhodopsin	0.0248	0.2205	0.2205
Entamoeba histolytica	cysteine proteinase, putative	0.011	0.0774	0.4913
Schistosoma mansoni	hypothetical protein	0.0172	0.1413	0.1413
Entamoeba histolytica	cysteine protease, putative	0.011	0.0774	0.4913
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0248	0.2205	0.2205
Loa Loa (eye worm)	hypothetical protein	0.0052	0.017	0.017
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0248	0.2205	0.2205
Echinococcus granulosus	neuropeptide Y receptor	0.0248	0.2205	0.2205
Entamoeba histolytica	cysteine proteinase, putative	0.0135	0.1026	0.6531
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0248	0.2205	0.2205
Plasmodium vivax	serine-repeat antigen 4 (SERA), putative	0.0058	0.0233	0.0451
Loa Loa (eye worm)	hypothetical protein	0.0248	0.2205	0.2205
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0187	0.1567	1
Schistosoma mansoni	amine GPCR	0.0248	0.2205	0.2205
Loa Loa (eye worm)	hypothetical protein	0.0248	0.2205	0.2205
Brugia malayi	Cathepsin L-like precursor	0.0187	0.1567	0.1567
Giardia lamblia	Cathepsin B precursor	0.0349	0.3253	1
Brugia malayi	hypothetical protein	0.0248	0.2205	0.2205
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0155	0.0155
Echinococcus granulosus	cathepsin l1	0.0135	0.1026	0.1026
Trypanosoma cruzi	cysteine proteinase, putative	0.011	0.0774	0.0681
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0233	0.0233
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0097	0.0634	0.0634
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0187	0.1567	0.4754
Plasmodium vivax	dipeptidyl aminopeptidase 3, putative	0.0058	0.0233	0.0451
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0187	0.1567	0.4754
Schistosoma mansoni	amine GPCR	0.0248	0.2205	0.2205
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0248	0.2205	0.2205
Schistosoma mansoni	amine GPCR	0.0248	0.2205	0.2205
Trichomonas vaginalis	chromobox protein, putative	0.0071	0.0362	0.1003
Leishmania major	cathepsin L-like protease	0.0187	0.1567	0.4654
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0058	0.0233	0.0233
Echinococcus multilocularis	neuropeptides capa receptor	0.0248	0.2205	0.2205
Echinococcus granulosus	rhodopsin orphan GPCR	0.0248	0.2205	0.2205
Echinococcus multilocularis	dna polymerase eta	0.0045	0.01	0.01
Schistosoma mansoni	cathepsin B (C01 family)	0.0058	0.0233	0.0233
Echinococcus granulosus	rhodopsin orphan GPCR	0.0248	0.2205	0.2205
Loa Loa (eye worm)	hypothetical protein	0.0248	0.2205	0.2205
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0097	0.0634	0.0634
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0248	0.2205	0.2205
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0248	0.2205	0.2205
Leishmania major	protein kinase, putative,polo-like protein kinase, putative	0.0096	0.0623	0.1659
Brugia malayi	G-protein coupled receptor	0.0248	0.2205	0.2205
Echinococcus multilocularis	serine:threonine protein kinase PLK1	0.0096	0.0623	0.0623
Echinococcus granulosus	neuropeptide s receptor	0.0248	0.2205	0.2205
Onchocerca volvulus		0.0248	0.2205	1
Loa Loa (eye worm)	hypothetical protein	0.0248	0.2205	0.2205
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0349	0.3253	0.3253
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0187	0.1567	0.4754
Trichomonas vaginalis	CAMK family protein kinase	0.0096	0.0623	0.1816
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0349	0.3253	1
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0248	0.2205	0.2205
Brugia malayi	sulfakinin receptor protein	0.0248	0.2205	0.2205
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0248	0.2205	0.2205
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0248	0.2205	0.2205
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0999	1	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0058	0.0233	0.0233
Echinococcus granulosus	jumonji domain containing protein	0.0041	0.0056	0.0056
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0187	0.1567	0.4754
Trypanosoma cruzi	cysteine protease, putative	0.011	0.0774	0.0681
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0248	0.2205	0.2205
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0248	0.2205	0.2205
Schistosoma mansoni	cathepsin C	0.0058	0.0233	0.0233
Schistosoma mansoni	chromobox protein	0.0071	0.0362	0.0362
Trypanosoma cruzi	cysteine peptidase, putative	0.0187	0.1567	0.1482
Brugia malayi	Papain family cysteine protease containing protein	0.0058	0.0233	0.0233
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0248	0.2205	0.2205
Brugia malayi	Cathepsin L-like precursor	0.0135	0.1026	0.1026
Brugia malayi	Papain family cysteine protease containing protein	0.0187	0.1567	0.1567
Echinococcus multilocularis	neuropeptide receptor A26	0.0248	0.2205	0.2205
Echinococcus multilocularis	serotonin receptor	0.0248	0.2205	0.2205
Brugia malayi	RE15519p	0.0248	0.2205	0.2205
Loa Loa (eye worm)	hypothetical protein	0.0248	0.2205	0.2205
Trichomonas vaginalis	CAMK family protein kinase	0.0096	0.0623	0.1816
Entamoeba histolytica	cysteine proteinase 1, putative	0.011	0.0774	0.4913
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0248	0.2205	0.2205
Onchocerca volvulus	Cathepsin L homolog	0.0187	0.1567	0.7054
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0248	0.2205	0.2205
Echinococcus granulosus	g-protein coupled receptor	0.0248	0.2205	0.2205
Schistosoma mansoni	opsin-like receptor	0.0248	0.2205	0.2205
Plasmodium falciparum	cysteine proteinase falcipain 1	0.011	0.0774	0.4054
Echinococcus multilocularis	g protein coupled receptor	0.0248	0.2205	0.2205
Entamoeba histolytica	cysteine protease, putative	0.011	0.0774	0.4913
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0135	0.1026	0.307
Echinococcus granulosus	g protein coupled receptor	0.0248	0.2205	0.2205
Echinococcus granulosus	neuropeptides capa receptor	0.0248	0.2205	0.2205
Loa Loa (eye worm)	hypothetical protein	0.0248	0.2205	0.2205
Plasmodium vivax	serine-repeat antigen 4 (SERA)	0.0058	0.0233	0.0451
Brugia malayi	ORL1-like opioid receptor	0.0248	0.2205	0.2205
Entamoeba histolytica	cysteine protease, putative	0.011	0.0774	0.4913
Loa Loa (eye worm)	G-protein coupled receptor	0.0248	0.2205	0.2205
Loa Loa (eye worm)	hypothetical protein	0.0248	0.2205	0.2205
Brugia malayi	hypothetical protein	0.0248	0.2205	0.2205
Loa Loa (eye worm)	hypothetical protein	0.0135	0.1026	0.1026
Schistosoma mansoni	jumonji domain containing protein	0.0077	0.0427	0.0427
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0248	0.2205	0.2205
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0248	0.2205	0.2205
Echinococcus granulosus	cathepsin L cysteine protease	0.011	0.0774	0.0774
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0248	0.2205	0.2205
Schistosoma mansoni	neuropeptide receptor	0.0248	0.2205	0.2205
Trypanosoma cruzi	cysteine peptidase, putative	0.0187	0.1567	0.1482
Schistosoma mansoni	hypothetical protein	0.0248	0.2205	0.2205
Plasmodium vivax	dipeptidyl aminopeptidase 1, putative	0.0058	0.0233	0.0451
Echinococcus multilocularis	dro:myosuppressin receptor	0.0248	0.2205	0.2205
Echinococcus multilocularis	cathepsin L	0.011	0.0774	0.0774
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0187	0.1567	0.4654
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0187	0.1567	0.4754
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0999	1	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0187	0.1567	0.1482
Schistosoma mansoni	DNA polymerase eta	0.0045	0.01	0.01
Toxoplasma gondii	cathepsin CPL	0.0187	0.1567	0.4419
Brugia malayi	serine/threonine-protein kinase plk-2	0.0096	0.0623	0.0623
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0052	0.017	0.017
Entamoeba histolytica	cysteine protease, putative	0.011	0.0774	0.4913
Echinococcus granulosus	allatostatin A receptor	0.0248	0.2205	0.2205
Echinococcus granulosus	sex peptide receptor	0.0248	0.2205	0.2205
Echinococcus multilocularis	cathepsin b	0.0999	1	1
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0248	0.2205	0.2205
Echinococcus granulosus	neuropeptide receptor A26	0.0248	0.2205	0.2205
Echinococcus granulosus	neuropeptide receptor	0.0248	0.2205	0.2205
Echinococcus multilocularis	G protein coupled receptor 139	0.0248	0.2205	0.2205
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0135	0.1026	0.1026
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0187	0.1567	0.4754
Loa Loa (eye worm)	hypothetical protein	0.0248	0.2205	0.2205
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0187	0.1567	0.1567
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0187	0.1567	0.1567
Echinococcus granulosus	G protein coupled receptor 139	0.0248	0.2205	0.2205
Brugia malayi	putative neuropeptide receptor NPR1	0.0248	0.2205	0.2205
Onchocerca volvulus		0.0248	0.2205	1
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0248	0.2205	0.2205
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0248	0.2205	0.2205
Plasmodium vivax	vivapain-2	0.0187	0.1567	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0187	0.1567	0.4654
Brugia malayi	Cathepsin L-like precursor	0.0187	0.1567	0.1567
Loa Loa (eye worm)	hypothetical protein	0.0248	0.2205	0.2205
Echinococcus granulosus	cathepsin b	0.0999	1	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0058	0.0233	0.0233
Entamoeba histolytica	cysteine protease, putative	0.011	0.0774	0.4913
Trichomonas vaginalis	Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase	0.0058	0.0233	0.06
Brugia malayi	cathepsin F-like cysteine proteinase	0.0052	0.017	0.017
Loa Loa (eye worm)	hypothetical protein	0.0248	0.2205	0.2205
Schistosoma mansoni	neuropeptide F-like receptor	0.0248	0.2205	0.2205
Onchocerca volvulus		0.0187	0.1567	0.7054
Loa Loa (eye worm)	hypothetical protein	0.0248	0.2205	0.2205
Brugia malayi	cathepsin F-like cysteine proteinase	0.0058	0.0233	0.0233
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0058	0.0233	0.0233
Echinococcus granulosus	cathepsin l1	0.0187	0.1567	0.1567
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0248	0.2205	0.2205
Trichomonas vaginalis	chromobox protein, putative	0.0043	0.0071	0.0097
Schistosoma mansoni	neuropeptide F-like receptor	0.0248	0.2205	0.2205
Entamoeba histolytica	hypothetical protein	0.0058	0.0233	0.1444
Echinococcus granulosus	serotonin receptor	0.0248	0.2205	0.2205
Schistosoma mansoni	chromobox protein	0.0071	0.0362	0.0362
Echinococcus multilocularis	cysteine protease	0.0187	0.1567	0.1567
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0058	0.0233	0.06
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0248	0.2205	0.2205
Loa Loa (eye worm)	neuropeptide F receptor	0.0248	0.2205	0.2205
Schistosoma mansoni	amine GPCR	0.0248	0.2205	0.2205
Brugia malayi	hypothetical protein	0.0248	0.2205	0.2205
Trypanosoma cruzi	polo-like protein kinase, putative	0.0096	0.0623	0.0529
Onchocerca volvulus		0.0248	0.2205	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0187	0.1567	0.4754
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0058	0.0233	0.06
Echinococcus granulosus	geminin	0.0172	0.1413	0.1413
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0187	0.1567	0.4754
Loa Loa (eye worm)	hypothetical protein	0.0248	0.2205	0.2205
Brugia malayi	larval opioid receptor	0.0248	0.2205	0.2205
Loa Loa (eye worm)	hypothetical protein	0.0248	0.2205	0.2205
Loa Loa (eye worm)	hypothetical protein	0.0135	0.1026	0.1026
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0248	0.2205	0.2205
Toxoplasma gondii	cathepsin B	0.0349	0.3253	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0248	0.2205	0.2205
Loa Loa (eye worm)	hypothetical protein	0.0248	0.2205	0.2205
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0058	0.0233	0.0233
Onchocerca volvulus		0.0187	0.1567	0.7054
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0058	0.0233	0.06
Echinococcus granulosus	7tm_1 domain containing protein	0.0248	0.2205	0.2205
Brugia malayi	neuropeptide F receptor	0.0248	0.2205	0.2205
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0187	0.1567	0.1567
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0999	1	1
Onchocerca volvulus	Cathepsin F homolog	0.0187	0.1567	0.7054
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0058	0.0233	0.1444
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0999	1	1
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0248	0.2205	0.2205
Onchocerca volvulus		0.0248	0.2205	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.011	0.0774	0.2284
Schistosoma mansoni	growth hormone secretagogue receptor	0.0248	0.2205	0.2205
Trypanosoma cruzi	cruzipain precursor, putative	0.0052	0.017	0.007
Echinococcus granulosus	rhodopsin orphan GPCR	0.0248	0.2205	0.2205
Schistosoma mansoni	amine GPCR	0.0248	0.2205	0.2205
Echinococcus granulosus	cathepsin L	0.011	0.0774	0.0774
Onchocerca volvulus	Cathepsin L homolog	0.0058	0.0233	0.089
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0248	0.2205	0.2205
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0248	0.2205	0.2205
Loa Loa (eye worm)	fibroinase	0.0187	0.1567	0.1567
Loa Loa (eye worm)	hypothetical protein	0.0248	0.2205	0.2205
Loa Loa (eye worm)	hypothetical protein	0.0248	0.2205	0.2205
Schistosoma mansoni	biogenic amine receptor	0.0248	0.2205	0.2205
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0037	0.0007	0.0007
Brugia malayi	putative neuropeptide receptor	0.0248	0.2205	0.2205
Brugia malayi	hypothetical protein	0.0248	0.2205	0.2205
Loa Loa (eye worm)	TYRA-2 protein	0.0248	0.2205	0.2205
Loa Loa (eye worm)	hypothetical protein	0.0248	0.2205	0.2205
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.011	0.0774	0.2137
Brugia malayi	G-protein coupled receptor	0.0248	0.2205	0.2205
Entamoeba histolytica	cysteine protease, putative	0.0187	0.1567	1
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0248	0.2205	0.2205
Echinococcus granulosus	serine:threonine protein kinase PLK1	0.0096	0.0623	0.0623
Loa Loa (eye worm)	hypothetical protein	0.0248	0.2205	0.2205
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0058	0.0233	0.06
Giardia lamblia	Cathepsin B precursor	0.0349	0.3253	1
Echinococcus multilocularis	fmrfamide receptor	0.0248	0.2205	0.2205
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0058	0.0233	0.0451
Trichomonas vaginalis	chromobox protein, putative	0.0043	0.0071	0.0097
Loa Loa (eye worm)	hypothetical protein	0.0248	0.2205	0.2205
Entamoeba histolytica	cysteine proteinase 2	0.011	0.0774	0.4913
Trypanosoma cruzi	major cysteine proteinase, putative	0.0058	0.0233	0.0134
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0187	0.1567	0.4754
Schistosoma mansoni	neuropeptide receptor	0.0248	0.2205	0.2205
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0058	0.0233	0.06
Echinococcus multilocularis	cathepsin L cysteine protease	0.0187	0.1567	0.1567
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0248	0.2205	0.2205
Loa Loa (eye worm)	hypothetical protein	0.0052	0.017	0.017
Onchocerca volvulus		0.0187	0.1567	0.7054
Echinococcus multilocularis	g-protein coupled receptor	0.0248	0.2205	0.2205
Onchocerca volvulus		0.0248	0.2205	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0052	0.017	0.007
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0248	0.2205	0.2205
Echinococcus multilocularis	sex peptide receptor	0.0248	0.2205	0.2205
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0248	0.2205	0.2205
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0248	0.2205	0.2205
Loa Loa (eye worm)	G-protein coupled receptor	0.0248	0.2205	0.2205
Echinococcus multilocularis	g protein coupled receptor	0.0248	0.2205	0.2205
Loa Loa (eye worm)	hypothetical protein	0.0248	0.2205	0.2205
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0248	0.2205	0.2205
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0058	0.0233	0.06
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0187	0.1567	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0248	0.2205	0.2205
Onchocerca volvulus		0.0187	0.1567	0.7054
Entamoeba histolytica	cysteine protease, putative	0.011	0.0774	0.4913
Schistosoma mansoni	neuropeptide f receptor 76f	0.0248	0.2205	0.2205
Brugia malayi	ImpB/MucB/SamB family protein	0.0045	0.01	0.01
Loa Loa (eye worm)	hypothetical protein	0.0248	0.2205	0.2205
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0248	0.2205	0.2205
Trypanosoma cruzi	cysteine peptidase, putative	0.0187	0.1567	0.1482
Brugia malayi	Heterochromatin protein 1	0.0071	0.0362	0.0362
Brugia malayi	follicle stimulating hormone receptor	0.0248	0.2205	0.2205
Entamoeba histolytica	cysteine proteinase, putative	0.011	0.0774	0.4913
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0187	0.1567	0.4654
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0248	0.2205	0.2205
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0248	0.2205	0.2205
Entamoeba histolytica	serine/threonine protein kinase, putative	0.0096	0.0623	0.3948
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0248	0.2205	0.2205
Trichomonas vaginalis	Clan CA, family C1, cathepsin F-like cysteine peptidase	0.0058	0.0233	0.06
Echinococcus granulosus	cathepsin L	0.0058	0.0233	0.0233
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0043	0.0071	0.0144
Brugia malayi	Cathepsin L-like precursor	0.0187	0.1567	0.1567
Schistosoma mansoni	cathepsin F (C01 family)	0.0187	0.1567	0.1567
Plasmodium vivax	vivapain-1	0.011	0.0774	0.4322
Loa Loa (eye worm)	hypothetical protein	0.0248	0.2205	0.2205
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0187	0.1567	1
Trypanosoma cruzi	cysteine proteinase, putative	0.011	0.0774	0.0681
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0233	0.0233
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0248	0.2205	1
Echinococcus multilocularis	cysteine protease	0.0187	0.1567	0.1567
Leishmania major	cathepsin L-like protease	0.0187	0.1567	0.4654
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0248	0.2205	0.2205
Loa Loa (eye worm)	hypothetical protein	0.0248	0.2205	0.2205
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0248	0.2205	0.2205
Brugia malayi	hypothetical protein	0.0037	0.0007	0.0007
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0248	0.2205	0.2205
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0248	0.2205	0.2205
Loa Loa (eye worm)	hypothetical protein	0.0248	0.2205	0.2205
Loa Loa (eye worm)	PLK/PLK1 protein kinase	0.0096	0.0623	0.0623
Loa Loa (eye worm)	cathepsin B	0.0349	0.3253	0.3253
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0248	0.2205	0.2205
Schistosoma mansoni	biogenic amine receptor	0.0248	0.2205	0.2205
Schistosoma mansoni	hypothetical protein	0.0037	0.0007	0.0007
Loa Loa (eye worm)	ctsf protein	0.0187	0.1567	0.1567
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0187	0.1567	0.4754
Entamoeba histolytica	cysteine protease, putative	0.011	0.0774	0.4913
Loa Loa (eye worm)	hypothetical protein	0.0052	0.017	0.017
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0187	0.1567	0.4654
Schistosoma mansoni	cathepsin S (C01 family)	0.0058	0.0233	0.0233
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0135	0.1026	0.0936
Echinococcus granulosus	tm gpcr rhodopsin	0.0248	0.2205	0.2205
Brugia malayi	cathepsin L-like precursor	0.0135	0.1026	0.1026
Echinococcus multilocularis	neuropeptide receptor	0.0248	0.2205	0.2205
Echinococcus multilocularis	orexin receptor type 2	0.0248	0.2205	0.2205
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.011	0.0774	0.0774
Entamoeba histolytica	cysteine protease, putative	0.0058	0.0233	0.1444
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0248	0.2205	0.2205
Brugia malayi	Papain family cysteine protease containing protein	0.0058	0.0233	0.0233
Entamoeba histolytica	cysteine protease, putative	0.011	0.0774	0.4913
Schistosoma mansoni	hypothetical protein	0.0172	0.1413	0.1413
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0058	0.0233	0.06
Loa Loa (eye worm)	hypothetical protein	0.0248	0.2205	0.2205
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0187	0.1567	0.4754
Brugia malayi	Serotonin receptor	0.0248	0.2205	0.2205
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0248	0.2205	0.2205
Loa Loa (eye worm)	hypothetical protein	0.0248	0.2205	0.2205
Brugia malayi	hypothetical protein	0.0248	0.2205	0.2205
Echinococcus granulosus	chromobox protein 1	0.0071	0.0362	0.0362
Echinococcus granulosus	g protein coupled receptor	0.0248	0.2205	0.2205
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0058	0.0233	0.0451
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0187	0.1567	0.4754
Echinococcus multilocularis	chromobox protein 1	0.0071	0.0362	0.0362
Loa Loa (eye worm)	melatonin receptor type 1A	0.0248	0.2205	0.2205
Loa Loa (eye worm)	hypothetical protein	0.0248	0.2205	0.2205
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.0058	0.0233	0.0233
Brugia malayi	hypothetical protein	0.0248	0.2205	0.2205
Trypanosoma cruzi	major cysteine proteinase, putative	0.0058	0.0233	0.0134
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0233	0.0233
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0058	0.0233	0.0233
Echinococcus granulosus	neuropeptide receptor	0.0248	0.2205	0.2205
Brugia malayi	Serotonin receptor	0.0248	0.2205	0.2205
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0248	0.2205	0.2205
Loa Loa (eye worm)	cysteine protease	0.0187	0.1567	0.1567
Loa Loa (eye worm)	hypothetical protein	0.0248	0.2205	0.2205
Onchocerca volvulus	Cathepsin L homolog	0.0187	0.1567	0.7054
Plasmodium vivax	dipeptidyl aminopeptidase 2, putative	0.0058	0.0233	0.0451
Trichomonas vaginalis	CAMK family protein kinase	0.0096	0.0623	0.1816
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0187	0.1567	0.4754
Loa Loa (eye worm)	hypothetical protein	0.0248	0.2205	0.2205
Brugia malayi	fibroinase precursor	0.0058	0.0233	0.0233
Entamoeba histolytica	cysteine protease, putative	0.0058	0.0233	0.1444
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0187	0.1567	0.4754
Brugia malayi	Melatonin receptor type 1A	0.0248	0.2205	0.2205
Echinococcus granulosus	neuropeptide FF receptor 2	0.0248	0.2205	0.2205
Onchocerca volvulus		0.0248	0.2205	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0187	0.1567	0.4754
Trichomonas vaginalis	CAMK family protein kinase	0.0096	0.0623	0.1816
Loa Loa (eye worm)	hypothetical protein	0.0248	0.2205	0.2205
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.011	0.0774	0.0774
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0037	0.0007	0.0007
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0187	0.1567	0.4754
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0248	0.2205	0.2205
Loa Loa (eye worm)	hypothetical protein	0.0248	0.2205	0.2205
Echinococcus granulosus	g protein coupled receptor	0.0248	0.2205	0.2205
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.011	0.0774	0.2284
Loa Loa (eye worm)	hypothetical protein	0.0999	1	1
Trypanosoma cruzi	polo-like protein kinase, putative	0.0096	0.0623	0.0529
Brugia malayi	hypothetical protein	0.0248	0.2205	0.2205
Brugia malayi	hypothetical protein	0.0248	0.2205	0.2205
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0248	0.2205	0.2205
Schistosoma mansoni	kinase	0.0049	0.0134	0.0134
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0349	0.3253	1
Schistosoma mansoni	cathepsin s	0.0052	0.017	0.017
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0187	0.1567	0.4754
Schistosoma mansoni	cathepsin F (C01 family)	0.0187	0.1567	0.1567
Brugia malayi	Cathepsin L-like precursor	0.0052	0.017	0.017
Brugia malayi	Dopamine receptor protein 2	0.0248	0.2205	0.2205
Onchocerca volvulus		0.0248	0.2205	1
Plasmodium vivax	serine-repeat antigen (SERA)	0.0058	0.0233	0.0451
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0058	0.0233	0.0233
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0248	0.2205	0.2205
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0187	0.1567	0.4654
Entamoeba histolytica	cysteine protease, putative	0.011	0.0774	0.4913
Onchocerca volvulus		0.0187	0.1567	0.7054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0187	0.1567	0.4754
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0248	0.2205	0.2205
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0187	0.1567	0.1567
Trichomonas vaginalis	Clan CA, family C1, cathepsin H-like cysteine peptidase	0.0058	0.0233	0.06
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.0058	0.0233	0.0233
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0187	0.1567	0.4754
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0187	0.1567	0.4654
Echinococcus multilocularis	cathepsin L cysteine protease	0.0187	0.1567	0.1567
Schistosoma mansoni	serine/threonine protein kinase	0.0096	0.0623	0.0623
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0187	0.1567	0.4654
Brugia malayi	Papain family cysteine protease containing protein	0.0058	0.0233	0.0233
Plasmodium vivax	serine-repeat antigen 3 (SERA)	0.0058	0.0233	0.0451
Plasmodium vivax	vivapain-3	0.011	0.0774	0.4322
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0187	0.1567	0.1567
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0248	0.2205	0.2205
Loa Loa (eye worm)	hypothetical protein	0.0045	0.01	0.01
Loa Loa (eye worm)	heterochromatin protein 1	0.0071	0.0362	0.0362

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 905721