Detailed information for compound 905801

Basic information

Technical information
  • TDR Targets ID: 905801
  • Name: N-[(3-methoxyphenyl)methylideneamino]pyridine -3-carboxamide
  • MW: 255.272 | Formula: C14H13N3O2
  • H donors: 1 H acceptors: 2 LogP: 1.73 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cccc(c1)C=NNC(=O)c1cccnc1
  • InChi: 1S/C14H13N3O2/c1-19-13-6-2-4-11(8-13)9-16-17-14(18)12-5-3-7-15-10-12/h2-10H,1H3,(H,17,18)/b16-9+
  • InChiKey: POWSWZVCYANQRY-CXUHLZMHSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-[(3-methoxyphenyl)methyleneamino]pyridine-3-carboxamide
  • N-[(3-methoxyphenyl)methyleneamino]-3-pyridinecarboxamide
  • N-[(3-methoxybenzylidene)amino]nicotinamide
  • AIDS-008906
  • AIDS008906
  • Niazid 3MeOPhCH
  • STK166156
  • 3-Methoxybenzaldehyde nicotinoyl hydrazone

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0188 0.2208 0.5186
Loa Loa (eye worm) RNA binding protein 0.0062 0.0584 0.0761
Trypanosoma cruzi thymidylate kinase, putative 0.0323 0.3946 1
Trypanosoma brucei thymidylate kinase, putative 0.0323 0.3946 1
Schistosoma mansoni smad 0.0033 0.0212 0.0384
Loa Loa (eye worm) MH2 domain-containing protein 0.0033 0.0212 0.0259
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein 0.0077 0.0789 0.059
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0114 0.0239
Onchocerca volvulus Putative thymidylate kinase 0.0323 0.3946 1
Entamoeba histolytica hypothetical protein 0.0077 0.0789 0.059
Echinococcus multilocularis thymidine kinase 0.0346 0.4239 0.4227
Leishmania major thymidylate kinase-like protein 0.0323 0.3946 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0188 0.2208 0.2192
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0114 0.0239
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0047 0.0395 0.0954
Loa Loa (eye worm) transcription factor SMAD2 0.0478 0.5945 0.8
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0033 0.0212 0.0384
Trypanosoma cruzi thymidylate kinase, putative 0.0323 0.3946 1
Leishmania major hypothetical protein, conserved 0.0025 0.0114 0.0239
Brugia malayi MH1 domain containing protein 0.0033 0.0212 0.0285
Brugia malayi MH1 domain containing protein 0.0018 0.0024 0.0033
Trypanosoma cruzi histone deacetylase 1, putative 0.0062 0.0591 0.1453
Echinococcus multilocularis Smad4 0.0033 0.0212 0.0192
Loa Loa (eye worm) hypothetical protein 0.0025 0.0114 0.0127
Loa Loa (eye worm) histone deacetylase 1 0.0062 0.0591 0.077
Giardia lamblia Deoxyguanosine kinase/deoxyadenosine kinase subunit, putative 0.0077 0.0789 0.059
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0594 0.7426 1
Trypanosoma cruzi histone deacetylase 1, putative 0.0062 0.0591 0.1453
Entamoeba histolytica hypothetical protein 0.0077 0.0789 0.059
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.0789 0.059
Mycobacterium tuberculosis Thymidylate kinase Tmk (dTMP kinase) (thymidylic acid kinase) (TMPK) 0.0323 0.3946 1
Schistosoma mansoni hypothetical protein 0.0323 0.3946 0.7867
Loa Loa (eye worm) hypothetical protein 0.0018 0.0024 0.0006
Giardia lamblia Hypothetical protein 0.0077 0.0789 0.059
Toxoplasma gondii isocitrate dehydrogenase 0.0047 0.0395 0.0954
Schistosoma mansoni hypothetical protein 0.0406 0.5011 1
Loa Loa (eye worm) hypothetical protein 0.0594 0.7426 1
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein 0.0077 0.0789 0.059
Loa Loa (eye worm) Smad1 0.0033 0.0212 0.0259
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0594 0.7426 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0584 0.0761
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0047 0.0395 0.0888
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0188 0.2208 0.2973
Schistosoma mansoni NADH-ubiquinone oxidoreductase 0.0077 0.0789 0.154
Entamoeba histolytica hypothetical protein 0.0077 0.0789 0.059
Loa Loa (eye worm) MH1 domain-containing protein 0.0033 0.0212 0.0259
Schistosoma mansoni thymidine kinase 0.0346 0.4239 0.8453
Loa Loa (eye worm) isocitrate dehydrogenase 0.0047 0.0395 0.0506
Trypanosoma brucei histone deacetylase 1 0.0062 0.0591 0.1453
Brugia malayi Smad1 0.0033 0.0212 0.0285
Loa Loa (eye worm) histone deacetylase 3 0.0062 0.0591 0.077
Schistosoma mansoni hypothetical protein 0.0188 0.2208 0.4384
Brugia malayi MH2 domain containing protein 0.0478 0.5945 0.8006
Toxoplasma gondii histone deacetylase HDAC3 0.0062 0.0591 0.1453
Schistosoma mansoni smad1 5 8 and 0.0033 0.0212 0.0384
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0047 0.0395 0.0954
Entamoeba histolytica hypothetical protein 0.0077 0.0789 0.059
Plasmodium falciparum histone deacetylase 1 0.0062 0.0591 0.1453
Brugia malayi Latrophilin receptor protein 2 0.0188 0.2208 0.2973
Giardia lamblia Deoxynucleoside kinase 0.0077 0.0789 0.059
Loa Loa (eye worm) deoxynucleoside kinase 0.0077 0.0789 0.1037
Brugia malayi Calcitonin receptor-like protein seb-1 0.0594 0.7426 1
Trypanosoma brucei thymidylate kinase, putative 0.0323 0.3946 1
Schistosoma mansoni hypothetical protein 0.0188 0.2208 0.4384
Echinococcus granulosus smad 0.0033 0.0212 0.0454
Trypanosoma cruzi UMP-CMP kinase, mitochondrial, putative 0.0127 0.1423 0.3573
Loa Loa (eye worm) nuclear factor I 0.0018 0.0024 0.0006
Chlamydia trachomatis thymidylate kinase 0.0323 0.3946 0.5
Echinococcus multilocularis histone deacetylase 3 0.0062 0.0591 0.0572
Wolbachia endosymbiont of Brugia malayi thymidylate kinase 0.0323 0.3946 0.5
Schistosoma mansoni hypothetical protein 0.0188 0.2208 0.4384
Entamoeba histolytica hypothetical protein 0.0077 0.0789 0.059
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.0789 0.059
Echinococcus granulosus mothers against decapentaplegic 5 0.0033 0.0212 0.0454
Echinococcus granulosus tar DNA binding protein 0.0062 0.0584 0.1335
Brugia malayi Histone deacetylase family protein 0.0018 0.002 0.0027
Echinococcus granulosus Smad4 0.0033 0.0212 0.0454
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein 0.0077 0.0789 0.059
Trichomonas vaginalis thymidylate kinase, putative 0.0323 0.3946 1
Leishmania major histone deacetylase, putative 0.0062 0.0591 0.1453
Brugia malayi MH2 domain containing protein 0.0033 0.0212 0.0285
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0584 0.1129
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0047 0.0395 0.0375
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0182 0.2134 0.5384
Loa Loa (eye worm) latrophilin receptor protein 2 0.0188 0.2208 0.2954
Echinococcus granulosus thymidine kinase 0.0346 0.4239 1
Schistosoma mansoni histone deacetylase 0.0062 0.0591 0.1143
Brugia malayi thymidylate kinase 0.0323 0.3946 0.5314
Brugia malayi histone deacetylase 3 (HD3) 0.0062 0.0591 0.0795
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0114 0.0239
Brugia malayi MH1 domain containing protein 0.0033 0.0212 0.0285
Trichomonas vaginalis thymidylate kinase, putative 0.0323 0.3946 1
Brugia malayi latrophilin 2 splice variant baaae 0.0406 0.5011 0.6748
Schistosoma mansoni Smad4 0.0033 0.0212 0.0384
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0584 0.1129
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0584 0.1129
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0114 0.0239
Schistosoma mansoni thymidylate kinase 0.0323 0.3946 0.7867
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0047 0.0395 0.0751
Brugia malayi histone deacetylase 11 0.0018 0.002 0.0027
Echinococcus granulosus thymidylate kinase 0.0323 0.3946 0.9307
Mycobacterium ulcerans thymidylate kinase 0.0323 0.3946 0.5
Echinococcus multilocularis NADH ubiquinone oxidoreductase 42 kDa subunit 0.0077 0.0789 0.077
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein 0.0077 0.0789 0.059
Loa Loa (eye worm) hypothetical protein 0.0406 0.5011 0.6739
Brugia malayi Isocitrate dehydrogenase 0.0047 0.0395 0.0532
Echinococcus granulosus NADH ubiquinone oxidoreductase 42 kDa subunit 0.0077 0.0789 0.1821
Giardia lamblia Hypothetical protein 0.0077 0.0789 0.059
Loa Loa (eye worm) hypothetical protein 0.0062 0.0591 0.077
Loa Loa (eye worm) MH2 domain-containing protein 0.0478 0.5945 0.8
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0047 0.0395 0.0954
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0188 0.2208 0.2192
Echinococcus multilocularis transfer RNA-Ile 0.0346 0.4239 0.4227
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0033 0.0212 0.0192
Brugia malayi MH2 domain containing protein 0.0033 0.0212 0.0285
Plasmodium vivax thymidylate kinase, putative 0.0323 0.3946 1
Brugia malayi MH1 domain containing protein 0.0018 0.0024 0.0033
Brugia malayi N-terminal motif family protein 0.0182 0.2134 0.2874
Plasmodium falciparum thymidylate kinase 0.0323 0.3946 1
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0584 0.1129
Giardia lamblia CDC8 0.0323 0.3946 1
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0047 0.0395 0.0954
Entamoeba histolytica hypothetical protein 0.0077 0.0789 0.059
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.0789 0.059
Brugia malayi Histone deacetylase family protein 0.0018 0.002 0.0027
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0188 0.2208 0.5186
Echinococcus granulosus histone deacetylase 3 0.0062 0.0591 0.1352
Schistosoma mansoni smad1 5 8 and 0.0033 0.0212 0.0384
Leishmania major hypothetical protein, conserved 0.0127 0.1423 0.3573
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0114 0.0239
Entamoeba histolytica hypothetical protein 0.0077 0.0789 0.059
Entamoeba histolytica Thymidylate kinase, putative 0.0323 0.3946 1
Echinococcus granulosus GPCR family 2 0.0188 0.2208 0.5186
Echinococcus granulosus TGF beta signal transducer SmadC 0.0033 0.0212 0.0454
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0047 0.0395 0.0375
Brugia malayi hypothetical protein 0.0025 0.0114 0.0153
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0047 0.0395 0.0375
Treponema pallidum thymidylate kinase (tmk) 0.0323 0.3946 0.5
Entamoeba histolytica hypothetical protein 0.0077 0.0789 0.059
Mycobacterium leprae probable thymidylate kinase Tmk (dTMP KINASE) (THYMIDYLIC ACID KINASE) (TMPK) 0.0323 0.3946 0.5
Echinococcus granulosus thymidine kinase 0.0346 0.4239 1
Trypanosoma cruzi UMP-CMP kinase, mitochondrial, putative 0.0127 0.1423 0.3573
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0047 0.0395 0.0954
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0047 0.0395 0.0954
Loa Loa (eye worm) thymidylate kinase 0.0323 0.3946 0.5301
Schistosoma mansoni hypothetical protein 0.0188 0.2208 0.4384
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0047 0.0395 0.0954
Echinococcus multilocularis GPCR, family 2 0.0188 0.2208 0.2192
Toxoplasma gondii histone deacetylase HDAC2 0.0062 0.0591 0.1453
Schistosoma mansoni thymidylate kinase 0.0323 0.3946 0.7867
Echinococcus multilocularis isocitrate dehydrogenase 0.0047 0.0395 0.0375
Brugia malayi isocitrate dehydrogenase 0.0047 0.0395 0.0532
Brugia malayi Deoxynucleoside kinase family protein 0.0077 0.0789 0.1062
Toxoplasma gondii thymidylate kinase 0.0323 0.3946 1
Entamoeba histolytica hypothetical protein 0.0077 0.0789 0.059
Echinococcus multilocularis histone deacetylase 1 0.0062 0.0591 0.0572
Brugia malayi Histone deacetylase 1 0.0062 0.0591 0.0795
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0584 0.0761
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.0789 0.059
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0114 0.0239
Echinococcus multilocularis thymidine kinase 0.0346 0.4239 0.4227
Echinococcus multilocularis mothers against decapentaplegic 5 0.0033 0.0212 0.0192
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0584 0.0565
Brugia malayi RNA binding protein 0.0062 0.0584 0.0786
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0584 0.0786
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0584 0.1129
Echinococcus granulosus Thymidine kinase 2 mitochondrial 0.0346 0.4239 1
Schistosoma mansoni histone deacetylase 0.0062 0.0591 0.1143
Brugia malayi TAR-binding protein 0.0062 0.0584 0.0786
Toxoplasma gondii isocitrate dehydrogenase 0.0047 0.0395 0.0954
Echinococcus multilocularis smad 0.0033 0.0212 0.0192
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0114 0.0239
Echinococcus multilocularis thymidylate kinase 0.0323 0.3946 0.3934
Schistosoma mansoni smad1 5 8 and 0.0033 0.0212 0.0384
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.0789 0.059
Loa Loa (eye worm) hypothetical protein 0.0182 0.2134 0.2854
Brugia malayi histone deacetylase 1 (HD1) 0.0062 0.0591 0.0795
Leishmania major histone deacetylase, putative 0.0062 0.0591 0.1453
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0047 0.0395 0.0375
Loa Loa (eye worm) hypothetical protein 0.0188 0.2208 0.2954
Echinococcus granulosus histone deacetylase 1 0.0062 0.0591 0.1352
Plasmodium vivax histone deacetylase 1, putative 0.0062 0.0591 0.1453

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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