Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ataxin 2 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | delta-4 fatty acid desaturase | 0.0244 | 0.0716 | 0.0716 |
Mycobacterium ulcerans | linoleoyl-CoA desaturase, DesA3 | 0.0244 | 0.0716 | 0.5 |
Trypanosoma cruzi | cytochrome b5-dependent oleate desaturase | 0.0244 | 0.0716 | 0.0716 |
Leishmania major | fatty acid desaturase, putative | 0.0244 | 0.0716 | 0.0716 |
Trypanosoma brucei | cytochrome b5-dependent oleate desaturase | 0.0244 | 0.0716 | 0.0716 |
Trypanosoma brucei | delta-4 fatty acid desaturase | 0.0244 | 0.0716 | 0.0716 |
Toxoplasma gondii | sphingolipid delta 4 desaturase/c-4 hydroxylase protein des2 family protein | 0.0244 | 0.0716 | 1 |
Trypanosoma cruzi | delta-4 fatty acid desaturase, putative | 0.0244 | 0.0716 | 0.0716 |
Mycobacterium ulcerans | electron transfer protein FdxB | 0.0244 | 0.0716 | 0.5 |
Brugia malayi | acyl-CoA desaturase | 0.2773 | 0.9182 | 1 |
Echinococcus multilocularis | Fatty acid desaturase, type 1 | 0.0244 | 0.0716 | 0.5 |
Mycobacterium ulcerans | transmembrane alkane 1-monooxygenase AlkB | 0.0244 | 0.0716 | 0.5 |
Trypanosoma cruzi | delta-4 fatty acid desaturase, putative | 0.0244 | 0.0716 | 0.0716 |
Loa Loa (eye worm) | acyl-CoA desaturase | 0.2773 | 0.9182 | 1 |
Loa Loa (eye worm) | FAT-3 protein | 0.0244 | 0.0716 | 0.0779 |
Leishmania major | fatty acid desaturase, putative,sphingolipid delta 4 desaturase, putative | 0.0244 | 0.0716 | 0.0716 |
Schistosoma mansoni | fatty acid desaturase | 0.0244 | 0.0716 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0244 | 0.0716 | 0.0779 |
Leishmania major | fatty acid desaturase, putative | 0.0244 | 0.0716 | 0.0716 |
Echinococcus multilocularis | Peptidase M, neutral zinc metallopeptidases, zinc binding site | 0.0244 | 0.0716 | 0.5 |
Trypanosoma cruzi | sphingolipid delta 4 desaturase, putative | 0.0244 | 0.0716 | 0.0716 |
Mycobacterium tuberculosis | Probable conserved membrane protein | 0.0244 | 0.0716 | 0.5 |
Leishmania major | fatty-acid desaturase, putative | 0.3017 | 1 | 1 |
Leishmania major | delta-12 fatty acid desaturase | 0.0244 | 0.0716 | 0.0716 |
Onchocerca volvulus | 0.3017 | 1 | 1 | |
Leishmania major | delta-6 fatty acid desaturase | 0.0244 | 0.0716 | 0.0716 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.0244 | 0.0716 | 0.0716 |
Leishmania major | fatty acid desaturase, putative,sphingolipid delta 4 desaturase, putative | 0.0244 | 0.0716 | 0.0716 |
Mycobacterium ulcerans | hypothetical protein | 0.0244 | 0.0716 | 0.5 |
Trypanosoma brucei | sphingolipid delta 4 desaturase, putative | 0.0244 | 0.0716 | 0.0716 |
Mycobacterium ulcerans | linoleoyl-CoA desaturase, DesA3_2 | 0.0244 | 0.0716 | 0.5 |
Leishmania major | delta-5 fatty acid desaturase | 0.0244 | 0.0716 | 0.0716 |
Mycobacterium ulcerans | linoleoyl-CoA desaturase, DesA3 | 0.0244 | 0.0716 | 0.5 |
Loa Loa (eye worm) | fatty acid desaturase | 0.0244 | 0.0716 | 0.0779 |
Onchocerca volvulus | 0.3017 | 1 | 1 | |
Brugia malayi | Delta5 fatty acid desaturase | 0.0244 | 0.0716 | 0.0779 |
Leishmania major | fatty acid desaturase, putative,sphingolipid delta 4 desaturase, putative | 0.0244 | 0.0716 | 0.0716 |
Brugia malayi | Fatty acid desaturase family protein | 0.0244 | 0.0716 | 0.0779 |
Mycobacterium ulcerans | hypothetical protein | 0.0244 | 0.0716 | 0.5 |
Plasmodium falciparum | stearoyl-CoA desaturase | 0.2773 | 0.9182 | 1 |
Brugia malayi | Fatty acid desaturase family protein | 0.0244 | 0.0716 | 0.0779 |
Mycobacterium tuberculosis | Possible electron transfer protein FdxB | 0.0244 | 0.0716 | 0.5 |
Leishmania major | fatty acid desaturase, putative,sphingolipid delta 4 desaturase, putative | 0.0244 | 0.0716 | 0.0716 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.0244 | 0.0716 | 0.0716 |
Loa Loa (eye worm) | fatty acid desaturase | 0.0244 | 0.0716 | 0.0779 |
Echinococcus granulosus | Sphingolipid delta4 desaturase DES1 | 0.0244 | 0.0716 | 0.5 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.2773 | 0.9182 | 0.9182 |
Echinococcus granulosus | Fatty acid desaturase type 1 | 0.0244 | 0.0716 | 0.5 |
Trypanosoma brucei | delta-6 fatty acid desaturase, putative | 0.0244 | 0.0716 | 0.0716 |
Echinococcus multilocularis | Peptidase M, neutral zinc metallopeptidases, zinc binding site | 0.0244 | 0.0716 | 0.5 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.2773 | 0.9182 | 0.9182 |
Mycobacterium tuberculosis | Probable transmembrane alkane 1-monooxygenase AlkB (alkane 1-hydroxylase) (lauric acid omega-hydroxylase) (omega-hydroxylase) (f | 0.0244 | 0.0716 | 0.5 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.3017 | 1 | 1 |
Plasmodium vivax | stearoyl-CoA desaturase (acyl-CoA desaturase, faty acid desaturase), putative | 0.2773 | 0.9182 | 1 |
Trypanosoma brucei | fatty acid desaturase, putative | 0.3017 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.3981 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.