Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0015 | 0.0007 | 0.0008 |
Echinococcus multilocularis | Fatty acid desaturase, type 1 | 0.0406 | 0.0736 | 0.3769 |
Plasmodium falciparum | stearoyl-CoA desaturase | 0.4975 | 0.9243 | 1 |
Mycobacterium ulcerans | linoleoyl-CoA desaturase, DesA3 | 0.0406 | 0.0736 | 1 |
Leishmania major | delta-6 fatty acid desaturase | 0.0406 | 0.0736 | 0.0736 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0015 | 0.0007 | 0.0008 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.0406 | 0.0736 | 0.0736 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0015 | 0.0007 | 0.0007 |
Toxoplasma gondii | sphingolipid delta 4 desaturase/c-4 hydroxylase protein des2 family protein | 0.0406 | 0.0736 | 1 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0015 | 0.0007 | 0.0008 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.0406 | 0.0736 | 0.0736 |
Trypanosoma cruzi | delta-4 fatty acid desaturase, putative | 0.0406 | 0.0736 | 0.0736 |
Mycobacterium ulcerans | linoleoyl-CoA desaturase, DesA3 | 0.0406 | 0.0736 | 1 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0015 | 0.0007 | 0.5 |
Trypanosoma brucei | sphingolipid delta 4 desaturase, putative | 0.0406 | 0.0736 | 0.0736 |
Echinococcus multilocularis | Peptidase M, neutral zinc metallopeptidases, zinc binding site | 0.0406 | 0.0736 | 0.3769 |
Plasmodium vivax | stearoyl-CoA desaturase (acyl-CoA desaturase, faty acid desaturase), putative | 0.4975 | 0.9243 | 1 |
Schistosoma mansoni | fatty acid desaturase | 0.0406 | 0.0736 | 0.3769 |
Mycobacterium tuberculosis | Probable transmembrane alkane 1-monooxygenase AlkB (alkane 1-hydroxylase) (lauric acid omega-hydroxylase) (omega-hydroxylase) (f | 0.0406 | 0.0736 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0406 | 0.0736 | 1 |
Echinococcus granulosus | Fatty acid desaturase type 1 | 0.0406 | 0.0736 | 0.3769 |
Echinococcus granulosus | Sphingolipid delta4 desaturase DES1 | 0.0406 | 0.0736 | 0.3769 |
Loa Loa (eye worm) | acyl-CoA desaturase | 0.4975 | 0.9243 | 1 |
Trypanosoma brucei | delta-4 fatty acid desaturase | 0.0406 | 0.0736 | 0.0736 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0015 | 0.0007 | 0.0037 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0043 | 0.0058 | 0.0298 |
Trypanosoma brucei | fatty acid desaturase, putative | 0.5382 | 1 | 1 |
Trypanosoma brucei | delta-6 fatty acid desaturase, putative | 0.0406 | 0.0736 | 0.0736 |
Brugia malayi | acyl-CoA desaturase | 0.4975 | 0.9243 | 1 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.5382 | 1 | 1 |
Schistosoma mansoni | ap endonuclease | 0.0015 | 0.0007 | 0.0037 |
Trypanosoma cruzi | delta-4 fatty acid desaturase, putative | 0.0406 | 0.0736 | 0.0736 |
Leishmania major | fatty-acid desaturase, putative | 0.5382 | 1 | 1 |
Mycobacterium tuberculosis | Possible electron transfer protein FdxB | 0.0406 | 0.0736 | 1 |
Brugia malayi | Delta5 fatty acid desaturase | 0.0406 | 0.0736 | 0.0796 |
Mycobacterium ulcerans | electron transfer protein FdxB | 0.0406 | 0.0736 | 1 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0015 | 0.0007 | 0.0037 |
Schistosoma mansoni | ap endonuclease | 0.0015 | 0.0007 | 0.0037 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0043 | 0.0058 | 0.0298 |
Brugia malayi | jmjC domain containing protein | 0.0043 | 0.0058 | 0.0063 |
Leishmania major | delta-12 fatty acid desaturase | 0.0406 | 0.0736 | 0.0736 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0015 | 0.0007 | 0.5 |
Leishmania major | delta-4 fatty acid desaturase | 0.0406 | 0.0736 | 0.0736 |
Brugia malayi | Fatty acid desaturase family protein | 0.0406 | 0.0736 | 0.0796 |
Onchocerca volvulus | 0.5382 | 1 | 1 | |
Trypanosoma brucei | cytochrome b5-dependent oleate desaturase | 0.0406 | 0.0736 | 0.0736 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0015 | 0.0007 | 0.0008 |
Trypanosoma cruzi | cytochrome b5-dependent oleate desaturase | 0.0406 | 0.0736 | 0.0736 |
Toxoplasma gondii | exonuclease III APE | 0.0015 | 0.0007 | 0.0099 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0015 | 0.0007 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0406 | 0.0736 | 1 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0043 | 0.0058 | 0.0298 |
Loa Loa (eye worm) | FAT-3 protein | 0.0406 | 0.0736 | 0.0796 |
Echinococcus granulosus | microtubule associated protein 2 | 0.1059 | 0.1951 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0015 | 0.0007 | 0.5 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.1059 | 0.1951 | 1 |
Echinococcus multilocularis | Peptidase M, neutral zinc metallopeptidases, zinc binding site | 0.0406 | 0.0736 | 0.3769 |
Mycobacterium ulcerans | transmembrane alkane 1-monooxygenase AlkB | 0.0406 | 0.0736 | 1 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0015 | 0.0007 | 0.5 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0015 | 0.0007 | 0.0007 |
Trypanosoma cruzi | sphingolipid delta 4 desaturase, putative | 0.0406 | 0.0736 | 0.0736 |
Leishmania major | fatty acid desaturase, putative,sphingolipid delta 4 desaturase, putative | 0.0406 | 0.0736 | 0.0736 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0043 | 0.0058 | 0.0298 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0043 | 0.0058 | 0.0063 |
Brugia malayi | jmjC domain containing protein | 0.0043 | 0.0058 | 0.0063 |
Schistosoma mansoni | microtubule-associated protein tau | 0.1059 | 0.1951 | 1 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.4975 | 0.9243 | 0.9243 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0015 | 0.0007 | 0.0007 |
Loa Loa (eye worm) | hypothetical protein | 0.0406 | 0.0736 | 0.0796 |
Loa Loa (eye worm) | fatty acid desaturase | 0.0406 | 0.0736 | 0.0796 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0015 | 0.0007 | 0.5 |
Mycobacterium ulcerans | linoleoyl-CoA desaturase, DesA3_2 | 0.0406 | 0.0736 | 1 |
Leishmania major | fatty acid desaturase, putative | 0.0406 | 0.0736 | 0.0736 |
Leishmania major | fatty acid desaturase, putative,sphingolipid delta 4 desaturase, putative | 0.0406 | 0.0736 | 0.0736 |
Brugia malayi | Fatty acid desaturase family protein | 0.0406 | 0.0736 | 0.0796 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0015 | 0.0007 | 0.0007 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0043 | 0.0058 | 0.0298 |
Onchocerca volvulus | 0.5382 | 1 | 1 | |
Leishmania major | fatty acid desaturase, putative,sphingolipid delta 4 desaturase, putative | 0.0406 | 0.0736 | 0.0736 |
Leishmania major | fatty acid desaturase, putative | 0.0406 | 0.0736 | 0.0736 |
Leishmania major | fatty acid desaturase, putative,sphingolipid delta 4 desaturase, putative | 0.0406 | 0.0736 | 0.0736 |
Loa Loa (eye worm) | fatty acid desaturase | 0.0406 | 0.0736 | 0.0796 |
Mycobacterium tuberculosis | Probable conserved membrane protein | 0.0406 | 0.0736 | 1 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.4975 | 0.9243 | 0.9243 |
Leishmania major | delta-5 fatty acid desaturase | 0.0406 | 0.0736 | 0.0736 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0043 | 0.0058 | 0.0298 |
Schistosoma mansoni | jumonji domain containing protein | 0.0043 | 0.0058 | 0.0298 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.