Detailed information for compound 912250

Basic information

Technical information
  • TDR Targets ID: 912250
  • Name: ethyl 6-[(4-methoxy-2-nitrophenyl)carbamoyl]p yridine-2-carboxylate
  • MW: 345.307 | Formula: C16H15N3O6
  • H donors: 1 H acceptors: 5 LogP: 2.93 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)c1cccc(n1)C(=O)Nc1ccc(cc1[N+](=O)[O-])OC
  • InChi: 1S/C16H15N3O6/c1-3-25-16(21)13-6-4-5-12(17-13)15(20)18-11-8-7-10(24-2)9-14(11)19(22)23/h4-9H,3H2,1-2H3,(H,18,20)
  • InChiKey: XKHSWMLBBGEQAF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • ethyl 6-[(4-methoxy-2-nitro-phenyl)carbamoyl]pyridine-2-carboxylate
  • 6-[[(4-methoxy-2-nitrophenyl)amino]-oxomethyl]-2-pyridinecarboxylic acid ethyl ester
  • 6-[(4-methoxy-2-nitro-phenyl)carbamoyl]picolinic acid ethyl ester
  • EU-0033905
  • Oprea1_835680
  • ZINC03897694

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni o-methyltransferase 0.0062 0.0302 0.1548
Mycobacterium ulcerans methyltransferase 0.0062 0.0302 0.0737
Mycobacterium leprae PROBABLE METHYLTRANSFERASE 0.0062 0.0302 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0113 0.0089
Chlamydia trachomatis DNA ligase 0.0019 0.0035 0.5
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0091 0.6178
Loa Loa (eye worm) hypothetical protein 0.0014 0 0.0001
Entamoeba histolytica hypothetical protein 0.0019 0.0035 0.068
Echinococcus multilocularis snurportin 1 0.0305 0.1818 0.1798
Brugia malayi latrophilin 2 splice variant baaae 0.0069 0.0345 0.3553
Loa Loa (eye worm) hypothetical protein 0.0062 0.0302 0.1661
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0091 0.5011
Onchocerca volvulus Huntingtin homolog 0.0118 0.0653 1
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0324 0.1671
Schistosoma mansoni ran 0.0021 0.0044 0.011
Loa Loa (eye worm) hypothetical protein 0.0018 0.0024 0.0134
Brugia malayi O-methyltransferase family protein 0.0062 0.0302 0.3111
Brugia malayi TAR-binding protein 0.0066 0.0324 0.3339
Brugia malayi Carboxylesterase family protein 0.0018 0.0024 0.025
Leishmania major hypothetical protein, conserved 0.0026 0.0074 0.5013
Loa Loa (eye worm) hypothetical protein 0.0019 0.0035 0.0191
Loa Loa (eye worm) hypothetical protein 0.0026 0.0074 0.0407
Echinococcus multilocularis Niemann Pick C1 protein 0.0136 0.0763 0.074
Onchocerca volvulus 0.0062 0.0302 0.4624
Schistosoma mansoni hypothetical protein 0.0039 0.0159 0.075
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0044 0.298
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0057 0.3414
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0097 0.0517 0.2745
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0019 0.0035 0.2055
Echinococcus granulosus Niemann Pick C1 protein 0.0095 0.0507 0.2504
Brugia malayi Carboxylesterase family protein 0.0018 0.0024 0.025
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0147 1
Brugia malayi Carboxylesterase family protein 0.0018 0.0024 0.025
Loa Loa (eye worm) hypothetical protein 0.0019 0.0035 0.0191
Brugia malayi hypothetical protein 0.0019 0.0035 0.0357
Schistosoma mansoni alpha-glucosidase 0.0146 0.0823 0.4455
Onchocerca volvulus 0.0026 0.0076 0.1156
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0091 0.6178
Brugia malayi Pax transcription activation domain interacting protein 0.0019 0.0035 0.0357
Echinococcus multilocularis lysosomal alpha glucosidase 0.0169 0.0971 0.0949
Brugia malayi hypothetical protein 0.0019 0.0035 0.0357
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0038 0.0147 0.0811
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0044 1
Brugia malayi Carboxylesterase family protein 0.0018 0.0024 0.025
Schistosoma mansoni hypothetical protein 0.0305 0.1818 1
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0019 0.0035 0.2055
Mycobacterium tuberculosis Probable catechol-O-methyltransferase 0.0538 0.3274 1
Onchocerca volvulus 0.0018 0.0024 0.037
Echinococcus multilocularis tumor protein p63 0.0326 0.1954 0.1934
Loa Loa (eye worm) O-methyltransferase 0.0062 0.0302 0.1661
Echinococcus granulosus tumor protein p63 0.0326 0.1954 1
Brugia malayi hypothetical protein 0.0118 0.0653 0.6725
Loa Loa (eye worm) hypothetical protein 0.0095 0.0507 0.2791
Loa Loa (eye worm) TAR-binding protein 0.0066 0.0324 0.1783
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0074 0.5013
Brugia malayi Niemann-Pick C1 protein precursor 0.0095 0.0507 0.5228
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0019 0.0035 0.234
Brugia malayi RNA recognition motif domain containing protein 0.0066 0.0324 0.3339
Echinococcus granulosus snurportin 1 0.0305 0.1818 0.9295
Echinococcus multilocularis expressed conserved protein 0.0089 0.0471 0.0448
Echinococcus granulosus Protein patched homolog 1 0.0041 0.0168 0.0744
Loa Loa (eye worm) hypothetical protein 0.0019 0.0035 0.0191
Onchocerca volvulus 0.0026 0.0076 0.1156
Onchocerca volvulus 0.0018 0.0024 0.037
Loa Loa (eye worm) hypothetical protein 0.0101 0.0545 0.2998
Brugia malayi topoisomerase 0.0019 0.0035 0.0357
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0211 0.1044
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0041 0.0168 0.0924
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0074 0.349
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0038 0.0147 0.8781
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0057 0.3414
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0113 0.0089
Echinococcus multilocularis replication factor c subunit 1 0.0019 0.0035 0.001
Loa Loa (eye worm) hypothetical protein 0.0018 0.0024 0.0134
Brugia malayi hypothetical protein 0.0017 0.0017 0.0174
Loa Loa (eye worm) hypothetical protein 0.0018 0.0024 0.0134
Brugia malayi DKFZp564C0469 protein 0.0019 0.0035 0.0357
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0044 0.0454
Giardia lamblia Sgs1 DNA helicase, putative 0.0021 0.0041 0.7192
Loa Loa (eye worm) hypothetical protein 0.0019 0.0035 0.0191
Echinococcus granulosus nibrin 0.0019 0.0035 0.0054
Schistosoma mansoni hypothetical protein 0.0039 0.0159 0.075
Schistosoma mansoni topbp1 0.0019 0.0035 0.0058
Echinococcus multilocularis protein dispatched 1 0.0047 0.0204 0.018
Schistosoma mansoni DNA helicase recq1 0.0021 0.0041 0.0096
Echinococcus multilocularis sterol regulatory element binding protein 0.0041 0.0168 0.0144
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0324 0.1671
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.021 0.0186
Brugia malayi Calcitonin receptor-like protein seb-1 0.0101 0.0545 0.5614
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0074 0.5013
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0076 0.0416
Echinococcus multilocularis neutral alpha glucosidase AB 0.0038 0.0147 0.0123
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0113 0.0459
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0044 0.298
Brugia malayi intermediate filament protein 0.0026 0.0076 0.0779
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.021 0.0961
Trypanosoma cruzi hypothetical protein, conserved 0.0019 0.0035 0.234
Loa Loa (eye worm) carboxylesterase 0.0018 0.0024 0.0134
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0044 0.0836
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0074 0.6964
Entamoeba histolytica recQ family helicase, putative 0.0021 0.0041 0.0813
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0048 0.021 0.2161
Brugia malayi CHE-14 protein 0.0041 0.0168 0.173
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.0019 0.0035 0.0357
Echinococcus multilocularis protein patched 0.0041 0.0168 0.0144
Echinococcus multilocularis GPCR, family 2 0.0032 0.0113 0.0089
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0041 0.2459
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0021 0.0041 0.2801
Loa Loa (eye worm) hypothetical protein 0.0018 0.0024 0.0134
Brugia malayi Importin beta-1 subunit 0.0029 0.0091 0.0939
Mycobacterium tuberculosis Carboxylesterase LipT 0.0157 0.0892 0.2669
Loa Loa (eye worm) hypothetical protein 0.0026 0.0073 0.04
Loa Loa (eye worm) hypothetical protein 0.0019 0.0035 0.0191
Loa Loa (eye worm) hypothetical protein 0.0029 0.0091 0.0502
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0021 0.0041 0.2801
Brugia malayi O-methyltransferase 0.0062 0.0302 0.3111
Schistosoma mansoni hypothetical protein 0.0032 0.0113 0.0493
Echinococcus granulosus expressed conserved protein 0.0089 0.0471 0.2317
Echinococcus granulosus sterol regulatory element binding protein 0.0041 0.0168 0.0744
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.021 0.1034
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0147 0.8781
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0168 1
Schistosoma mansoni intermediate filament proteins 0.0026 0.0076 0.0286
Onchocerca volvulus 0.0018 0.0024 0.037
Loa Loa (eye worm) hypothetical protein 0.0069 0.0345 0.1897
Brugia malayi RNA binding protein 0.0066 0.0324 0.3339
Loa Loa (eye worm) hypothetical protein 0.005 0.0225 0.124
Schistosoma mansoni topbp1 0.0019 0.0035 0.0058
Echinococcus multilocularis Niemann Pick C1 protein 0.0095 0.0507 0.0484
Onchocerca volvulus 0.0019 0.0035 0.0528
Schistosoma mansoni importin beta-1 0.0029 0.0091 0.0373
Loa Loa (eye worm) hypothetical protein 0.0018 0.0024 0.0134
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0147 0.8781
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0035 0.2055
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0324 0.1671
Loa Loa (eye worm) RecQ helicase 0.0021 0.0041 0.0228
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0019 0.0035 0.2055
Schistosoma mansoni alpha-glucosidase 0.0146 0.0823 0.4455
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0021 0.0041 0.0089
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0041 0.2459
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0305 0.1818 1
Schistosoma mansoni DNA helicase recq5 0.0021 0.0041 0.0096
Wolbachia endosymbiont of Brugia malayi O-methyltransferase 0.0062 0.0302 1
Brugia malayi hypothetical protein 0.0026 0.0074 0.0763
Loa Loa (eye worm) carboxylesterase 0.0018 0.0024 0.0134
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0021 0.0041 0.0228
Loa Loa (eye worm) hypothetical protein 0.0018 0.0024 0.0134
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0091 0.0067
Schistosoma mansoni hypothetical protein 0.0032 0.0113 0.0493
Echinococcus multilocularis nibrin 0.0019 0.0035 0.001
Brugia malayi Carboxylesterase family protein 0.0018 0.0024 0.025
Onchocerca volvulus Huntingtin homolog 0.0118 0.0653 1
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0035 0.2055
Loa Loa (eye worm) hypothetical protein 0.0026 0.0076 0.0416
Mycobacterium ulcerans O-methyltransferase 0.06 0.3663 1
Loa Loa (eye worm) hypothetical protein 0.0118 0.0653 0.3591
Echinococcus multilocularis tar DNA binding protein 0.0066 0.0324 0.0301
Mycobacterium tuberculosis Probable methyltransferase 0.0062 0.0302 0.0855
Schistosoma mansoni chromosome transmission fidelity factor 0.0019 0.0035 0.0058
Loa Loa (eye worm) hypothetical protein 0.0018 0.0024 0.0134
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.021 0.1034
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0044 0.298
Loa Loa (eye worm) RNA binding protein 0.0066 0.0324 0.1783
Trichomonas vaginalis sucrase-isomaltase, putative 0.0038 0.0147 0.8781
Loa Loa (eye worm) hypothetical protein 0.0048 0.0211 0.1163
Trichomonas vaginalis maltase-glucoamylase, putative 0.0038 0.0147 0.8781
Echinococcus granulosus replication factor c subunit 1 0.0019 0.0035 0.0054
Loa Loa (eye worm) carboxylesterase 0.0018 0.0024 0.0134
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0113 0.062
Brugia malayi Bloom's syndrome protein homolog 0.0021 0.0041 0.0427
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0035 0.2055
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0113 0.1162
Treponema pallidum DNA ligase (lig) 0.0019 0.0035 0.5
Onchocerca volvulus 0.0062 0.0302 0.4624
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.021 0.1034
Trypanosoma cruzi FHA domain containing protein, putative 0.0019 0.0035 0.234
Echinococcus granulosus GPCR family 2 0.0032 0.0113 0.0459
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0076 0.0416
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0018 0.0024 0.1438
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0019 0.0035 0.234
Brugia malayi hypothetical protein 0.0018 0.0024 0.025
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0113 0.0459
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0147 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0074 0.5013
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0074 0.6964
Trichomonas vaginalis ran, putative 0.0021 0.0044 0.2617
Schistosoma mansoni patched 1 0.0041 0.0168 0.0801
Trichomonas vaginalis replication factor C large subunit, putative 0.0019 0.0035 0.2055
Schistosoma mansoni o-methyltransferase 0.0062 0.0302 0.1548
Leishmania major importin beta-1 subunit, putative 0.0023 0.0057 0.3887
Loa Loa (eye worm) hypothetical protein 0.0041 0.0168 0.0924
Leishmania major GTP-binding protein, putative 0.0021 0.0044 0.298
Echinococcus granulosus neutral alpha glucosidase AB 0.0038 0.0147 0.0638
Brugia malayi O-methyltransferase family protein 0.0062 0.0302 0.3111
Echinococcus granulosus Niemann Pick C1 protein 0.0136 0.0763 0.3827
Plasmodium vivax importin-beta 2, putative 0.0029 0.0091 1
Trichomonas vaginalis DNA helicase recq1, putative 0.0021 0.0041 0.2459
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.0019 0.0035 0.068
Brugia malayi Glycosyl hydrolases family 31 protein 0.0169 0.0971 1
Echinococcus granulosus tar DNA binding protein 0.0066 0.0324 0.1554
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0113 0.1162
Loa Loa (eye worm) hypothetical protein 0.0018 0.0024 0.0134
Loa Loa (eye worm) hypothetical protein 0.0118 0.0653 0.3591
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0041 0.0427
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0041 0.0601
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0021 0.0041 0.0089
Loa Loa (eye worm) hypothetical protein 0.0018 0.0024 0.0134
Schistosoma mansoni hypothetical protein 0.0039 0.0159 0.075
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0324 0.1671
Schistosoma mansoni ran 0.0021 0.0044 0.011
Echinococcus multilocularis musashi 0.0026 0.0076 0.0051
Schistosoma mansoni lamin 0.0026 0.0076 0.0286
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0021 0.0041 0.0017
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0101 0.0545 0.2998
Echinococcus multilocularis lamin 0.0026 0.0076 0.0051
Schistosoma mansoni hypothetical protein 0.0069 0.0345 0.1788
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0021 0.0041 0.2801
Echinococcus granulosus lysosomal alpha glucosidase 0.0169 0.0971 0.4905
Schistosoma mansoni hypothetical protein 0.0032 0.0113 0.0493
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0044 0.0242
Brugia malayi Glycosyl hydrolases family 31 protein 0.0038 0.0147 0.1519
Brugia malayi Carboxylesterase family protein 0.0018 0.0024 0.025
Echinococcus granulosus intermediate filament protein 0.0026 0.0076 0.0266
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0076 0.0779
Loa Loa (eye worm) hypothetical protein 0.0032 0.0113 0.062
Brugia malayi RNA, U transporter 1 0.0081 0.042 0.4329
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0147 0.8781
Schistosoma mansoni hypothetical protein 0.0032 0.0113 0.0493
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0169 0.0971 0.534
Trichomonas vaginalis spcc417.12 protein, putative 0.0018 0.0024 0.1438
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0035 0.2055
Schistosoma mansoni lamin 0.0026 0.0076 0.0286
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0038 0.0147 0.2904
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0021 0.0041 0.1199
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0044 0.1667
Loa Loa (eye worm) hypothetical protein 0.0021 0.0041 0.0228
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0044 0.1667
Brugia malayi O-methyltransferase family protein 0.0062 0.0302 0.3111
Brugia malayi Glycosyl hydrolases family 31 protein 0.0014 0 0.0002
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0035 0.2055
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0038 0.0147 0.2904
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0044 0.002
Schistosoma mansoni o-methyltransferase 0.0062 0.0302 0.1548
Loa Loa (eye worm) acetylcholinesterase 1 0.0018 0.0024 0.0134
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0021 0.0041 0.1199
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0021 0.0041 0.0017
Echinococcus multilocularis lysosomal alpha glucosidase 0.0169 0.0971 0.0949
Schistosoma mansoni hypothetical protein 0.0039 0.0159 0.075
Mycobacterium ulcerans carboxylesterase, LipT 0.0157 0.0892 0.2362
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0101 0.0545 0.5614
Leishmania major alpha glucosidase II subunit, putative 0.0038 0.0147 1
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0095 0.0507 1
Schistosoma mansoni alpha glucosidase 0.0038 0.0147 0.0687
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0147 0.8781
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0057 0.3887
Onchocerca volvulus 0.0098 0.0525 0.8036
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0044 0.0103
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0038 0.0147 1
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0324 0.1671
Loa Loa (eye worm) hypothetical protein 0.0019 0.0035 0.0191
Entamoeba histolytica hypothetical protein 0.0023 0.0057 0.1129
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.021 0.0186
Schistosoma mansoni o-methyltransferase 0.0062 0.0302 0.1548
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0041 0.0601
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.021 0.0961
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0019 0.0035 0.2055
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0038 0.0147 0.8781
Plasmodium falciparum importin beta, putative 0.0029 0.0091 1
Echinococcus granulosus lamin 0.0026 0.0076 0.0266
Onchocerca volvulus 0.0018 0.0024 0.037
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0057 0.3414
Echinococcus granulosus lamin dm0 0.0026 0.0076 0.0266
Echinococcus granulosus importin subunit beta 1 0.0029 0.0091 0.0347
Onchocerca volvulus 0.0048 0.0211 0.3238
Echinococcus multilocularis bloom syndrome protein 0.0021 0.0041 0.0017
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0066 0.0324 0.1783
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0041 0.0427
Entamoeba histolytica Ran family GTPase 0.0021 0.0044 0.0866
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0074 0.6964
Echinococcus granulosus bloom syndrome protein 0.0021 0.0041 0.0089
Trypanosoma cruzi hypothetical protein, conserved 0.0019 0.0035 0.234
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0048 0.021 0.1154
Echinococcus multilocularis lamin dm0 0.0026 0.0076 0.0051
Schistosoma mansoni DNA ligase IV 0.0019 0.0035 0.0058
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0147 0.8781
Trypanosoma brucei glucosidase, putative 0.0038 0.0147 1
Onchocerca volvulus 0.0018 0.0024 0.037

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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