Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | bromodomain adjacent to zinc finger domain, 2B | Starlite/ChEMBL | No references |
Homo sapiens | euchromatic histone-lysine N-methyltransferase 2 | Starlite/ChEMBL | No references |
Homo sapiens | microtubule-associated protein tau | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Bromodomain containing protein | 0.0046 | 0.0307 | 0.0529 |
Leishmania major | protein kinase, putative | 0.0336 | 0.3872 | 0.5 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0025 | 0.0044 | 0.0114 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0308 | 0.0795 |
Brugia malayi | Pre-SET motif family protein | 0.0251 | 0.2832 | 0.7239 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0343 | 0.0886 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.006 | 0.0473 | 0.0446 |
Loa Loa (eye worm) | PEK/HRI protein kinase | 0.0336 | 0.3872 | 1 |
Trichomonas vaginalis | set domain proteins, putative | 0.0286 | 0.326 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.0435 | 0.1123 |
Trypanosoma brucei | eukaryotic translation initiation factor 2-alpha kinase 1, putative | 0.0336 | 0.3872 | 0.5 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0057 | 0.0435 | 0.0408 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0035 | 0.0165 | 0.0137 |
Brugia malayi | Bromodomain containing protein | 0.0091 | 0.0853 | 0.1979 |
Schistosoma mansoni | bromodomain containing protein | 0.0076 | 0.0678 | 0.0652 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0036 | 0.0181 | 0.0153 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0057 | 0.0435 | 0.0408 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0372 | 0.096 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0833 | 1 | 1 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0036 | 0.0181 | 0.0153 |
Plasmodium vivax | SET domain protein, putative | 0.0036 | 0.0181 | 0.5 |
Echinococcus multilocularis | tumor protein p63 | 0.0408 | 0.4762 | 0.4747 |
Onchocerca volvulus | 0.006 | 0.0473 | 0.0947 | |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0043 | 0.0272 | 0.0244 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0057 | 0.0435 | 0.0408 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0072 | 0.0625 | 0.0598 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0036 | 0.0181 | 0.5 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0027 | 0.0073 | 0.0044 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0072 | 0.0625 | 0.0598 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0336 | 0.3872 | 0.5 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0043 | 0.0272 | 0.0244 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0027 | 0.0073 | 0.0044 |
Schistosoma mansoni | hypothetical protein | 0.0025 | 0.0044 | 0.0016 |
Echinococcus multilocularis | eukaryotic translation initiation factor 2 alpha | 0.0336 | 0.3872 | 0.3854 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0473 | 0.1221 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0027 | 0.0073 | 0.0044 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0036 | 0.0181 | 0.0153 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.0789 | 0.2038 |
Brugia malayi | hypothetical protein | 0.0336 | 0.3872 | 1 |
Echinococcus granulosus | eukaryotic translation initiation factor 2 alpha | 0.0336 | 0.3872 | 0.3854 |
Onchocerca volvulus | 0.0286 | 0.326 | 1 | |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0251 | 0.2832 | 0.7316 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0057 | 0.0435 | 0.0408 |
Brugia malayi | Pre-SET motif family protein | 0.0036 | 0.0181 | 0.0195 |
Trypanosoma brucei | protein kinase, putative | 0.0336 | 0.3872 | 0.5 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0833 | 1 | 1 |
Echinococcus granulosus | tumor protein p63 | 0.0408 | 0.4762 | 0.4747 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0336 | 0.3872 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 5.6234 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Potency (functional) | 11.2202 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Potency (functional) | 15.8489 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
Potency (binding) | = 19.9526 um | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.