TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 579.654 | Formula: C34H29N9O
H donors: 2 H acceptors: 7 LogP: 5.51 Rotable bonds: 6
Rule of 5 violations (Lipinski): 2
SMILES: Oc1nnc2n1ccc1c2cc(c(n1)c1ccc(cc1)CN1CCC(CC1)c1n[nH]c(n1)c1ccccn1)c1ccccc1
InChi: 1S/C34H29N9O/c44-34-41-40-33-27-20-26(23-6-2-1-3-7-23)30(36-28(27)15-19-43(33)34)24-11-9-22(10-12-24)21-42-17-13-25(14-18-42)31-37-32(39-38-31)29-8-4-5-16-35-29/h1-12,15-16,19-20,25H,13-14,17-18,21H2,(H,41,44)(H,37,38,39)
InChiKey: QZAVQVPYZPNEQB-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	v-akt murine thymoma viral oncogene homolog 1	Starlite/ChEMBL	References
Homo sapiens	potassium voltage-gated channel, subfamily H (eag-related), member 2	Starlite/ChEMBL	References
Homo sapiens	v-akt murine thymoma viral oncogene homolog 2	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	Get druggable targets OG5_128858	All targets in OG5_128858
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Echinococcus multilocularis	nervana 2	Get druggable targets OG5_126635	All targets in OG5_126635
Echinococcus granulosus	calcium:calmodulin dependent protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Echinococcus granulosus	nervana 2	Get druggable targets OG5_126635	All targets in OG5_126635
Schistosoma mansoni	voltage-gated potassium channel	Get druggable targets OG5_128858	All targets in OG5_128858
Schistosoma japonicum	ko:K04910 potassium voltage-gated channel, Eag-related subfamily H, member 7, putative	Get druggable targets OG5_128858	All targets in OG5_128858
Entamoeba histolytica	protein kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Echinococcus multilocularis	serine threonine protein kinase nrc serine threonine protein kinase gad	Get druggable targets OG5_126635	All targets in OG5_126635
Trypanosoma brucei	rac serine-threonine kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Giardia lamblia	Kinase, AGC PKA	Get druggable targets OG5_126635	All targets in OG5_126635
Echinococcus multilocularis	Glutaredoxin protein 5	Get druggable targets OG5_126635	All targets in OG5_126635
Trypanosoma cruzi	rac serine-threonine kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128858	All targets in OG5_128858
Schistosoma mansoni	serine/threonine-protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Trypanosoma congolense	rac serine-threonine kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Entamoeba histolytica	PH domain containing protein kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Echinococcus granulosus	nervana 2	Get druggable targets OG5_126635	All targets in OG5_126635
Echinococcus granulosus	Glutaredoxin protein 5	Get druggable targets OG5_126635	All targets in OG5_126635
Plasmodium falciparum	RAC-beta serine/threonine protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Schistosoma japonicum	RAC serine/threonine-protein kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Schistosoma japonicum	Sodium/potassium-transporting ATPase subunit beta-1, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Brugia malayi	Protein kinase domain containing protein	Get druggable targets OG5_126635	All targets in OG5_126635
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Plasmodium vivax	rac-beta serine/threonine protein kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Echinococcus granulosus	potassium voltage gated channel subfamily H	Get druggable targets OG5_128858	All targets in OG5_128858
Loa Loa (eye worm)	AGC/AKT protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Neospora caninum	Ribosomal protein S6 kinase alpha-6 (EC 2.7.11.1), related	Get druggable targets OG5_126635	All targets in OG5_126635
Entamoeba histolytica	protein kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Echinococcus granulosus	sodium:potassium dependent atpase beta subunit	Get druggable targets OG5_126635	All targets in OG5_126635
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Schistosoma japonicum	ko:K04910 potassium voltage-gated channel, Eag-related subfamily H, member 7, putative	Get druggable targets OG5_128858	All targets in OG5_128858
Schistosoma japonicum	ko:K08792 serum/glucocorticoid regulated kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Schistosoma japonicum	ko:K04456 RAC serine/threonine-protein kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Entamoeba histolytica	protein kinase 2, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Entamoeba histolytica	PH domain containing protein kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Candida albicans	likely protein kinase similar to S. cerevisiae YPK2 (YMR104C)	Get druggable targets OG5_126635	All targets in OG5_126635
Echinococcus multilocularis	rac serine:threonine kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Schistosoma mansoni	voltage-gated potassium channel	Get druggable targets OG5_128858	All targets in OG5_128858
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Echinococcus multilocularis	potassium voltage gated channel subfamily H	Get druggable targets OG5_128858	All targets in OG5_128858
Trypanosoma cruzi	Protein kinase B	Get druggable targets OG5_126635	All targets in OG5_126635
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Trypanosoma brucei gambiense	rac serine-threonine kinase, putative,protein kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Plasmodium yoelii	kinase Akt/PKB-related	Get druggable targets OG5_126635	All targets in OG5_126635
Plasmodium knowlesi	RAC-beta serine/threonine protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Loa Loa (eye worm)	AGC/RSK/P70 protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Schistosoma mansoni	serine/threonine-protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	Get druggable targets OG5_128858	All targets in OG5_128858
Echinococcus multilocularis	sodium:potassium dependent atpase beta subunit	Get druggable targets OG5_126635	All targets in OG5_126635
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Schistosoma japonicum	ko:K07390 monothiol glutaredoxin, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Trypanosoma cruzi	rac serine-threonine kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Entamoeba histolytica	protein kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Echinococcus granulosus	serine threonine protein kinase nrc	Get druggable targets OG5_126635	All targets in OG5_126635
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	Get druggable targets OG5_128858	All targets in OG5_128858
Plasmodium berghei	rac-beta serine/threonine protein kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Brugia malayi	p70 ribosomal S6 kinase beta	Get druggable targets OG5_126635	All targets in OG5_126635
Echinococcus multilocularis	nervana 2	Get druggable targets OG5_126635	All targets in OG5_126635
Candida albicans	protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Schistosoma japonicum	Potassium voltage-gated channel subfamily H member 2, putative	Get druggable targets OG5_128858	All targets in OG5_128858
Echinococcus granulosus	serine/threonine protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Toxoplasma gondii	AGC kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Loa Loa (eye worm)	voltage and ligand gated potassium channel	Get druggable targets OG5_128858	All targets in OG5_128858

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Chlamydia trachomatis	cAMP-dependent protein kinase regulatory subunit	0.0006	0	0.5
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0045	0.4577	0.7029
Loa Loa (eye worm)	AGC/RSK/P70 protein kinase	0.0088	0.9707	0.9707
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0006	0	0.5
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0009	0.0347	0.0533
Brugia malayi	Protein kinase domain containing protein	0.003	0.2869	0.2869
Trichomonas vaginalis	AGC family protein kinase	0.009	1	1
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0006	0	0.5
Brugia malayi	Hr1 repeat family protein	0.003	0.2869	0.2869
Trichomonas vaginalis	AGC family protein kinase	0.003	0.2869	0.2869
Trichomonas vaginalis	AGC family protein kinase	0.003	0.2869	0.2869
Loa Loa (eye worm)	AGC/RSK/RSK protein kinase	0.003	0.2869	0.2869
Schistosoma mansoni	serine/threonine protein kinase	0.003	0.2869	0.4405
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0831	0.0831
Toxoplasma gondii	AGC kinase	0.0088	0.9707	1
Schistosoma mansoni	voltage-gated potassium channel	0.0013	0.0831	0.1277
Loa Loa (eye worm)	cyclic-nucleotide gated cation channel	0.0009	0.0347	0.0347
Trichomonas vaginalis	AGC family protein kinase	0.0033	0.3162	0.3162
Echinococcus granulosus	protein kinase C gamma type	0.003	0.2869	0.4405
Echinococcus multilocularis	sodium:potassium dependent atpase beta subunit	0.0058	0.6142	0.9431
Schistosoma mansoni	atypical protein kinase C	0.003	0.2869	0.4405
Toxoplasma gondii	protein kinase G AGC kinase family member PKG	0.0007	0.0077	0.0079
Entamoeba histolytica	protein kinase 2, putative	0.0058	0.6219	0.4697
Loa Loa (eye worm)	hypothetical protein	0.003	0.2869	0.2869
Echinococcus granulosus	serine threonine protein kinase nrc	0.0058	0.6219	0.955
Brugia malayi	Protein kinase domain containing protein	0.003	0.2869	0.2869
Echinococcus granulosus	serine:threonine protein kinase N2	0.003	0.2869	0.4405
Brugia malayi	Egg laying defective protein 4	0.0007	0.0077	0.0077
Schistosoma mansoni	serine/threonine protein kinase	0.003	0.2869	0.4405
Schistosoma mansoni	voltage-gated potassium channel	0.0049	0.5062	0.7773
Entamoeba histolytica	protein kinase, putative	0.0088	0.9707	0.9589
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0009	0.0347	0.0533
Echinococcus multilocularis	cGMP dependent protein kinase 1	0.0007	0.0077	0.0118
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0058	0.6219	0.955
Trichomonas vaginalis	AGC family protein kinase	0.009	1	1
Treponema pallidum	catabolite gene activator	0.0006	0	0.5
Echinococcus multilocularis	ribosomal protein S6 kinase alpha 3	0.003	0.2869	0.4405
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.0009	0.0347	0.0533
Echinococcus granulosus	voltage gated potassium channel	0.0013	0.0831	0.1277
Echinococcus multilocularis	protein kinase c epsilon type	0.003	0.2869	0.4405
Plasmodium falciparum	RAC-beta serine/threonine protein kinase	0.0058	0.6219	1
Echinococcus granulosus	protein kinase c iota type	0.003	0.2869	0.4405
Mycobacterium tuberculosis	Probable conserved transmembrane protein	0.0006	0	0.5
Echinococcus multilocularis	hyperpolarization activated cyclic	0.0009	0.0347	0.0533
Echinococcus multilocularis	Ribosomal protein S6 kinase beta 2	0.003	0.2869	0.4405
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0061	0.6512	0.5109
Trichomonas vaginalis	AGC family protein kinase	0.009	1	1
Echinococcus granulosus	serine/threonine protein kinase	0.0061	0.6512	1
Schistosoma mansoni	serine/threonine protein kinase	0.003	0.2869	0.4405
Mycobacterium tuberculosis	Probable transcriptional regulatory protein Cmr	0.0006	0	0.5
Trichomonas vaginalis	AGC family protein kinase	0.009	1	1
Schistosoma mansoni	voltage-gated potassium channel	0.0049	0.5062	0.7773
Echinococcus granulosus	potassium:sodium hyperpolarization activated	0.0009	0.0347	0.0533
Mycobacterium tuberculosis	Probable conserved transmembrane transport protein	0.0006	0	0.5
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0042	0.423	0.423
Echinococcus multilocularis	potassium:sodium hyperpolarization activated	0.0009	0.0347	0.0533
Treponema pallidum	cyclic nucleotide binding protein	0.0006	0	0.5
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0013	0.0831	0.1277
Echinococcus multilocularis	ribosomal protein s6 kinase beta 1	0.003	0.2869	0.4405
Echinococcus multilocularis	Protein kinase C, brain isozyme	0.003	0.2869	0.4405
Schistosoma mansoni	serine/threonine protein kinase	0.003	0.2869	0.4405
Echinococcus granulosus	calcium:calmodulin dependent protein kinase	0.0058	0.6219	0.955
Schistosoma mansoni	serine/threonine-protein kinase	0.0061	0.6512	1
Echinococcus multilocularis	serine:threonine protein kinase 38	0.003	0.2869	0.4405
Schistosoma mansoni	serine/threonine protein kinase	0.0007	0.0077	0.0118
Echinococcus multilocularis	serine:threonine protein kinase N2	0.003	0.2869	0.4405
Leishmania major	protein kinase, putative	0.0007	0.0077	1
Mycobacterium ulcerans	hypothetical protein	0.0006	0	0.5
Onchocerca volvulus		0.0006	0	0.5
Mycobacterium tuberculosis	Conserved protein	0.0006	0	0.5
Echinococcus granulosus	nervana 2	0.0058	0.6142	0.9431
Echinococcus granulosus	cGMP dependent protein kinase 1	0.0007	0.0077	0.0118
Echinococcus multilocularis	Glutaredoxin protein 5	0.0058	0.6142	0.9431
Treponema pallidum	catabolite gene activator (Crp)	0.0006	0	0.5
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0013	0.0831	0.1277
Echinococcus multilocularis	nervana 2	0.0058	0.6142	0.9431
Mycobacterium tuberculosis	Probable glutamine-transport ATP-binding protein ABC transporter GlnQ	0.0006	0	0.5
Entamoeba histolytica	protein kinase, putative	0.009	1	1
Echinococcus granulosus	nervana 2	0.0058	0.6142	0.9431
Trichomonas vaginalis	serine/threonine-protein kinase sgk, putative	0.0029	0.2792	0.2792
Giardia lamblia	Kinase, AGC PKA	0.0058	0.6219	1
Echinococcus granulosus	cGMP dependent protein kinase	0.0007	0.0077	0.0118
Echinococcus granulosus	ribosomal protein S6 kinase alpha 3	0.003	0.2869	0.4405
Echinococcus granulosus	sodium:potassium dependent atpase beta subunit	0.0058	0.6142	0.9431
Echinococcus multilocularis	voltage gated potassium channel	0.0013	0.0831	0.1277
Echinococcus multilocularis	serine threonine protein kinase	0.003	0.2869	0.4405
Echinococcus granulosus	Ribosomal protein S6 kinase beta 2	0.003	0.2869	0.4405
Trypanosoma cruzi	Protein kinase B	0.0061	0.6512	1
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0042	0.423	0.423
Echinococcus granulosus	Protein kinase C brain isozyme	0.003	0.2869	0.4405
Echinococcus granulosus	protein kinase c epsilon type	0.003	0.2869	0.4405
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0061	0.6512	0.5109
Onchocerca volvulus		0.0006	0	0.5
Echinococcus multilocularis	serine threonine protein kinase nrc serine threonine protein kinase gad	0.0058	0.6219	0.955
Echinococcus granulosus	Glutaredoxin protein 5	0.0058	0.6142	0.9431
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0045	0.4577	0.7029
Schistosoma mansoni	voltage-gated potassium channel	0.0009	0.0347	0.0533
Echinococcus multilocularis	cyclic nucleotide gated cation channel	0.0009	0.0347	0.0533
Schistosoma mansoni	serine/threonine protein kinase	0.0007	0.0077	0.0118
Brugia malayi	Cyclic-nucleotide gated cation channel	0.0009	0.0347	0.0347
Echinococcus granulosus	NDR protein kinase	0.003	0.2869	0.4405
Echinococcus granulosus	hyperpolarization activated cyclic	0.0009	0.0347	0.0533
Schistosoma mansoni	voltage-gated potassium channel	0.0007	0.0135	0.0207
Onchocerca volvulus	Rap guanine nucleotide exchange factor 1 homolog	0.0006	0	0.5
Echinococcus multilocularis	protein kinase c iota type	0.003	0.2869	0.4405
Trichomonas vaginalis	AGC family protein kinase	0.003	0.2869	0.2869
Echinococcus multilocularis	cGMP dependent protein kinase 1	0.0007	0.0077	0.0118
Echinococcus granulosus	hyperpolarization activated cyclic	0.0009	0.0347	0.0533
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0009	0.0347	0.0347
Mycobacterium ulcerans	hypothetical protein	0.0006	0	0.5
Echinococcus granulosus	cyclic nucleotide gated cation channel alpha 3	0.0009	0.0347	0.0533
Loa Loa (eye worm)	AGC/PKC/ETA protein kinase	0.003	0.2869	0.2869
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0009	0.0347	0.0347
Mycobacterium ulcerans	regulatory protein	0.0006	0	0.5
Echinococcus granulosus	cGMP dependent protein kinase 1	0.0007	0.0077	0.0118
Plasmodium falciparum	cGMP-dependent protein kinase	0.0007	0.0077	0.0124
Echinococcus granulosus	ribosomal protein s6 kinase beta 1	0.003	0.2869	0.4405
Trichomonas vaginalis	AGC family protein kinase	0.009	1	1
Mycobacterium leprae	Conserved hypothetical protein	0.0006	0	0.5
Loa Loa (eye worm)	AGC/DMPK/GEK protein kinase	0.003	0.2869	0.2869
Mycobacterium ulcerans	transmembrane transport protein	0.0006	0	0.5
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0061	0.6512	1
Entamoeba histolytica	protein kinase, putative	0.009	1	1
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.0009	0.0347	0.0533
Brugia malayi	protein kinase C II.	0.003	0.2869	0.2869
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0045	0.4577	0.4577
Brugia malayi	Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog	0.0013	0.0831	0.0831
Loa Loa (eye worm)	AGC/AKT protein kinase	0.009	1	1
Loa Loa (eye worm)	AGC/PKN protein kinase	0.003	0.2869	0.2869
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0347	0.0347
Echinococcus multilocularis	expressed conserved protein	0.0007	0.0077	0.0118
Trichomonas vaginalis	AGC family protein kinase	0.009	1	1
Schistosoma mansoni	60S ribosomal protein L21	0.0007	0.0135	0.0207
Schistosoma mansoni	serine/threonine protein kinase	0.003	0.2869	0.4405
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0009	0.0347	0.0533
Schistosoma mansoni	serine/threonine protein kinase	0.003	0.2869	0.4405
Echinococcus multilocularis	hyperpolarization activated cyclic	0.0009	0.0347	0.0533
Mycobacterium ulcerans	transcriptional regulatory protein	0.0006	0	0.5
Schistosoma mansoni	serine/threonine kinase	0.003	0.2869	0.4405
Schistosoma mansoni	serine/threonine protein kinase	0.0007	0.0077	0.0118
Loa Loa (eye worm)	cyclic-nucleotide gated cation channel	0.0009	0.0347	0.0347
Leishmania major	protein kinase, putative	0.0007	0.0077	1
Loa Loa (eye worm)	AGC/RSK/MSK protein kinase	0.003	0.2869	0.2869
Mycobacterium ulcerans	hypothetical protein	0.0006	0	0.5
Echinococcus multilocularis	nervana 2	0.0058	0.6142	0.9431
Schistosoma mansoni	serine/threonine-protein kinase	0.0061	0.6512	1
Loa Loa (eye worm)	AGC/PKG protein kinase	0.0007	0.0077	0.0077
Loa Loa (eye worm)	hypothetical protein	0.0039	0.3881	0.3881
Echinococcus multilocularis	rac serine:threonine kinase	0.0061	0.6512	1
Trypanosoma brucei	rac serine-threonine kinase, putative	0.009	1	1
Schistosoma mansoni	voltage-gated potassium channel	0.0013	0.0831	0.1277
Mycobacterium ulcerans	hypothetical protein	0.0006	0	0.5
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0009	0.0347	0.0533
Echinococcus multilocularis	serine:threonine protein kinase N2	0.003	0.2869	0.4405
Echinococcus multilocularis	cyclic nucleotide gated cation channel alpha 3	0.0009	0.0347	0.0533
Plasmodium vivax	rac-beta serine/threonine protein kinase, putative	0.0058	0.6219	1
Brugia malayi	p70 ribosomal S6 kinase beta	0.0088	0.9707	0.9707
Treponema pallidum	cyclic nucleotide binding protein	0.0006	0	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.003	0.2869	0.4405
Loa Loa (eye worm)	AGC/NDR protein kinase	0.003	0.2869	0.2869
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0045	0.4577	0.4577
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0009	0.0347	0.0533
Trichomonas vaginalis	AGC family protein kinase	0.009	1	1

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 2.6 nM	Inhibition of human cloned Akt1 expressed in Drosophila S2 cells by HTRF assay	ChEMBL.	19097777
IC50 (binding)	= 6.7 nM	Inhibition of human cloned Akt2 expressed in Drosophila S2 cells by HTRF assay	ChEMBL.	19097777
IC50 (binding)	= 27 nM	Inhibition of Akt1 by cell based assay	ChEMBL.	19097777
IC50 (binding)	= 167.7 nM	Inhibition of Akt2 by cell based assay	ChEMBL.	19097777
IC50 (binding)	= 5312 nM	Inhibition of human ERG expressed in HEK cells by competitive radioligand binding assay	ChEMBL.	19097777
IC50 (binding)	> 50000 nM	Inhibition of SGK	ChEMBL.	19097777

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL506077

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 913877