Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | polyprenyl synthetase superfamily protein | 0.0788 | 0.2789 | 0.228 |
Echinococcus granulosus | decaprenyl diphosphate synthase subunit 1 | 0.0788 | 0.2789 | 0.228 |
Wolbachia endosymbiont of Brugia malayi | geranylgeranyl pyrophosphate synthase | 0.0788 | 0.2789 | 0.5 |
Mycobacterium tuberculosis | Probable multifunctional geranylgeranyl pyrophosphate synthetase IdsA1 (GGPP synthetase) (ggppsase) (geranylgeranyl diphosphate | 0.0788 | 0.2789 | 0.227 |
Plasmodium falciparum | V-type K+-independent H+-translocating inorganic pyrophosphatase | 0.031 | 0.0917 | 0.0275 |
Trichomonas vaginalis | geranylgeranyl pyrophosphate synthase, putative | 0.263 | 1 | 0.5 |
Plasmodium vivax | vacuolar-type H+ pumping pyrophosphatase, putative | 0.031 | 0.0917 | 0.0275 |
Echinococcus granulosus | farnesyl pyrophosphate synthase | 0.263 | 1 | 1 |
Loa Loa (eye worm) | hexokinase type II | 0.0244 | 0.066 | 0.066 |
Chlamydia trachomatis | geranylgeranyl pyrophosphate synthase | 0.0788 | 0.2789 | 0.5 |
Mycobacterium ulcerans | polyprenyl synthetase IdsB | 0.0788 | 0.2789 | 0.227 |
Trypanosoma brucei | squalene synthase, putative | 0.0793 | 0.281 | 0.2301 |
Brugia malayi | Hexokinase family protein | 0.0153 | 0.0304 | 0.0304 |
Giardia lamblia | Farnesyl diphosphate synthase | 0.263 | 1 | 0.5 |
Trichomonas vaginalis | geranylgeranyl pyrophosphate synthase, putative | 0.263 | 1 | 0.5 |
Trypanosoma cruzi | solanesyl-diphosphate synthase, putative | 0.0788 | 0.2789 | 0.228 |
Trypanosoma brucei | Pyrophosphate-energized vacuolar membrane proton pump 1 | 0.031 | 0.0917 | 0.0275 |
Trypanosoma brucei | solanesyl-diphosphate synthase, putative | 0.0788 | 0.2789 | 0.228 |
Loa Loa (eye worm) | hypothetical protein | 0.0167 | 0.0356 | 0.0356 |
Entamoeba histolytica | geranylgeranyl pyrophosphate synthetase, putative | 0.0788 | 0.2789 | 1 |
Mycobacterium ulcerans | geranylgeranyl pyrophosphate synthase | 0.263 | 1 | 1 |
Leishmania major | vacuolar-type proton translocating pyrophosphatase 1, putative | 0.031 | 0.0917 | 0.0275 |
Onchocerca volvulus | 0.0244 | 0.066 | 0.9681 | |
Loa Loa (eye worm) | hypothetical protein | 0.0247 | 0.0672 | 0.0672 |
Trypanosoma cruzi | farnesyl pyrophosphate synthase | 0.263 | 1 | 1 |
Trypanosoma cruzi | polyprenyl synthase, putative | 0.13 | 0.4795 | 0.4427 |
Mycobacterium tuberculosis | Probable geranylgeranyl pyrophosphate synthetase IdsA2 (ggppsase) (GGPP synthetase) (geranylgeranyl diphosphate synthase) | 0.263 | 1 | 1 |
Mycobacterium ulcerans | geranylgeranyl pyrophosphate synthase | 0.263 | 1 | 1 |
Plasmodium vivax | V-type H(+)-translocating pyrophosphatase, putative | 0.031 | 0.0917 | 0.0275 |
Echinococcus multilocularis | decaprenyl diphosphate synthase subunit 1 | 0.0788 | 0.2789 | 0.228 |
Echinococcus granulosus | prenyl decaprenyl diphosphate synthase | 0.0788 | 0.2789 | 0.228 |
Leishmania major | polyprenyl synthase, putative | 0.13 | 0.4795 | 0.4427 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.0008 | 0.0008 |
Loa Loa (eye worm) | geranylgeranyl pyrophosphate synthetase | 0.13 | 0.4795 | 0.4795 |
Schistosoma mansoni | trans-prenyltransferase | 0.0788 | 0.2789 | 0.228 |
Onchocerca volvulus | 0.0244 | 0.066 | 0.9681 | |
Mycobacterium ulcerans | polyprenyl diphosphate synthetase, GrcC1 | 0.0788 | 0.2789 | 0.227 |
Brugia malayi | Polyprenyl synthetase family protein | 0.0788 | 0.2789 | 0.2789 |
Plasmodium vivax | octaprenyl pyrophosphate synthase, putative | 0.0788 | 0.2789 | 0.228 |
Leishmania major | squalene synthase, putative | 0.0793 | 0.281 | 0.2301 |
Trypanosoma cruzi | phytoene synthase, putative | 0.0247 | 0.0672 | 0.0013 |
Schistosoma mansoni | geranylgeranyl pyrophosphate synthase | 0.13 | 0.4795 | 0.4427 |
Brugia malayi | Hexokinase family protein | 0.0244 | 0.066 | 0.066 |
Plasmodium falciparum | octaprenyl pyrophosphate synthase | 0.0788 | 0.2789 | 0.228 |
Onchocerca volvulus | NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 homolog | 0.0247 | 0.0672 | 1 |
Entamoeba histolytica | geranylgeranyl pyrophosphate synthase, putative | 0.0788 | 0.2789 | 1 |
Treponema pallidum | octaprenyl-diphosphate synthase | 0.13 | 0.4795 | 1 |
Mycobacterium tuberculosis | Probable polyprenyl-diphosphate synthase GrcC2 (polyprenyl pyrophosphate synthetase) | 0.0788 | 0.2789 | 0.227 |
Entamoeba histolytica | bifunctional short chain isoprenyl diphosphate synthase, putative | 0.0788 | 0.2789 | 1 |
Echinococcus granulosus | Squalene phytoene synthase | 0.0247 | 0.0672 | 0.0013 |
Echinococcus multilocularis | farnesyl pyrophosphate synthase | 0.263 | 1 | 1 |
Schistosoma mansoni | glutathione synthetase | 0.0788 | 0.2789 | 0.228 |
Trypanosoma cruzi | squalene synthase, putative | 0.0793 | 0.281 | 0.2301 |
Trypanosoma cruzi | farnesyl pyrophosphate synthase, putative | 0.263 | 1 | 1 |
Schistosoma mansoni | farnesyl pyrophosphate synthase | 0.263 | 1 | 1 |
Plasmodium vivax | geranylgeranyl pyrophosphate synthase | 0.263 | 1 | 1 |
Toxoplasma gondii | polyprenyl synthetase superfamily protein | 0.263 | 1 | 1 |
Leishmania major | farnesyl pyrophosphate synthase | 0.263 | 1 | 1 |
Trypanosoma cruzi | solanesyl-diphosphate synthase | 0.0788 | 0.2789 | 0.228 |
Echinococcus multilocularis | Squalene phytoene synthase | 0.0247 | 0.0672 | 0.0013 |
Trypanosoma cruzi | polyprenyl synthase, putative | 0.13 | 0.4795 | 0.4427 |
Loa Loa (eye worm) | polyprenyl synthetase | 0.0788 | 0.2789 | 0.2789 |
Onchocerca volvulus | 0.0244 | 0.066 | 0.9681 | |
Leishmania major | hypothetical protein, conserved | 0.0247 | 0.0672 | 0.0013 |
Loa Loa (eye worm) | hexokinase | 0.0153 | 0.0304 | 0.0304 |
Plasmodium falciparum | V-type H(+)-translocating pyrophosphatase, putative | 0.031 | 0.0917 | 0.0275 |
Mycobacterium leprae | PROBABLE POLYPRENYL-DIPHOSPHATE SYNTHASE GRCC1 (POLYPRENYL PYROPHOSPHATE SYNTHETASE) | 0.0788 | 0.2789 | 0.5 |
Trichomonas vaginalis | geranylgeranyl diphosphate synthase, putative | 0.263 | 1 | 0.5 |
Echinococcus multilocularis | prenyl (decaprenyl) diphosphate synthase | 0.0788 | 0.2789 | 0.228 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.0008 | 0.0008 |
Wolbachia endosymbiont of Brugia malayi | geranylgeranyl pyrophosphate synthase | 0.0788 | 0.2789 | 0.5 |
Loa Loa (eye worm) | hexokinase | 0.0244 | 0.066 | 0.066 |
Plasmodium falciparum | geranylgeranyl pyrophosphate synthase, putative | 0.263 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0247 | 0.0672 | 0.0013 |
Loa Loa (eye worm) | hexokinase | 0.0244 | 0.066 | 0.066 |
Mycobacterium tuberculosis | Possible polyprenyl synthetase IdsB (polyprenyl transferase) (polyprenyl diphosphate synthase) | 0.0788 | 0.2789 | 0.227 |
Leishmania major | solanesyl-diphosphate synthase, putative | 0.0788 | 0.2789 | 0.228 |
Trypanosoma cruzi | solanesyl-diphosphate synthase, putative | 0.0788 | 0.2789 | 0.228 |
Echinococcus multilocularis | geranylgeranyl pyrophosphate synthase | 0.13 | 0.4795 | 0.4427 |
Brugia malayi | geranylgeranyl pyrophosphate synthetase | 0.13 | 0.4795 | 0.4795 |
Trypanosoma brucei | farnesyl pyrophosphate synthase | 0.263 | 1 | 1 |
Trypanosoma cruzi | vacuolar-type proton translocating pyrophosphatase 1 | 0.031 | 0.0917 | 0.0275 |
Loa Loa (eye worm) | polyprenyl synthetase | 0.263 | 1 | 1 |
Trypanosoma brucei | Pyrophosphate-energized vacuolar membrane proton pump 2, putative | 0.031 | 0.0917 | 0.0275 |
Toxoplasma gondii | V-type H(+)-translocating pyrophosphatase VP1 | 0.031 | 0.0917 | 0.0275 |
Brugia malayi | hexokinase | 0.0244 | 0.066 | 0.066 |
Brugia malayi | hexokinase type II | 0.0078 | 0.0008 | 0.0008 |
Trypanosoma cruzi | Vacuolar proton pyrophosphatase 1, putative | 0.031 | 0.0917 | 0.0275 |
Echinococcus granulosus | geranylgeranyl pyrophosphate synthase | 0.13 | 0.4795 | 0.4427 |
Trypanosoma cruzi | squalene synthase, putative | 0.0793 | 0.281 | 0.2301 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Delta latency time (functional) | = 78.2 s | Change in the latency time on day 1 to that of day 2 | ChEMBL. | 10821709 |
Delta latency time (functional) | = 78.2 s | Change in the latency time on day 1 to that of day 2 | ChEMBL. | 10821709 |
Dose (functional) | = 10 mg kg-1 | Minimal effective i.p. dose to reverse Scopolamine induced amnesia in mouse passive-avoidance test. | ChEMBL. | 10821709 |
Dose (functional) | = 10 mg kg-1 | Minimal effective i.p. dose to reverse Scopolamine induced amnesia in mouse passive-avoidance test. | ChEMBL. | 10821709 |
Latency time (functional) | = 18 s | Latency time on 1st day of mouse passive-avoidance test. | ChEMBL. | 10821709 |
Latency time (functional) | = 18 s | Latency time on 1st day of mouse passive-avoidance test. | ChEMBL. | 10821709 |
Latency time (functional) | = 96.2 s | Latency time on 2nd (post-treatment) day of mouse passive-avoidance test. | ChEMBL. | 10821709 |
Latency time (functional) | = 96.2 s | Latency time on 2nd (post-treatment) day of mouse passive-avoidance test. | ChEMBL. | 10821709 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.