Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0036 | 0.004 | 0.0168 |
Schistosoma mansoni | multidrug resistance protein | 0.0089 | 0.0669 | 0.2011 |
Echinococcus multilocularis | suppression of tumorigenicity 18 protein | 0.0055 | 0.0264 | 0.0222 |
Leishmania major | p-glycoprotein e | 0.0089 | 0.0669 | 1 |
Schistosoma mansoni | inositol monophosphatase | 0.0037 | 0.0046 | 0.0009 |
Entamoeba histolytica | ATP-binding cassette protein, putative | 0.0089 | 0.0669 | 0.7557 |
Loa Loa (eye worm) | inward rectifying k channel family protein 1 | 0.0271 | 0.2848 | 1 |
Giardia lamblia | Multidrug resistance-associated protein 1 | 0.0089 | 0.0669 | 1 |
Echinococcus multilocularis | transient receptor potential gamma protein | 0.0098 | 0.0779 | 0.074 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.0264 | 0.091 |
Brugia malayi | C2-HC type zinc finger protein C.e-MyT1 | 0.0055 | 0.0264 | 0.2668 |
Loa Loa (eye worm) | hypothetical protein | 0.0271 | 0.2848 | 1 |
Echinococcus granulosus | multidrug resistance associated protein 1 | 0.0089 | 0.0669 | 0.3326 |
Entamoeba histolytica | multidrug resistance protein, putative | 0.0089 | 0.0669 | 0.7557 |
Onchocerca volvulus | 0.0048 | 0.0186 | 1 | |
Entamoeba histolytica | ABC transporter, putative | 0.0089 | 0.0669 | 0.7557 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0043 | 0.0133 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0048 | 0.0186 | 0.078 |
Echinococcus multilocularis | endonuclease exonuclease phosphatase | 0.0194 | 0.1925 | 0.189 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0048 | 0.0186 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.016 | 0.0377 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0037 | 0.0046 | 0.0269 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0107 | 0.089 | 0.2721 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0034 | 0.0016 | 0.0069 |
Schistosoma mansoni | inositol monophosphatase | 0.0037 | 0.0046 | 0.0009 |
Entamoeba histolytica | ATP-binding cassette protein, putative | 0.0089 | 0.0669 | 0.7557 |
Loa Loa (eye worm) | hypothetical protein | 0.0271 | 0.2848 | 1 |
Echinococcus granulosus | endonuclease exonuclease phosphatase | 0.0194 | 0.1925 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0271 | 0.2848 | 1 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0037 | 0.0046 | 0.5 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0048 | 0.0186 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0034 | 0.0016 | 0.0069 |
Mycobacterium ulcerans | hypothetical protein | 0.0036 | 0.0043 | 0.0205 |
Mycobacterium leprae | conserved hypothetical protein | 0.0036 | 0.0043 | 0.231 |
Brugia malayi | Transient-receptor-potential like protein | 0.0036 | 0.0044 | 0.0014 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0048 | 0.0184 | 0.0453 |
Brugia malayi | AMP-binding enzyme family protein | 0.0048 | 0.0186 | 0.1728 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0043 | 0.0133 |
Schistosoma mansoni | transient receptor potential channel | 0.0098 | 0.0779 | 0.2367 |
Leishmania major | ABC-thiol transporter | 0.0089 | 0.0669 | 1 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0037 | 0.0046 | 0.001 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0037 | 0.0046 | 0.0046 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0036 | 0.004 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.004 | 0.0123 |
Brugia malayi | mbt repeat family protein | 0.0048 | 0.0184 | 0.1705 |
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 0.0779 | 0.2724 |
Echinococcus granulosus | geminin | 0.0171 | 0.1653 | 0.8554 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.016 | 0.0377 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0036 | 0.0043 | 0.0205 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0037 | 0.0046 | 0.0269 |
Entamoeba histolytica | Niemann-Pick C1 protein, putative | 0.0106 | 0.087 | 1 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0037 | 0.0046 | 0.0046 |
Loa Loa (eye worm) | MBCTL1 | 0.0055 | 0.0264 | 0.091 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0106 | 0.087 | 0.0831 |
Schistosoma mansoni | transient receptor potential channel | 0.0065 | 0.0383 | 0.1093 |
Trypanosoma brucei | multidrug resistance-associated protein, putative | 0.0089 | 0.0669 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.016 | 0.0118 |
Loa Loa (eye worm) | inositol-1 | 0.0037 | 0.0046 | 0.0143 |
Schistosoma mansoni | hypothetical protein | 0.0297 | 0.3155 | 1 |
Leishmania major | ATP-binding cassette protein subfamily C, member 5, putative | 0.0089 | 0.0669 | 1 |
Echinococcus granulosus | expressed conserved protein | 0.0099 | 0.0794 | 0.399 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0045 | 0.015 | 0.0569 |
Echinococcus granulosus | multidrug resistance associated protein 7 | 0.0089 | 0.0669 | 0.3326 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0106 | 0.087 | 0.4397 |
Schistosoma mansoni | multidrug resistance protein | 0.0089 | 0.0669 | 0.2011 |
Loa Loa (eye worm) | hypothetical protein | 0.0089 | 0.0669 | 0.2335 |
Giardia lamblia | MRP-like ABC transporter | 0.0089 | 0.0669 | 1 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0036 | 0.004 | 0.5 |
Loa Loa (eye worm) | ABC transporter transmembrane region family protein | 0.0089 | 0.0669 | 0.2335 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0037 | 0.0046 | 0.0003 |
Loa Loa (eye worm) | hypothetical protein | 0.0106 | 0.087 | 0.3043 |
Brugia malayi | ABC transporter transmembrane region family protein | 0.0089 | 0.0669 | 0.7565 |
Echinococcus multilocularis | expressed conserved protein | 0.0099 | 0.0794 | 0.0754 |
Trypanosoma cruzi | multidrug resistance-associated protein, putative | 0.0089 | 0.0669 | 1 |
Giardia lamblia | Multidrug resistance-associated protein 1 | 0.0089 | 0.0669 | 1 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0048 | 0.0186 | 0.1699 |
Loa Loa (eye worm) | hypothetical protein | 0.0089 | 0.0669 | 0.2335 |
Giardia lamblia | ABC transporter, putative | 0.0089 | 0.0669 | 1 |
Brugia malayi | multidrug resistance related protein 1 | 0.0089 | 0.0669 | 0.7565 |
Toxoplasma gondii | hypothetical protein | 0.0271 | 0.2848 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.016 | 0.0624 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0048 | 0.0186 | 1 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0036 | 0.0043 | 0.018 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0045 | 0.015 | 0.051 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.0037 | 0.0046 | 0.0402 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0186 | 0.0636 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0048 | 0.0186 | 0.2284 |
Entamoeba histolytica | ATP-binding cassette protein, putative | 0.0089 | 0.0669 | 0.7557 |
Brugia malayi | AMP-binding enzyme family protein | 0.0048 | 0.0186 | 0.1728 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0037 | 0.0046 | 0.0015 |
Trypanosoma cruzi | multidrug resistance-associated protein, putative | 0.0089 | 0.0669 | 1 |
Echinococcus multilocularis | short transient receptor potential channel 6 | 0.0065 | 0.0383 | 0.0342 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0043 | 0.0133 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.016 | 0.0118 |
Toxoplasma gondii | ABC transporter transmembrane region domain-containing protein | 0.0089 | 0.0669 | 0.2231 |
Echinococcus granulosus | short transient receptor potential channel 6 | 0.0065 | 0.0383 | 0.1807 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0043 | 0.0133 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.004 | 0.0123 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0048 | 0.0186 | 0.1699 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0048 | 0.0186 | 1 |
Echinococcus multilocularis | histone acetyltransferase MYST2 | 0.0055 | 0.0264 | 0.0222 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0036 | 0.0043 | 0.018 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0048 | 0.0186 | 1 |
Echinococcus multilocularis | transient receptor potential ion channel A | 0.0095 | 0.074 | 0.07 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0046 | 0.016 | 0.142 |
Echinococcus granulosus | polycomb protein SCMH1 | 0.0048 | 0.0184 | 0.075 |
Loa Loa (eye worm) | hypothetical protein | 0.0088 | 0.066 | 0.2305 |
Echinococcus multilocularis | short transient receptor potential channel 6 | 0.0065 | 0.0383 | 0.0342 |
Echinococcus granulosus | Protein patched homolog 1 | 0.0045 | 0.015 | 0.0569 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0043 | 0.0133 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0186 | 0.0636 |
Echinococcus multilocularis | protein dispatched 1 | 0.0052 | 0.0227 | 0.0184 |
Trypanosoma cruzi | multidrug resistance protein E, putative | 0.0089 | 0.0669 | 1 |
Brugia malayi | Inositol-1 | 0.0037 | 0.0046 | 0.0035 |
Echinococcus multilocularis | TRP (transient receptor potential) channel | 0.0036 | 0.0044 | 0.0001 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0048 | 0.0186 | 1 |
Leishmania major | ATP-binding cassette protein subfamily C, member 6, putative | 0.0089 | 0.0669 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.016 | 0.0624 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0151 | 0.1412 | 0.1375 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.004 | 0.0123 |
Echinococcus granulosus | transient receptor potential ion channel A | 0.0095 | 0.074 | 0.3707 |
Mycobacterium ulcerans | lipase LipD | 0.0036 | 0.0043 | 0.0205 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0044 | 0.0137 |
Onchocerca volvulus | 0.0048 | 0.0184 | 0.987 | |
Trypanosoma brucei | multidrug resistance-associated protein, putative | 0.0089 | 0.0669 | 1 |
Schistosoma mansoni | patched 1 | 0.0045 | 0.015 | 0.0344 |
Echinococcus multilocularis | multidrug resistance associated protein 4 | 0.0068 | 0.0423 | 0.0381 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0036 | 0.0043 | 0.018 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.016 | 0.0377 |
Echinococcus multilocularis | polycomb protein SCMH1 | 0.0048 | 0.0184 | 0.0142 |
Schistosoma mansoni | hypothetical protein | 0.0044 | 0.0131 | 0.0281 |
Entamoeba histolytica | ATP-binding cassette protein, putative | 0.0089 | 0.0669 | 0.7557 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0272 | 0.0939 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0036 | 0.0043 | 0.0133 |
Loa Loa (eye worm) | multidrug resistance-associated protein | 0.0069 | 0.0431 | 0.1499 |
Trypanosoma brucei | multidrug resistance protein E | 0.0089 | 0.0669 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0036 | 0.0043 | 1 |
Leishmania major | ATP-binding cassette protein subfamily C, member 2, putative | 0.0089 | 0.0669 | 1 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0048 | 0.0186 | 0.2284 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0232 | 0.2383 | 1 |
Brugia malayi | Niemann-Pick C1 protein precursor | 0.0106 | 0.087 | 1 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0048 | 0.0186 | 0.078 |
Mycobacterium ulcerans | beta-lactamase | 0.0036 | 0.0043 | 0.0205 |
Leishmania major | ATP-binding cassette protein subfamily C, member 1, putative | 0.0089 | 0.0669 | 1 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0036 | 0.0043 | 0.018 |
Echinococcus multilocularis | protein patched | 0.0045 | 0.015 | 0.0108 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0037 | 0.0046 | 0.0046 |
Schistosoma mansoni | scm-relatedprotein containing 4 mbt domains (sfmbt) | 0.0048 | 0.0184 | 0.0453 |
Schistosoma mansoni | hypothetical protein | 0.0044 | 0.0131 | 0.0281 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0186 | 0.0636 |
Echinococcus granulosus | short transient receptor potential channel 6 | 0.0065 | 0.0383 | 0.1807 |
Echinococcus multilocularis | multidrug resistance associated protein 7 | 0.0089 | 0.0669 | 0.0629 |
Echinococcus granulosus | multidrug resistance associated protein 4 | 0.0068 | 0.0423 | 0.2018 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.004 | 0.0123 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.015 | 0.051 |
Loa Loa (eye worm) | mbt repeat family protein | 0.0048 | 0.0184 | 0.063 |
Schistosoma mansoni | multidrug resistance protein | 0.0089 | 0.0669 | 0.2011 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0048 | 0.0186 | 0.2284 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0045 | 0.015 | 0.0108 |
Schistosoma mansoni | hypothetical protein | 0.0044 | 0.0131 | 0.0281 |
Schistosoma mansoni | transient receptor potential channel 4 | 0.0098 | 0.0779 | 0.2367 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0037 | 0.0046 | 0.0269 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0045 | 0.015 | 1 |
Schistosoma mansoni | transient receptor potential channel | 0.0065 | 0.0383 | 0.1093 |
Trypanosoma brucei | p-glycoprotein | 0.0089 | 0.0669 | 1 |
Echinococcus granulosus | suppression of tumorigenicity 18 protein | 0.0055 | 0.0264 | 0.1173 |
Loa Loa (eye worm) | beta-lactamase | 0.0036 | 0.0043 | 0.0133 |
Mycobacterium leprae | Probable lipase LipE | 0.0036 | 0.0043 | 0.231 |
Mycobacterium ulcerans | hypothetical protein | 0.0048 | 0.0186 | 1 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0048 | 0.0184 | 0.0453 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0037 | 0.0046 | 0.0046 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0046 | 0.016 | 0.0546 |
Echinococcus multilocularis | geminin | 0.0171 | 0.1653 | 0.1617 |
Onchocerca volvulus | Polycomb protein Sfmbt homolog | 0.0048 | 0.0184 | 0.987 |
Schistosoma mansoni | hypothetical protein | 0.0171 | 0.1653 | 0.5172 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0048 | 0.0186 | 1 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0036 | 0.0043 | 0.018 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.004 | 0.0123 |
Brugia malayi | AMP-binding enzyme family protein | 0.0048 | 0.0186 | 0.1728 |
Schistosoma mansoni | multidrug resistance protein | 0.0089 | 0.0669 | 0.2011 |
Mycobacterium tuberculosis | Conserved protein | 0.0036 | 0.0043 | 0.018 |
Echinococcus granulosus | histone acetyltransferase MYST2 | 0.0055 | 0.0264 | 0.1173 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0048 | 0.0186 | 1 |
Schistosoma mansoni | myelin transcription factor 1 myt1 | 0.0055 | 0.0264 | 0.0709 |
Schistosoma mansoni | hypothetical protein | 0.0171 | 0.1653 | 0.5172 |
Echinococcus granulosus | SAM and MBT domain containing protein | 0.0048 | 0.0184 | 0.075 |
Mycobacterium tuberculosis | Conserved protein | 0.0036 | 0.0043 | 0.018 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0344 | 0.1192 |
Echinococcus granulosus | TRP transient receptor potential channel | 0.0036 | 0.0044 | 0.0006 |
Leishmania major | pentamidine resistance protein 1 | 0.0089 | 0.0669 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0034 | 0.0016 | 0.0069 |
Entamoeba histolytica | hypothetical protein | 0.0089 | 0.0669 | 0.7557 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0048 | 0.0186 | 1 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0048 | 0.0186 | 0.1699 |
Brugia malayi | mbt repeat family protein | 0.0048 | 0.0184 | 0.1705 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0184 | 0.063 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0151 | 0.1412 | 0.7274 |
Echinococcus granulosus | transient receptor potential gamma protein | 0.0098 | 0.0779 | 0.3914 |
Trypanosoma cruzi | hypothetical protein | 0.0068 | 0.0423 | 0.6068 |
Echinococcus multilocularis | multidrug resistance associated protein 1 | 0.0089 | 0.0669 | 0.0629 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0036 | 0.0043 | 0.018 |
Mycobacterium tuberculosis | Conserved protein | 0.0036 | 0.0043 | 0.018 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0036 | 0.0043 | 0.0205 |
Schistosoma mansoni | hypothetical protein | 0.0044 | 0.0131 | 0.0281 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0034 | 0.0016 | 0.0069 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0043 | 0.0133 |
Echinococcus multilocularis | SAM and MBT domain containing protein | 0.0048 | 0.0184 | 0.0142 |
Brugia malayi | CHE-14 protein | 0.0045 | 0.015 | 0.1295 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0036 | 0.0043 | 0.018 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.