Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ROS proto-oncogene 1, receptor tyrosine kinase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus multilocularis | tyrosine protein kinase | Get druggable targets OG5_135644 | All targets in OG5_135644 |
Echinococcus granulosus | tyrosine protein kinase | Get druggable targets OG5_135644 | All targets in OG5_135644 |
Loa Loa (eye worm) | TK protein kinase | Get druggable targets OG5_135644 | All targets in OG5_135644 |
Brugia malayi | Protein kinase domain containing protein | Get druggable targets OG5_135644 | All targets in OG5_135644 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_135644 | All targets in OG5_135644 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | hypothetical protein | 0.0035 | 0.0967 | 0.5 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0047 | 0.1386 | 0.1015 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0035 | 0.0967 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0035 | 0.0967 | 1 |
Schistosoma mansoni | blooms syndrome DNA helicase | 0.0009 | 0.0067 | 0.0486 |
Brugia malayi | beta-lactamase | 0.0035 | 0.0967 | 0.0578 |
Plasmodium falciparum | ATP-dependent DNA helicase Q1 | 0.0019 | 0.0413 | 0.5 |
Mycobacterium ulcerans | beta-lactamase | 0.0035 | 0.0967 | 0.5 |
Plasmodium vivax | ADP-dependent DNA helicase RecQ, putative | 0.001 | 0.008 | 0.0146 |
Echinococcus multilocularis | ATP dependent DNA helicase Q1 | 0.0019 | 0.0413 | 0.0413 |
Leishmania major | hypothetical protein, conserved | 0.0035 | 0.0967 | 1 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0035 | 0.0967 | 0.5 |
Brugia malayi | hypothetical protein | 0.0228 | 0.7831 | 0.7738 |
Echinococcus multilocularis | ATP dependent DNA helicase Q5 | 0.0019 | 0.0413 | 0.0413 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0035 | 0.0967 | 1 |
Trypanosoma cruzi | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0019 | 0.0413 | 0.3751 |
Loa Loa (eye worm) | ATP-dependent DNA helicase | 0.0019 | 0.0413 | 0.0335 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0035 | 0.0967 | 1 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0222 | 0.7611 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0967 | 0.0894 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0035 | 0.0967 | 1 |
Loa Loa (eye worm) | RecQ helicase | 0.0019 | 0.0413 | 0.0335 |
Loa Loa (eye worm) | hypothetical protein | 0.0288 | 0.994 | 0.9939 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0228 | 0.7831 | 0.7831 |
Echinococcus multilocularis | bloom syndrome protein | 0.0019 | 0.0413 | 0.0413 |
Echinococcus granulosus | tyrosine protein kinase | 0.029 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.008 | 0.00000000028208 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0035 | 0.0967 | 0.0967 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.001 | 0.008 | 0.0146 |
Echinococcus granulosus | bloom syndrome protein | 0.0019 | 0.0413 | 0.0413 |
Loa Loa (eye worm) | beta-lactamase | 0.0035 | 0.0967 | 0.0894 |
Echinococcus multilocularis | tyrosine protein kinase | 0.029 | 1 | 1 |
Mycobacterium ulcerans | lipase LipD | 0.0035 | 0.0967 | 0.5 |
Mycobacterium leprae | conserved hypothetical protein | 0.0035 | 0.0967 | 0.5 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0228 | 0.7831 | 0.7831 |
Brugia malayi | beta-lactamase family protein | 0.0035 | 0.0967 | 0.0578 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0035 | 0.0967 | 0.0967 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0035 | 0.0967 | 0.0578 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0413 | 0.0335 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0035 | 0.0967 | 0.6979 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0019 | 0.0413 | 0.3843 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0967 | 0.0894 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.1386 | 1 |
Toxoplasma gondii | ABC1 family protein | 0.0035 | 0.0967 | 1 |
Echinococcus granulosus | ATP dependent DNA helicase Q1 | 0.0019 | 0.0413 | 0.0413 |
Schistosoma mansoni | blooms syndrome DNA helicase | 0.001 | 0.008 | 0.0581 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0967 | 0.0894 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0035 | 0.0967 | 0.5 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0035 | 0.0967 | 0.0894 |
Giardia lamblia | Sgs1 DNA helicase, putative | 0.0019 | 0.0413 | 0.5 |
Schistosoma mansoni | survival motor neuron protein | 0.0047 | 0.1386 | 1 |
Schistosoma mansoni | DNA helicase recq1 | 0.0019 | 0.0413 | 0.2981 |
Mycobacterium leprae | Probable lipase LipE | 0.0035 | 0.0967 | 0.5 |
Plasmodium falciparum | ADP-dependent DNA helicase RecQ | 0.0019 | 0.0413 | 0.5 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0019 | 0.0413 | 0.3843 |
Loa Loa (eye worm) | hypothetical protein | 0.0228 | 0.7831 | 0.7814 |
Brugia malayi | beta-lactamase family protein | 0.0035 | 0.0967 | 0.0578 |
Loa Loa (eye worm) | TK protein kinase | 0.029 | 1 | 1 |
Schistosoma mansoni | DNA helicase recq5 | 0.0019 | 0.0413 | 0.2981 |
Trichomonas vaginalis | esterase, putative | 0.0035 | 0.0967 | 1 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0035 | 0.0967 | 0.6979 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0967 | 0.0894 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0967 | 0.0894 |
Plasmodium vivax | hypothetical protein, conserved | 0.0035 | 0.0967 | 1 |
Treponema pallidum | ATP-dependent DNA helicase | 0.001 | 0.008 | 0.5 |
Entamoeba histolytica | recQ family helicase, putative | 0.0019 | 0.0413 | 1 |
Echinococcus granulosus | ATP dependent DNA helicase Q5 | 0.0019 | 0.0413 | 0.0413 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0035 | 0.0967 | 1 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0035 | 0.0967 | 1 |
Onchocerca volvulus | 0.0047 | 0.1386 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0967 | 0.0894 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0035 | 0.0967 | 1 |
Entamoeba histolytica | recQ family DNA helicase | 0.001 | 0.008 | 0.0381 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 59.1 nM | Inhibition of ROS1 (unknown origin) assessed as remaining activity | ChEMBL. | 24997577 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.