Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0069 | 0.3181 | 0.3181 |
Brugia malayi | FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 | 0.0104 | 0.5797 | 0.5788 |
Trichomonas vaginalis | immunophilin, putative | 0.0104 | 0.5797 | 0.5788 |
Schistosoma mansoni | chromobox protein-related (chromobox 1) (heterochromatin 1) | 0.0026 | 0.0022 | 0.0022 |
Echinococcus multilocularis | Chromobox protein 3 | 0.0026 | 0.0022 | 0.0022 |
Giardia lamblia | 70 kDa peptidylprolyl isomerase, putative | 0.0104 | 0.5797 | 0.5 |
Toxoplasma gondii | 'chromo' (CHRromatin Organization MOdifier) domain-containing protein | 0.0026 | 0.0022 | 0.5 |
Brugia malayi | FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 | 0.0104 | 0.5797 | 0.5788 |
Echinococcus granulosus | chromodomain helicase DNA binding protein 4 | 0.0029 | 0.0186 | 0.0186 |
Echinococcus multilocularis | peptidyl prolyl cis trans isomerase FKBP4 | 0.0104 | 0.5797 | 0.5797 |
Trichomonas vaginalis | chromobox protein, putative | 0.0161 | 1 | 1 |
Echinococcus multilocularis | chromodomain helicase DNA binding protein 4 | 0.0029 | 0.0186 | 0.0186 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP4 | 0.0104 | 0.5797 | 0.5797 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0069 | 0.3181 | 0.3181 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase, putative | 0.0104 | 0.5797 | 0.5 |
Echinococcus multilocularis | chromobox protein 1 | 0.0161 | 1 | 1 |
Trichomonas vaginalis | fk506-binding protein, putative | 0.0104 | 0.5797 | 0.5788 |
Trichomonas vaginalis | peptidylprolyl isomerase, putative | 0.0104 | 0.5797 | 0.5788 |
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, FKBP-type , putative | 0.0104 | 0.5797 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.1558 | 0.1539 |
Echinococcus multilocularis | peptidyl prolyl cis trans isomerase FKBP4 | 0.009 | 0.4734 | 0.4734 |
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, FKBP-type, putative | 0.0104 | 0.5797 | 1 |
Brugia malayi | chromobox protein homolog 3 | 0.009 | 0.4757 | 0.4746 |
Trichomonas vaginalis | chromobox protein, putative | 0.0097 | 0.5265 | 0.5254 |
Echinococcus granulosus | Chromo domain | 0.0026 | 0.0022 | 0.0022 |
Schistosoma mansoni | chromobox protein | 0.0161 | 1 | 1 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP4 | 0.009 | 0.4734 | 0.4734 |
Schistosoma mansoni | chromodomain helicase DNA binding protein | 0.0029 | 0.0186 | 0.0186 |
Schistosoma mansoni | immunophilin | 0.009 | 0.4734 | 0.4734 |
Schistosoma mansoni | immunophilin | 0.0104 | 0.5797 | 0.5797 |
Leishmania major | fk506-binding protein 1-like protein | 0.0104 | 0.5797 | 0.5 |
Loa Loa (eye worm) | CHromoDomain protein family member | 0.0029 | 0.0186 | 0.0164 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0097 | 0.5265 | 1 |
Brugia malayi | Bromodomain containing protein | 0.0044 | 0.1349 | 0.1329 |
Trichomonas vaginalis | conserved hypothetical protein | 0.009 | 0.4757 | 0.4746 |
Schistosoma mansoni | immunophilin | 0.0104 | 0.5797 | 0.5797 |
Plasmodium falciparum | peptidyl-prolyl cis-trans isomerase FKBP35 | 0.0104 | 0.5797 | 1 |
Trichomonas vaginalis | chromobox protein, putative | 0.0161 | 1 | 1 |
Echinococcus granulosus | chromobox protein 1 | 0.0161 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.4125 | 0.4112 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.1721 | 0.1703 |
Loa Loa (eye worm) | FKBP-type peptidyl-prolyl cis-trans isomerase-12 | 0.0104 | 0.5797 | 0.5788 |
Schistosoma mansoni | chromodomain helicase DNA binding protein | 0.0026 | 0.0022 | 0.0022 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0026 | 0.0022 | 0.0022 |
Schistosoma mansoni | bromodomain containing protein | 0.0073 | 0.3488 | 0.3488 |
Schistosoma mansoni | immunophilin FK506 binding protein FKBP12 | 0.0104 | 0.5797 | 0.5797 |
Echinococcus multilocularis | chromodomain helicase DNA binding protein 1 | 0.0026 | 0.0022 | 0.0022 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.009 | 0.4757 | 0.9031 |
Treponema pallidum | peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) | 0.0104 | 0.5797 | 0.5 |
Brugia malayi | CHD4 protein | 0.0029 | 0.0186 | 0.0164 |
Schistosoma mansoni | chromobox protein-related (chromobox 1) (heterochromatin 1) | 0.0026 | 0.0022 | 0.0022 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0041 | 0.1146 | 0.1146 |
Echinococcus granulosus | chromodomain helicase DNA binding protein 1 | 0.0026 | 0.0022 | 0.0022 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.3313 | 0.3297 |
Trichomonas vaginalis | conserved hypothetical protein | 0.009 | 0.4757 | 0.4746 |
Trypanosoma cruzi | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.0104 | 0.5797 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.009 | 0.4734 | 0.4722 |
Brugia malayi | Bromodomain containing protein | 0.0087 | 0.4491 | 0.4479 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase, putative | 0.0104 | 0.5797 | 0.5 |
Brugia malayi | PHD-finger family protein | 0.0029 | 0.0203 | 0.0181 |
Schistosoma mansoni | chromobox protein | 0.0161 | 1 | 1 |
Loa Loa (eye worm) | FKBP5 protein | 0.0104 | 0.5797 | 0.5788 |
Leishmania major | peptidylprolyl isomerase-like protein | 0.0104 | 0.5797 | 0.5 |
Echinococcus granulosus | chromobox protein 2 | 0.0026 | 0.0022 | 0.0022 |
Trichomonas vaginalis | peptidylprolyl isomerase, putative | 0.0104 | 0.5797 | 0.5788 |
Echinococcus granulosus | chromobox protein 1 | 0.0161 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0064 | 0.2805 | 0.2789 |
Mycobacterium ulcerans | FK-506 binding protein, peptidyl-prolyl cis-trans isomerase | 0.0104 | 0.5797 | 0.5 |
Echinococcus multilocularis | chromobox protein 1 | 0.0161 | 1 | 1 |
Echinococcus multilocularis | fk506 binding protein | 0.0104 | 0.5797 | 0.5797 |
Schistosoma mansoni | chromobox protein | 0.0026 | 0.0022 | 0.0022 |
Echinococcus granulosus | Chromobox protein 3 | 0.0026 | 0.0022 | 0.0022 |
Toxoplasma gondii | 'chromo' (CHRromatin Organization MOdifier) domain-containing protein | 0.0026 | 0.0022 | 0.5 |
Plasmodium vivax | 70 kDa peptidylprolyl isomerase, putative | 0.0104 | 0.5797 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.009 | 0.4757 | 0.4746 |
Echinococcus multilocularis | chromobox protein 2 | 0.0026 | 0.0022 | 0.0022 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0064 | 0.2805 | 0.2789 |
Trichomonas vaginalis | chromobox protein, putative | 0.0097 | 0.5265 | 0.5254 |
Trypanosoma cruzi | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.0104 | 0.5797 | 0.5 |
Loa Loa (eye worm) | heterochromatin protein 1 | 0.0161 | 1 | 1 |
Echinococcus multilocularis | Chromo domain | 0.0026 | 0.0022 | 0.0022 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0041 | 0.1146 | 0.1146 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.1355 | 0.1336 |
Schistosoma mansoni | hypothetical protein | 0.0026 | 0.0022 | 0.0022 |
Trypanosoma brucei | peptidyl-prolyl cis-trans isomerase, putative | 0.0104 | 0.5797 | 0.5 |
Schistosoma mansoni | chromobox protein | 0.0026 | 0.0022 | 0.0022 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP1A | 0.0104 | 0.5797 | 0.5797 |
Trypanosoma brucei | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.0104 | 0.5797 | 0.5 |
Onchocerca volvulus | 0.0071 | 0.3313 | 0.6276 | |
Toxoplasma gondii | chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 | 0.0026 | 0.0022 | 0.5 |
Giardia lamblia | FKBP-type peptidyl-prolyl cis-trans isomerase | 0.0104 | 0.5797 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | > 128 ug ml-1 | Antibacterial activity against Escherichia coli ATCC 25922 after 18 to 24 hrs by microtiter plate method | ChEMBL. | 20537903 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.