Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Torpedo californica | Acetylcholinesterase | Starlite/ChEMBL | References |
Equus caballus | Cholinesterase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Onchocerca volvulus | Molybdopterin synthase catalytic subunit homolog | Acetylcholinesterase | 586 aa | 588 aa | 28.1 % |
Echinococcus granulosus | neuroligin | Acetylcholinesterase | 586 aa | 493 aa | 21.5 % |
Loa Loa (eye worm) | hypothetical protein | Acetylcholinesterase | 586 aa | 509 aa | 24.8 % |
Onchocerca volvulus | Acetylcholinesterase | 586 aa | 612 aa | 25.5 % | |
Echinococcus granulosus | BC026374 protein S09 family | Acetylcholinesterase | 586 aa | 648 aa | 32.6 % |
Loa Loa (eye worm) | hypothetical protein | Acetylcholinesterase | 586 aa | 571 aa | 25.0 % |
Brugia malayi | Carboxylesterase family protein | Acetylcholinesterase | 586 aa | 592 aa | 28.0 % |
Echinococcus multilocularis | BC026374 protein (S09 family) | Acetylcholinesterase | 586 aa | 643 aa | 32.2 % |
Brugia malayi | Carboxylesterase family protein | Acetylcholinesterase | 586 aa | 546 aa | 29.3 % |
Echinococcus multilocularis | neuroligin | Acetylcholinesterase | 586 aa | 487 aa | 23.0 % |
Schistosoma japonicum | ko:K01050 cholinesterase [EC3.1.1.8], putative | Acetylcholinesterase | 586 aa | 577 aa | 33.6 % |
Schistosoma mansoni | gliotactin | Acetylcholinesterase | 586 aa | 474 aa | 31.6 % |
Onchocerca volvulus | Galectin homolog | Cholinesterase | 574 aa | 531 aa | 39.7 % |
Onchocerca volvulus | Carnitine O-palmitoyltransferase 2, mitochondrial homolog | Acetylcholinesterase | 586 aa | 552 aa | 37.7 % |
Onchocerca volvulus | Putative nuclear protein | Acetylcholinesterase | 586 aa | 551 aa | 40.7 % |
Onchocerca volvulus | Acetylcholinesterase | 586 aa | 564 aa | 29.4 % | |
Brugia malayi | Carboxylesterase family protein | Acetylcholinesterase | 586 aa | 480 aa | 24.6 % |
Drosophila melanogaster | CG10175 gene product from transcript CG10175-RE | Acetylcholinesterase | 586 aa | 535 aa | 31.4 % |
Onchocerca volvulus | Acetylcholinesterase | 586 aa | 562 aa | 25.1 % | |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | Acetylcholinesterase | 586 aa | 602 aa | 24.4 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | acetylcholinesterase | 0.0205 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0205 | 0.5 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.0205 | 0.5 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0205 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0205 | 0.5 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0205 | 0.5 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0205 | 0.5 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0205 | 0.5 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0205 | 0.5 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0205 | 0.5 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0205 | 0.5 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0205 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | = 30.4 % | Inhibition of AChE in human SH-SY5Y cells assessed as enzyme activity at 5 uM after 1 hr by Ellman's method | ChEMBL. | 25017625 |
Activity (binding) | = 67.3 % | Inhibition of AChE in human SH-SY5Y cells assessed as enzyme activity at 1 uM after 1 hr by Ellman's method | ChEMBL. | 25017625 |
IC50 (binding) | = 3.2 uM | Inhibition of Torpedo californica AChE by spectrophotometry based Ellman's method | ChEMBL. | 25017625 |
IC50 (binding) | = 10.3 uM | Inhibition of horse serum BChE by spectrophotometry based Ellman's method | ChEMBL. | 25017625 |
Ki (binding) | = 4.6 uM | Mixed type inhibition of Torpedo californica AChE by Lineweaver-Burk plot | ChEMBL. | 25017625 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.