TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 307.37 | Formula: C17H13N3OS
H donors: 1 H acceptors: 2 LogP: 4.59 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: Cc1cccc(n1)Nc1scc(n1)c1cc2c(o1)cccc2
InChi: 1S/C17H13N3OS/c1-11-5-4-8-16(18-11)20-17-19-13(10-22-17)15-9-12-6-2-3-7-14(12)21-15/h2-10H,1H3,(H,18,19,20)
InChiKey: HGNDFIFFLGOZES-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma cruzi	casein kinase II, putative	0.0143	0.078	0.4143
Toxoplasma gondii	AGC kinase	0.0071	0.0259	0.1272
Echinococcus granulosus	N acetylglucosaminyl phosphatidylinositol	0.0047	0.0087	0.0142
Echinococcus multilocularis	cyclins	0.0036	0.0007	0.0007
Echinococcus multilocularis	lachesin	0.0035	0.0004	0.0003
Echinococcus multilocularis	roundabout 2	0.0047	0.0087	0.0142
Schistosoma mansoni	tyrosine kinase	0.0061	0.0188	0.0315
Trichomonas vaginalis	glucosamine-6-phosphate isomerase, putative	0.0047	0.0087	0.0428
Brugia malayi	serine/threonine-protein kinase 6	0.0234	0.1437	0.2414
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0047	0.0087	0.0146
Trichomonas vaginalis	AGC family protein kinase	0.0075	0.0288	0.1508
Leishmania major	protein kinase, putative	0.0234	0.1437	0.7664
Schistosoma mansoni	septate junction protein	0.0035	0.0004	0.0008
Brugia malayi	hypothetical protein	0.008	0.0328	0.055
Echinococcus granulosus	neurotracting:lsamp:neurotrimin:obcam	0.0089	0.0389	0.0649
Echinococcus granulosus	roundabout 2	0.0047	0.0087	0.0142
Plasmodium vivax	casein kinase 2, alpha subunit, putative	0.0143	0.078	0.5135
Echinococcus multilocularis	insulin receptor	0.0737	0.5079	0.8527
Loa Loa (eye worm)	TK/INSR protein kinase	0.0737	0.5079	0.7369
Entamoeba histolytica	protein kinase, putative	0.0075	0.0288	0.1508
Trichomonas vaginalis	AGC family protein kinase	0.0234	0.1437	0.7664
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0004	0.0006
Entamoeba histolytica	protein kinase, putative	0.0075	0.0288	0.1508
Giardia lamblia	Kinase, CMGC CK2	0.0143	0.078	0.4143
Echinococcus multilocularis	roundabout 2	0.0116	0.0584	0.0976
Echinococcus granulosus	cyclin B3 1	0.0036	0.0007	0.0007
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0099	0.0465	0.0776
Echinococcus multilocularis	serine:threonine protein kinase PLK1	0.0294	0.1874	0.3143
Schistosoma mansoni	kinase	0.0425	0.2817	0.4731
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0054	0.0136	0.0692
Echinococcus multilocularis	nervana 2	0.0041	0.0047	0.0075
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0099	0.0465	0.0776
Loa Loa (eye worm)	TK/ROR protein kinase	0.0041	0.0044	0.0064
Plasmodium falciparum	serine/threonine protein kinase, putative	0.0234	0.1437	1
Onchocerca volvulus		0.011	0.0543	0.1189
Loa Loa (eye worm)	hypothetical protein	0.011	0.0543	0.0788
Trichomonas vaginalis	CAMK family protein kinase	0.0102	0.0484	0.2557
Schistosoma mansoni	vesicular amine transporter	0.0069	0.0245	0.0412
Loa Loa (eye worm)	SRC-1	0.0099	0.0465	0.0674
Schistosoma mansoni	neuroglian	0.0047	0.0087	0.0146
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0007	0.001
Loa Loa (eye worm)	AUR protein kinase	0.0234	0.1437	0.2086
Echinococcus granulosus	c src tyrosine kinase	0.004	0.004	0.0063
Schistosoma mansoni	tyrosine kinase	0.0555	0.3762	0.6317
Schistosoma mansoni	serine/threonine-protein kinase	0.0054	0.0136	0.0229
Entamoeba histolytica	protein kinase, putative	0.0084	0.0356	0.1872
Trichomonas vaginalis	AGC family protein kinase	0.0075	0.0288	0.1508
Schistosoma mansoni	tyrosine kinase	0.0555	0.3762	0.6317
Echinococcus multilocularis	Serine:threonine protein kinase PLK4	0.0232	0.1428	0.2395
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0099	0.0465	0.0776
Schistosoma mansoni	tyrosine kinase	0.0581	0.3945	0.6625
Schistosoma mansoni	serine/threonine protein kinase	0.0035	0.0002	0.0004
Loa Loa (eye worm)	AUR protein kinase	0.0234	0.1437	0.2086
Echinococcus granulosus	Immunoglobulin	0.0069	0.0245	0.0408
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0035	0.0004	0.0008
Entamoeba histolytica	serine/threonine- protein kinase 6, putative	0.0234	0.1437	0.7664
Entamoeba histolytica	protein kinase domain containing protein	0.0234	0.1437	0.7664
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0245	0.0356
Schistosoma mansoni	protein kinase	0.0234	0.1437	0.2414
Echinococcus multilocularis	microtubule associated protein 2	0.0704	0.4835	0.8118
Loa Loa (eye worm)	CAMK/MLCK protein kinase	0.0035	0.0002	0.0004
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0859	0.5955	0.8641
Echinococcus multilocularis	peroxidasin	0.0035	0.0004	0.0003
Echinococcus multilocularis	basement membrane specific heparan sulfate	0.0069	0.0245	0.0408
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0099	0.0465	0.0776
Echinococcus granulosus	epidermal growth factor receptor	0.0859	0.5955	1
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0036	0.0007	0.0012
Plasmodium falciparum	protein kinase 5	0.0094	0.0429	0.2953
Giardia lamblia	Kinase, AGC PKA	0.005	0.0106	0.0532
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.004	0.004	0.0067
Echinococcus multilocularis	cyclin dependent kinase 1	0.0094	0.0429	0.0717
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0004	0.0006
Trichomonas vaginalis	AGC family protein kinase	0.0075	0.0288	0.1508
Trypanosoma cruzi	cdc2-related kinase 3	0.0094	0.0429	0.2263
Trichomonas vaginalis	CAMK family protein kinase	0.0294	0.1874	1
Schistosoma mansoni	serine/threonine protein kinase	0.0294	0.1874	0.3146
Trichomonas vaginalis	AGC family protein kinase	0.0075	0.0288	0.1508
Loa Loa (eye worm)	hypothetical protein	0.0288	0.1828	0.2652
Echinococcus multilocularis	roundabout 2	0.0047	0.0087	0.0142
Loa Loa (eye worm)	PLK/PLK1 protein kinase	0.0294	0.1874	0.2719
Trichomonas vaginalis	AGC family protein kinase	0.0234	0.1437	0.7664
Trichomonas vaginalis	AGC family protein kinase	0.0234	0.1437	0.7664
Brugia malayi	Prion-like-	0.0035	0.0004	0.0008
Echinococcus multilocularis	cyclin B	0.0036	0.0007	0.0007
Echinococcus granulosus	cyclin b3	0.0036	0.0007	0.0007
Echinococcus granulosus	peroxidasin	0.0035	0.0004	0.0003
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0099	0.0465	0.0776
Trypanosoma brucei	rac serine-threonine kinase, putative	0.0075	0.0288	0.1508
Brugia malayi	Furin-like cysteine rich region family protein	0.0859	0.5955	1
Echinococcus granulosus	Glutaredoxin protein 5	0.0041	0.0047	0.0075
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0099	0.0465	0.0776
Echinococcus granulosus	tyrosine protein kinase otk	0.0035	0.0004	0.0003
Echinococcus granulosus	cyclins	0.0036	0.0007	0.0007
Brugia malayi	Protein kinase domain containing protein	0.0538	0.364	0.6113
Trichomonas vaginalis	CAMK family protein kinase	0.0294	0.1874	1
Onchocerca volvulus	Basement membrane proteoglycan homolog	0.0035	0.0004	0.001
Trypanosoma cruzi	polo-like protein kinase, putative	0.0294	0.1874	1
Echinococcus granulosus	twitchin	0.0093	0.0417	0.0696
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0092	0.0411	0.0686
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0099	0.0465	0.0776
Loa Loa (eye worm)	AGC/AKT protein kinase	0.0075	0.0288	0.0418
Echinococcus multilocularis	plexin a4	0.0041	0.0046	0.0073
Echinococcus granulosus	G2:mitotic specific cyclin B3	0.0036	0.0007	0.0007
Echinococcus multilocularis	hemicentin 1	0.0035	0.0004	0.0003
Schistosoma mansoni	neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule	0.0035	0.0004	0.0008
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0581	0.3945	0.6623
Brugia malayi	cell division control protein 2 homolog	0.0094	0.0429	0.0721
Trichomonas vaginalis	CMGC family protein kinase	0.0143	0.078	0.4143
Plasmodium falciparum	casein kinase 2, alpha subunit	0.0143	0.078	0.5406
Loa Loa (eye worm)	hypothetical protein	0.008	0.0328	0.0475
Brugia malayi	Immunoglobulin I-set domain containing protein	0.008	0.0328	0.055
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0047	0.0087	0.0142
Entamoeba histolytica	N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase, putative	0.0047	0.0087	0.0428
Trichomonas vaginalis	CMGC family protein kinase	0.0094	0.0429	0.2263
Brugia malayi	plexin A	0.0041	0.0046	0.0077
Plasmodium vivax	serine/threonine protein kinase 6, putative	0.0234	0.1437	1
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0035	0.0004	0.0008
Brugia malayi	serine/threonine-protein kinase plk-2	0.0294	0.1874	0.3146
Loa Loa (eye worm)	hypothetical protein	0.008	0.0328	0.0475
Schistosoma mansoni	cell adhesion molecule	0.01	0.0471	0.0791
Brugia malayi	serine/threonine kinase 12	0.0234	0.1437	0.2414
Trichomonas vaginalis	AGC family protein kinase	0.0234	0.1437	0.7664
Echinococcus granulosus	roundabout 2	0.0116	0.0584	0.0976
Echinococcus multilocularis	tyrosine protein kinase Abl	0.004	0.004	0.0063
Trichomonas vaginalis	CMGC family protein kinase	0.0143	0.078	0.4143
Echinococcus granulosus	nervana 2	0.0041	0.0047	0.0075
Echinococcus granulosus	protein tyrosine kinase	0.0532	0.3597	0.6038
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0056	0.0155	0.0257
Echinococcus granulosus	microtubule associated protein 2	0.0704	0.4835	0.8118
Trypanosoma cruzi	aurora B kinase, putative	0.0234	0.1437	0.7664
Entamoeba histolytica	protein kinase domain containing protein	0.0143	0.078	0.4143
Trypanosoma cruzi	Protein kinase B	0.0054	0.0136	0.0692
Plasmodium falciparum	RAC-beta serine/threonine protein kinase	0.005	0.0106	0.0694
Schistosoma mansoni	cyclin B	0.0036	0.0007	0.0012
Schistosoma mansoni	roundabout	0.0035	0.0004	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0089	0.0389	0.0564
Echinococcus granulosus	serine/threonine protein kinase	0.0054	0.0136	0.0225
Echinococcus granulosus	sodium:potassium dependent atpase beta subunit	0.0041	0.0047	0.0075
Echinococcus granulosus	cyclin dependent kinase 1	0.0094	0.0429	0.0717
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0245	0.0356
Loa Loa (eye worm)	CMGC/CK2 protein kinase	0.0143	0.078	0.1132
Schistosoma mansoni	ephrin receptor	0.0135	0.0726	0.122
Loa Loa (eye worm)	AUR protein kinase	0.0234	0.1437	0.2086
Echinococcus multilocularis	tyrosine protein kinase otk	0.0035	0.0004	0.0003
Schistosoma mansoni	titin	0.0035	0.0002	0.0004
Entamoeba histolytica	glucosamine-6-phosphate isomerase, putative	0.0047	0.0087	0.0428
Echinococcus multilocularis	protein tyrosine kinase	0.0532	0.3597	0.6038
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.005	0.0106	0.0532
Echinococcus multilocularis	cyclin b3	0.0036	0.0007	0.0007
Trichomonas vaginalis	AGC family protein kinase	0.0075	0.0288	0.1508
Echinococcus multilocularis	Immunoglobulin	0.0069	0.0245	0.0408
Entamoeba histolytica	serine/threonine protein kinase 6, putative	0.0234	0.1437	0.7664
Echinococcus granulosus	tyrosine protein kinase HCK	0.0084	0.0356	0.0594
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0035	0.0002	0.0004
Echinococcus multilocularis	epidermal growth factor receptor	0.0581	0.3945	0.6623
Trypanosoma brucei	cdc2-related kinase 1	0.0094	0.0429	0.2263
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	0.0094	0.0429	0.0623
Onchocerca volvulus	Tyrosine kinase homolog	0.0667	0.4567	1
Loa Loa (eye worm)	TK protein kinase	0.0092	0.0411	0.0597
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0047	0.0087	0.0146
Echinococcus granulosus	contactin	0.0047	0.0087	0.0142
Schistosoma mansoni	serine/threonine protein kinase	0.0094	0.0429	0.0721
Brugia malayi	Protein kinase domain containing protein	0.0075	0.0288	0.0484
Brugia malayi	serine/threonine protein kinase 6	0.0234	0.1437	0.2414
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0004	0.0006
Brugia malayi	Protein kinase domain containing protein	0.0737	0.5079	0.8528
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0035	0.0004	0.0006
Brugia malayi	Protein kinase domain containing protein	0.0313	0.2011	0.3377
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0054	0.0136	0.0692
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.004	0.004	0.0063
Loa Loa (eye worm)	hypothetical protein	0.0086	0.037	0.0537
Schistosoma mansoni	cell adhesion molecule	0.0035	0.0004	0.0008
Schistosoma mansoni	cyclin B3	0.0036	0.0007	0.0012
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0084	0.0356	0.0594
Echinococcus multilocularis	serine threonine protein kinase nrc serine threonine protein kinase gad	0.005	0.0106	0.0174
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0041	0.0044	0.007
Echinococcus multilocularis	N acetylglucosaminyl phosphatidylinositol	0.0047	0.0087	0.0142
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0004	0.0006
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0099	0.0465	0.0776
Echinococcus multilocularis	G2:mitotic specific cyclin B3	0.0036	0.0007	0.0007
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0099	0.0465	0.0776
Schistosoma mansoni	N-acetylglucosaminyl-phosphatidylinositol de-n-acetylase	0.0047	0.0087	0.0146
Onchocerca volvulus		0.0036	0.0007	0.0015
Schistosoma mansoni	cell adhesion molecule	0.0047	0.0087	0.0146
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0099	0.0465	0.0776
Loa Loa (eye worm)	AGC/RSK/P70 protein kinase	0.0071	0.0259	0.0375
Entamoeba histolytica	protein kinase, putative	0.0071	0.0259	0.1348
Echinococcus multilocularis	nervana 2	0.0041	0.0047	0.0075
Echinococcus granulosus	nervana 2	0.0041	0.0047	0.0075
Entamoeba histolytica	serine/threonine protein kinase, putative	0.0294	0.1874	1
Echinococcus multilocularis	cyclin dependent kinase 1	0.0094	0.0429	0.0717
Echinococcus granulosus	cyclins	0.0036	0.0007	0.0007
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0036	0.0007	0.0012
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0047	0.0087	0.0142
Trichomonas vaginalis	AGC family protein kinase	0.0075	0.0288	0.1508
Loa Loa (eye worm)	TK/EPH protein kinase	0.0165	0.0944	0.137
Schistosoma mansoni	serine/threonine protein kinase	0.0094	0.0429	0.0721
Plasmodium vivax	unspecified product	0.0143	0.078	0.5135
Schistosoma mansoni	tyrosine kinase	0.004	0.004	0.0067
Giardia lamblia	Glucosamine-6-phosphate isomerase, putative	0.0047	0.0087	0.0428
Schistosoma mansoni	tyrosine kinase	0.0737	0.5079	0.8528
Echinococcus granulosus	cyclins	0.0036	0.0007	0.0007
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0056	0.0155	0.0257
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0041	0.0044	0.007
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0036	0.0007	0.0012
Echinococcus multilocularis	receptor type tyrosine protein phosphatase F	0.0047	0.0087	0.0142
Echinococcus multilocularis	cyclins	0.0036	0.0007	0.0007
Loa Loa (eye worm)	TK protein kinase	0.0041	0.0044	0.0064
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0035	0.0004	0.0008
Leishmania major	casein kinase II, putative	0.0143	0.078	0.4143
Trichomonas vaginalis	CAMK family protein kinase	0.0294	0.1874	1
Schistosoma mansoni	titin	0.0035	0.0004	0.0008
Schistosoma mansoni	serine/threonine-protein kinase	0.0054	0.0136	0.0229
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0087	0.0126
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0047	0.0087	0.0142
Brugia malayi	Peroxidasin	0.0035	0.0004	0.0008
Leishmania major	cell division protein kinase 2,cdc2-related kinase	0.0094	0.0429	0.2263
Plasmodium vivax	rac-beta serine/threonine protein kinase, putative	0.005	0.0106	0.0145
Schistosoma mansoni	Neurotrimin precursor (hNT)	0.0069	0.0245	0.0412
Leishmania major	protein kinase, putative,polo-like protein kinase, putative	0.0294	0.1874	1
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0092	0.0411	0.0686
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0066	0.0228	0.0379
Echinococcus multilocularis	contactin neuroglian septate junction protein	0.0047	0.0087	0.0142
Loa Loa (eye worm)	plexin A	0.0041	0.0046	0.0067
Echinococcus multilocularis	cyclins	0.0036	0.0007	0.0007
Toxoplasma gondii	cell-cycle-associated protein kinase CDK, putative	0.0094	0.0429	0.2537
Trypanosoma cruzi	cdc2-related kinase 1	0.0094	0.0429	0.2263
Echinococcus granulosus	epidermal growth factor receptor	0.0581	0.3945	0.6623
Loa Loa (eye worm)	CMGC/CDK/CDK5 protein kinase	0.0094	0.0429	0.0623
Schistosoma mansoni	nephrin	0.0047	0.0087	0.0146
Echinococcus multilocularis	cyclins	0.0036	0.0007	0.0007
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0047	0.0087	0.0146
Trypanosoma cruzi	polo-like protein kinase, putative	0.0294	0.1874	1
Trichomonas vaginalis	CMGC family protein kinase	0.0143	0.078	0.4143
Plasmodium vivax	protein kinase Crk2	0.0094	0.0429	0.2537
Brugia malayi	protein unc-22	0.0035	0.0002	0.0004
Trypanosoma brucei	N-acetyl-D-glucosaminylphosphatidylinositol de-N-acetylase	0.0047	0.0087	0.0428
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0041	0.0044	0.0074
Brugia malayi	Casein kinase II, alpha chain	0.0143	0.078	0.131
Toxoplasma gondii	aurora kinase	0.0234	0.1437	1
Schistosoma mansoni	cyclins	0.0036	0.0007	0.0012
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0035	0.0004	0.0006
Trichomonas vaginalis	CAMK family protein kinase	0.0294	0.1874	1
Trichomonas vaginalis	AGC family protein kinase	0.0075	0.0288	0.1508
Echinococcus multilocularis	cyclin dependent kinase 5	0.0094	0.0429	0.0717
Onchocerca volvulus		0.0035	0.0002	0.0005
Schistosoma mansoni	cell adhesion molecule	0.0047	0.0087	0.0146
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0099	0.0465	0.0776
Echinococcus granulosus	cyclins	0.0036	0.0007	0.0007
Trichomonas vaginalis	CAMK family protein kinase	0.0294	0.1874	1
Echinococcus granulosus	cyclins	0.0036	0.0007	0.0007
Entamoeba histolytica	casein kinase, putative	0.0143	0.078	0.4143
Trichomonas vaginalis	CMGC family protein kinase	0.0143	0.078	0.4143
Trichomonas vaginalis	CAMK family protein kinase	0.0102	0.0484	0.2557
Schistosoma mansoni	septate junction protein	0.0035	0.0004	0.0008
Leishmania major	N-acetyl-D-acetylglucosaminylphosphatidylinositol deacetylase	0.0047	0.0087	0.0428
Trypanosoma brucei	polo-like protein kinase	0.0294	0.1874	1
Entamoeba histolytica	protein kinase , putative	0.0234	0.1437	0.7664
Echinococcus granulosus	serine threonine protein kinase nrc	0.005	0.0106	0.0174
Brugia malayi	Tyrosine-protein kinase abl-1	0.004	0.004	0.0067
Echinococcus granulosus	defective proboscis extension response	0.0069	0.0245	0.0408
Loa Loa (eye worm)	hypothetical protein	0.0104	0.0501	0.0727
Loa Loa (eye worm)	CAMK protein kinase	0.0035	0.0002	0.0004
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0054	0.0136	0.0692
Trichomonas vaginalis	CMGC family protein kinase	0.0094	0.0429	0.2263
Echinococcus granulosus	calcium:calmodulin dependent protein kinase	0.005	0.0106	0.0174
Echinococcus granulosus	cyclin dependent kinase	0.0094	0.0429	0.0717
Giardia lamblia	Kinase, PLK	0.0294	0.1874	1
Echinococcus granulosus	insulin receptor	0.0737	0.5079	0.8527
Echinococcus granulosus	Serine:threonine protein kinase PLK4	0.0232	0.1428	0.2395
Loa Loa (eye worm)	TK/FAK protein kinase	0.0538	0.364	0.5282
Trichomonas vaginalis	CAMK family protein kinase	0.0294	0.1874	1
Echinococcus multilocularis	sodium:potassium dependent atpase beta subunit	0.0041	0.0047	0.0075
Schistosoma mansoni	nephrin	0.0096	0.044	0.0739
Schistosoma mansoni	serine/threonine protein kinase	0.0234	0.1437	0.2414
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0245	0.0356
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0007	0.001
Trypanosoma cruzi	N-Acetyl-D-glucosaminylphosphatidylinositol de-N-acetylase, putative	0.0047	0.0087	0.0428
Trypanosoma brucei	cdc2-related kinase 3	0.0094	0.0429	0.2263
Schistosoma mansoni	tyrosine kinase	0.0532	0.3597	0.604
Echinococcus multilocularis	epidermal growth factor receptor	0.0859	0.5955	1
Mycobacterium ulcerans	mycothiol conjugate amidase Mca	0.1418	1	1
Trichomonas vaginalis	CMGC family protein kinase	0.0143	0.078	0.4143
Echinococcus multilocularis	neurotracting:lsamp:neurotrimin:obcam	0.0035	0.0004	0.0003
Loa Loa (eye worm)	cyclin domain-containing protein	0.0036	0.0007	0.001
Echinococcus multilocularis	serine:threonine protein kinase 12 B	0.0234	0.1437	0.2411
Loa Loa (eye worm)	phosphatidylinositol glycan anchor biosynthesis protein	0.0047	0.0087	0.0126
Schistosoma mansoni	defective proboscis extension response (dpr)-related	0.0069	0.0245	0.0412
Echinococcus granulosus	neuroglian	0.0084	0.0358	0.0597
Echinococcus multilocularis	cyclins	0.0036	0.0007	0.0007
Echinococcus granulosus	ephrin type A receptor 4 A	0.0161	0.0916	0.1534
Echinococcus granulosus	neuroglian	0.0047	0.0087	0.0142
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0749	0.5161	0.8666
Loa Loa (eye worm)	hypothetical protein	0.008	0.0328	0.0475
Brugia malayi	Immunoglobulin I-set domain containing protein	0.074	0.5095	0.8555
Entamoeba histolytica	cell division protein kinase 2, putative	0.0094	0.0429	0.2263
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0004	0.0006
Trichomonas vaginalis	CMGC family protein kinase	0.0143	0.078	0.4143
Echinococcus multilocularis	hemicentin 1	0.0035	0.0004	0.0003
Onchocerca volvulus	Serine\/threonine kinase homolog	0.0294	0.1874	0.4103
Echinococcus multilocularis	cyclin B3 1	0.0036	0.0007	0.0007
Entamoeba histolytica	cell division protein kinase 2, putative	0.0094	0.0429	0.2263
Schistosoma mansoni	microtubule-associated protein tau	0.0704	0.4835	0.8118
Schistosoma mansoni	ephrin receptor	0.0037	0.0014	0.0023
Giardia lamblia	Kinase, CMGC CDK	0.0094	0.0429	0.2263
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.004	0.004	0.0063
Schistosoma mansoni	tyrosine kinase	0.0737	0.5079	0.8528
Schistosoma mansoni	tyrosine kinase	0.0555	0.3762	0.6317
Echinococcus granulosus	5'partial\|cyclin dependent kinase 1	0.0094	0.0429	0.0717
Trypanosoma cruzi	cdc2-related kinase 3	0.0094	0.0429	0.2263
Entamoeba histolytica	protein kinase, putative	0.0234	0.1437	0.7664
Trichomonas vaginalis	CAMK family protein kinase	0.0294	0.1874	1
Brugia malayi	SRC-1	0.0099	0.0465	0.078
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0066	0.0228	0.0379
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0099	0.0465	0.0776
Echinococcus multilocularis	c src tyrosine kinase	0.004	0.004	0.0063
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0035	0.0004	0.0008
Echinococcus multilocularis	cyclins	0.0036	0.0007	0.0007
Brugia malayi	p70 ribosomal S6 kinase beta	0.0071	0.0259	0.0434
Echinococcus granulosus	lachesin	0.0035	0.0004	0.0003
Echinococcus multilocularis	Glutaredoxin protein 5	0.0041	0.0047	0.0075
Echinococcus multilocularis	aurora kinase A	0.0234	0.1437	0.2411
Loa Loa (eye worm)	CAMK/CAMKL/NUAK protein kinase	0.0988	0.6892	1
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0092	0.0411	0.0686
Entamoeba histolytica	serine/threonine- protein kinase 6 , putative	0.0234	0.1437	0.7664
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0035	0.0004	0.0008
Leishmania major	cell division related protein kinase 2,cdc2-related kinase	0.0094	0.0429	0.2263
Brugia malayi	ephrin receptor 1 precursor	0.0077	0.0306	0.0514
Echinococcus multilocularis	cyclins	0.0036	0.0007	0.0007
Echinococcus granulosus	cyclin dependent kinase 5	0.0094	0.0429	0.0717
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0107	0.0524	0.0876
Entamoeba histolytica	protein kinase 2, putative	0.005	0.0106	0.0532
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0047	0.0087	0.0126
Schistosoma mansoni	tyrosine kinase	0.004	0.004	0.0067
Echinococcus granulosus	plexin a4	0.0041	0.0046	0.0073
Echinococcus multilocularis	casein kinase ii subunit alpha	0.0143	0.078	0.1307
Echinococcus granulosus	serine:threonine protein kinase PLK1	0.0294	0.1874	0.3143
Trichomonas vaginalis	CMGC family protein kinase	0.0143	0.078	0.4143
Echinococcus granulosus	serine:threonine protein kinase 12 B	0.0234	0.1437	0.2411
Trypanosoma cruzi	N-Acetyl-D-glucosaminylphosphatidylinositol de-N-acetylase, putative	0.0047	0.0087	0.0428
Echinococcus granulosus	roundabout 2	0.0047	0.0087	0.0142
Brugia malayi	Protein kinase domain containing protein	0.0094	0.0429	0.0721
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0205	0.0298
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0035	0.0004	0.0008
Schistosoma mansoni	protein kinase	0.0143	0.078	0.131
Schistosoma mansoni	tyrosine kinase	0.0581	0.3945	0.6625
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0099	0.0465	0.0776
Echinococcus multilocularis	neuroglian	0.0084	0.0358	0.0597
Schistosoma mansoni	tyrosine kinase	0.0099	0.0465	0.078
Echinococcus granulosus	casein kinase ii subunit alpha	0.0143	0.078	0.1307
Loa Loa (eye worm)	TK protein kinase	0.0084	0.0356	0.0517
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0092	0.0411	0.0686
Echinococcus granulosus	cyclin B	0.0036	0.0007	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0004	0.0006
Echinococcus granulosus	hemicentin 1	0.0035	0.0004	0.0003
Schistosoma mansoni	lipoxygenase	0.0056	0.0155	0.0261
Trypanosoma cruzi	cdc2-related kinase 1	0.0094	0.0429	0.2263
Loa Loa (eye worm)	hypothetical protein	0.0104	0.0501	0.0727
Brugia malayi	Uncharacterized LmbE-like protein, COG2120 containing protein	0.0047	0.0087	0.0146
Toxoplasma gondii	CMGC kinase, CK2 family	0.0143	0.078	0.5135
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0099	0.0465	0.0776
Echinococcus granulosus	tyrosine kinase	0.0092	0.0411	0.0686
Brugia malayi	protein-tyrosine kinase	0.0092	0.0411	0.069
Brugia malayi	Fibronectin type III domain containing protein	0.008	0.0328	0.055
Echinococcus multilocularis	Immunoglobulin	0.0069	0.0245	0.0408
Echinococcus multilocularis		0.0255	0.1591	0.2669
Giardia lamblia	Kinase, CMGC CDK	0.0094	0.0429	0.2263
Onchocerca volvulus		0.0626	0.4271	0.9353
Echinococcus multilocularis	rac serine:threonine kinase	0.0054	0.0136	0.0225
Trypanosoma brucei	Casein kinase II	0.0143	0.078	0.4143
Echinococcus multilocularis	neuroglian	0.0047	0.0087	0.0142
Echinococcus granulosus	tyrosine protein kinase Blk	0.0092	0.0411	0.0686
Echinococcus granulosus	aurora kinase A	0.0234	0.1437	0.2411
Plasmodium falciparum	N-acetylglucosaminylphosphatidylinositol deacetylase, putative	0.0047	0.0087	0.0558
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0099	0.0465	0.0776
Entamoeba histolytica	protein kinase, putative	0.0234	0.1437	0.7664
Trichomonas vaginalis	CMGC family protein kinase	0.0094	0.0429	0.2263
Giardia lamblia	Aurora kinase	0.0234	0.1437	0.7664
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	0.0094	0.0429	0.0623
Mycobacterium tuberculosis	Mycothiol conjugate amidase Mca (mycothiol S-conjugate amidase)	0.1372	0.9662	1
Trypanosoma brucei	aurora B kinase	0.0234	0.1437	0.7664
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.074	0.5095	0.7392
Echinococcus multilocularis	cyclin dependent kinase	0.0094	0.0429	0.0717
Echinococcus multilocularis	ephrin type A receptor 4 A	0.0161	0.0916	0.1534
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0749	0.5161	0.8666
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0004	0.0006
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0047	0.0087	0.0146
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0099	0.0465	0.0776
Schistosoma mansoni	tyrosine kinase	0.0859	0.5955	1
Loa Loa (eye worm)	CAMK/MLCK protein kinase	0.0055	0.0146	0.0212
Schistosoma mansoni	tyrosine kinase	0.0099	0.0465	0.078

Activities

Activity type	Activity value	Assay description	Source	Reference
Css (ADMET)	= 2.7 uM	Drug concentration at steady state in mouse brain assessed as total compound level in brain homogenates at 80 mg/kg/day, po measured after 3 days	ChEMBL.	24762293

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL3321863

Bibliographic References

No literature references available for this target.

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Detailed information for compound 922902