Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | TTK protein kinase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | linoleoyl-CoA desaturase, DesA3 | 0.0117 | 0 | 0.5 |
Onchocerca volvulus | 0.1335 | 1 | 1 | |
Echinococcus multilocularis | Fatty acid desaturase, type 1 | 0.0117 | 0 | 0.5 |
Trypanosoma brucei | fatty acid desaturase, putative | 0.1335 | 1 | 1 |
Mycobacterium ulcerans | electron transfer protein FdxB | 0.0117 | 0 | 0.5 |
Schistosoma mansoni | fatty acid desaturase | 0.0117 | 0 | 0.5 |
Mycobacterium ulcerans | transmembrane alkane 1-monooxygenase AlkB | 0.0117 | 0 | 0.5 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.1335 | 1 | 1 |
Mycobacterium tuberculosis | Probable conserved membrane protein | 0.0117 | 0 | 0.5 |
Plasmodium vivax | stearoyl-CoA desaturase (acyl-CoA desaturase, faty acid desaturase), putative | 0.1218 | 0.9039 | 0.5 |
Echinococcus granulosus | Sphingolipid delta4 desaturase DES1 | 0.0117 | 0 | 0.5 |
Echinococcus granulosus | Fatty acid desaturase type 1 | 0.0117 | 0 | 0.5 |
Mycobacterium ulcerans | linoleoyl-CoA desaturase, DesA3 | 0.0117 | 0 | 0.5 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.1218 | 0.9039 | 0.9039 |
Echinococcus multilocularis | Peptidase M, neutral zinc metallopeptidases, zinc binding site | 0.0117 | 0 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0117 | 0 | 0.5 |
Echinococcus multilocularis | Peptidase M, neutral zinc metallopeptidases, zinc binding site | 0.0117 | 0 | 0.5 |
Plasmodium falciparum | stearoyl-CoA desaturase | 0.1218 | 0.9039 | 0.5 |
Toxoplasma gondii | sphingolipid delta 4 desaturase/c-4 hydroxylase protein des2 family protein | 0.0117 | 0 | 0.5 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.1218 | 0.9039 | 0.9039 |
Mycobacterium ulcerans | linoleoyl-CoA desaturase, DesA3_2 | 0.0117 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable transmembrane alkane 1-monooxygenase AlkB (alkane 1-hydroxylase) (lauric acid omega-hydroxylase) (omega-hydroxylase) (f | 0.0117 | 0 | 0.5 |
Mycobacterium tuberculosis | Possible electron transfer protein FdxB | 0.0117 | 0 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0117 | 0 | 0.5 |
Onchocerca volvulus | 0.1335 | 1 | 1 | |
Brugia malayi | acyl-CoA desaturase | 0.1218 | 0.9039 | 1 |
Leishmania major | fatty-acid desaturase, putative | 0.1335 | 1 | 1 |
Loa Loa (eye worm) | acyl-CoA desaturase | 0.1218 | 0.9039 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.018 uM | Inhibition of SUMO-tagged human TTK (1-275 residues) compound pre-incubated for 15 mins prior ATP addition by MBP-based assay | ChEMBL. | 25043312 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.