Detailed information for compound 927719

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 315.385 | Formula: C18H22FN3O
  • H donors: 1 H acceptors: 2 LogP: 1.96 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#C[C@@H]1C[C@H]2[C@@H](N1C(=O)C[C@@H](Cc1cccc(c1)F)N)CCC2
  • InChi: 1S/C18H22FN3O/c19-14-5-1-3-12(7-14)8-15(21)10-18(23)22-16(11-20)9-13-4-2-6-17(13)22/h1,3,5,7,13,15-17H,2,4,6,8-10,21H2/t13-,15+,16-,17-/m0/s1
  • InChiKey: LJMGNDMZAPMRBO-ORQFMDKSSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens dipeptidyl-peptidase 4 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Candida albicans dipeptidyl aminopeptidase B Get druggable targets OG5_128614 All targets in OG5_128614
Candida albicans dipeptidyl aminopeptidase B Get druggable targets OG5_128614 All targets in OG5_128614
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog Get druggable targets OG5_128614 All targets in OG5_128614
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) Get druggable targets OG5_128614 All targets in OG5_128614
Schistosoma japonicum ko:K01278 dipeptidyl-peptidase 4, putative Get druggable targets OG5_128614 All targets in OG5_128614
Brugia malayi prolyl oligopeptidase family protein Get druggable targets OG5_128614 All targets in OG5_128614
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein Get druggable targets OG5_128614 All targets in OG5_128614
Echinococcus granulosus dipeptidyl aminopeptidaseprotein Get druggable targets OG5_128614 All targets in OG5_128614
Loa Loa (eye worm) prolyl oligopeptidase Get druggable targets OG5_128614 All targets in OG5_128614
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0505 0.0535 0.0575
Echinococcus granulosus tyrosine protein kinase Lyn 0.0177 0.0153 0.0728
Loa Loa (eye worm) hypothetical protein 0.0503 0.0532 0.053
Echinococcus granulosus protein kinase c epsilon type 0.1849 0.2102 1
Echinococcus granulosus tyrosine protein kinase Fyn 0.0159 0.0132 0.063
Echinococcus granulosus Dipeptidyl peptidase 9 0.007 0.0029 0.0137
Loa Loa (eye worm) AGC/NDR protein kinase 0.074 0.081 0.0808
Echinococcus multilocularis protein kinase c eta type 0.0503 0.0532 0.2533
Echinococcus multilocularis Protein kinase C, brain isozyme 0.1383 0.1558 0.7413
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.074 0.081 0.3852
Brugia malayi Protein kinase c protein 2 0.066 0.0716 0.3405
Brugia malayi Pleckstrin Homology Domain 0.0505 0.0535 0.2546
Brugia malayi diacylglycerol kinase 0.0503 0.0532 0.2533
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.007 0.0029 0.0137
Brugia malayi protein kinase C II. 0.1849 0.2102 1
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0503 0.0532 0.053
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0159 0.0132 0.063
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0169 0.0144 0.0685
Echinococcus granulosus unc 13 munc13 0.0517 0.055 0.2615
Echinococcus multilocularis Rac GTPase activating protein 1 0.0503 0.0532 0.2533
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0548 0.0586 0.2787
Echinococcus multilocularis cyclin dependent kinase 0.0065 0.0023 0.0109
Brugia malayi hypothetical protein 0.0055 0.001 0.0049
Schistosoma mansoni serine/threonine kinase 0.074 0.081 0.3852
Entamoeba histolytica diacylglycerol kinase, putative 0.0503 0.0532 0.63
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0548 0.0586 0.2787
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0834 0.0919 0.4371
Schistosoma mansoni nck2/grb4 0.008 0.004 0.0191
Entamoeba histolytica diacylglycerol kinase, putative 0.0503 0.0532 0.63
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.074 0.081 0.3852
Onchocerca volvulus 0.0503 0.0532 0.0572
Echinococcus multilocularis growth factor receptor bound protein 2 0.008 0.004 0.0191
Schistosoma mansoni hypothetical protein 0.0503 0.0532 0.2533
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.007 0.0029 0.0071
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0065 0.0023 0.0021
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.1849 0.2102 0.21
Loa Loa (eye worm) Ras association domain family 1 isoform A 0.0503 0.0532 0.053
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.052 0.0553 0.2631
Echinococcus multilocularis tyrosine kinase 0.0055 0.001 0.0049
Echinococcus multilocularis raf serine:threonine protein kinase 0.0517 0.0549 0.2611
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.0157 0.013 0.0128
Brugia malayi SRC-1 0.0159 0.0132 0.063
Schistosoma mansoni tyrosine kinase 0.0055 0.001 0.0049
Echinococcus granulosus cyclin dependent kinase 5 0.0065 0.0023 0.0109
Schistosoma mansoni serine/threonine protein kinase 0.0065 0.0023 0.0109
Schistosoma mansoni atypical protein kinase C 0.1243 0.1395 0.6639
Loa Loa (eye worm) TK/ABL protein kinase 0.0285 0.0279 0.0277
Schistosoma mansoni serine/threonine protein kinase 0.074 0.081 0.3852
Echinococcus multilocularis tyrosine protein kinase Blk 0.012 0.0086 0.0411
Brugia malayi Variant SH3 domain containing protein 0.0543 0.058 0.2759
Loa Loa (eye worm) hypothetical protein 0.0505 0.0535 0.0533
Entamoeba histolytica protein kinase, putative 0.0766 0.0839 1
Echinococcus granulosus tyrosine kinase 0.0055 0.001 0.0049
Entamoeba histolytica protein kinase, putative 0.0766 0.0839 1
Echinococcus granulosus C2 calcium dependent membrane targeting 0.0517 0.055 0.2615
Echinococcus granulosus tyrosine protein kinase shark 0.0055 0.001 0.0049
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0834 0.0919 0.4371
Echinococcus granulosus N chimaerin 0.0543 0.058 0.2759
Echinococcus multilocularis cyclin dependent kinase 1 0.0065 0.0023 0.0109
Brugia malayi prolyl oligopeptidase family protein 0.007 0.0029 0.0137
Echinococcus granulosus tyrosine protein kinase HCK 0.0079 0.0039 0.0185
Echinococcus granulosus tyrosine protein kinase ABL1 0.0285 0.0279 0.1329
Echinococcus granulosus Rac GTPase activating protein 1 0.0503 0.0532 0.2533
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.008 0.004 0.0191
Schistosoma mansoni unc-13 (munc13) 0.0517 0.055 0.2615
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.007 0.0029 1
Echinococcus granulosus tyrosine protein kinase Src42A 0.0106 0.007 0.0333
Echinococcus multilocularis intersectin 2 0.0054 0.001 0.0048
Brugia malayi RhoGAP domain containing protein 0.0503 0.0532 0.2533
Loa Loa (eye worm) TK/FER protein kinase 0.0055 0.001 0.0008
Trichomonas vaginalis AGC family protein kinase 0.0766 0.0839 1
Trypanosoma brucei rac serine-threonine kinase, putative 0.0766 0.0839 1
Echinococcus granulosus raf serine:threonine protein kinase 0.0517 0.0549 0.2611
Brugia malayi RhoGAP domain containing protein 0.0543 0.058 0.2759
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0094 0.0056 0.0269
Loa Loa (eye worm) TK protein kinase 0.0079 0.0039 0.0037
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.007 0.0029 0.1026
Loa Loa (eye worm) RasGEF domain-containing protein 0.0503 0.0532 0.053
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.0209 0.0191 0.0907
Brugia malayi p70 ribosomal S6 kinase beta 0.0763 0.0836 0.398
Echinococcus granulosus tyrosine protein kinase Fyn 0.0159 0.0132 0.063
Echinococcus granulosus myotubularin protein 13 0.0505 0.0535 0.2546
Loa Loa (eye worm) hypothetical protein 0.0125 0.0092 0.009
Echinococcus granulosus protein kinase c iota type 0.1243 0.1395 0.6639
Loa Loa (eye worm) TK/FER protein kinase 0.0055 0.001 0.0008
Echinococcus granulosus c src tyrosine kinase 0.0094 0.0056 0.0269
Onchocerca volvulus 0.0057 0.0013 0.0003
Brugia malayi Protein kinase domain containing protein 0.0055 0.001 0.0049
Loa Loa (eye worm) prolyl oligopeptidase 0.0209 0.0191 0.0188
Echinococcus multilocularis tyrosine protein kinase Fyn 0.012 0.0086 0.0411
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0106 0.007 0.0333
Brugia malayi SH2 domain containing protein 0.0055 0.001 0.0049
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0159 0.0132 0.063
Brugia malayi diacylglycerol kinase 0.0503 0.0532 0.2533
Entamoeba histolytica protein kinase, putative 0.074 0.081 0.9645
Loa Loa (eye worm) hypothetical protein 0.0055 0.001 0.0008
Echinococcus granulosus tyrosine protein kinase Blk 0.012 0.0086 0.0411
Loa Loa (eye worm) hypothetical protein 0.0054 0.0009 0.0007
Brugia malayi Tyrosine-protein kinase abl-1 0.0143 0.0113 0.0537
Brugia malayi C1-like domain containing protein 0.052 0.0553 0.2631
Loa Loa (eye worm) TK/FER protein kinase 0.0055 0.001 0.0008
Giardia lamblia Kinase, AGC AKT 0.0111 0.0076 1
Brugia malayi Protein kinase domain containing protein 0.0766 0.0839 0.3992
Schistosoma mansoni growth factor receptor-bound protein 0.008 0.004 0.0191
Schistosoma mansoni serine/threonine protein kinase 0.0548 0.0586 0.2787
Echinococcus granulosus protein kinase C gamma type 0.088 0.0972 0.4626
Loa Loa (eye worm) TK/FER protein kinase 0.0055 0.001 0.0008
Echinococcus multilocularis protein kinase c epsilon type 0.1849 0.2102 1
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0159 0.0132 0.063
Brugia malayi SH2 domain containing protein 0.0055 0.001 0.0049
Echinococcus multilocularis unc 13 (munc13) 0.0517 0.055 0.2615
Loa Loa (eye worm) hypothetical protein 0.0503 0.0532 0.053
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0125 0.0092 0.0439
Schistosoma mansoni serine/threonine protein kinase 0.1383 0.1558 0.7413
Schistosoma mansoni protein kinase C mu 0.052 0.0553 0.2631
Entamoeba histolytica hypothetical protein 0.0503 0.0532 0.63
Loa Loa (eye worm) hypothetical protein 0.0505 0.0535 0.0533
Schistosoma mansoni serine/threonine protein kinase 0.074 0.081 0.3852
Brugia malayi ribosomal protein S6 kinase alpha 3 0.0111 0.0076 0.0363
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0763 0.0836 0.0834
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0543 0.058 0.2759
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.074 0.081 0.0808
Brugia malayi Protein kinase domain containing protein 0.0055 0.001 0.0049
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0094 0.0056 0.0269
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0065 0.0023 0.0021
Trichomonas vaginalis AGC family protein kinase 0.0766 0.0839 1
Loa Loa (eye worm) TK/FER protein kinase 0.0055 0.001 0.0008
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0159 0.0132 0.063
Schistosoma mansoni serine/threonine protein kinase 0.1383 0.1558 0.7413
Brugia malayi Variant SH3 domain containing protein 0.0058 0.0014 0.0066
Schistosoma mansoni serine/threonine protein kinase 0.0834 0.0919 0.4371
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.0517 0.055 0.2615
Entamoeba histolytica protein kinase, putative 0.0079 0.0039 0.0346
Echinococcus granulosus tyrosine protein kinase Fyn 0.0159 0.0132 0.063
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0159 0.0132 0.063
Loa Loa (eye worm) hypothetical protein 0.0102 0.0066 0.0063
Echinococcus multilocularis tyrosine protein kinase Abl 0.0182 0.0159 0.0758
Echinococcus granulosus intersectin 2 0.0054 0.001 0.0048
Trichomonas vaginalis AGC family protein kinase 0.074 0.081 0.964
Echinococcus multilocularis tyrosine protein kinase HCK 0.0079 0.0039 0.0185
Echinococcus granulosus tyrosine protein kinase Src42A 0.0159 0.0132 0.063
Brugia malayi Protein kinase domain containing protein 0.0055 0.001 0.0049
Entamoeba histolytica cell division protein kinase 2, putative 0.0065 0.0023 0.0153
Echinococcus multilocularis tyrosine protein kinase shark 0.0055 0.001 0.0049
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0065 0.0023 0.0109
Loa Loa (eye worm) hypothetical protein 0.0503 0.0532 0.053
Brugia malayi Protein kinase domain containing protein 0.052 0.0553 0.2631
Brugia malayi Protein kinase domain containing protein 0.0169 0.0144 0.0685
Echinococcus multilocularis myotubularin protein 13 0.0505 0.0535 0.2546
Schistosoma mansoni diacylglycerol kinase theta 0.0503 0.0532 0.2533
Schistosoma mansoni tyrosine kinase 0.0055 0.001 0.0049
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0055 0.001 0.0049
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.007 0.0029 1
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0159 0.0132 0.063
Loa Loa (eye worm) STE/STE20/KHS protein kinase 0.0169 0.0144 0.0142
Echinococcus multilocularis protein kinase c iota type 0.1243 0.1395 0.6639
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.012 0.0086 0.0411
Brugia malayi cell division control protein 2 homolog 0.0065 0.0023 0.0109
Loa Loa (eye worm) hypothetical protein 0.0503 0.0532 0.053
Brugia malayi RhoGEF domain containing protein 0.0503 0.0532 0.2533
Onchocerca volvulus Tyrosine kinase homolog 0.0175 0.0151 0.0154
Schistosoma mansoni diacylglycerol kinase theta 0.0503 0.0532 0.2533
Brugia malayi Protein kinase domain containing protein 0.074 0.081 0.3852
Brugia malayi Protein kinase domain containing protein 0.0065 0.0023 0.0109
Schistosoma mansoni serine/threonine protein kinase 0.0054 0.0009 0.0043
Loa Loa (eye worm) hypothetical protein 0.0503 0.0532 0.053
Brugia malayi Variant SH3 domain containing protein 0.008 0.004 0.0191
Brugia malayi Tyrosine-protein kinase abl-1 0.0182 0.0159 0.0758
Trichomonas vaginalis AGC family protein kinase 0.074 0.081 0.964
Onchocerca volvulus 0.7885 0.9137 1
Loa Loa (eye worm) hypothetical protein 0.0517 0.055 0.0547
Loa Loa (eye worm) TK protein kinase 0.012 0.0086 0.0084
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.074 0.081 0.0808
Schistosoma mansoni serine/threonine protein kinase 0.0141 0.0111 0.0529
Brugia malayi hypothetical protein 0.0054 0.0009 0.0045
Brugia malayi Immunoglobulin I-set domain containing protein 0.0182 0.0159 0.0756
Loa Loa (eye worm) CAMK/PKD protein kinase 0.052 0.0553 0.0551
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0834 0.0919 0.0917
Loa Loa (eye worm) hypothetical protein 0.8388 0.9723 0.9723
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.074 0.081 0.3852
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0285 0.0279 0.1329
Brugia malayi Protein kinase domain containing protein 0.0055 0.001 0.0049
Loa Loa (eye worm) TK/FER protein kinase 0.0055 0.001 0.0008
Loa Loa (eye worm) hypothetical protein 0.008 0.004 0.0038
Loa Loa (eye worm) sex muscle abnormal protein 5 0.008 0.004 0.0038
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0065 0.0023 0.0021
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0543 0.058 0.2759
Echinococcus granulosus Diacylglycerol kinase theta 0.0503 0.0532 0.2533
Loa Loa (eye worm) AGC/PKN protein kinase 0.074 0.081 0.0808
Echinococcus granulosus NCK adaptor protein 0.008 0.004 0.0191
Schistosoma mansoni tyrosine kinase 0.0094 0.0056 0.0269
Brugia malayi Hr1 repeat family protein 0.074 0.081 0.3852
Toxoplasma gondii AGC kinase 0.0763 0.0836 1
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0159 0.0132 0.063
Entamoeba histolytica protein kinase, putative 0.0058 0.0015 0.0052
Leishmania major rac serine-threonine kinase, putative,protein kinase, putative 0.0114 0.0079 1
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0058 0.0015 0.0052
Toxoplasma gondii diacylglycerol kinase, putative 0.0503 0.0532 0.6264
Loa Loa (eye worm) hypothetical protein 0.0503 0.0532 0.053
Schistosoma mansoni serine/threonine protein kinase 0.0065 0.0023 0.0109
Schistosoma mansoni protein kinase C mu 0.0503 0.0532 0.2533
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.074 0.081 0.3852
Echinococcus granulosus growth factor receptor bound protein 2 0.008 0.004 0.0191
Echinococcus multilocularis serine:threonine protein kinase 38 0.074 0.081 0.3852
Brugia malayi protein-tyrosine kinase 0.012 0.0086 0.0411
Brugia malayi Variant SH3 domain containing protein 0.008 0.004 0.0191
Entamoeba histolytica protein kinase, putative 0.0763 0.0836 0.9968
Brugia malayi Protein kinase domain containing protein 0.0204 0.0185 0.088
Loa Loa (eye worm) TK/FER protein kinase 0.0055 0.001 0.0008
Echinococcus multilocularis NCK adaptor protein 0.008 0.004 0.0191
Brugia malayi Ras association domain family 1 isoform A 0.0503 0.0532 0.2533
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0055 0.001 0.0049
Loa Loa (eye worm) AGC/AKT protein kinase 0.0766 0.0839 0.0837
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.0209 0.0191 0.0907
Echinococcus granulosus tyrosine protein kinase Src64B 0.0159 0.0132 0.063
Loa Loa (eye worm) hypothetical protein 0.7885 0.9137 0.9137
Schistosoma mansoni unc-13 (munc13) 0.0517 0.055 0.2615
Schistosoma mansoni serine/threonine protein kinase 0.074 0.081 0.3852
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.007 0.0029 0.007
Schistosoma mansoni protein kinase 0.0169 0.0144 0.0685
Schistosoma mansoni serine/threonine protein kinase 0.1849 0.2102 1
Loa Loa (eye worm) hypothetical protein 0.7885 0.9137 0.9137
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0159 0.0132 0.063
Echinococcus granulosus NDR protein kinase 0.074 0.081 0.3852
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.0209 0.0191 0.0907
Echinococcus multilocularis Dipeptidyl peptidase 9 0.007 0.0029 0.0137
Schistosoma mansoni tyrosine kinase 0.0094 0.0056 0.0269
Trichomonas vaginalis AGC family protein kinase 0.0766 0.0839 1
Schistosoma mansoni serine/threonine protein kinase 0.0204 0.0185 0.088
Echinococcus multilocularis RNA directed DNA polymerase 0.0125 0.0092 0.0439
Echinococcus granulosus RNA directed DNA polymerase 0.0125 0.0092 0.0439
Echinococcus multilocularis serine threonine protein kinase 0.088 0.0972 0.4626
Trichomonas vaginalis AGC family protein kinase 0.0766 0.0839 1
Echinococcus multilocularis serine:threonine protein kinase N2 0.074 0.081 0.3852
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0723 0.0789 0.9388
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0543 0.058 0.0578
Brugia malayi protein kinase C3,putative 0.052 0.0553 0.2631
Loa Loa (eye worm) hypothetical protein 0.0503 0.0532 0.053
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.052 0.0553 0.0551
Loa Loa (eye worm) CAMK/CAMKL/CHK1 protein kinase 0.0204 0.0185 0.0183
Brugia malayi Protein kinase domain containing protein 0.0055 0.001 0.0049
Trichomonas vaginalis AGC family protein kinase 0.0743 0.0812 0.9673
Echinococcus granulosus protein kinase c eta type 0.0503 0.0532 0.2533
Echinococcus granulosus Protein kinase C brain isozyme 0.1383 0.1558 0.7413
Echinococcus multilocularis tyrosine protein kinase Srms 0.012 0.0086 0.0411
Echinococcus multilocularis c src tyrosine kinase 0.0094 0.0056 0.0269
Entamoeba histolytica PH domain containing protein kinase, putative 0.0611 0.0659 0.7828
Echinococcus multilocularis cyclin dependent kinase 1 0.0065 0.0023 0.0109
Echinococcus multilocularis cyclin dependent kinase 5 0.0065 0.0023 0.0109
Loa Loa (eye worm) variant SH3 domain-containing protein 0.008 0.004 0.0038
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0058 0.0014 0.0012
Schistosoma mansoni protein kinase C 0.0517 0.055 0.2615
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.0209 0.0191 0.0198
Schistosoma mansoni tyrosine kinase 0.0159 0.0132 0.063
Plasmodium vivax protein kinase Crk2 0.0065 0.0023 0.5
Loa Loa (eye worm) SRC-1 0.0159 0.0132 0.013
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0543 0.058 0.2759
Brugia malayi Protein kinase domain containing protein 0.074 0.081 0.3852
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0159 0.0132 0.063
Trichomonas vaginalis AGC family protein kinase 0.0766 0.0839 1
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0169 0.0144 0.0685
Schistosoma mansoni adapter molecule crk 0.008 0.004 0.0191
Loa Loa (eye worm) raf kinase 0.0503 0.0532 0.053
Schistosoma mansoni rac gtpase activating protein 0.0503 0.0532 0.2533
Schistosoma mansoni tyrosine kinase 0.0159 0.0132 0.063
Echinococcus multilocularis Diacylglycerol kinase theta 0.0503 0.0532 0.2533
Schistosoma mansoni vav2 0.0546 0.0582 0.2771
Loa Loa (eye worm) hypothetical protein 0.7885 0.9137 0.9137
Loa Loa (eye worm) hypothetical protein 0.0627 0.0678 0.0676
Schistosoma mansoni tyrosine kinase 0.0245 0.0232 0.1103
Loa Loa (eye worm) TK/FER protein kinase 0.0055 0.001 0.0008
Loa Loa (eye worm) TK/FER protein kinase 0.0055 0.001 0.0008
Brugia malayi Sex muscle abnormal protein 5 0.008 0.004 0.0191
Echinococcus granulosus cyclin dependent kinase 1 0.0065 0.0023 0.0109
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0094 0.0056 0.0269
Echinococcus granulosus serine:threonine protein kinase N2 0.0609 0.0656 0.3123
Trichomonas vaginalis AGC family protein kinase 0.074 0.081 0.964
Echinococcus granulosus tyrosine kinase 0.012 0.0086 0.0411
Onchocerca volvulus 0.0154 0.0127 0.0128
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0182 0.0159 0.0157
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0159 0.0132 0.063
Brugia malayi prolyl oligopeptidase family protein 0.0209 0.0191 0.0907
Echinococcus granulosus tyrosine protein kinase Srms 0.0055 0.001 0.0049
Trichomonas vaginalis AGC family protein kinase 0.0766 0.0839 1
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0543 0.058 0.2759
Plasmodium falciparum protein kinase 5 0.0065 0.0023 0.5
Schistosoma mansoni serine/threonine protein kinase 0.0517 0.0549 0.2611
Echinococcus granulosus cyclin dependent kinase 0.0065 0.0023 0.0109
Trichomonas vaginalis AGC family protein kinase 0.0766 0.0839 1
Echinococcus multilocularis N chimaerin 0.0543 0.058 0.2759
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0159 0.0132 0.063
Echinococcus granulosus serine:threonine protein kinase N2 0.074 0.081 0.3852
Schistosoma mansoni growth factor receptor-bound protein 0.008 0.004 0.0191
Entamoeba histolytica cell division protein kinase 2, putative 0.0065 0.0023 0.0153
Loa Loa (eye worm) TK/FER protein kinase 0.0055 0.001 0.0008
Onchocerca volvulus 0.0517 0.055 0.0591
Schistosoma mansoni serine/threonine protein kinase 0.0548 0.0586 0.2787
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.007 0.0029 0.007
Echinococcus multilocularis serine:threonine protein kinase N2 0.1332 0.1499 0.7131

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) Inhibition of DPP7 (unknown origin) expressed in baculovirus expression system using Nle-Pro-AMC as substrate by continuous fluorometric assay ChEMBL. 25164763
IC50 (binding) Inhibition of FAP (unknown origin) expressed in baculovirus expression system using Nle-Pro-AMC as substrate by continuous fluorometric assay ChEMBL. 25164763
IC50 (binding) = 0.13 uM Inhibition of human recombinant DPP4 expressed in baculovirus expression system using Ala-Pro-AMC as substrate by continuous fluorometric assay ChEMBL. 25164763
IC50 (binding) = 21.62 uM Inhibition of DPP9 (unknown origin) expressed in baculovirus expression system using Ala-Pro-AMC as substrate by continuous fluorometric assay ChEMBL. 25164763
IC50 (binding) = 36.53 uM Inhibition of DPP8 (unknown origin) expressed in baculovirus expression system using Ala-Pro-AMC as substrate by continuous fluorometric assay ChEMBL. 25164763

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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