TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 328.859 | Formula: C18H17ClN2S
H donors: 1 H acceptors: 1 LogP: 6.24 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: Clc1ccc(cc1)c1csc(n1)Nc1ccc(cc1)C(C)C
InChi: 1S/C18H17ClN2S/c1-12(2)13-5-9-16(10-6-13)20-18-21-17(11-22-18)14-3-7-15(19)8-4-14/h3-12H,1-2H3,(H,20,21)
InChiKey: UUIMNGDAQNZIJP-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Onchocerca volvulus		0.0014	0.0178	0.6502
Plasmodium falciparum	DNA polymerase delta catalytic subunit	0.0018	0.0274	0.0241
Brugia malayi	major facilitator superfamily protein	0.0014	0.0178	0.0797
Toxoplasma gondii	facilitative glucose transporter GT1	0.0102	0.2235	0.3385
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0178	0.0797
Leishmania major	glucose transporter, lmgt1	0.0031	0.0584	0.8604
Brugia malayi	Major Facilitator Superfamily protein	0.0014	0.0178	0.0797
Trypanosoma brucei	glucose transporter, putative	0.0031	0.0584	0.8604
Echinococcus multilocularis	transient receptor potential cation channel	0.0007	0.000000081566	0.00000036493
Mycobacterium ulcerans	sugar-transport integral membrane protein SugI	0.0014	0.0178	0.2954
Trypanosoma brucei	glucose transporter, putative	0.0031	0.0584	0.8604
Toxoplasma gondii	DNA polymerase family B protein	0.0018	0.0274	0.0415
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0178	0.0797
Trypanosoma cruzi	hexose transporter	0.0031	0.0584	0.8604
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0178	0.0797
Echinococcus multilocularis	DNA polymerase delta catalytic subunit	0.0018	0.0274	0.1226
Loa Loa (eye worm)	hypothetical protein	0.0007	0.000000081566	0.00000036493
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0178	0.0797
Plasmodium vivax	mitogen-activated protein kinase 2, putative	0.0164	0.3709	0.3595
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0178	0.0797
Leishmania major	DNA polymerase I alpha catalytic subunit, putative	0.0018	0.0274	0.4039
Trypanosoma brucei	DNA polymerase epsilon catalytic subunit, putative	0.0018	0.0274	0.4039
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0017	0.024	0.1074
Onchocerca volvulus		0.0014	0.0178	0.6502
Loa Loa (eye worm)	hypothetical protein	0.0007	0.000000081566	0.00000036493
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0178	0.0797
Echinococcus multilocularis	calcium activated potassium channel	0.0009	0.0046	0.0205
Echinococcus granulosus	transient receptor potential cation channel	0.0007	0.000000081566	0.00000036493
Loa Loa (eye worm)	hypothetical protein	0.003	0.056	0.2504
Chlamydia trachomatis	lysine--tRNA ligase	0.0023	0.0376	1
Mycobacterium ulcerans	fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT	0.0014	0.0178	0.2954
Brugia malayi	olfactory channel protein osm-9	0.0007	0.000000081566	0.00000036493
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0178	0.0797
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0178	0.0797
Mycobacterium ulcerans	sugar transporter	0.0014	0.0178	0.2954
Trypanosoma cruzi	glucose transporter, putative	0.0014	0.0178	0.2626
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0034	0.0152
Schistosoma mansoni	glucose transport protein	0.0102	0.2235	1
Loa Loa (eye worm)	sugar transporter	0.0014	0.0178	0.0797
Echinococcus multilocularis	General substrate transporter	0.0087	0.1899	0.8494
Trypanosoma brucei	glucose transporter, putative	0.0031	0.0584	0.8604
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0036	0.0679	1
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0178	0.0797
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0178	0.0797
Schistosoma mansoni	DNA polymerase epsilon catalytic subunit	0.0018	0.0274	0.1226
Plasmodium vivax	CDK-related protein kinase 6, putative	0.0431	1	1
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0178	0.0797
Onchocerca volvulus		0.0014	0.0178	0.6502
Onchocerca volvulus		0.0014	0.0178	0.6502
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0102	0.2235	1
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0178	0.0797
Leishmania major	DNA polymerase epsilon catalytic subunit, putative	0.0018	0.0274	0.4039
Brugia malayi	isocitrate dehydrogenase	0.0017	0.024	0.1074
Mycobacterium leprae	Possible lysyl-tRNA synthetase 2 LysX	0.0023	0.0376	0.3046
Schistosoma mansoni	serine/threonine protein kinase	0.0031	0.0575	0.2571
Trypanosoma cruzi	hexose transporter, putative	0.0031	0.0584	0.8604
Echinococcus granulosus	lysyl tRNA synthetase	0.0023	0.0376	0.1682
Toxoplasma gondii	sugar transporter ST2	0.0014	0.0178	0.027
Trichomonas vaginalis	DNA polymerase delta catalytic subunit, putative	0.0018	0.0274	0.1226
Echinococcus granulosus	transient receptor potential cation channel	0.0007	0.000000081566	0.00000036493
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0178	0.0797
Trypanosoma brucei	lysyl-tRNA synthetase, putative	0.0023	0.0376	0.5539
Trypanosoma cruzi	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0017	0.024	0.3536
Toxoplasma gondii	DNA polymerase family B protein	0.0008	0.0034	0.0052
Onchocerca volvulus		0.0014	0.0178	0.6502
Trypanosoma brucei	glucose transporter, putative	0.0031	0.0584	0.8604
Echinococcus granulosus	DNA polymerase zeta catalytic subunit	0.0018	0.0274	0.1226
Leishmania major	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0017	0.024	0.3536
Echinococcus granulosus	synaptic vesicle 2 protein	0.0014	0.0178	0.0797
Plasmodium falciparum	isocitrate dehydrogenase [NADP], mitochondrial	0.0017	0.024	0.0207
Brugia malayi	DNA polymerase family B, exonuclease domain containing protein	0.0018	0.0274	0.1226
Toxoplasma gondii	calcium-dependent protein kinase CDPK2B	0.0031	0.0575	0.0871
Toxoplasma gondii	transporter, major facilitator family protein	0.0014	0.0178	0.027
Schistosoma mansoni	protein kinase	0.0031	0.0575	0.2571
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0036	0.0679	1
Trichomonas vaginalis	DNA polymerase alpha catalytic subunit, putative	0.0018	0.0274	0.1226
Plasmodium vivax	proline--tRNA ligase, putative	0.0036	0.0679	0.051
Wolbachia endosymbiont of Brugia malayi	major facilitator superfamily permease	0.0014	0.0178	0.5
Schistosoma mansoni	sugar transporter	0.0014	0.0178	0.0797
Schistosoma mansoni	ryanodine receptor related	0.0007	0	0.0002
Echinococcus multilocularis	isocitrate dehydrogenase	0.0017	0.024	0.1074
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0031	0.0575	0.2571
Trypanosoma cruzi	hexose transporter, putative	0.0031	0.0584	0.8604
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0017	0.024	0.1074
Toxoplasma gondii	DNA polymerase	0.0018	0.0274	0.0415
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0178	0.0797
Onchocerca volvulus		0.0014	0.0178	0.6502
Brugia malayi	DNA polymerase alpha catalytic subunit	0.0018	0.0274	0.1226
Toxoplasma gondii	sugar transporter ST3	0.0014	0.0178	0.027
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0425	0.1902
Plasmodium falciparum	calcium-dependent protein kinase 1	0.0031	0.0575	0.0543
Leishmania major	glucose transporter, lmgt3	0.0031	0.0584	0.8604
Leishmania major	glucose transporter, lmgt2	0.0031	0.0584	0.8604
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0178	0.0797
Trichomonas vaginalis	glucose transporter, putative	0.0014	0.0178	0.0797
Trypanosoma cruzi	DNA polymerase epsilon catalytic subunit, putative	0.0018	0.0274	0.4039
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0031	0.0584	0.8604
Trypanosoma cruzi	DNA polymerase zeta catalytic subunit, putative	0.0008	0.0034	0.0502
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0178	0.0797
Echinococcus granulosus	transient receptor potential cation channel	0.0007	0.000000081566	0.00000036493
Trypanosoma cruzi	DNA polymerase delta catalytic subunit, putative	0.0008	0.0034	0.0502
Toxoplasma gondii	protein kinase, putative	0.0287	0.6604	1
Loa Loa (eye worm)	calcium/calmodulin-dependent protein kinase ID	0.0031	0.0575	0.2571
Loa Loa (eye worm)	DNA polymerase epsilon catalytic subunit	0.0008	0.0034	0.0152
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0584	0.2613
Echinococcus multilocularis	DNA polymerase alpha catalytic subunit	0.0018	0.0274	0.1226
Trypanosoma cruzi	hexose transporter, putative	0.0014	0.0178	0.2626
Trypanosoma brucei	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0017	0.024	0.3536
Trichomonas vaginalis	DNA polymerase II, putative	0.0018	0.0274	0.1226
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0178	0.0797
Toxoplasma gondii	DNA polymerase (pol2) superfamily protein	0.0018	0.0274	0.0415
Echinococcus granulosus	General substrate transporter	0.0087	0.1899	0.8494
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	0.0017	0.024	0.1074
Schistosoma mansoni	glucose transport protein	0.0102	0.2235	1
Trypanosoma cruzi	hexose transporter, putative	0.0031	0.0584	0.8604
Plasmodium falciparum	mitogen-activated protein kinase 2	0.0164	0.3709	0.3688
Giardia lamblia	Hexose transporter	0.0014	0.0178	0.2742
Plasmodium falciparum	proline--tRNA ligase	0.0036	0.0679	0.0647
Leishmania major	glucose transporter/membrane transporter D2, putative	0.0031	0.0584	0.8604
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0178	0.0797
Toxoplasma gondii	isocitrate dehydrogenase	0.0017	0.024	0.0363
Echinococcus granulosus	dna polymerase epsilon catalytic subunit a	0.0018	0.0274	0.1226
Echinococcus multilocularis	solute carrier family 2, facilitated glucose	0.0102	0.2235	1
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0178	0.0797
Schistosoma mansoni	sugar transporter	0.0014	0.0178	0.0797
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0178	0.0797
Echinococcus multilocularis	lysyl tRNA synthetase	0.0023	0.0376	0.1682
Echinococcus granulosus	DNA polymerase alpha catalytic subunit	0.0018	0.0274	0.1226
Trichomonas vaginalis	sugar transport protein, putative	0.0014	0.0178	0.0797
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0023	0.0376	1
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0178	0.0797
Brugia malayi	Ryanodine Receptor TM 4-6 family protein	0.0007	0	0.0002
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0584	0.2613
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0178	0.0797
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0036	0.0679	1
Echinococcus granulosus	Sugar transporter ERD6 protein	0.0014	0.0178	0.0797
Leishmania major	DNA polymerase delta catalytic subunit, putative	0.0018	0.0274	0.4039
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0178	0.0797
Trypanosoma cruzi	DNA polymerase I alpha catalytic subunit, putative	0.0018	0.0274	0.4039
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0.0584	0.2613
Schistosoma mansoni	protein kinase	0.0031	0.0575	0.2571
Schistosoma mansoni	sugar transporter	0.0014	0.0178	0.0797
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 2 LysX	0.0019	0.0295	1
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0.0584	0.2613
Plasmodium vivax	lysine--tRNA ligase, putative	0.0023	0.0376	0.0201
Toxoplasma gondii	lysine-tRNA ligase	0.0023	0.0376	0.0569
Loa Loa (eye worm)	bifunctional aminoacyl-tRNA synthetase	0.0013	0.0136	0.061
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0178	0.0797
Loa Loa (eye worm)	DNA polymerase epsilon catalytic subunit	0.001	0.0082	0.0366
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0178	0.0797
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0014	0.0178	0.0797
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0031	0.0575	0.2571
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0178	0.0797
Echinococcus multilocularis	ryanodine receptor 44f	0.0007	0	0.0002
Plasmodium vivax	hexose transporter	0.0102	0.2235	0.2094
Echinococcus granulosus	ryanodine receptor 44f	0.0007	0	0.0002
Giardia lamblia	DNA polymerase delta, catalytic subunit	0.0018	0.0274	0.4566
Trichomonas vaginalis	DNA polymerase alpha catalytic subunit, putative	0.001	0.0082	0.0366
Toxoplasma gondii	cell-cycle-associated protein kinase MAPK, putative	0.0164	0.3709	0.5617
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0575	0.2571
Trypanosoma brucei	glucose transporter, putative	0.0031	0.0584	0.8604
Trichomonas vaginalis	glucose transporter, putative	0.0031	0.0584	0.2613
Brugia malayi	hypothetical protein	0.0014	0.0178	0.0797
Onchocerca volvulus	DNA polymerase alpha catalytic subunit homolog	0.0018	0.0274	1
Echinococcus multilocularis	solute carrier family 22	0.0014	0.0178	0.0797
Trypanosoma brucei	calcium/calmodulin-dependent protein kinase, putative	0.0031	0.0575	0.8466
Schistosoma mansoni	DNA polymerase zeta catalytic subunit	0.0018	0.0274	0.1226
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0178	0.0797
Plasmodium vivax	DNA polymerase alpha, putative	0.0018	0.0274	0.0098
Loa Loa (eye worm)	hypothetical protein	0.001	0.0082	0.0366
Plasmodium vivax	DNA polymerase epsilon, catalytic subunit a, putative	0.0018	0.0274	0.0098
Brugia malayi	Major Facilitator Superfamily protein	0.0014	0.0178	0.0797
Onchocerca volvulus	DNA polymerase delta catalytic subunit homolog	0.0018	0.0274	1
Echinococcus granulosus	DNA polymerase delta catalytic subunit	0.0018	0.0274	0.1226
Onchocerca volvulus	Putative transporter	0.0014	0.0178	0.6502
Trypanosoma brucei	glucose transporter, putative	0.0031	0.0584	0.8604
Brugia malayi	Calcium/calmodulin-dependent protein kinase type II alpha chain	0.0031	0.0575	0.2571
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0102	0.2235	1
Trypanosoma cruzi	hexose transporter, putative	0.0017	0.0247	0.3645
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0031	0.0575	0.2571
Leishmania major	lysyl-tRNA synthetase, putative	0.0023	0.0376	0.5539
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0178	0.0797
Trypanosoma brucei	glucose transporter 2A	0.0031	0.0584	0.8604
Onchocerca volvulus		0.0014	0.0178	0.6502
Trypanosoma brucei	glucose transporter, putative	0.0031	0.0584	0.8604
Trypanosoma cruzi	DNA polymerase delta catalytic subunit, putative	0.0018	0.0274	0.4039
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0178	0.0797
Brugia malayi	hypothetical protein	0.0014	0.0178	0.0797
Trypanosoma brucei	sugar transporter, putative	0.0014	0.0178	0.2626
Schistosoma mansoni	glucose transporter	0.0014	0.0178	0.0797
Leishmania major	myo-inositol/proton symporter (MIT)	0.0014	0.0178	0.2626
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.002	0.031	0.1387
Trypanosoma brucei	DNA polymerase zeta catalytic subunit, putative	0.0018	0.0274	0.4039
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0178	0.0797
Schistosoma mansoni	protein kinase	0.0031	0.0575	0.2571
Trypanosoma brucei	myo-inositol/proton symporter (MIT)	0.0014	0.0178	0.2626
Echinococcus multilocularis	solute carrier family 22	0.0014	0.0178	0.0797
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0178	0.0797
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0023	0.0376	0.1682
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0178	0.0797
Trypanosoma cruzi	sugar transporter, putative	0.0014	0.0178	0.2626
Treponema pallidum	prolyl-tRNA synthetase	0.0011	0.0095	0.5
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0023	0.0376	1
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0178	0.0797
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0014	0.0178	0.0797
Entamoeba histolytica	protein kinase, putative	0.0031	0.0575	1
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0178	0.0797
Leishmania major	hypothetical protein, conserved	0.0014	0.0178	0.2626
Brugia malayi	lysyl-tRNA synthetase	0.0023	0.0376	0.1682
Brugia malayi	Cam kinase protein 1	0.0031	0.0575	0.2571
Plasmodium vivax	isocitrate dehydrogenase [NADP], mitochondrial, putative	0.0017	0.024	0.0063
Brugia malayi	Isocitrate dehydrogenase	0.0017	0.024	0.1074
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0178	0.0797
Onchocerca volvulus		0.0014	0.0178	0.6502
Plasmodium falciparum	lysine--tRNA ligase	0.0023	0.0376	0.0343
Plasmodium vivax	calcium-dependent protein kinase, putative	0.0031	0.0575	0.0404
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0017	0.024	0.1074
Loa Loa (eye worm)	CAMK/CAMK2 protein kinase	0.0031	0.0575	0.2571
Toxoplasma gondii	sugar transporter ST1	0.0014	0.0178	0.027
Loa Loa (eye worm)	hypothetical protein	0.003	0.056	0.2504
Trypanosoma brucei	isocitrate dehydrogenase, putative	0.0017	0.024	0.3536
Loa Loa (eye worm)	DNA-directed DNA polymerase III	0.0018	0.0274	0.1226
Mycobacterium ulcerans	integral membrane transport protein	0.0014	0.0178	0.2954
Entamoeba histolytica	DNA polymerase delta catalytic subunit, putative	0.0018	0.0274	0.4441
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	0.0017	0.024	0.1074
Onchocerca volvulus		0.0014	0.0178	0.6502
Plasmodium vivax	DNA polymerase zeta catalytic subunit, putative	0.0018	0.0274	0.0098
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0102	0.2235	1
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0031	0.0584	0.8604
Plasmodium falciparum	calcium-dependent protein kinase 4	0.0031	0.0575	0.0543
Echinococcus granulosus	solute carrier family 22	0.0014	0.0178	0.0797
Onchocerca volvulus		0.0014	0.0178	0.6502
Trypanosoma brucei	glucose transporter 1E	0.0031	0.0584	0.8604
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0178	0.0797
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0178	0.0797
Giardia lamblia	DNA polymerase epsilon, catalytic subunit	0.0018	0.0274	0.4566
Echinococcus multilocularis	synaptic vesicle 2 protein	0.0014	0.0178	0.0797
Plasmodium falciparum	calcium-dependent protein kinase 2	0.0031	0.0575	0.0543
Trypanosoma brucei	DNA polymerase alpha catalytic subunit	0.0018	0.0274	0.4039
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0178	0.0797
Mycobacterium tuberculosis	Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP)	0.0017	0.024	0.5271
Mycobacterium leprae	Probable prolyl tRNA synthetase ProS	0.003	0.056	1
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0178	0.0797
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0178	0.0797
Entamoeba histolytica	hypothetical protein	0.0023	0.0376	0.6325
Trichomonas vaginalis	DNA polymerase zeta catalytic subunit, putative	0.0018	0.0274	0.1226
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0178	0.0797
Onchocerca volvulus	DNA polymerase homolog	0.0018	0.0274	1
Brugia malayi	Sugar transporter family protein	0.0014	0.0178	0.0797
Echinococcus multilocularis	solute carrier family 22	0.0014	0.0178	0.0797
Brugia malayi	Bifunctional aminoacyl-tRNA synthetase	0.003	0.056	0.2504
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0178	0.0797
Onchocerca volvulus	DNA polymerase epsilon catalytic subunit A homolog	0.0018	0.0274	1
Schistosoma mansoni	lysyl-tRNA synthetase	0.0023	0.0376	0.1682
Trypanosoma cruzi	DNA polymerase epsilon catalytic subunit, putative	0.0018	0.0274	0.4039
Trichomonas vaginalis	prolyl-tRNA synthetase, putative	0.003	0.056	0.2504
Echinococcus granulosus	solute carrier family 22	0.0014	0.0178	0.0797
Echinococcus granulosus	glutamyl tRNA synthetase cytoplasmic	0.003	0.056	0.2504
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0102	0.2235	1
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0274	0.1226
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.0019	0.0295	1
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type 1	0.0031	0.0575	0.2571
Loa Loa (eye worm)	isocitrate dehydrogenase	0.0017	0.024	0.1074
Plasmodium falciparum	major facilitator superfamily domain-containing protein, putative	0.0014	0.0178	0.0145
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0031	0.0575	0.2571
Entamoeba histolytica	prolyl-tRNA synthetase, putative	0.003	0.056	0.9725
Onchocerca volvulus		0.0014	0.0178	0.6502
Schistosoma mansoni	DNA polymerase alpha catalytic subunit	0.0018	0.0274	0.1226
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0031	0.0575	0.2571
Leishmania major	protein kinase, putative	0.0031	0.0575	0.8466
Schistosoma mansoni	glucose transport protein	0.0102	0.2235	1
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0178	0.0797
Echinococcus granulosus	solute carrier family 22	0.0014	0.0178	0.0797
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0031	0.0575	0.2571
Brugia malayi	major facilitator superfamily protein	0.0014	0.0178	0.0797
Echinococcus multilocularis	dna polymerase epsilon catalytic subunit a	0.0018	0.0274	0.1226
Plasmodium vivax	DNA polymerase delta catalytic subunit, putative	0.0018	0.0274	0.0098
Onchocerca volvulus		0.0014	0.0178	0.6502
Onchocerca volvulus		0.0014	0.0178	0.6502
Trypanosoma cruzi	lysyl-tRNA synthetase, putative	0.0023	0.0376	0.5539
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0178	0.0797
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0034	0.0152
Schistosoma mansoni	transient receptor potential channel	0.0007	0.000000081566	0.00000036493
Plasmodium vivax	calcium-dependent protein kinase 3, putative	0.0031	0.0575	0.0404
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0178	0.0797
Trichomonas vaginalis	glucose transporter, putative	0.0031	0.0584	0.2613
Plasmodium falciparum	hexose transporter	0.0102	0.2235	0.2209
Schistosoma mansoni	hypothetical protein	0.0102	0.2235	1
Brugia malayi	Major Facilitator Superfamily protein	0.0014	0.0178	0.0797
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0584	0.2613
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0178	0.0797
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	0.0017	0.024	0.1074
Toxoplasma gondii	isocitrate dehydrogenase	0.0017	0.024	0.0363
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0178	0.0797
Loa Loa (eye worm)	hypothetical protein	0.001	0.0082	0.0366
Plasmodium falciparum	protein kinase 7	0.0287	0.6604	0.6592
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0102	0.2235	1
Toxoplasma gondii	calcium-dependent protein kinase CDPK3	0.0031	0.0575	0.0871
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0031	0.0584	0.8604
Plasmodium falciparum	DNA polymerase epsilon catalytic subunit A, putative	0.001	0.0082	0.0048
Toxoplasma gondii	calcium-dependent protein kinase CDPK2A	0.0031	0.0575	0.0871
Echinococcus multilocularis	solute carrier family 22	0.0014	0.0178	0.0797
Plasmodium vivax	calcium-dependent protein kinase 4, putative	0.0031	0.0575	0.0404
Schistosoma mansoni	transient receptor potential channel	0.0007	0.000000081566	0.00000036493
Echinococcus granulosus	calcium dependent protein kinase	0.0029	0.0529	0.2368
Loa Loa (eye worm)	sugar transporter	0.0102	0.2235	1
Trichomonas vaginalis	myo-inositol transporter, putative	0.0014	0.0178	0.0797
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0178	0.0797
Trypanosoma cruzi	isocitrate dehydrogenase, putative	0.0017	0.024	0.3536
Trichomonas vaginalis	DNA polymerase alpha catalytic subunit, putative	0.0018	0.0274	0.1226
Trypanosoma brucei	bifunctional aminoacyl-tRNA synthetase, putative	0.0036	0.0679	1
Onchocerca volvulus		0.0014	0.0178	0.6502
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0178	0.0797
Echinococcus granulosus	solute carrier family 22	0.0014	0.0178	0.0797
Toxoplasma gondii	prolyl-tRNA synthetase (ProRS)	0.0036	0.0679	0.1028
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0178	0.0797
Leishmania major	DNA polymerase zeta catalytic subunit, putative	0.0008	0.0034	0.0502
Echinococcus multilocularis	transient receptor potential cation channel	0.0007	0.000000081566	0.00000036493
Echinococcus multilocularis	DNA polymerase zeta catalytic subunit	0.0018	0.0274	0.1226
Onchocerca volvulus		0.0014	0.0178	0.6502
Schistosoma mansoni	DNA polymerase delta catalytic subunit	0.0018	0.0274	0.1226
Brugia malayi	Sugar transporter family protein	0.0014	0.0178	0.0797
Trypanosoma brucei	glucose transporter, putative	0.0031	0.0584	0.8604
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0102	0.2235	1
Plasmodium falciparum	calcium-dependent protein kinase 5	0.0031	0.0575	0.0543
Plasmodium falciparum	calcium-dependent protein kinase 3	0.0031	0.0575	0.0543
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.0034	0.0152
Giardia lamblia	Prolyl-tRNA synthetase	0.003	0.056	1
Echinococcus multilocularis	glutamyl tRNA synthetase cytoplasmic	0.003	0.056	0.2504
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.003	0.056	0.2504
Schistosoma mansoni	lysyl-tRNA synthetase	0.0023	0.0376	0.1682
Brugia malayi	bifunctional aminoacyl-tRNA synthetase	0.003	0.056	0.2504
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0031	0.0575	0.2571
Plasmodium vivax	calcium-dependent protein kinase 1, putative	0.0031	0.0575	0.0404
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0036	0.0679	1
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0178	0.0797
Brugia malayi	DNA polymerase family B containing protein	0.0018	0.0274	0.1226
Echinococcus multilocularis	Sugar transporter ERD6 protein	0.0014	0.0178	0.0797
Schistosoma mansoni	sugar transporter	0.0014	0.0178	0.0797
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0102	0.2235	1
Trichomonas vaginalis	CAMK family protein kinase	0.0031	0.0575	0.2571
Echinococcus multilocularis	transient receptor potential cation channel	0.0007	0.000000081566	0.00000036493
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.003	0.056	0.2504
Loa Loa (eye worm)	hypothetical protein	0.0007	0.000000081566	0.00000036493
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0178	0.0797
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0178	0.0797
Brugia malayi	Sugar transporter family protein	0.0102	0.2235	1
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0178	0.0797
Schistosoma mansoni	nuclear transcription factor X-box binding 1 (nfx1)	0.0014	0.0178	0.0797
Trichomonas vaginalis	conserved hypothetical protein	0.0102	0.2235	1
Giardia lamblia	Sugar-proton symporter	0.0014	0.0178	0.2742
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0178	0.0797
Trypanosoma brucei	DNA polymerase delta catalytic subunit, putative	0.0018	0.0274	0.4039
Entamoeba histolytica	protein kinase, putative	0.0031	0.0575	1
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0376	0.1682
Echinococcus multilocularis	calcium dependent protein kinase	0.0029	0.0529	0.2368
Giardia lamblia	Lysyl-tRNA synthetase	0.0023	0.0376	0.6503
Brugia malayi	hypothetical protein	0.0014	0.0178	0.0797
Brugia malayi	DNA polymerase delta catalytic subunit	0.0018	0.0274	0.1226
Echinococcus granulosus	calcium activated potassium channel	0.0009	0.0046	0.0205
Onchocerca volvulus		0.0014	0.0178	0.6502

Activities

Activity type	Activity value	Assay description	Source	Reference
Inhibition (binding)		Inhibition of human recombinant Sphk1 at 10 uM after 30 mins by ADP2 fluorescence intensity assay	ChEMBL.	25150091

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3334673

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 931301