TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 368.453 | Formula: C19H20N4O2S
H donors: 1 H acceptors: 4 LogP: 2.54 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: O=S(=O)(N1CCCCC1c1cnc[nH]1)c1cccc(n1)c1ccccc1
InChi: 1S/C19H20N4O2S/c24-26(25,23-12-5-4-10-18(23)17-13-20-14-21-17)19-11-6-9-16(22-19)15-7-2-1-3-8-15/h1-3,6-9,11,13-14,18H,4-5,10,12H2,(H,20,21)
InChiKey: YVQZXFQGNDBOKU-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	hydroxysteroid (11-beta) dehydrogenase 1	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Mycobacterium tuberculosis	Probable oxidoreductase	Get druggable targets OG5_132866	All targets in OG5_132866
Mycobacterium ulcerans	short chain dehydrogenase	Get druggable targets OG5_132866	All targets in OG5_132866

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Plasmodium falciparum	steroid dehydrogenase, putative	hydroxysteroid (11-beta) dehydrogenase 1	292 aa	250 aa	24.8 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Mycobacterium ulcerans	short chain dehydrogenase	0.0338	0.2496	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0076	0.0444	0.1306
Leishmania major	cathepsin L-like protease	0.0243	0.175	0.5148
Giardia lamblia	Hypothetical protein	0.0076	0.0444	0.1306
Entamoeba histolytica	cysteine protease, putative	0.0143	0.0974	0.4555
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0454	0.34	1
Leishmania major	cathepsin L-like protease	0.0243	0.175	0.5148
Echinococcus multilocularis	cathepsin L	0.0143	0.0974	0.0974
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0243	0.175	0.5148
Plasmodium falciparum	serine repeat antigen 1	0.0076	0.0444	0.2538
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0076	0.0444	0.1306
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0243	0.175	0.5148
Giardia lamblia	Cathepsin L-like protease	0.0076	0.0444	0.1306
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0243	0.175	1
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0076	0.0444	0.1306
Brugia malayi	Hypothetical tyrosinase-like protein C02C2.1 in chromosome III	0.0199	0.1411	0.1411
Giardia lamblia	Cysteine protease	0.0076	0.0444	0.1306
Plasmodium vivax	serine-repeat antigen 5 (SERA)	0.0076	0.0444	0.2538
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0076	0.0444	0.2538
Entamoeba histolytica	cysteine proteinase, putative	0.0243	0.175	0.8188
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0444	0.0444
Mycobacterium tuberculosis	Probable fructose-bisphosphate aldolase Fba	0.0143	0.0969	0.3881
Plasmodium vivax	unspecified product	0.0068	0.0382	0.2185
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0243	0.175	0.175
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0076	0.0444	0.1306
Giardia lamblia	Cathepsin B precursor	0.0454	0.34	1
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0175	0.1221	0.1221
Onchocerca volvulus		0.0199	0.1411	0.7404
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0243	0.175	0.5148
Giardia lamblia	Cathepsin L precursor	0.0076	0.0444	0.1306
Brugia malayi	Cathepsin L-like precursor	0.0175	0.1221	0.1221
Toxoplasma gondii	cathepsin CPC2	0.0076	0.0444	0.1306
Onchocerca volvulus	Cathepsin F homolog	0.0243	0.175	1
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0444	0.0444
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0243	0.175	0.5148
Leishmania major	cysteine peptidase A (CPA)	0.0243	0.175	0.5148
Leishmania major	cathepsin L-like protease	0.0243	0.175	0.5148
Entamoeba histolytica	cysteine protease, putative	0.0143	0.0974	0.4555
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0243	0.175	0.5148
Plasmodium falciparum	serine repeat antigen 7	0.0076	0.0444	0.2538
Plasmodium vivax	serine-repeat antigen 2 (SERA)	0.0076	0.0444	0.2538
Brugia malayi	RNA binding protein	0.0063	0.0348	0.0348
Schistosoma mansoni	cathepsin F (C01 family)	0.0243	0.175	0.175
Echinococcus granulosus	cathepsin b	0.1298	1	1
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0076	0.0444	0.0444
Schistosoma mansoni	cathepsin F (C01 family)	0.0243	0.175	0.175
Giardia lamblia	Cysteine protease	0.0076	0.0444	0.1306
Loa Loa (eye worm)	ctsf protein	0.0243	0.175	0.175
Mycobacterium leprae	Probable fructose bisphosphate aldolase Fba	0.0143	0.0969	0.5
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.1298	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0076	0.0444	0.1306
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0243	0.175	0.5148
Loa Loa (eye worm)	hypothetical protein	0.0199	0.1411	0.1411
Loa Loa (eye worm)	hypothetical protein	0.0175	0.1221	0.1221
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0076	0.0444	0.0444
Schistosoma mansoni	tyrosinase precursor	0.0199	0.1411	0.1411
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0243	0.175	0.5148
Mycobacterium tuberculosis	Probable oxidoreductase	0.0338	0.2496	1
Schistosoma mansoni	cathepsin B (C01 family)	0.0076	0.0444	0.0444
Giardia lamblia	Cathepsin L-like protease	0.0076	0.0444	0.1306
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0243	0.175	0.5148
Brugia malayi	TAR-binding protein	0.0063	0.0348	0.0348
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.1298	1	1
Trypanosoma cruzi	cysteine proteinase, putative	0.0143	0.0974	0.0974
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0444	0.0444
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0143	0.0974	0.2864
Plasmodium vivax	serine-repeat antigen 3 (SERA)	0.0076	0.0444	0.2538
Entamoeba histolytica	cysteine protease, putative	0.0143	0.0974	0.4555
Brugia malayi	cathepsin F-like cysteine proteinase	0.0068	0.0382	0.0382
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.0348	0.0348
Plasmodium vivax	dipeptidyl aminopeptidase 2, putative	0.0076	0.0444	0.2538
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0243	0.175	0.5148
Giardia lamblia	Cathepsin B precursor	0.0076	0.0444	0.1306
Entamoeba histolytica	cysteine proteinase 1, putative	0.0143	0.0974	0.4555
Entamoeba histolytica	cysteine protease, putative	0.0076	0.0444	0.2078
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0068	0.0382	0.0382
Entamoeba histolytica	hypothetical protein	0.0076	0.0444	0.2078
Brugia malayi	Hypothetical tyrosinase-like protein C02C2.1 in chromosome III	0.0199	0.1411	0.1411
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1298	1	1
Brugia malayi	Papain family cysteine protease containing protein	0.0243	0.175	0.175
Entamoeba histolytica	cysteine protease, putative	0.0143	0.0974	0.4555
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0243	0.175	0.5148
Leishmania major	cathepsin L-like protease	0.0243	0.175	0.5148
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0076	0.0444	0.0444
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0243	0.175	0.5148
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0454	0.34	1
Trichomonas vaginalis	conserved hypothetical protein	0.0076	0.0444	0.1306
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0076	0.0444	0.0444
Plasmodium vivax	unspecified product	0.0143	0.0974	0.5563
Plasmodium falciparum	serine repeat antigen 9	0.0076	0.0444	0.2538
Plasmodium vivax	serine-repeat antigen (SERA)	0.0076	0.0444	0.2538
Loa Loa (eye worm)	hypothetical protein	0.0199	0.1411	0.1411
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0076	0.0444	0.1306
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0243	0.175	0.5148
Giardia lamblia	Cysteine protease	0.0076	0.0444	0.1306
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1298	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0243	0.175	0.5148
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0243	0.175	0.5148
Trypanosoma cruzi	cruzipain precursor, putative	0.0068	0.0382	0.0382
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0382	0.0382
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0243	0.175	0.5148
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0076	0.0444	0.1306
Trypanosoma cruzi	cruzipain precursor, putative	0.0243	0.175	0.175
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0382	0.0382
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.0348	0.0348
Schistosoma mansoni	cathepsin F (C01 family)	0.0175	0.1221	0.1221
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0292	0.2137	0.6287
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0243	0.175	0.5148
Giardia lamblia	Cathepsin L precursor	0.0076	0.0444	0.1306
Echinococcus multilocularis	cysteine protease	0.0243	0.175	0.175
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0076	0.0444	0.0444
Brugia malayi	Cathepsin L-like precursor	0.0243	0.175	0.175
Plasmodium vivax	serine-repeat antigen (SERA)	0.0076	0.0444	0.2538
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0243	0.175	0.5148
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0076	0.0444	0.2538
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0076	0.0444	0.1306
Plasmodium vivax	serine-repeat antigen 4 (SERA), putative	0.0076	0.0444	0.2538
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0243	0.175	0.175
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0076	0.0444	0.1306
Brugia malayi	cathepsin L precursor	0.0076	0.0444	0.0444
Trypanosoma cruzi	cysteine peptidase, putative	0.0143	0.0974	0.0974
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0292	0.2137	0.6287
Entamoeba histolytica	cysteine protease, putative	0.0076	0.0444	0.2078
Brugia malayi	fibroinase precursor	0.0076	0.0444	0.0444
Entamoeba histolytica	cysteine protease, putative	0.0143	0.0974	0.4555
Leishmania major	cathepsin L-like protease	0.0243	0.175	0.5148
Plasmodium vivax	vivapain-2	0.0243	0.175	1
Plasmodium falciparum	serine repeat antigen 5	0.0076	0.0444	0.2538
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0143	0.0974	0.0974
Loa Loa (eye worm)	hypothetical protein	0.0243	0.175	0.175
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0243	0.175	0.5148
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0243	0.175	0.5148
Trypanosoma cruzi	cysteine peptidase, putative	0.0243	0.175	0.175
Plasmodium vivax	vivapain-2	0.0243	0.175	1
Echinococcus multilocularis	cathepsin L	0.0076	0.0444	0.0444
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0243	0.175	0.5148
Plasmodium falciparum	dipeptidyl aminopeptidase 1	0.0076	0.0444	0.2538
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0243	0.175	0.5148
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0243	0.175	0.5148
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.0348	0.0348
Brugia malayi	Cathepsin L-like precursor	0.0243	0.175	0.175
Mycobacterium ulcerans	fructose-bisphosphate aldolase	0.0143	0.0969	0.3881
Entamoeba histolytica	cysteine protease, putative	0.0143	0.0974	0.4555
Trypanosoma cruzi	major cysteine proteinase, putative	0.0076	0.0444	0.0444
Trichomonas vaginalis	Clan CA, family C1, cathepsin H-like cysteine peptidase	0.0076	0.0444	0.1306
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0444	0.0444
Echinococcus granulosus	cathepsin L cysteine protease	0.0143	0.0974	0.0974
Trichomonas vaginalis	conserved hypothetical protein	0.0076	0.0444	0.1306
Brugia malayi	Hypothetical tyrosinase-like protein C02C2.1 in chromosome III	0.0199	0.1411	0.1411
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0243	0.175	0.5148
Giardia lamblia	Cathepsin B precursor	0.0076	0.0444	0.1306
Trypanosoma cruzi	major cysteine proteinase, putative	0.0076	0.0444	0.0444
Entamoeba histolytica	cysteine proteinase 2	0.0143	0.0974	0.4555
Onchocerca volvulus		0.0243	0.175	1
Loa Loa (eye worm)	cysteine protease	0.0243	0.175	0.175
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0243	0.175	1
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0243	0.175	0.175
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0243	0.175	0.5148
Loa Loa (eye worm)	cathepsin B	0.0454	0.34	0.34
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0292	0.2137	0.6287
Loa Loa (eye worm)	TAR-binding protein	0.0063	0.0348	0.0348
Loa Loa (eye worm)	hypothetical protein	0.1298	1	1
Plasmodium falciparum	serine repeat antigen 8	0.0076	0.0444	0.2538
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0076	0.0444	0.1306
Leishmania major	cathepsin L-like protease	0.0243	0.175	0.5148
Echinococcus granulosus	cathepsin b	0.1298	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0243	0.175	0.5148
Brugia malayi	Papain family cysteine protease containing protein	0.0143	0.0974	0.0974
Entamoeba histolytica	cysteine protease, putative	0.0143	0.0974	0.4555
Plasmodium vivax	dipeptidyl aminopeptidase 1, putative	0.0076	0.0444	0.2538
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0076	0.0444	0.0444
Giardia lamblia	Cathepsin L precursor	0.0076	0.0444	0.1306
Entamoeba histolytica	cysteine protease, putative	0.0143	0.0974	0.4555
Brugia malayi	cathepsin L-like precursor	0.0175	0.1221	0.1221
Onchocerca volvulus		0.0199	0.1411	0.7404
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0175	0.1221	0.3591
Giardia lamblia	Cathepsin B precursor	0.0076	0.0444	0.1306
Loa Loa (eye worm)	tyrosinase 1	0.0199	0.1411	0.1411
Plasmodium falciparum	serine repeat antigen 2	0.0076	0.0444	0.2538
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0063	0.0348	0.0348
Toxoplasma gondii	cathepsin B	0.0454	0.34	1
Entamoeba histolytica	cysteine proteinase, putative	0.0175	0.1221	0.5711
Brugia malayi	ShTK domain containing protein	0.0199	0.1411	0.1411
Entamoeba histolytica	cysteine protease, putative	0.0143	0.0974	0.4555
Onchocerca volvulus		0.0243	0.175	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0076	0.0444	0.1306
Echinococcus granulosus	tar DNA binding protein	0.0063	0.0348	0.0348
Plasmodium vivax	unspecified product	0.0076	0.0444	0.2538
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0292	0.2137	0.6287
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0076	0.0444	0.1306
Onchocerca volvulus		0.0243	0.175	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0243	0.175	0.5148
Trypanosoma cruzi	cysteine protease, putative	0.0143	0.0974	0.0974
Entamoeba histolytica	cysteine proteinase, putative	0.0143	0.0974	0.4555
Brugia malayi	Papain family cysteine protease containing protein	0.0076	0.0444	0.0444
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0143	0.0974	0.2864
Entamoeba histolytica	cysteine protease, putative	0.0143	0.0974	0.4555
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0243	0.175	0.5148
Giardia lamblia	Cathepsin L precursor	0.0076	0.0444	0.1306
Echinococcus granulosus	cathepsin l1	0.0175	0.1221	0.1221
Plasmodium vivax	vivapain-3	0.0143	0.0974	0.5563
Trypanosoma cruzi	cysteine peptidase, putative	0.0068	0.0382	0.0382
Onchocerca volvulus		0.0243	0.175	1
Onchocerca volvulus	Cathepsin L homolog	0.0243	0.175	1
Onchocerca volvulus		0.0199	0.1411	0.7404
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0444	0.0444
Loa Loa (eye worm)	ShTK domain-containing protein	0.0199	0.1411	0.1411
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0454	0.34	1
Entamoeba histolytica	cysteine protease, putative	0.0143	0.0974	0.4555
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0076	0.0444	0.2078
Brugia malayi	Cathepsin L-like precursor	0.0175	0.1221	0.1221
Plasmodium falciparum	serine repeat antigen 4	0.0076	0.0444	0.2538
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0076	0.0444	0.1306
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0292	0.2137	1
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0382	0.0382
Giardia lamblia	Cathepsin B precursor	0.0076	0.0444	0.1306
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0243	0.175	0.175
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0243	0.175	0.5148
Echinococcus multilocularis	cathepsin L cysteine protease	0.0243	0.175	0.175
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0454	0.34	0.34
Leishmania major	cathepsin L-like protease	0.0243	0.175	0.5148
Schistosoma mansoni	cathepsin C	0.0076	0.0444	0.0444
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0292	0.2137	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0243	0.175	0.5148
Brugia malayi	cathepsin L-like cysteine proteinase	0.0076	0.0444	0.0444
Trichomonas vaginalis	Clan CA, family C1, cathepsin F-like cysteine peptidase	0.0076	0.0444	0.1306
Echinococcus granulosus	cathepsin l1	0.0243	0.175	0.175
Echinococcus multilocularis	cathepsin L cysteine protease	0.0243	0.175	0.175
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.0348	0.0348
Brugia malayi	Hypothetical tyrosinase-like protein F21C3.2 in chromosome I	0.0199	0.1411	0.1411
Loa Loa (eye worm)	hypothetical protein	0.0175	0.1221	0.1221
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0076	0.0444	0.0444
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0292	0.2137	0.6287
Entamoeba histolytica	cysteine protease, putative	0.0076	0.0444	0.2078
Brugia malayi	RNA recognition motif domain containing protein	0.0063	0.0348	0.0348
Onchocerca volvulus		0.0243	0.175	1
Onchocerca volvulus		0.0175	0.1221	0.5946
Echinococcus multilocularis	tar DNA binding protein	0.0063	0.0348	0.0348
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.0348	0.0348
Echinococcus multilocularis	cathepsin b	0.1298	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or H-like cysteine peptidase	0.0076	0.0444	0.1306
Entamoeba histolytica	cysteine proteinase, putative	0.0143	0.0974	0.4555
Toxoplasma gondii	cathepsin CPC1	0.0076	0.0444	0.1306
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0076	0.0444	0.1306
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0243	0.175	0.175
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0076	0.0444	0.0444
Plasmodium falciparum	dipeptidyl aminopeptidase 3	0.0076	0.0444	0.2538
Schistosoma mansoni	cathepsin s	0.0068	0.0382	0.0382
Toxoplasma gondii	cathepsin CPL	0.0243	0.175	0.5148
Brugia malayi	Common central domain of tyrosinase family protein	0.0199	0.1411	0.1411
Onchocerca volvulus	Cathepsin L homolog	0.0243	0.175	1
Entamoeba histolytica	cysteine protease, putative	0.0243	0.175	0.8188
Entamoeba histolytica	cysteine protease, putative	0.0143	0.0974	0.4555
Giardia lamblia	Hypothetical protein	0.0076	0.0444	0.1306
Onchocerca volvulus		0.0243	0.175	1
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.0076	0.0444	0.0444
Entamoeba histolytica	cysteine protease, putative	0.0143	0.0974	0.4555
Brugia malayi	Papain family cysteine protease containing protein	0.0076	0.0444	0.0444
Echinococcus granulosus	cathepsin L	0.0076	0.0444	0.0444
Plasmodium falciparum	serine repeat antigen 3	0.0076	0.0444	0.2538
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0143	0.0974	0.0974
Giardia lamblia	Cathepsin L precursor	0.0076	0.0444	0.1306
Plasmodium vivax	dipeptidyl aminopeptidase 3, putative	0.0076	0.0444	0.2538
Loa Loa (eye worm)	RNA binding protein	0.0063	0.0348	0.0348
Giardia lamblia	Fructose-bisphosphate aldolase	0.0292	0.2137	0.6287
Schistosoma mansoni	cathepsin S (C01 family)	0.0076	0.0444	0.0444
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0292	0.2137	0.6287
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0243	0.175	0.5148
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0076	0.0444	0.0444
Trichomonas vaginalis	Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase	0.0076	0.0444	0.1306
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0019	0	0.5
Toxoplasma gondii	preprocathepsin c precursor, putative	0.0076	0.0444	0.1306
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0175	0.1221	0.3591
Trypanosoma cruzi	cysteine peptidase, putative	0.0243	0.175	0.175
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0143	0.0974	0.2864
Onchocerca volvulus		0.0199	0.1411	0.7404
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0143	0.0974	0.2864
Plasmodium vivax	vivapain-1	0.0143	0.0974	0.5563
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.0076	0.0444	0.0444
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0143	0.0974	0.5563
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0243	0.175	0.175
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0444	0.0444
Entamoeba histolytica	cysteine protease, putative	0.0076	0.0444	0.2078
Giardia lamblia	Cathepsin B precursor	0.0454	0.34	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0143	0.0974	0.0974
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0243	0.175	0.5148
Giardia lamblia	Cysteine protease	0.0076	0.0444	0.1306
Echinococcus granulosus	cathepsin L	0.0143	0.0974	0.0974
Plasmodium vivax	serine-repeat antigen 4 (SERA)	0.0076	0.0444	0.2538
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0243	0.175	0.5148
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0292	0.2137	0.6287
Entamoeba histolytica	cysteine proteinase, putative	0.0243	0.175	0.8188
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0068	0.0382	0.0382
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0243	0.175	0.5148
Plasmodium falciparum	serine repeat antigen 6	0.0076	0.0444	0.2538
Treponema pallidum	fructose-bisphosphate aldolase	0.0292	0.2137	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0076	0.0444	0.1306
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0076	0.0444	0.0444
Brugia malayi	Papain family cysteine protease containing protein	0.0143	0.0974	0.0974
Schistosoma mansoni	tyrosinase precursor	0.0199	0.1411	0.1411
Giardia lamblia	Cathepsin B precursor	0.0076	0.0444	0.1306
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0076	0.0444	0.1306
Brugia malayi	Cathepsin L-like precursor	0.0243	0.175	0.175
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0454	0.34	0.34
Echinococcus multilocularis	cysteine protease	0.0243	0.175	0.175
Giardia lamblia	Cathepsin B precursor	0.0454	0.34	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0076	0.0444	0.0444
Brugia malayi	Cathepsin L-like precursor	0.0243	0.175	0.175
Brugia malayi	cathepsin F-like cysteine proteinase	0.0076	0.0444	0.0444
Brugia malayi	Cathepsin L-like precursor	0.0243	0.175	0.175
Trypanosoma cruzi	cysteine peptidase, putative	0.0243	0.175	0.175
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0292	0.2137	0.6287
Giardia lamblia	Cathepsin B-like cysteine proteinase 3 precursor	0.0076	0.0444	0.1306
Trypanosoma cruzi	cysteine proteinase, putative	0.0143	0.0974	0.0974
Onchocerca volvulus		0.0243	0.175	1
Entamoeba histolytica	cysteine protease, putative	0.0076	0.0444	0.2078
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1298	1	1
Loa Loa (eye worm)	ShTK domain-containing protein	0.0199	0.1411	0.1411
Echinococcus multilocularis	cathepsin b	0.1298	1	1
Plasmodium falciparum	dipeptidyl aminopeptidase 2	0.0076	0.0444	0.2538
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0243	0.175	0.5148
Giardia lamblia	Encystation-specific protease	0.0076	0.0444	0.1306
Entamoeba histolytica	cysteine protease, putative	0.0076	0.0444	0.2078
Leishmania major	cathepsin L-like protease	0.0243	0.175	0.5148
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0175	0.1221	0.1221
Echinococcus granulosus	cysteine protease	0.0143	0.0974	0.0974
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0243	0.175	0.5148
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0143	0.0974	0.0974
Brugia malayi	Papain family cysteine protease containing protein	0.0076	0.0444	0.0444
Trypanosoma cruzi	cysteine peptidase, putative	0.0243	0.175	0.175
Brugia malayi	Cathepsin L-like precursor	0.0068	0.0382	0.0382
Loa Loa (eye worm)	fibroinase	0.0243	0.175	0.175
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0076	0.0444	0.0444
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0243	0.175	0.5148
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0076	0.0444	0.2078
Entamoeba histolytica	cysteine proteinase, putative	0.0143	0.0974	0.4555
Loa Loa (eye worm)	hypothetical protein	0.0175	0.1221	0.1221
Entamoeba histolytica	cysteine proteinase, putative	0.0143	0.0974	0.4555
Giardia lamblia	Cathepsin L precursor	0.0076	0.0444	0.1306
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0243	0.175	1
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0076	0.0444	0.0444
Brugia malayi	Cathepsin L-like precursor	0.0243	0.175	0.175

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 2600 nM	Inhibition of human 11-betaHSD1 by biochemical assay	ChEMBL.	25266782

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3339185

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 932872