TDR Targets

Basic information

Technical information

TDR Targets ID: 938129
Name: (2S,3S,4R,5R)-3,4-dihydroxy-5-[6-[(3-iodophen yl)methylamino]-2-methylaminopurin-9-yl]-N,3- dimethyloxolane-2-carboxamide
MW: 553.354 | Formula: C20H24IN7O4
H donors: 5 H acceptors: 6 LogP: 1.4 Rotable bonds: 7
Rule of 5 violations (Lipinski): 2
SMILES: CNC(=O)[C@H]1O[C@H]([C@@H]([C@]1(C)O)O)n1cnc2c1nc(NC)nc2NCc1cccc(c1)I
InChi: 1S/C20H24IN7O4/c1-20(31)13(29)18(32-14(20)17(30)22-2)28-9-25-12-15(26-19(23-3)27-16(12)28)24-8-10-5-4-6-11(21)7-10/h4-7,9,13-14,18,29,31H,8H2,1-3H3,(H,22,30)(H2,23,24,26,27)/t13-,14+,18+,20-/m0/s1
InChiKey: BCBWBWYAEYYGGB-LOSGSANQSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

(2S,3S,4R,5R)-3,4-dihydroxy-5-[6-[(3-iodophenyl)methylamino]-2-methylamino-purin-9-yl]-N,3-dimethyl-tetrahydrofuran-2-carboxamide
(2S,3S,4R,5R)-3,4-dihydroxy-5-[6-[(3-iodophenyl)methylamino]-2-methylamino-9-purinyl]-N,3-dimethyl-2-tetrahydrofurancarboxamide
(2S,3S,4R,5R)-3,4-dihydroxy-5-[6-[(3-iodobenzyl)amino]-2-methylamino-purin-9-yl]-N,3-dimethyl-tetrahydrofuran-2-carboxamide
(2S,3S,4R,5R)-3,4-dihydroxy-5-[6-[(3-iodophenyl)methylamino]-2-methylamino-purin-9-yl]-N,3-dimethyl-oxolane-2-carboxamide

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	adenosine A3 receptor	Starlite/ChEMBL	References
Homo sapiens	adenosine A2a receptor	Starlite/ChEMBL	References
Bos taurus	Adenosine A1 receptor	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Schistosoma japonicum	ko:K04209 neuropeptide Y receptor, invertebrate, putative	Adenosine A1 receptor	326 aa	318 aa	22.3 %
Brugia malayi	hypothetical protein	Adenosine A1 receptor	326 aa	311 aa	21.9 %
Onchocerca volvulus		Adenosine A1 receptor	326 aa	311 aa	21.9 %
Schistosoma mansoni	neuropeptide receptor	Adenosine A1 receptor	326 aa	314 aa	21.7 %
Schistosoma japonicum	5-hydroxytryptamine receptor 4, putative	Adenosine A1 receptor	326 aa	301 aa	25.6 %
Loa Loa (eye worm)	neuropeptide F receptor	Adenosine A1 receptor	326 aa	316 aa	19.3 %
Echinococcus multilocularis	allatostatin A receptor	Adenosine A1 receptor	326 aa	306 aa	26.1 %
Schistosoma mansoni	opsin-like receptor	Adenosine A1 receptor	326 aa	312 aa	22.1 %
Brugia malayi	follicle stimulating hormone receptor	adenosine A2a receptor	412 aa	336 aa	22.3 %
Echinococcus granulosus	allatostatin A receptor	Adenosine A1 receptor	326 aa	304 aa	25.3 %
Schistosoma mansoni	neuropeptide receptor	Adenosine A1 receptor	326 aa	277 aa	23.8 %
Schistosoma mansoni	opsin-like receptor	Adenosine A1 receptor	326 aa	315 aa	23.8 %
Onchocerca volvulus		Adenosine A1 receptor	326 aa	307 aa	21.2 %
Onchocerca volvulus	Ubiquinol-cytochrome-c reductase complex assembly factor 1 homolog	Adenosine A1 receptor	326 aa	286 aa	22.7 %
Onchocerca volvulus		Adenosine A1 receptor	326 aa	326 aa	20.2 %
Schistosoma japonicum	ko:K04134 cholinergic receptor, invertebrate, putative	Adenosine A1 receptor	326 aa	331 aa	25.7 %
Loa Loa (eye worm)	hypothetical protein	Adenosine A1 receptor	326 aa	296 aa	22.6 %
Schistosoma mansoni	peptide (allatostatin)-like receptor	Adenosine A1 receptor	326 aa	312 aa	24.0 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Onchocerca volvulus		0.0039	0.0059	0.0238
Echinococcus granulosus	cpg binding protein	0.0034	0.0047	0.0282
Brugia malayi	histone deacetylase 3 (HD3)	0.032	0.0732	1
Echinococcus multilocularis	cpg binding protein	0.0034	0.0047	0.0282
Schistosoma mansoni	cpg binding protein	0.0034	0.0047	0.0282
Mycobacterium tuberculosis	Mycothiol conjugate amidase Mca (mycothiol S-conjugate amidase)	0.4137	0.9887	1
Schistosoma mansoni	histone deacetylase 1 2 3	0.0135	0.0289	0.1873
Trichomonas vaginalis	NAD dependent epimerase/dehydratase, putative	0.0053	0.0092	0.1168
Leishmania major	modification methylase-like protein	0.002	0.0013	0.0084
Brugia malayi	CXXC zinc finger family protein	0.0034	0.0047	0.0644
Trichomonas vaginalis	histone deacetylase, putative	0.032	0.0732	1
Trichomonas vaginalis	histone deacetylase, putative	0.032	0.0732	1
Toxoplasma gondii	histone deacetylase HDAC5	0.0135	0.0289	0.3889
Toxoplasma gondii	hypothetical protein	0.0087	0.0173	0.2285
Entamoeba histolytica	DNA (cytosine-5)-methyltransferase, putative	0.002	0.0013	0.0084
Echinococcus granulosus	neuroglian	0.0021	0.0014	0.0067
Schistosoma mansoni	histone deacetylase hda2	0.0291	0.0662	0.4327
Mycobacterium tuberculosis	N-acetyl-1-D-myo-inosityl-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase MshB (GlcNAc-Ins deacetylase)	0.0047	0.0078	0.0071
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0027	0.0316
Loa Loa (eye worm)	histone deacetylase 11	0.0135	0.0289	0.3914
Brugia malayi	Fibronectin type III domain containing protein	0.0017	0.0004	0.0059
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0017	0.0004	0.0059
Schistosoma mansoni	cell adhesion molecule	0.0022	0.0017	0.0085
Onchocerca volvulus	Tyrosine kinase homolog	0.0251	0.0566	1
Loa Loa (eye worm)	histone deacetylase 3	0.032	0.0732	1
Toxoplasma gondii	histone deacetylase HDAC2	0.032	0.0732	1
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0019	0.0207
Trypanosoma cruzi	histone deacetylase, putative	0.0278	0.0632	0.8628
Trypanosoma cruzi	PAB1-binding protein , putative	0.0023	0.0019	0.0168
Loa Loa (eye worm)	hypothetical protein	0.0156	0.0338	0.4584
Plasmodium vivax	N-acetylglucosaminylphosphatidylinositol deacetylase, putative	0.0047	0.0078	0.0971
Toxoplasma gondii	histone deacetylase HDAC3	0.032	0.0732	1
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0039	0.0471
Giardia lamblia	Histone deacetylase	0.032	0.0732	1
Loa Loa (eye worm)	phosphatidylinositol glycan anchor biosynthesis protein	0.0047	0.0078	0.1007
Brugia malayi	exodeoxyribonuclease III family protein	0.0018	0.0007	0.0099
Echinococcus multilocularis	DNA methyltransferase 2, putative	0.002	0.0013	0.0059
Schistosoma mansoni	hypothetical protein	0.0031	0.0039	0.0226
Trypanosoma brucei	N-acetyl-D-glucosaminylphosphatidylinositol de-N-acetylase	0.0047	0.0078	0.0971
Brugia malayi	histone deacetylase 11	0.0135	0.0289	0.3949
Echinococcus multilocularis	disco interacting protein 2	0.0039	0.0059	0.0363
Entamoeba histolytica	UDP-glucose 4-epimerase, putative	0.0053	0.0092	0.1168
Trichomonas vaginalis	histone deacetylase 1, 2 ,3, putative	0.032	0.0732	1
Leishmania major	udp-glc 4-epimerase, putative	0.0051	0.0087	0.1106
Loa Loa (eye worm)	histone deacetylase 1	0.032	0.0732	1
Trypanosoma cruzi	UDP-galactose 4-epimerase	0.0053	0.0092	0.1168
Schistosoma mansoni	DNA (cytosine-5)-methyltransferase	0.002	0.0013	0.0059
Plasmodium vivax	DNA (cytosine-5)-methyltransferase, putative	0.002	0.0013	0.0084
Plasmodium vivax	histone deacetylase 1, putative	0.032	0.0732	1
Loa Loa (eye worm)	histone deacetylase	0.0278	0.0632	0.8634
Entamoeba histolytica	glucosamine-6-phosphate isomerase, putative	0.0047	0.0078	0.0971
Leishmania major	histone deacetylase, putative	0.0278	0.0632	0.8628
Entamoeba histolytica	N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase, putative	0.0047	0.0078	0.0971
Echinococcus granulosus	histone deacetylase 8	0.0135	0.0289	0.1873
Plasmodium falciparum	N-acetylglucosaminylphosphatidylinositol deacetylase, putative	0.0047	0.0078	0.0971
Trypanosoma cruzi	UDP-galactose 4-epimerase, putative	0.0053	0.0092	0.1168
Leishmania major	N-acetyl-D-acetylglucosaminylphosphatidylinositol deacetylase	0.0047	0.0078	0.0971
Trypanosoma brucei	histone deacetylase 1	0.032	0.0732	1
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0018	0.0007	0.0019
Schistosoma mansoni	histone deacetylase hda2	0.0135	0.0289	0.1873
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0045	0.0073	0.0995
Plasmodium vivax	histone deacetylase, putative	0.0278	0.0632	0.8628
Echinococcus granulosus	microtubule associated protein 2	0.065	0.1524	1
Mycobacterium ulcerans	N-acetyl-1-D-myo-inosityl-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase MshB	0.0047	0.0078	0.007
Plasmodium vivax	histone deacetylase, putative	0.0135	0.0289	0.3889
Echinococcus multilocularis	histone deacetylase 8	0.0135	0.0289	0.1873
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0018	0.0007	0.004
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0059	0.0758
Trichomonas vaginalis	glucosamine-6-phosphate isomerase, putative	0.0047	0.0078	0.0971
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0268	0.0608	0.8301
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0087	0.0173	0.2285
Leishmania major	hypothetical protein, conserved	0.0023	0.0019	0.0168
Onchocerca volvulus	Histone deacetylase 10 homolog	0.0135	0.0289	0.4664
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0018	0.0007	0.5
Echinococcus multilocularis	histone deacetylase 6	0.0291	0.0662	0.4327
Echinococcus multilocularis	histone deacetylase 3	0.032	0.0732	0.4786
Echinococcus granulosus	DNA methyltransferase 2, putative	0.002	0.0013	0.0059
Echinococcus multilocularis	roundabout 2	0.0026	0.0027	0.0151
Brugia malayi	hypothetical protein	0.0023	0.0019	0.0265
Entamoeba histolytica	histone deacetylase, putative	0.032	0.0732	1
Plasmodium vivax	ataxin-2 like protein, putative	0.0023	0.0019	0.0168
Trichomonas vaginalis	histone deacetylase 1, 2 ,3, putative	0.032	0.0732	1
Trypanosoma cruzi	N-Acetyl-D-glucosaminylphosphatidylinositol de-N-acetylase, putative	0.0047	0.0078	0.0971
Echinococcus granulosus	histone deacetylase 1	0.032	0.0732	0.4786
Echinococcus multilocularis	neuroglian	0.0021	0.0014	0.0067
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0018	0.0007	0.5
Giardia lamblia	Glucosamine-6-phosphate isomerase, putative	0.0047	0.0078	0.0971
Schistosoma mansoni	histone deacetylase 4 5	0.0278	0.0632	0.4132
Brugia malayi	hypothetical protein	0.0017	0.0004	0.0059
Brugia malayi	latrophilin 2 splice variant baaae	0.0031	0.0039	0.0528
Echinococcus multilocularis	histone deacetylase	0.0278	0.0632	0.4132
Echinococcus multilocularis	UDP glucose 4 epimerase	0.0053	0.0092	0.0576
Echinococcus multilocularis	microtubule associated protein 2	0.065	0.1524	1
Trypanosoma brucei	histone deacetylase 4	0.0278	0.0632	0.8628
Trichomonas vaginalis	histone deacetylase 1, 2 ,3, putative	0.032	0.0732	1
Echinococcus multilocularis	histone deacetylase 1	0.032	0.0732	0.4786
Echinococcus granulosus	neurotracting:lsamp:neurotrimin:obcam	0.0022	0.0017	0.0085
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0027	0.0316
Schistosoma mansoni	histone deacetylase	0.032	0.0732	0.4786
Mycobacterium ulcerans	mycothiol conjugate amidase Mca	0.4184	1	1
Echinococcus granulosus	roundabout 2	0.0026	0.0027	0.0151
Leishmania major	histone deacetylase, putative	0.0278	0.0632	0.8628
Loa Loa (eye worm)	UDP galactose 4'-epimerase	0.0053	0.0092	0.1203
Trypanosoma cruzi	histone deacetylase, putative	0.0135	0.0289	0.3889
Echinococcus multilocularis	histone deacetylase 6	0.0278	0.0632	0.4132
Trypanosoma brucei	histone deacetylase, putative	0.0278	0.0632	0.8628
Echinococcus multilocularis	histone deacetylase 7	0.0278	0.0632	0.4132
Trichomonas vaginalis	histone deacetylase, putative	0.032	0.0732	1
Schistosoma mansoni	ap endonuclease	0.0018	0.0007	0.0019
Leishmania major	histone deacetylase, putative	0.032	0.0732	1
Leishmania major	histone deacetylase, putative	0.032	0.0732	1
Trypanosoma cruzi	histone deacetylase, putative	0.0278	0.0632	0.8628
Loa Loa (eye worm)	histone deacetylase 7A	0.0278	0.0632	0.8634
Toxoplasma gondii	histone deacetylase HDAC1	0.0278	0.0632	0.8628
Trypanosoma brucei	PAB1-binding protein , putative	0.0023	0.0019	0.0168
Trypanosoma brucei	histone deacetylase 3	0.0278	0.0632	0.8628
Schistosoma mansoni	ap endonuclease	0.0018	0.0007	0.0019
Toxoplasma gondii	C-5 cytosine-specific DNA methylase superfamily protein	0.002	0.0013	0.0084
Plasmodium falciparum	ataxin-2 like protein, putative	0.0023	0.0019	0.0168
Toxoplasma gondii	UDP-glucose 4-epimerase	0.0053	0.0092	0.1168
Trypanosoma cruzi	histone deacetylase 1, putative	0.032	0.0732	1
Echinococcus granulosus	histone deacetylase 7	0.0278	0.0632	0.4132
Trypanosoma cruzi	PAB1-binding protein , putative	0.0023	0.0019	0.0168
Trichomonas vaginalis	histone deacetylase, putative	0.032	0.0732	1
Schistosoma mansoni	histone deacetylase	0.032	0.0732	0.4786
Schistosoma mansoni	microtubule-associated protein tau	0.065	0.1524	1
Plasmodium falciparum	DNA (cytosine-5)-methyltransferase	0.002	0.0013	0.0084
Schistosoma mansoni	cpg binding protein	0.0034	0.0047	0.0282
Brugia malayi	Histone deacetylase family protein	0.0278	0.0632	0.8642
Onchocerca volvulus		0.0245	0.0552	0.9736
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0073	0.0942
Loa Loa (eye worm)	hypothetical protein	0.0143	0.0308	0.4176
Trypanosoma cruzi	histone deacetylase, putative	0.0278	0.0632	0.8628
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0268	0.0608	0.8311
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0045	0.0073	0.0995
Giardia lamblia	UDP-glucose 4-epimerase	0.0051	0.0087	0.1106
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0034	0.0047	0.0588
Echinococcus granulosus	histone deacetylase 3	0.032	0.0732	0.4786
Echinococcus granulosus	histone deacetylase 6	0.0291	0.0662	0.4327
Echinococcus granulosus	histone deacetylase 6	0.0278	0.0632	0.4132
Loa Loa (eye worm)	hypothetical protein	0.032	0.0732	1
Brugia malayi	UDP galactose 4'-epimerase	0.0053	0.0092	0.1255
Brugia malayi	Uncharacterized LmbE-like protein, COG2120 containing protein	0.0047	0.0078	0.106
Schistosoma mansoni	disco-interacting protein 2 (dip2)	0.0039	0.0059	0.0363
Plasmodium falciparum	histone deacetylase, putative	0.0278	0.0632	0.8628
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0018	0.0007	0.0019
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0045	0.0073	0.0942
Echinococcus granulosus	disco interacting protein 2	0.0039	0.0059	0.0363
Plasmodium falciparum	histone deacetylase 1	0.032	0.0732	1
Toxoplasma gondii	histone deacetylase HDAC4	0.0135	0.0289	0.3889
Schistosoma mansoni	cpg binding protein	0.0034	0.0047	0.0282
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0047	0.0078	0.0071
Echinococcus multilocularis	N acetylglucosaminyl phosphatidylinositol	0.0047	0.0078	0.0482
Echinococcus multilocularis	histone deacetylase 6	0.0278	0.0632	0.4132
Plasmodium falciparum	ataxin-2 like protein, putative	0.0023	0.0019	0.0168
Trypanosoma brucei	UDP-galactose 4-epimerase	0.0051	0.0087	0.1106
Plasmodium vivax	histone deacetylase 2, putative	0.0278	0.0632	0.8628
Trypanosoma cruzi	histone deacetylase 1, putative	0.032	0.0732	1
Trypanosoma brucei	histone deacetylase 2	0.0135	0.0289	0.3889
Echinococcus granulosus	N acetylglucosaminyl phosphatidylinositol	0.0047	0.0078	0.0482
Echinococcus granulosus	histone deacetylase	0.0278	0.0632	0.4132
Plasmodium falciparum	histone deacetylase 2	0.0278	0.0632	0.8628
Toxoplasma gondii	N-acetylglucosaminylphosphatidylinositol deacetylase	0.0047	0.0078	0.0971
Brugia malayi	Disco-interacting protein 2 homolog	0.0039	0.0059	0.0812
Toxoplasma gondii	LsmAD domain-containing protein	0.0023	0.0019	0.0168
Toxoplasma gondii	DNA methyltransferase 2, putative	0.002	0.0013	0.0084
Schistosoma mansoni	N-acetylglucosaminyl-phosphatidylinositol de-n-acetylase	0.0047	0.0078	0.0482
Trichomonas vaginalis	histone deacetylase, putative	0.032	0.0732	1
Trypanosoma brucei	cytosine-specific DNA methylase, putative	0.002	0.0013	0.0084
Brugia malayi	Histone deacetylase 1	0.032	0.0732	1
Trichomonas vaginalis	histone deacetylase, putative	0.032	0.0732	1
Trypanosoma cruzi	N-Acetyl-D-glucosaminylphosphatidylinositol de-N-acetylase, putative	0.0047	0.0078	0.0971
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0017	0.0177
Loa Loa (eye worm)	hypothetical protein	0.0135	0.0289	0.3914
Trichomonas vaginalis	UDP-glucose 4-epimerase, putative	0.0053	0.0092	0.1168
Echinococcus granulosus	histone deacetylase 6	0.0278	0.0632	0.4132
Trypanosoma cruzi	histone deacetylase, putative	0.0135	0.0289	0.3889
Brugia malayi	histone deacetylase 1 (HD1)	0.032	0.0732	1
Echinococcus granulosus	twitchin	0.0021	0.0014	0.0067
Schistosoma mansoni	UDP-glucose 4-epimerase	0.0053	0.0092	0.0576
Brugia malayi	Histone deacetylase family protein	0.0278	0.0632	0.8642
Schistosoma mansoni	nephrin	0.0021	0.0014	0.0067
Trichomonas vaginalis	NAD dependent epimerase/dehydratase, putative	0.0053	0.0092	0.1168
Schistosoma mansoni	histone deacetylase 4 5	0.0278	0.0632	0.4132
Echinococcus granulosus	UDP glucose 4 epimerase	0.0053	0.0092	0.0576

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	= 1200 nM	Displacement of [125I]-AB-MECA from adenosine A3 receptors in bovine cortical membranes	ChEMBL.	15743197
Ki (binding)	= 1310 nM	Displacement of [3H]-DPCPX binding to adenosine A1 receptors of bovine cortical membranes	ChEMBL.	15743197
Ki (binding)	= 4000 nM	Displacement of [3H]-CGS-21,680 binding to adenosine A2A receptors of bovine striatal membranes	ChEMBL.	15743197

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2113640

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 938129