Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | thromboxane A synthase 1 (platelet) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | cytochrome P450, putative | thromboxane A synthase 1 (platelet) | 534 aa | 498 aa | 21.5 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | acyl-CoA desaturase | 0.1025 | 0.7875 | 1 |
Mycobacterium ulcerans | electron transfer protein FdxB | 0.0271 | 0.1957 | 1 |
Trypanosoma cruzi | delta-4 fatty acid desaturase, putative | 0.0271 | 0.1957 | 0.1957 |
Toxoplasma gondii | sphingolipid delta 4 desaturase/c-4 hydroxylase protein des2 family protein | 0.0271 | 0.1957 | 0.5 |
Trypanosoma brucei | delta-4 fatty acid desaturase | 0.0271 | 0.1957 | 0.1957 |
Trypanosoma cruzi | delta-4 fatty acid desaturase, putative | 0.0271 | 0.1957 | 0.1957 |
Mycobacterium ulcerans | transmembrane alkane 1-monooxygenase AlkB | 0.0271 | 0.1957 | 1 |
Echinococcus multilocularis | Fatty acid desaturase, type 1 | 0.0271 | 0.1957 | 0.5 |
Mycobacterium ulcerans | linoleoyl-CoA desaturase, DesA3 | 0.0271 | 0.1957 | 1 |
Leishmania major | delta-4 fatty acid desaturase | 0.0271 | 0.1957 | 0.1957 |
Trypanosoma brucei | cytochrome b5-dependent oleate desaturase | 0.0271 | 0.1957 | 0.1957 |
Leishmania major | fatty acid desaturase, putative | 0.0271 | 0.1957 | 0.1957 |
Trypanosoma cruzi | cytochrome b5-dependent oleate desaturase | 0.0271 | 0.1957 | 0.1957 |
Leishmania major | fatty acid desaturase, putative | 0.0271 | 0.1957 | 0.1957 |
Loa Loa (eye worm) | hypothetical protein | 0.0271 | 0.1957 | 0.2485 |
Trypanosoma cruzi | sphingolipid delta 4 desaturase, putative | 0.0271 | 0.1957 | 0.1957 |
Echinococcus multilocularis | Peptidase M, neutral zinc metallopeptidases, zinc binding site | 0.0271 | 0.1957 | 0.5 |
Leishmania major | fatty acid desaturase, putative,sphingolipid delta 4 desaturase, putative | 0.0271 | 0.1957 | 0.1957 |
Loa Loa (eye worm) | acyl-CoA desaturase | 0.1025 | 0.7875 | 1 |
Loa Loa (eye worm) | FAT-3 protein | 0.0271 | 0.1957 | 0.2485 |
Schistosoma mansoni | fatty acid desaturase | 0.0271 | 0.1957 | 0.5 |
Leishmania major | fatty acid desaturase, putative,sphingolipid delta 4 desaturase, putative | 0.0271 | 0.1957 | 0.1957 |
Onchocerca volvulus | 0.1295 | 1 | 1 | |
Brugia malayi | Delta5 fatty acid desaturase | 0.0271 | 0.1957 | 0.2485 |
Mycobacterium tuberculosis | Possible electron transfer protein FdxB | 0.0271 | 0.1957 | 0.5 |
Leishmania major | fatty acid desaturase, putative,sphingolipid delta 4 desaturase, putative | 0.0271 | 0.1957 | 0.1957 |
Brugia malayi | Fatty acid desaturase family protein | 0.0271 | 0.1957 | 0.2485 |
Brugia malayi | Fatty acid desaturase family protein | 0.0271 | 0.1957 | 0.2485 |
Mycobacterium ulcerans | hypothetical protein | 0.0271 | 0.1957 | 1 |
Plasmodium falciparum | stearoyl-CoA desaturase | 0.1025 | 0.7875 | 0.5 |
Leishmania major | delta-12 fatty acid desaturase | 0.0271 | 0.1957 | 0.1957 |
Leishmania major | fatty-acid desaturase, putative | 0.1295 | 1 | 1 |
Mycobacterium tuberculosis | Probable conserved membrane protein | 0.0271 | 0.1957 | 0.5 |
Loa Loa (eye worm) | fatty acid desaturase | 0.0271 | 0.1957 | 0.2485 |
Leishmania major | delta-5 fatty acid desaturase | 0.0271 | 0.1957 | 0.1957 |
Mycobacterium ulcerans | linoleoyl-CoA desaturase, DesA3_2 | 0.0271 | 0.1957 | 1 |
Trypanosoma brucei | sphingolipid delta 4 desaturase, putative | 0.0271 | 0.1957 | 0.1957 |
Mycobacterium ulcerans | linoleoyl-CoA desaturase, DesA3 | 0.0271 | 0.1957 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0271 | 0.1957 | 1 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.0271 | 0.1957 | 0.1957 |
Leishmania major | fatty acid desaturase, putative,sphingolipid delta 4 desaturase, putative | 0.0271 | 0.1957 | 0.1957 |
Leishmania major | delta-6 fatty acid desaturase | 0.0271 | 0.1957 | 0.1957 |
Onchocerca volvulus | 0.1295 | 1 | 1 | |
Plasmodium vivax | stearoyl-CoA desaturase (acyl-CoA desaturase, faty acid desaturase), putative | 0.1025 | 0.7875 | 0.5 |
Trypanosoma brucei | fatty acid desaturase, putative | 0.1295 | 1 | 1 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.1295 | 1 | 1 |
Mycobacterium tuberculosis | Probable transmembrane alkane 1-monooxygenase AlkB (alkane 1-hydroxylase) (lauric acid omega-hydroxylase) (omega-hydroxylase) (f | 0.0271 | 0.1957 | 0.5 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.1025 | 0.7875 | 0.7875 |
Echinococcus granulosus | Sphingolipid delta4 desaturase DES1 | 0.0271 | 0.1957 | 0.5 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.1025 | 0.7875 | 0.7875 |
Loa Loa (eye worm) | fatty acid desaturase | 0.0271 | 0.1957 | 0.2485 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.0271 | 0.1957 | 0.1957 |
Trypanosoma brucei | delta-6 fatty acid desaturase, putative | 0.0271 | 0.1957 | 0.1957 |
Echinococcus multilocularis | Peptidase M, neutral zinc metallopeptidases, zinc binding site | 0.0271 | 0.1957 | 0.5 |
Echinococcus granulosus | Fatty acid desaturase type 1 | 0.0271 | 0.1957 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 2.2 uM | Inhibition of Thromboxane A2 synthase after oral administration of 0.03 mmol/kg | ChEMBL. | 2299629 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.