TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 346.854 | Formula: C18H23ClN4O
H donors: 2 H acceptors: 3 LogP: 4.77 Rotable bonds: 10
Rule of 5 violations (Lipinski): 1
SMILES: CCCCCCCNc1cnc(cn1)C(=O)Nc1ccccc1Cl
InChi: 1S/C18H23ClN4O/c1-2-3-4-5-8-11-20-17-13-21-16(12-22-17)18(24)23-15-10-7-6-9-14(15)19/h6-7,9-10,12-13H,2-5,8,11H2,1H3,(H,20,22)(H,23,24)
InChiKey: LPTBNSNHEIGGHJ-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	kinesin eg-5	0.0818	0.125	0.1438
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0242	0.033	0.038
Brugia malayi	Papain family cysteine protease containing protein	0.0242	0.033	0.1621
Schistosoma mansoni	cathepsin F (C01 family)	0.0877	0.1345	0.1547
Entamoeba histolytica	cysteine proteinase 1, putative	0.0675	0.1022	0.4054
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.131	0.2036	1
Echinococcus granulosus	cathepsin L	0.0675	0.1022	0.0978
Entamoeba histolytica	cysteine protease, putative	0.0675	0.1022	0.4054
Entamoeba histolytica	cysteine protease, putative	0.0675	0.1022	0.4054
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.131	0.2036	1
Entamoeba histolytica	cysteine protease, putative	0.0675	0.1022	0.4054
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0877	0.1345	0.6603
Entamoeba histolytica	cysteine protease, putative	0.0675	0.1022	0.4054
Leishmania major	cathepsin L-like protease	0.131	0.2036	1
Brugia malayi	Papain family cysteine protease containing protein	0.0242	0.033	0.1621
Brugia malayi	Cathepsin L-like precursor	0.131	0.2036	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.131	0.2036	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.131	0.2036	0.1998
Brugia malayi	cathepsin F-like cysteine proteinase	0.0433	0.0636	0.3121
Plasmodium vivax	unspecified product	0.0675	0.1022	0.4054
Brugia malayi	Kinesin motor domain containing protein	0.0818	0.125	0.614
Plasmodium falciparum	cysteine proteinase falcipain 3	0.131	0.2036	1
Brugia malayi	RNA recognition motif domain containing protein	0.0065	0.0048	0.0237
Loa Loa (eye worm)	hypothetical protein	0.0242	0.033	0.1621
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0242	0.033	0.1621
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.131	0.2036	0.1998
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0675	0.1022	0.4054
Plasmodium vivax	unspecified product	0.0433	0.0636	0.1791
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.131	0.2036	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.131	0.2036	1
Plasmodium falciparum	kinesin-5	0.0818	0.125	0.5393
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.131	0.2036	1
Loa Loa (eye worm)	hypothetical protein	0.0242	0.033	0.1621
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.131	0.2036	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.131	0.2036	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0877	0.1345	0.5946
Echinococcus multilocularis	cathepsin L	0.0675	0.1022	0.0978
Loa Loa (eye worm)	hypothetical protein	0.0877	0.1345	0.6603
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.131	0.2036	0.1998
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0242	0.033	0.038
Loa Loa (eye worm)	hypothetical protein	0.0242	0.033	0.1621
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.131	0.2036	1
Brugia malayi	Cathepsin L-like precursor	0.131	0.2036	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.131	0.2036	1
Trypanosoma cruzi	cysteine peptidase, putative	0.131	0.2036	1
Plasmodium vivax	vivapain-3	0.0675	0.1022	0.4054
Entamoeba histolytica	kinesin, putative	0.0818	0.125	0.5393
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0242	0.033	0.1621
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0242	0.033	0.038
Echinococcus multilocularis	cathepsin L	0.0242	0.033	0.0283
Trypanosoma cruzi	cysteine peptidase, putative	0.131	0.2036	1
Trypanosoma cruzi	cysteine proteinase, putative	0.0675	0.1022	0.4054
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0242	0.033	0.038
Brugia malayi	fibroinase precursor	0.0242	0.033	0.1621
Echinococcus multilocularis	cathepsin b	0.0242	0.033	0.0283
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.131	0.2036	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.131	0.2036	1
Loa Loa (eye worm)	cathepsin B	0.0242	0.033	0.1621
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0433	0.0636	0.3121
Entamoeba histolytica	cysteine proteinase, putative	0.131	0.2036	1
Leishmania major	cathepsin L-like protease	0.131	0.2036	1
Entamoeba histolytica	cysteine proteinase, putative	0.0675	0.1022	0.4054
Brugia malayi	Papain family cysteine protease containing protein	0.0675	0.1022	0.5018
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0232	0.0314	0.0268
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0242	0.033	0.1621
Plasmodium vivax	vivapain-1	0.0675	0.1022	0.4054
Brugia malayi	cathepsin L-like precursor	0.0877	0.1345	0.6603
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.131	0.2036	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0675	0.1022	0.1175
Leishmania major	cathepsin L-like protease	0.131	0.2036	1
Loa Loa (eye worm)	hypothetical protein	0.0242	0.033	0.1621
Leishmania major	cathepsin L-like protease	0.131	0.2036	1
Brugia malayi	Cathepsin L-like precursor	0.131	0.2036	1
Entamoeba histolytica	cysteine proteinase, putative	0.0675	0.1022	0.4054
Schistosoma mansoni	cathepsin F (C01 family)	0.131	0.2036	0.2342
Giardia lamblia	Kinesin-5	0.0818	0.125	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0877	0.1345	0.5946
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0242	0.033	0.038
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0242	0.033	0.038
Echinococcus multilocularis	cathepsin b	0.0242	0.033	0.0283
Schistosoma mansoni	cathepsin F (C01 family)	0.131	0.2036	0.2342
Loa Loa (eye worm)	hypothetical protein	0.0877	0.1345	0.6603
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0242	0.033	0.038
Schistosoma mansoni	tar DNA-binding protein	0.0065	0.0048	0.0055
Loa Loa (eye worm)	ctsf protein	0.131	0.2036	1
Plasmodium vivax	vivapain-2	0.131	0.2036	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0242	0.033	0.038
Brugia malayi	Cathepsin L-like precursor	0.0877	0.1345	0.6603
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0065	0.0048	0.0237
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0675	0.1022	0.1175
Schistosoma mansoni	hypothetical protein	0.0175	0.0223	0.0256
Brugia malayi	Papain family cysteine protease containing protein	0.0242	0.033	0.1621
Echinococcus multilocularis	cysteine protease	0.131	0.2036	0.1998
Schistosoma mansoni	hypothetical protein	0.0175	0.0223	0.0256
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.131	0.2036	1
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0232	0.0314	0.1544
Entamoeba histolytica	cysteine proteinase, putative	0.131	0.2036	1
Entamoeba histolytica	cysteine proteinase 2	0.0675	0.1022	0.4054
Onchocerca volvulus		0.0877	0.1345	0.5946
Trypanosoma cruzi	cysteine peptidase, putative	0.0675	0.1022	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.131	0.2036	1
Schistosoma mansoni	cathepsin B (C01 family)	0.0242	0.033	0.038
Onchocerca volvulus		0.131	0.2036	1
Onchocerca volvulus		0.131	0.2036	1
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0051	0.0026	0.0128
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0242	0.033	0.038
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0242	0.033	0.1621
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.131	0.2036	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.131	0.2036	1
Brugia malayi	Papain family cysteine protease containing protein	0.0675	0.1022	0.5018
Onchocerca volvulus	Cathepsin F homolog	0.131	0.2036	1
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0877	0.1345	0.5946
Entamoeba histolytica	cysteine protease, putative	0.0675	0.1022	0.4054
Loa Loa (eye worm)	hypothetical protein	0.0433	0.0636	0.3121
Onchocerca volvulus		0.131	0.2036	1
Loa Loa (eye worm)	RNA binding protein	0.0065	0.0048	0.0237
Leishmania major	cysteine peptidase A (CPA)	0.131	0.2036	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.131	0.2036	1
Leishmania major	cathepsin L-like protease	0.131	0.2036	1
Brugia malayi	Papain family cysteine protease containing protein	0.131	0.2036	1
Entamoeba histolytica	cysteine protease, putative	0.0675	0.1022	0.4054
Loa Loa (eye worm)	hypothetical protein	0.131	0.2036	1
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0221	0.0298	0.0342
Brugia malayi	Cathepsin L-like precursor	0.0433	0.0636	0.3121
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.131	0.2036	1
Onchocerca volvulus		0.131	0.2036	1
Echinococcus multilocularis	kinesin family 1	0.6295	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0675	0.1022	0.4054
Leishmania major	cathepsin L-like protease	0.131	0.2036	1
Echinococcus multilocularis	geminin	0.0175	0.0223	0.0176
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.131	0.2036	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0675	0.1022	0.1175
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.131	0.2036	1
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.131	0.2036	1
Brugia malayi	Cathepsin L-like precursor	0.131	0.2036	1
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0242	0.033	0.1621
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0675	0.1022	0.4054
Entamoeba histolytica	cysteine protease, putative	0.0675	0.1022	0.4054
Onchocerca volvulus		0.131	0.2036	1
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0051	0.0026	0.0128
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0675	0.1022	0.4054
Loa Loa (eye worm)	hypothetical protein	0.0242	0.033	0.1621
Trypanosoma cruzi	cysteine protease, putative	0.0675	0.1022	0.4054
Entamoeba histolytica	cysteine protease, putative	0.0675	0.1022	0.4054
Leishmania major	cathepsin L-like protease	0.131	0.2036	1
Echinococcus granulosus	cathepsin b	0.0242	0.033	0.0283
Trypanosoma cruzi	cysteine peptidase, putative	0.131	0.2036	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.131	0.2036	1
Onchocerca volvulus	Cathepsin L homolog	0.131	0.2036	1
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0051	0.0026	0.0128
Onchocerca volvulus		0.131	0.2036	1
Brugia malayi	RNA binding protein	0.0065	0.0048	0.0237
Leishmania major	cathepsin L-like protease	0.131	0.2036	1
Brugia malayi	TAR-binding protein	0.0065	0.0048	0.0237
Trypanosoma cruzi	cysteine proteinase, putative	0.0675	0.1022	0.4054
Entamoeba histolytica	cysteine protease, putative	0.0675	0.1022	0.4054
Entamoeba histolytica	cysteine protease, putative	0.0675	0.1022	0.4054
Schistosoma mansoni	tar DNA-binding protein	0.0065	0.0048	0.0055
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0242	0.033	0.038
Loa Loa (eye worm)	hypothetical protein	0.0877	0.1345	0.6603
Entamoeba histolytica	cysteine protease, putative	0.0675	0.1022	0.4054
Echinococcus granulosus	cathepsin l1	0.131	0.2036	0.1998
Toxoplasma gondii	kinesin motor domain-containing protein	0.0818	0.125	0.5393
Loa Loa (eye worm)	TAR-binding protein	0.0065	0.0048	0.0237
Schistosoma mansoni	tar DNA-binding protein	0.0065	0.0048	0.0055
Plasmodium vivax	kinesin-5	0.0818	0.125	0.5393
Brugia malayi	cathepsin L precursor	0.0242	0.033	0.1621
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.131	0.2036	1
Echinococcus multilocularis	cysteine protease	0.131	0.2036	0.1998
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.131	0.2036	1
Entamoeba histolytica	cysteine proteinase, putative	0.0877	0.1345	0.5946
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.0242	0.033	0.038
Brugia malayi	cathepsin F-like cysteine proteinase	0.0242	0.033	0.1621
Trypanosoma cruzi	cysteine peptidase, putative	0.131	0.2036	1
Echinococcus granulosus	cathepsin L cysteine proteinase	0.131	0.2036	0.1998
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.131	0.2036	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.131	0.2036	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.131	0.2036	1
Echinococcus granulosus	cathepsin b	0.0242	0.033	0.0283
Onchocerca volvulus	Cathepsin L homolog	0.131	0.2036	1
Brugia malayi	Cathepsin L-like precursor	0.0877	0.1345	0.6603
Schistosoma mansoni	tar DNA-binding protein	0.0065	0.0048	0.0055
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.131	0.2036	1
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0433	0.0636	0.3121
Brugia malayi	Cathepsin L-like precursor	0.131	0.2036	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.131	0.2036	1
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0242	0.033	0.1621
Loa Loa (eye worm)	cysteine protease	0.131	0.2036	1
Onchocerca volvulus		0.131	0.2036	1
Echinococcus granulosus	cathepsin l cysteine peptidase	0.131	0.2036	0.1998
Toxoplasma gondii	cathepsin CPL	0.131	0.2036	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.131	0.2036	1
Schistosoma mansoni	hypothetical protein	0.5477	0.8694	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.131	0.2036	1
Echinococcus granulosus	cathepsin L	0.0242	0.033	0.0283
Trypanosoma cruzi	cruzipain precursor, putative	0.131	0.2036	1
Plasmodium vivax	vivapain-2	0.131	0.2036	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0433	0.0636	0.1791
Loa Loa (eye worm)	hypothetical protein	0.0242	0.033	0.1621
Loa Loa (eye worm)	kinesin-like protein KLP2	0.0818	0.125	0.614
Echinococcus granulosus	cathepsin L cysteine protease	0.0675	0.1022	0.0978
Entamoeba histolytica	cysteine proteinase, putative	0.0675	0.1022	0.4054
Entamoeba histolytica	cysteine protease, putative	0.0675	0.1022	0.4054
Echinococcus granulosus	cathepsin l1	0.0877	0.1345	0.1303
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.131	0.2036	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.131	0.2036	0.1998
Trypanosoma cruzi	cruzipain precursor, putative	0.0433	0.0636	0.1791
Echinococcus granulosus	geminin	0.0175	0.0223	0.0176
Loa Loa (eye worm)	hypothetical protein	0.0433	0.0636	0.3121
Loa Loa (eye worm)	hypothetical protein	0.0433	0.0636	0.3121
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0232	0.0314	0.1544
Entamoeba histolytica	cysteine protease, putative	0.131	0.2036	1
Loa Loa (eye worm)	hypothetical protein	0.0242	0.033	0.1621
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.131	0.2036	1
Brugia malayi	Cathepsin L-like precursor	0.131	0.2036	1
Schistosoma mansoni	tar DNA-binding protein	0.0065	0.0048	0.0055
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0242	0.033	0.038
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.0242	0.033	0.038
Schistosoma mansoni	cathepsin C	0.0242	0.033	0.038
Schistosoma mansoni	cathepsin S (C01 family)	0.0242	0.033	0.038
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0675	0.1022	0.4054
Entamoeba histolytica	cysteine proteinase, putative	0.0675	0.1022	0.4054
Brugia malayi	cathepsin B-like cysteine proteinase	0.0242	0.033	0.1621
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0232	0.0314	0.0268
Brugia malayi	cathepsin L-like cysteine proteinase	0.0242	0.033	0.1621
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.131	0.2036	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.131	0.2036	1
Echinococcus granulosus	cysteine protease	0.0675	0.1022	0.0978
Entamoeba histolytica	cysteine protease, putative	0.0675	0.1022	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.131	0.2036	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.131	0.2036	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0242	0.033	0.038
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0675	0.1022	0.4054
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0026	0.0128
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.131	0.2036	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.131	0.2036	1
Schistosoma mansoni	cathepsin s	0.0433	0.0636	0.0731
Loa Loa (eye worm)	fibroinase	0.131	0.2036	1

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (functional)		Antibacterial activity against Escherichia coli CCM 4517 after 24 to 48 hrs by broth microdilution method	ChEMBL.	25438883
Activity (functional)		Antifungal activity against Candida albicans ATCC 44859 after 24 to 48 hrs by two-fold dilution method	ChEMBL.	25438883
MIC (functional)	= 36 uM	Antimycobacterial activity against Mycobacterium tuberculosis H37Rv CNCTC My 331/88 after 10 to 14 days by AlamarBlue assay	ChEMBL.	25438883

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3355710

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 941889