Detailed information for compound 947292

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 713.265 | Formula: C39H45ClN6O5
  • H donors: 2 H acceptors: 5 LogP: 6.14 Rotable bonds: 16
    Rule of 5 violations (Lipinski): 2
  • SMILES: CCOc1cc(ccc1/C=C/C(=O)OCCN(C)C)NC(=O)C1(CCC1)NC(=O)c1ccc2c(c1)n(C)c(c2C1CCCC1)c1ncc(cn1)Cl
  • InChi: 1S/C39H45ClN6O5/c1-5-50-32-22-29(14-11-25(32)13-16-33(47)51-20-19-45(2)3)43-38(49)39(17-8-18-39)44-37(48)27-12-15-30-31(21-27)46(4)35(34(30)26-9-6-7-10-26)36-41-23-28(40)24-42-36/h11-16,21-24,26H,5-10,17-20H2,1-4H3,(H,43,49)(H,44,48)/b16-13+
  • InChiKey: JPCDVDVGKUAZHS-DTQAZKPQSA-N  


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Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) voltage-gated potassium channel 0.0034 0.0247 0.0247
Echinococcus multilocularis two pore calcium channel protein 1 0.0034 0.0247 0.0247
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0001 0 0.5
Schistosoma mansoni voltage-gated potassium channel KCNQ 0.0034 0.0247 0.0247
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0086 0.0639 0.0639
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0001 0 0.5
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0034 0.0247 0.0247
Schistosoma mansoni voltage-gated potassium channel 0.0034 0.0247 0.0247
Onchocerca volvulus Vesicular acetylcholine transporter homolog 0.1325 1 1
Entamoeba histolytica transporter, major facilitator family 0.0001 0 0.5
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0034 0.0247 0.0247
Echinococcus granulosus voltage gated hydrogen channel 1 0.0034 0.0247 0.0247
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0034 0.0247 0.0247
Echinococcus granulosus transient receptor potential cation channel 0.0034 0.0251 0.0251
Schistosoma mansoni voltage-gated potassium channel 0.0034 0.0247 0.0247
Loa Loa (eye worm) hypothetical protein 0.0034 0.0247 0.0247
Schistosoma mansoni voltage-gated ion channel 0.0034 0.0247 0.0247
Echinococcus granulosus transient receptor potential cation channel 0.0034 0.0247 0.0247
Mycobacterium tuberculosis Probable integral membrane nitrite extrusion protein NarU (nitrite facilitator) 0.0001 0 0.5
Echinococcus multilocularis voltage dependent calcium channel 0.0034 0.0247 0.0247
Schistosoma mansoni calcium-activated potassium channel 0.0034 0.0247 0.0247
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.0034 0.0247 0.0247
Echinococcus multilocularis two pore calcium channel protein 2 0.0034 0.0247 0.0247
Schistosoma mansoni vesicular amine transporter 0.0035 0.0256 0.0256
Loa Loa (eye worm) hypothetical protein 0.0034 0.0247 0.0247
Mycobacterium ulcerans integral membrane protein 0.0001 0 0.5
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0034 0.0247 0.0247
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0034 0.0247 0.0247
Echinococcus multilocularis potassium voltage gated channel protein 0.0034 0.0247 0.0247
Loa Loa (eye worm) hypothetical protein 0.0034 0.0247 0.0247
Mycobacterium tuberculosis Possible conserved integral membrane protein 0.0001 0 0.5
Mycobacterium ulcerans MFS transporter 0.0001 0 0.5
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0365 0.2746 0.2746
Echinococcus multilocularis hyperpolarization activated cyclic 0.0034 0.0247 0.0247
Schistosoma mansoni voltage-gated potassium channel 0.0034 0.0247 0.0247
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0086 0.0639 0.0639
Schistosoma mansoni voltage-gated potassium channel 0.0034 0.0247 0.0247
Echinococcus granulosus voltage gated potassium channel 0.0034 0.0247 0.0247
Brugia malayi Ryanodine Receptor TM 4-6 family protein 0.0034 0.0247 0.0247
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0034 0.0247 0.0247
Schistosoma mansoni voltage-gated potassium channel 0.0034 0.0247 0.0247
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0034 0.0247 1
Echinococcus granulosus potassium voltage gated channel subfamily C 0.0034 0.0247 0.0247
Mycobacterium tuberculosis Probable conserved integral membrane protein 0.0001 0 0.5
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0034 0.0247 0.0247
Toxoplasma gondii hypothetical protein 0.0034 0.0247 1
Schistosoma mansoni voltage-gated potassium channel 0.0034 0.0247 0.0247
Loa Loa (eye worm) hypothetical protein 0.0034 0.0247 0.0247
Loa Loa (eye worm) hypothetical protein 0.0365 0.2746 0.2746
Mycobacterium tuberculosis Possible integral membrane efflux protein EfpA 0.0001 0 0.5
Mycobacterium leprae PROBABLE NITRITE EXTRUSION PROTEIN 1 NARK (NITRITE FACILITATOR 1) 0.0001 0 0.5
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0034 0.0247 0.0247
Brugia malayi cation channel family protein 0.0034 0.0247 0.0247
Echinococcus granulosus calcium activated potassium channel 0.0034 0.0249 0.0249
Echinococcus granulosus two pore calcium channel protein 1 0.0034 0.0247 0.0247
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0034 0.0247 1
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0034 0.0247 0.0247
Mycobacterium ulcerans integral membrane drug efflux protein 0.0001 0 0.5
Mycobacterium ulcerans integral membrane transport protein 0.0001 0 0.5
Echinococcus multilocularis sodium leak channel non selective protein 0.0034 0.0247 0.0247
Leishmania major hypothetical protein, unknown function 0.0034 0.0247 0.09
Mycobacterium leprae POSSIBLE CONSERVED TRANSMEMBRANE PROTEIN 0.0001 0 0.5
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0001 0 0.5
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0034 0.0247 0.0247
Loa Loa (eye worm) voltage-dependent calcium channel 0.0034 0.0247 0.0247
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0034 0.0247 1
Plasmodium vivax monocarboxylate transporter, putative 0.0001 0 0.5
Entamoeba histolytica transporter, major facilitator family 0.0001 0 0.5
Echinococcus multilocularis voltage gated hydrogen channel 1 0.0034 0.0247 0.0247
Loa Loa (eye worm) hypothetical protein 0.0034 0.0247 0.0247
Entamoeba histolytica transporter, major facilitator family 0.0001 0 0.5
Entamoeba histolytica transporter, major facilitator family 0.0001 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0034 0.0247 0.0247
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0001 0 0.5
Entamoeba histolytica transporter, major facilitator family 0.0001 0 0.5
Mycobacterium ulcerans drug efflux membrane protein 0.0001 0 0.5
Mycobacterium tuberculosis Probable conserved integral membrane protein 0.0001 0 0.5
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0034 0.0247 0.0247
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0034 0.0247 0.0247
Mycobacterium tuberculosis Probable integral membrane nitrite extrusion protein NarK3 (nitrite facilitator) 0.0001 0 0.5
Echinococcus multilocularis sodium channel protein 0.0034 0.0247 0.0247
Onchocerca volvulus 0.0034 0.0247 0.0247
Giardia lamblia hypothetical protein 0.0001 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0034 0.0247 0.0247
Brugia malayi Large-conductance calcium-activated potassium channel Slo-1 (KCNMA) alpha subunit. C. elegans slo-1 ortholog 0.0034 0.0247 0.0247
Schistosoma mansoni voltage-dependent calcium channel 0.0034 0.0247 0.0247
Echinococcus multilocularis potassium large conductance calcium activated 0.0034 0.0247 0.0247
Leishmania major hypothetical protein, conserved 0.0034 0.0247 0.09
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0034 0.0247 0.0247
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0034 0.0247 0.0247
Schistosoma mansoni voltage-gated potassium channel 0.0034 0.0247 0.0247
Schistosoma mansoni voltage-gated potassium channel 0.0034 0.0247 0.0247
Plasmodium falciparum monocarboxylate transporter, putative 0.0001 0 0.5
Mycobacterium ulcerans transmembrane transport protein 0.0001 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0034 0.0247 0.0247
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0034 0.0247 0.0247
Mycobacterium leprae Aminoglycoside/tetracycline-transport integral membrane protein 0.0001 0 0.5
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0034 0.0247 0.0247
Loa Loa (eye worm) hypothetical protein 0.0034 0.0247 0.0247
Brugia malayi voltage-dependent calcium channel 0.0034 0.0247 0.0247
Schistosoma mansoni voltage-gated cation channel 0.0034 0.0247 0.0247
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0034 0.0247 0.0247
Mycobacterium tuberculosis Probable drug-transport integral membrane protein 0.0001 0 0.5
Mycobacterium ulcerans aminoglycosides/tetracycline-transport integral membrane protein 0.0001 0 0.5
Schistosoma mansoni serine/threonine protein kinase 0.0086 0.0639 0.0639
Loa Loa (eye worm) voltage-gated potassium channel 0.0034 0.0247 0.0247
Entamoeba histolytica major facilitator superfamily transporter, putative 0.0001 0 0.5
Toxoplasma gondii transporter, cation channel family protein 0.0034 0.0247 1
Echinococcus multilocularis potassium voltage gated channel subfamily KQT 0.0034 0.0247 0.0247
Entamoeba histolytica transporter, major facilitator family 0.0001 0 0.5
Trypanosoma brucei inositol 1,4,5-trisphosphate receptor 0.0034 0.0247 0.09
Echinococcus granulosus potassium channel KvQLT family member kqt 1 0.0034 0.0247 0.0247
Schistosoma mansoni voltage-gated potassium channel 0.0034 0.0247 0.0247
Schistosoma mansoni vesicular acetylcholine transporter 0.1325 1 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0247 0.0247
Echinococcus multilocularis transient receptor potential cation channel 0.0034 0.0247 0.0247
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0034 0.0247 0.09
Schistosoma mansoni voltage-gated potassium channel 0.0034 0.0247 0.0247
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0001 0 0.5
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0001 0 0.5
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0001 0 0.5
Plasmodium vivax transporter, putative 0.0001 0 0.5
Mycobacterium ulcerans integral membrane transport protein 0.0001 0 0.5
Entamoeba histolytica hypothetical protein 0.0001 0 0.5
Mycobacterium ulcerans intergral membrane protein 0.0001 0 0.5
Loa Loa (eye worm) ion channel NompC 0.0034 0.0247 0.0247
Schistosoma mansoni voltage-gated potassium channel 0.0034 0.0247 0.0247
Trypanosoma cruzi inositol 1,4,5-trisphosphate receptor, putative 0.0034 0.0247 0.09
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0034 0.0247 0.0247
Brugia malayi cation channel family protein 0.0034 0.0247 0.0247
Plasmodium falciparum monocarboxylate transporter, putative 0.0001 0 0.5
Mycobacterium tuberculosis Aminoglycosides/tetracycline-transport integral membrane protein 0.0001 0 0.5
Trypanosoma brucei C-8 sterol isomerase, putative 0.0365 0.2746 1
Echinococcus granulosus hyperpolarization activated cyclic 0.0034 0.0247 0.0247
Entamoeba histolytica major facilitator superfamily protein 0.0001 0 0.5
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0001 0 0.5
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0001 0 0.5
Plasmodium falciparum metabolite/drug transporter, putative 0.0001 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0034 0.0247 0.0247
Plasmodium falciparum major facilitator superfamily-related transporter, putative 0.0001 0 0.5
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0365 0.2746 1
Schistosoma mansoni transient receptor potential channel 0.0034 0.0247 0.0247
Mycobacterium ulcerans integral membrane nitrite extrusion protein NarK3 0.0001 0 0.5
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0034 0.0247 0.0247
Plasmodium falciparum pantothenate transporter 0.0001 0 0.5
Mycobacterium leprae POSSIBLE INTEGRAL MEMBRANE EFFLUX PROTEIN EFPA 0.0001 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0186 0.1399 0.1399
Echinococcus granulosus Potassium voltage gated channel protein Shaw 0.0034 0.0247 0.0247
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0034 0.0247 0.0247
Giardia lamblia Hypothetical protein 0.0001 0 0.5
Plasmodium vivax transporter, putative 0.0001 0 0.5
Loa Loa (eye worm) voltage-gated calcium channel 0.0034 0.0247 0.0247
Plasmodium falciparum major facilitator superfamily-related transporter, putative 0.0001 0 0.5
Giardia lamblia Multidrug resistance protein B 0.0001 0 0.5
Schistosoma mansoni calcium channel voltage-dependent p/q type alpha 1a-related 0.0034 0.0247 0.0247
Echinococcus granulosus potassium voltage gated channel protein 0.0034 0.0247 0.0247
Giardia lamblia Hypothetical protein 0.0001 0 0.5
Giardia lamblia Hypothetical protein 0.0001 0 0.5
Giardia lamblia Hypothetical protein 0.0001 0 0.5
Echinococcus granulosus potassium voltage gated channel subfamily A 0.0034 0.0247 0.0247
Loa Loa (eye worm) calcium channel 0.0034 0.0247 0.0247
Mycobacterium tuberculosis Probable conserved integral membrane protein 0.0001 0 0.5
Mycobacterium tuberculosis Probable nitrite extrusion protein 1 NarK1 (nitrite facilitator 1) 0.0001 0 0.5
Echinococcus multilocularis potassium voltage gated channel protein 0.0034 0.0247 0.0247
Leishmania major C-8 sterol isomerase-like protein 0.0365 0.2746 1
Echinococcus multilocularis transient receptor potential cation channel 0.0034 0.0247 0.0247
Entamoeba histolytica transporter, major facilitator family 0.0001 0 0.5
Echinococcus multilocularis transient receptor potential gamma protein 0.0034 0.0247 0.0247
Loa Loa (eye worm) hypothetical protein 0.0034 0.0247 0.0247
Plasmodium vivax transporter, putative 0.0001 0 0.5
Entamoeba histolytica transporter, major facilitator family 0.0001 0 0.5
Chlamydia trachomatis hexose phosphate transporter 0.0001 0 0.5
Echinococcus multilocularis potassium voltage gated channel subfamily A 0.0034 0.0247 0.0247
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0034 0.0247 0.0247
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0034 0.0247 1
Schistosoma mansoni voltage-gated potassium channel 0.0034 0.0247 0.0247
Giardia lamblia MDR-type permease 0.0001 0 0.5
Echinococcus granulosus voltage gated potassium channel 0.0034 0.0247 0.0247
Echinococcus granulosus transient receptor potential cation channel 0.0034 0.0247 0.0247
Schistosoma mansoni 60S ribosomal protein L21 0.0034 0.0247 0.0247
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0034 0.0247 0.0247
Entamoeba histolytica transporter, major facilitator family 0.0001 0 0.5
Entamoeba histolytica transporter, major facilitator family 0.0001 0 0.5
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit. C. elegans egl-36 ortholog 0.0034 0.0247 0.0247
Echinococcus granulosus ryanodine receptor 44f 0.0034 0.0247 0.0247
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog 0.0034 0.0247 0.0247
Schistosoma mansoni transient receptor potential channel 0.0034 0.0251 0.0251
Mycobacterium ulcerans integral membrane transport protein 0.0001 0 0.5
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0001 0 0.5
Echinococcus granulosus vesicular acetylcholine transporter 0.1325 1 1
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0034 0.0247 0.0247
Echinococcus multilocularis transient receptor potential cation channel 0.0034 0.0247 0.0247
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit 0.0034 0.0247 0.0247
Echinococcus granulosus short transient receptor potential channel 6 0.0034 0.0247 0.0247
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0034 0.0247 0.0247
Loa Loa (eye worm) hypothetical protein 0.0034 0.0247 0.0247
Plasmodium vivax sugar transporter, putative 0.0001 0 0.5
Echinococcus multilocularis short transient receptor potential channel 6 0.0034 0.0247 0.0247
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit 0.0034 0.0247 0.0247
Plasmodium vivax transporter, putative 0.0001 0 0.5
Echinococcus granulosus potassium voltage gated channel protein 0.0034 0.0247 0.0247
Giardia lamblia Multidrug resistance protein B 0.0001 0 0.5
Mycobacterium tuberculosis Possible multidrug resistance integral membrane efflux protein EmrB 0.0001 0 0.5
Entamoeba histolytica transporter, major facilitator family 0.0001 0 0.5
Giardia lamblia Sugar transport family protein 0.0001 0 0.5
Echinococcus multilocularis shaker cognate 0.0034 0.0247 0.0247
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0034 0.0247 0.0247
Mycobacterium ulcerans integral membrane protein 0.0001 0 0.5
Entamoeba histolytica transporter, major facilitator family 0.0001 0 0.5
Mycobacterium tuberculosis Possible drug efflux membrane protein 0.0001 0 0.5
Echinococcus multilocularis short transient receptor potential channel 6 0.0034 0.0251 0.0251
Entamoeba histolytica hypothetical protein 0.0001 0 0.5
Loa Loa (eye worm) ryanodine receptor 0.0034 0.0247 0.0247
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0034 0.0247 0.0247
Plasmodium vivax transporter, putative 0.0001 0 0.5
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0034 0.0247 0.0247
Brugia malayi hypothetical protein 0.0034 0.0247 0.0247
Loa Loa (eye worm) vesicular acetylcholine transporter unc-17 0.1325 1 1
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0001 0 0.5
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0001 0 0.5
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0001 0 0.5
Mycobacterium tuberculosis Probable conserved integral membrane protein 0.0001 0 0.5
Echinococcus granulosus potassium voltage gated channel protein 0.0034 0.0247 0.0247
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0034 0.0247 0.0247
Echinococcus multilocularis hyperpolarization activated cyclic 0.0034 0.0247 0.0247
Loa Loa (eye worm) hypothetical protein 0.0034 0.0251 0.0251
Schistosoma mansoni voltage-gated potassium channel 0.0034 0.0247 0.0247
Giardia lamblia TM efflux prot 0.0001 0 0.5
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0034 0.0247 0.0247
Leishmania major calcium channel protein, putative,ion transporter, putative 0.0034 0.0247 0.09
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0034 0.0247 0.0247
Echinococcus multilocularis potassium voltage gated channel protein 0.0034 0.0247 0.0247
Mycobacterium ulcerans nitrite extrusion protein, NarK3_3 0.0001 0 0.5
Toxoplasma gondii transporter, cation channel family protein 0.0034 0.0247 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0247 0.0247
Chlamydia trachomatis efflux protein 0.0001 0 0.5
Echinococcus granulosus hypothetical protein 0.0034 0.0247 0.0247
Echinococcus multilocularis transient receptor potential cation channel 0.0034 0.0247 0.0247
Echinococcus multilocularis conserved hypothetical protein 0.0034 0.0247 0.0247
Entamoeba histolytica phosphate transporter, putative 0.0001 0 0.5
Echinococcus granulosus transient receptor potential gamma protein 0.0034 0.0247 0.0247
Brugia malayi Cyclic-nucleotide gated cation channel 0.0034 0.0247 0.0247
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0034 0.0247 0.0247
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0034 0.0247 0.0247
Echinococcus granulosus sodium channel protein 0.0034 0.0247 0.0247
Brugia malayi Protein kinase domain containing protein 0.0086 0.0639 0.0639
Echinococcus multilocularis voltage gated potassium channel 0.0034 0.0247 0.0247
Plasmodium vivax pantothenate transporter, putative 0.0001 0 0.5
Schistosoma mansoni two-pore calcium channel 0.0034 0.0247 0.0247
Echinococcus granulosus potassium voltage gated channel protein 0.0034 0.0247 0.0247
Entamoeba histolytica transporter, major facilitator family 0.0001 0 0.5
Echinococcus granulosus transient receptor potential cation channel 0.0034 0.0247 0.0247
Schistosoma mansoni hypothetical protein 0.0034 0.0247 0.0247
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0034 0.0247 0.0247
Echinococcus multilocularis calcium activated potassium channel 0.0034 0.0249 0.0249
Mycobacterium ulcerans hypothetical protein 0.0001 0 0.5
Mycobacterium tuberculosis Possible conserved transmembrane protein 0.0001 0 0.5
Entamoeba histolytica sucrose transporter, putative 0.0001 0 0.5
Echinococcus granulosus potassium large conductance calcium activated 0.0034 0.0247 0.0247
Plasmodium falciparum major facilitator superfamily-related transporter, putative 0.0001 0 0.5
Echinococcus multilocularis transient receptor potential cation channel 0.0034 0.0251 0.0251
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0034 0.0247 0.0247
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0034 0.0247 0.0247
Brugia malayi Transient-receptor-potential like protein 0.0034 0.0247 0.0247
Loa Loa (eye worm) hypothetical protein 0.0034 0.0247 0.0247
Mycobacterium tuberculosis Probable conserved integral membrane protein 0.0001 0 0.5
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0086 0.0639 0.0639
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0034 0.0247 0.0247
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0034 0.0247 0.0247
Echinococcus granulosus short transient receptor potential channel 6 0.0034 0.0251 0.0251
Schistosoma mansoni inositol 145-trisphosphate receptor 0.0034 0.0247 0.0247
Brugia malayi olfactory channel protein osm-9 0.0034 0.0251 0.0251
Echinococcus granulosus two pore calcium channel protein 2 0.0034 0.0247 0.0247
Brugia malayi ion channel NompC 0.0034 0.0247 0.0247
Mycobacterium ulcerans hypothetical protein 0.0001 0 0.5
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0034 0.0247 0.0247
Echinococcus multilocularis transfer RNA-Gly 0.0034 0.0247 0.0247
Toxoplasma gondii transporter, cation channel family protein 0.0034 0.0247 1
Echinococcus granulosus voltage dependent calcium channel 0.0034 0.0247 0.0247
Entamoeba histolytica major facilitator superfamily protein 0.0001 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0034 0.0247 0.0247
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0086 0.0639 0.0639
Loa Loa (eye worm) hypothetical protein 0.0034 0.0247 0.0247
Echinococcus multilocularis voltage dependent calcium channel 0.0034 0.0247 0.0247
Schistosoma mansoni voltage-gated potassium channel 0.0034 0.0247 0.0247
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0034 0.0247 0.0247
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0034 0.0247 0.0247
Entamoeba histolytica transporter, major facilitator family 0.0001 0 0.5
Mycobacterium ulcerans integral membrane nitrite extrusion protein NarU 0.0001 0 0.5
Schistosoma mansoni voltage-gated potassium channel 0.0034 0.0247 0.0247
Plasmodium vivax metabolite/drug transporter, putative 0.0001 0 0.5
Echinococcus granulosus TRP transient receptor potential channel 0.0034 0.0247 0.0247
Echinococcus multilocularis vesicular acetylcholine transporter 0.1325 1 1
Schistosoma mansoni voltage-gated potassium channel 0.0034 0.0247 0.0247
Mycobacterium ulcerans integral membrane efflux protein EfpA 0.0001 0 0.5
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0034 0.0247 0.0247
Loa Loa (eye worm) hypothetical protein 0.0034 0.0247 0.0247
Echinococcus multilocularis voltage gated potassium channel 0.0034 0.0247 0.0247
Schistosoma mansoni ryanodine receptor related 0.0034 0.0247 0.0247
Echinococcus granulosus potassium voltage gated channel protein 0.0034 0.0247 0.0247
Giardia lamblia Major facilitator family transporter 0.0001 0 0.5
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0034 0.0247 0.0247
Mycobacterium ulcerans integral membrane transport protein 0.0001 0 0.5
Echinococcus granulosus hyperpolarization activated cyclic 0.0034 0.0247 0.0247
Echinococcus granulosus transient receptor potential cation channel 0.0034 0.0247 0.0247
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0034 0.0247 0.0247
Entamoeba histolytica major facilitator superfamily protein 0.0001 0 0.5
Mycobacterium ulcerans integral membrane transport protein 0.0001 0 0.5
Mycobacterium ulcerans integral membrane transport protein 0.0001 0 0.5
Giardia lamblia Hypothetical protein 0.0001 0 0.5
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0001 0 0.5
Mycobacterium ulcerans hypothetical protein 0.0001 0 0.5
Toxoplasma gondii hypothetical protein 0.0034 0.0247 1
Mycobacterium tuberculosis Probable conserved transmembrane transport protein 0.0001 0 0.5
Echinococcus granulosus voltage dependent calcium channel 0.0034 0.0247 0.0247
Mycobacterium ulcerans transmembrane protein 0.0001 0 0.5
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0034 0.0247 0.0247
Mycobacterium tuberculosis Integral membrane drug efflux protein Stp 0.0001 0 0.5
Echinococcus multilocularis ryanodine receptor 44f 0.0034 0.0247 0.0247
Mycobacterium ulcerans transmembrane carbohydrate transport protein 0.0001 0 0.5
Echinococcus granulosus sodium leak channel non selective protein 0.0034 0.0247 0.0247
Loa Loa (eye worm) hypothetical protein 0.0034 0.0247 0.0247
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0034 0.0247 0.0247
Echinococcus multilocularis transient receptor potential cation channel 0.0034 0.0251 0.0251
Brugia malayi Voltage-gated calcium channel, alpha subunit 0.0034 0.0247 0.0247
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0034 0.0247 0.0247
Echinococcus granulosus transient receptor potential cation channel 0.0034 0.0247 0.0247
Echinococcus multilocularis potassium voltage gated channel protein 0.0034 0.0247 0.0247
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.0034 0.0247 0.0247
Schistosoma mansoni voltage-gated potassium channel 0.0034 0.0247 0.0247
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0034 0.0247 0.0247
Mycobacterium ulcerans multidrug resistance integral membrane efflux protein 0.0001 0 0.5
Echinococcus granulosus shaker cognate 0.0034 0.0247 0.0247
Mycobacterium tuberculosis Possible nitrate/nitrite transporter NarK2 0.0001 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0034 0.0247 0.0247
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0034 0.0247 0.0247
Brugia malayi Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog 0.0034 0.0247 0.0247
Plasmodium vivax transporter, putative 0.0001 0 0.5
Schistosoma mansoni transient receptor potential channel 0.0034 0.0247 0.0247
Loa Loa (eye worm) hypothetical protein 0.0034 0.0247 0.0247
Mycobacterium ulcerans integral membrane protein 0.0001 0 0.5
Brugia malayi Voltage-gated calcium channel, P/Q-type, alpha subunit. C. elegans unc-2 ortholog 0.0034 0.0247 0.0247
Schistosoma mansoni voltage-gated potassium channel 0.0034 0.0247 0.0247
Echinococcus multilocularis potassium voltage gated channel subfamily C 0.0034 0.0247 0.0247
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0034 0.0247 0.09
Entamoeba histolytica transporter, major facilitator family 0.0001 0 0.5
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0034 0.0247 0.0247
Schistosoma mansoni transient receptor potential channel 4 0.0034 0.0247 0.0247
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0086 0.0639 0.0639
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0086 0.0639 0.0639

Activities

Activity type Activity value Assay description Source Reference
T1/2 (ADMET) = 90 min Prodrug conversion in human liver microsomes assessed as half life ChEMBL. 25515558

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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