Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Cavia porcellus | Leukotriene A-4 hydrolase | Starlite/ChEMBL | References |
Homo sapiens | angiotensin I converting enzyme | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Leishmania infantum | aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 | Leukotriene A-4 hydrolase | 611 aa | 508 aa | 21.5 % |
Dictyostelium discoideum | puromycin-sensitive aminopeptidase-like protein | Leukotriene A-4 hydrolase | 611 aa | 492 aa | 25.6 % |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | Leukotriene A-4 hydrolase | 611 aa | 519 aa | 22.7 % |
Leishmania donovani | aminopeptidase-like protein | Leukotriene A-4 hydrolase | 611 aa | 508 aa | 21.5 % |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | Leukotriene A-4 hydrolase | 611 aa | 510 aa | 23.3 % |
Brugia malayi | Peptidase family M1 containing protein | Leukotriene A-4 hydrolase | 611 aa | 508 aa | 22.4 % |
Onchocerca volvulus | Leukotriene A-4 hydrolase | 611 aa | 597 aa | 44.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | protein arginine n-methyltransferase 7 | 0.0289 | 0.0034 | 0.5 |
Trypanosoma cruzi | arginine N-methyltransferase, type I | 0.0289 | 0.0034 | 0.5 |
Trichomonas vaginalis | protein arginine N-methyltransferase, putative | 0.0289 | 0.0034 | 0.5 |
Loa Loa (eye worm) | protein arginine N-methyltransferase | 0.0289 | 0.0034 | 0.0034 |
Trypanosoma cruzi | arginine N-methyltransferase, type I | 0.0289 | 0.0034 | 0.5 |
Loa Loa (eye worm) | angiotensin-converting enzyme family protein | 0.0749 | 0.1601 | 0.1601 |
Trypanosoma cruzi | arginine N-methyltransferase, type III | 0.0289 | 0.0034 | 0.5 |
Schistosoma mansoni | protein arginine n-methyltransferase | 0.3213 | 1 | 1 |
Entamoeba histolytica | arginine N-methyltransferase 1, putative | 0.0289 | 0.0034 | 0.5 |
Trypanosoma cruzi | protein arginine n-methyltransferase 7 | 0.0289 | 0.0034 | 0.5 |
Leishmania major | arginine N-methyltransferase, type I | 0.0289 | 0.0034 | 0.5 |
Trypanosoma cruzi | arginine N-methyltransferase, putative | 0.0289 | 0.0034 | 0.5 |
Trypanosoma cruzi | arginine N-methyltransferase, putative | 0.0289 | 0.0034 | 0.5 |
Loa Loa (eye worm) | Carm1-pending protein | 0.3213 | 1 | 1 |
Echinococcus multilocularis | histone arginine methyltransferase CARMER | 0.3213 | 1 | 1 |
Trichomonas vaginalis | protein arginine N-methyltransferase, putative | 0.0289 | 0.0034 | 0.5 |
Trypanosoma brucei | Protein arginine N-methyltransferase 1 catalytic subunit | 0.0289 | 0.0034 | 0.5 |
Onchocerca volvulus | 0.2924 | 0.9015 | 0.5 | |
Echinococcus granulosus | histone arginine methyltransferase CARMER | 0.3213 | 1 | 1 |
Leishmania major | arginine N-methyltransferase, type III, putative;with=GeneDB:Tb927.7.5490 | 0.0289 | 0.0034 | 0.5 |
Toxoplasma gondii | histone arginine methyltransferase PRMT4/CARM1 | 0.3213 | 1 | 1 |
Brugia malayi | Angiotensin-converting enzyme family protein | 0.0749 | 0.1601 | 0.1573 |
Echinococcus granulosus | methyltransferase protein 5 | 0.0289 | 0.0034 | 0.0034 |
Echinococcus multilocularis | protein arginine N methyltransferase 7 | 0.0289 | 0.0034 | 0.0034 |
Echinococcus granulosus | protein arginine N methyltransferase 7 | 0.0289 | 0.0034 | 0.0034 |
Entamoeba histolytica | arginine N-methyltransferase protein, putative | 0.0289 | 0.0034 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0289 | 0.0034 | 0.0034 |
Schistosoma mansoni | hypothetical protein | 0.0289 | 0.0034 | 0.0034 |
Entamoeba histolytica | hypothetical protein | 0.0289 | 0.0034 | 0.5 |
Trichomonas vaginalis | protein arginine N-methyltransferase, putative | 0.0289 | 0.0034 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 6.21 | Inhibition of LTA4 hydrolase in guinea pig lung assessed as inhibition of LTB4 production | ChEMBL. | 19042128 |
IC50 (binding) | = 250 nM | Inhibition of angiotensin-converting enzyme in whole blood by HPLC | ChEMBL. | 19042128 |
IC50 (binding) | = 1700 nM | Inhibition of LTA4 hydrolase in guinea pig lung assessed as inhibition of LTB4 production | ChEMBL. | 19042128 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.