TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 394.51 | Formula: C21H18N2O2S2
H donors: 0 H acceptors: 2 LogP: 4.79 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: O=c1cc(oc2c1cccc2c1ncc(s1)c1cccs1)N1CCCCC1
InChi: 1S/C21H18N2O2S2/c24-16-12-19(23-9-2-1-3-10-23)25-20-14(16)6-4-7-15(20)21-22-13-18(27-21)17-8-5-11-26-17/h4-8,11-13H,1-3,9-10H2
InChiKey: XJNUXAOYAYFPPK-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	protein kinase, DNA-activated, catalytic polypeptide	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus multilocularis	DNA dependent protein kinase catalytic subunit	Get druggable targets OG5_132688	All targets in OG5_132688
Echinococcus granulosus	DNA dependent protein kinase catalytic subunit	Get druggable targets OG5_132688	All targets in OG5_132688

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	O-glycosyl hydrolase family 30 protein	0.0251	0.7946	1
Echinococcus multilocularis	cysteine protease	0.0016	0.0178	0.0132
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0012	0.0047	0.0059
Trichomonas vaginalis	glucosylceramidase, putative	0.0165	0.509	0.6405
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0361	0.0455
Brugia malayi	Papain family cysteine protease containing protein	0.0016	0.0178	0.0224
Schistosoma mansoni	ubiquitin-specific peptidase 2 (C19 family)	0.0036	0.0829	0.5784
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0361	0.0455
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0036	0.0827	0.2428
Onchocerca volvulus		0.0016	0.0178	0.035
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.1691	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0864	0.1087
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0178	0.0224
Brugia malayi	Cathepsin L-like precursor	0.0016	0.0178	0.0224
Trichomonas vaginalis	glucosylceramidase, putative	0.0165	0.509	0.6405
Onchocerca volvulus		0.0016	0.0178	0.035
Echinococcus granulosus	phosphatidylinositol 3 and 4 kinase	0.0022	0.0361	0.0361
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.1691	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0361	0.0455
Schistosoma mansoni	organic anion transporter	0.0054	0.1433	1
Trichomonas vaginalis	glucosylceramidase, putative	0.0165	0.509	0.6405
Leishmania major	cytochrome p450-like protein	0.0024	0.0445	0.0827
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0361	0.0455
Mycobacterium leprae	possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ).	0.0032	0.0703	0.5
Onchocerca volvulus		0.0054	0.1433	0.2816
Brugia malayi	secreted modular calcium-binding protein 1	0.0037	0.0864	0.1087
Echinococcus multilocularis	follistatin	0.0037	0.0864	0.0821
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0361	0.0455
Entamoeba histolytica	myo-inositol monophosphatase, putative	0.0036	0.0827	0.9983
Trichomonas vaginalis	glucosylceramidase, putative	0.0165	0.509	0.6405
Onchocerca volvulus		0.0016	0.0178	0.035
Entamoeba histolytica	cysteine proteinase, putative	0.0016	0.0178	0.2148
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0361	0.0455
Loa Loa (eye worm)	hypothetical protein	0.0054	0.1433	0.1804
Brugia malayi	Cathepsin L-like precursor	0.0016	0.0178	0.0224
Brugia malayi	sodium-independent organic anion transporter family protein	0.0054	0.1433	0.1804
Echinococcus multilocularis	phosphatidylinositol 3 and 4 kinase	0.0022	0.0361	0.0316
Trichomonas vaginalis	glucosylceramidase, putative	0.0251	0.7946	1
Schistosoma mansoni	ataxia telangiectasia mutated (atm)	0.0012	0.0047	0.0325
Toxoplasma gondii	non-specific serine/threonine protein kinase	0.0014	0.0093	0.0335
Leishmania major	phosphatidylinositol 3-related kinase, putative	0.0022	0.0361	0.0568
Schistosoma mansoni	inositol monophosphatase	0.0036	0.0827	0.5774
Onchocerca volvulus	Glucosylceramidase homolog	0.0165	0.509	1
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0016	0.0178	0.0178
Loa Loa (eye worm)	hypothetical protein	0.0054	0.1433	0.1804
Loa Loa (eye worm)	CYP4Cod1	0.0024	0.0445	0.056
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase domain containing protein	0.0036	0.0829	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0016	0.0178	0.0224
Toxoplasma gondii	target of rapamycin (TOR), putative	0.0022	0.0361	0.227
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0016	0.0178	0.0224
Onchocerca volvulus		0.0016	0.0178	0.035
Mycobacterium ulcerans	extragenic suppressor protein SuhB	0.0036	0.0827	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0361	0.0455
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0012	0.0047	0.0059
Loa Loa (eye worm)	ctsf protein	0.0016	0.0178	0.0224
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0361	0.0455
Entamoeba histolytica	Phosphatidylinositol 3- and 4-kinase family	0.0012	0.0047	0.0562
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.0022	0.0361	0.0316
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.0022	0.0361	0.0568
Toxoplasma gondii	protease inhibitor PI2	0.0037	0.0864	0.5896
Onchocerca volvulus		0.0054	0.1433	0.2816
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0361	0.0455
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0012	0.0047	0.0059
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0829	0.1043
Trichomonas vaginalis	glucosylceramidase, putative	0.0251	0.7946	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0361	0.0455
Echinococcus granulosus	serine:threonine protein kinase SMG1	0.0012	0.0047	0.0047
Trichomonas vaginalis	glucosylceramidase, putative	0.0165	0.509	0.6405
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0361	0.0455
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.0022	0.0361	0.0568
Plasmodium vivax	vivapain-2	0.0016	0.0178	0.5
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.0022	0.0361	0.4359
Loa Loa (eye worm)	cytochrome P450 family protein	0.0024	0.0445	0.056
Trichomonas vaginalis	glucosylceramidase, putative	0.0251	0.7946	1
Trypanosoma brucei	cytochrome P450, putative	0.0024	0.0445	0.2421
Loa Loa (eye worm)	hypothetical protein	0.0054	0.1433	0.1804
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0036	0.0829	0.1043
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0361	0.0455
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0361	0.0455
Trypanosoma cruzi	cysteine peptidase, putative	0.0062	0.1691	0.5114
Echinococcus granulosus	Solute carrier organic anion transporter family	0.0054	0.1433	0.1433
Loa Loa (eye worm)	inositol-1	0.0036	0.0827	0.1041
Toxoplasma gondii	Kazal-type serine protease inhibitor domain-containing protein	0.0037	0.0864	0.5896
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0016	0.0178	0.0224
Trypanosoma cruzi	hypothetical protein, conserved	0.011	0.3263	1
Brugia malayi	Kazal-type serine protease inhibitor domain containing protein	0.0037	0.0864	0.1087
Loa Loa (eye worm)	phosphatidylinositol 3	0.0022	0.0361	0.0455
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0047	0.0059
Onchocerca volvulus		0.0016	0.0178	0.035
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0012	0.0047	0.0059
Onchocerca volvulus	Putative organic anion transporter	0.0054	0.1433	0.2816
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.1691	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0012	0.0047	0.0059
Onchocerca volvulus	Cathepsin F homolog	0.0016	0.0178	0.035
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0036	0.0829	0.1043
Onchocerca volvulus	Putative organic anion transporter	0.0054	0.1433	0.2816
Echinococcus multilocularis	inositol monophosphatase 1	0.0036	0.0827	0.0785
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0178	0.0224
Giardia lamblia	Ubiquitin carboxyl-terminal hydrolase 4	0.0036	0.0829	1
Toxoplasma gondii	Kazal-type serine protease inhibitor domain-containing protein	0.0037	0.0864	0.5896
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0012	0.0047	0.0059
Schistosoma mansoni	fkbp-rapamycin associated protein	0.0012	0.0047	0.0325
Mycobacterium tuberculosis	Inositol-1-monophosphatase SuhB	0.0032	0.0703	0.5
Brugia malayi	Cathepsin L-like precursor	0.0016	0.0178	0.0224
Loa Loa (eye worm)	hypothetical protein	0.0054	0.1433	0.1804
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0178	0.0224
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0178	0.0224
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0178	0.0224
Loa Loa (eye worm)	phosphatidylinositol 3	0.0022	0.0361	0.0455
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0036	0.0829	0.2432
Echinococcus multilocularis	cathepsin L cysteine protease	0.0016	0.0178	0.0132
Echinococcus granulosus	follistatin	0.0037	0.0864	0.0864
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0178	0.0224
Brugia malayi	hypothetical protein	0.0054	0.1433	0.1804
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0178	0.0224
Onchocerca volvulus		0.0054	0.1433	0.2816
Brugia malayi	hypothetical protein	0.0054	0.1433	0.1804
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.0022	0.0361	0.4359
Schistosoma mansoni	follistatin	0.0037	0.0864	0.603
Trichomonas vaginalis	glucosylceramidase, putative	0.0251	0.7946	1
Echinococcus multilocularis	expressed protein	0.0037	0.0864	0.0821
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0178	0.0224
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0864	0.1087
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0022	0.0361	0.1913
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0012	0.0047	0.0059
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 8	0.0036	0.0829	0.0786
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0178	0.0224
Schistosoma mansoni	ubiquitin-specific peptidase 8 (C19 family)	0.0036	0.0829	0.5784
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0178	0.0224
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0213	0.0268
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0178	0.0224
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0361	0.0455
Trichomonas vaginalis	glucosylceramidase, putative	0.0165	0.509	0.6405
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.1691	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0016	0.0178	0.1242
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0016	0.0178	0.5
Loa Loa (eye worm)	agrin synaptic family protein	0.0037	0.0864	0.1087
Loa Loa (eye worm)	hypothetical protein	0.0054	0.1433	0.1804
Echinococcus multilocularis	Peptidase C19, ubiquitin carboxyl terminal hydrolase 2	0.0036	0.0829	0.0786
Echinococcus multilocularis	cysteine protease	0.0016	0.0178	0.0132
Brugia malayi	sodium-independent organic anion transporter family protein	0.0054	0.1433	0.1804
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0178	0.0224
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 8	0.0036	0.0829	0.0829
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0036	0.0829	0.1043
Brugia malayi	Inositol-1	0.0036	0.0827	0.1041
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0361	0.0455
Echinococcus granulosus	cathepsin l1	0.0016	0.0178	0.0178
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0057	0.1513	0.456
Trichomonas vaginalis	conserved hypothetical protein	0.0036	0.0829	0.1043
Brugia malayi	Kazal-type serine protease inhibitor domain containing protein	0.0037	0.0864	0.1087
Leishmania major	cathepsin L-like protease	0.0062	0.1691	0.4694
Loa Loa (eye worm)	kazal-type serine protease inhibitor domain-containing protein	0.0037	0.0864	0.1087
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0022	0.0361	0.0455
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.0022	0.0361	0.1913
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0036	0.0827	0.1041
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0361	0.0455
Echinococcus granulosus	agrin	0.0037	0.0864	0.0864
Echinococcus granulosus	serine protein kinase ATM	0.0012	0.0047	0.0047
Echinococcus multilocularis	organic anion transporting polypeptide 30B	0.0054	0.1433	0.1393
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0864	0.1087
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0361	0.0455
Trichomonas vaginalis	glucosylceramidase, putative	0.0174	0.5383	0.6775
Onchocerca volvulus		0.0016	0.0178	0.035
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.0022	0.0361	0.0568
Onchocerca volvulus	Cathepsin L homolog	0.0016	0.0178	0.035
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.1691	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.1691	1
Loa Loa (eye worm)	fibroinase	0.0016	0.0178	0.0224
Brugia malayi	Kazal-type serine protease inhibitor domain containing protein	0.0037	0.0864	0.1087
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0361	0.0455
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.1691	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.1691	1
Brugia malayi	Cathepsin L-like precursor	0.0016	0.0178	0.0224
Echinococcus multilocularis	cathepsin L cysteine protease	0.0016	0.0178	0.0132
Leishmania major	cathepsin L-like protease	0.0062	0.1691	0.4694
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.0022	0.0361	0.0978
Entamoeba histolytica	hypothetical protein	0.0012	0.0047	0.0562
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0361	0.0455
Loa Loa (eye worm)	cytochrome P450 family protein	0.0024	0.0445	0.056
Leishmania major	phosphatidylinositol 3-kinase, putative	0.0022	0.0361	0.0568
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0036	0.0827	0.1041
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0178	0.0224
Trypanosoma cruzi	cysteine peptidase, putative	0.0016	0.0178	0.0409
Echinococcus multilocularis	ubiquitin specific protease 41	0.0036	0.0829	0.0786
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0016	0.0178	0.5
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.0022	0.0361	0.2521
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0178	0.0224
Trichomonas vaginalis	glucosylceramidase, putative	0.0174	0.5383	0.6775
Onchocerca volvulus		0.0054	0.1433	0.2816
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0178	0.0224
Brugia malayi	Kazal-type serine protease inhibitor domain containing protein	0.0037	0.0864	0.1087
Trypanosoma cruzi	major cysteine proteinase, putative	0.0049	0.1252	0.3748
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0178	0.0224
Leishmania major	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	0.0036	0.0829	0.2019
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0016	0.0178	0.0224
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0361	0.0455
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0178	0.0224
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0022	0.0361	0.0978
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0012	0.0047	0.0059
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0012	0.0047	0.0059
Plasmodium vivax	vivapain-2	0.0016	0.0178	0.5
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0178	0.0224
Schistosoma mansoni	inositol monophosphatase	0.0036	0.0827	0.5774
Entamoeba histolytica	cysteine protease, putative	0.0016	0.0178	0.2148
Trypanosoma brucei	ubiquitin carboxyl-terminal hydrolase, putative	0.0036	0.0829	0.4756
Toxoplasma gondii	Kazal-type serine protease inhibitor domain-containing protein	0.0037	0.0864	0.5896
Echinococcus granulosus	ubiquitin specific protease 41	0.0036	0.0829	0.0829
Brugia malayi	Cytochrome P450 family protein	0.0024	0.0445	0.056
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.1691	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0864	0.1087
Echinococcus multilocularis	Solute carrier organic anion transporter family	0.0054	0.1433	0.1393
Brugia malayi	SPARC precursor	0.0037	0.0864	0.1087
Trypanosoma brucei	phosphatidylinositol 3-related kinase, putative	0.0022	0.0361	0.1913
Loa Loa (eye worm)	hypothetical protein	0.0054	0.1433	0.1804
Trypanosoma cruzi	cysteine peptidase, putative	0.0062	0.1691	0.5114
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.0022	0.0361	0.2521
Onchocerca volvulus		0.0016	0.0178	0.035
Schistosoma mansoni	organic anion transporter	0.0054	0.1433	1
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0022	0.0361	0.1913
Trypanosoma brucei	FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative	0.0014	0.0093	0.0283
Schistosoma mansoni	cathepsin F (C01 family)	0.0016	0.0178	0.1242
Trypanosoma brucei	inositol-1(or 4)-monophosphatase 1, putative	0.0036	0.0827	0.4748
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0178	0.0224
Brugia malayi	prostaglandin transporter	0.0054	0.1433	0.1804
Trypanosoma cruzi	cytochrome P450, putative	0.0024	0.0445	0.1238
Trypanosoma cruzi	cysteine peptidase, putative	0.0062	0.1691	0.5114
Echinococcus granulosus	Peptidase C19 ubiquitin carboxyl terminal hydrolase 2	0.0036	0.0829	0.0829
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0022	0.0361	0.0978
Trichomonas vaginalis	glucosylceramidase, putative	0.0251	0.7946	1
Brugia malayi	Cytochrome P450 family protein	0.0024	0.0445	0.056
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.0022	0.0361	0.0361
Toxoplasma gondii	Kazal-type serine protease inhibitor domain-containing protein	0.0037	0.0864	0.5896
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0361	0.0455
Wolbachia endosymbiont of Brugia malayi	fructose-1,6-bisphosphatase	0.0036	0.0827	0.5
Brugia malayi	sodium-independent organic anion transporter family protein	0.0054	0.1433	0.1804
Toxoplasma gondii	cathepsin CPL	0.0016	0.0178	0.0948
Trypanosoma cruzi	MFS transporter, putative	0.0054	0.1433	0.4311
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0012	0.0047	0.0059
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0361	0.0455
Schistosoma mansoni	agrin	0.0037	0.0864	0.603
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0361	0.0455
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0361	0.0455
Onchocerca volvulus		0.0054	0.1433	0.2816
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0093	0.0117
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.1691	1
Trypanosoma cruzi	target of rapamycin kinase 3	0.0022	0.0361	0.0978
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0016	0.0178	0.0178
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0361	0.0455
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0016	0.0178	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0093	0.0117
Trichomonas vaginalis	glucosylceramidase, putative	0.0251	0.7946	1
Loa Loa (eye worm)	hypothetical protein	0.0054	0.1433	0.1804
Leishmania major	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0036	0.0827	0.2014
Entamoeba histolytica	cysteine proteinase, putative	0.0016	0.0178	0.2148
Brugia malayi	O-Glycosyl hydrolase family 30 protein	0.0251	0.7946	1
Brugia malayi	Cathepsin L-like precursor	0.0016	0.0178	0.0224
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0178	0.0224
Echinococcus multilocularis	DNA dependent protein kinase catalytic subunit	0.0313	1	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0016	0.0178	0.0132
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0178	0.0224
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0036	0.0827	0.2428
Echinococcus granulosus	inositol monophosphatase 1	0.0036	0.0827	0.0827
Toxoplasma gondii	inositol(myo)-1(or 4)-monophosphatase 2, putative	0.0036	0.0827	0.5632
Trichomonas vaginalis	glucosylceramidase, putative	0.0165	0.509	0.6405
Onchocerca volvulus	Cathepsin L homolog	0.0016	0.0178	0.035
Loa Loa (eye worm)	sodium-independent organic anion transporter	0.0054	0.1433	0.1804
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.1691	1
Onchocerca volvulus	Putative organic anion transporter	0.0054	0.1433	0.2816
Trypanosoma cruzi	cruzipain precursor, putative	0.0062	0.1691	0.5114
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0361	0.0455
Toxoplasma gondii	transporter, major facilitator family protein	0.0054	0.1433	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0014	0.0093	0.0117
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0036	0.0829	0.2432
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0178	0.0224
Echinococcus granulosus	organic anion transporting polypeptide 30B	0.0054	0.1433	0.1433
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0178	0.0224
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0022	0.0361	0.0455
Echinococcus multilocularis	agrin	0.0037	0.0864	0.0821
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0361	0.0455
Leishmania major	cathepsin L-like protease	0.0062	0.1691	0.4694
Onchocerca volvulus		0.0037	0.0864	0.1698
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0361	0.0455
Trypanosoma cruzi	cytochrome P450, putative	0.0024	0.0445	0.1238
Trichomonas vaginalis	inositol monophosphatase, putative	0.0036	0.0827	0.1041
Loa Loa (eye worm)	cysteine protease	0.0016	0.0178	0.0224
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0178	0.0224
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.0022	0.0361	0.1913
Entamoeba histolytica	protein kinase rad3, putative	0.0012	0.0047	0.0562
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0361	0.0455
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0016	0.0178	0.0132
Leishmania major	hypothetical protein, conserved	0.0114	0.3402	1
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.0022	0.0361	0.0978
Brugia malayi	Cathepsin L-like precursor	0.0016	0.0178	0.0224

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.48 uM	Inhibition of DNA-dependent protein kinase	ChEMBL.	18678488

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL454659

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 950751