TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 442.631 | Formula: C28H42O4
H donors: 2 H acceptors: 4 LogP: 5.12 Rotable bonds: 0
Rule of 5 violations (Lipinski): 1
SMILES: C[C@@H]1C[C@@H]2[C@@]([C@@H](C1=O)O)(C)CC[C@]1([C@@]2(C)CC[C@@]2([C@@H]1CCC1=C(C(=O)[C@H](C[C@@H]21)O)C)C)C
InChi: 1S/C28H42O4/c1-15-13-21-26(4,24(32)22(15)30)10-12-27(5)20-8-7-17-16(2)23(31)19(29)14-18(17)25(20,3)9-11-28(21,27)6/h15,18-21,24,29,32H,7-14H2,1-6H3/t15-,18-,19+,20+,21-,24-,25+,26-,27-,28+/m1/s1
InChiKey: UUGCGHAFZPEHIC-OIOGIDCRSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Rattus norvegicus	Aldose reductase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trypanosoma brucei gambiense	aldo-keto reductase, putative	Get druggable targets OG5_126583	All targets in OG5_126583
Loa Loa (eye worm)	oxidoreductase	Get druggable targets OG5_126583	All targets in OG5_126583
Trichomonas vaginalis	aldo-keto reductase, putative	Get druggable targets OG5_126583	All targets in OG5_126583
Trichomonas vaginalis	aldo-keto reductase, putative	Get druggable targets OG5_126583	All targets in OG5_126583
Giardia lamblia	Aldose reductase	Get druggable targets OG5_126583	All targets in OG5_126583
Leishmania mexicana	aldo-keto reductase-like protein	Get druggable targets OG5_126583	All targets in OG5_126583
Leishmania major	aldo-keto reductase-like protein	Get druggable targets OG5_126583	All targets in OG5_126583
Echinococcus granulosus	aldo keto reductase family 1 member B4	Get druggable targets OG5_126583	All targets in OG5_126583
Entamoeba histolytica	aldose reductase, putative	Get druggable targets OG5_126583	All targets in OG5_126583
Schistosoma mansoni	pol-related	Get druggable targets OG5_126583	All targets in OG5_126583
Onchocerca volvulus		Get druggable targets OG5_126583	All targets in OG5_126583
Loa Loa (eye worm)	oxidoreductase	Get druggable targets OG5_126583	All targets in OG5_126583
Giardia lamblia	Aldose reductase	Get druggable targets OG5_126583	All targets in OG5_126583
Echinococcus granulosus	aldo keto reductase	Get druggable targets OG5_126583	All targets in OG5_126583
Leishmania braziliensis	prostaglandin f2-alpha synthase/D-arabinose dehydrogenase	Get druggable targets OG5_126583	All targets in OG5_126583
Echinococcus multilocularis	aldehyde reductase	Get druggable targets OG5_126583	All targets in OG5_126583
Onchocerca volvulus		Get druggable targets OG5_126583	All targets in OG5_126583
Trypanosoma brucei	prostaglandin f synthase	Get druggable targets OG5_126583	All targets in OG5_126583
Leishmania infantum	aldo-keto reductase-like protein	Get druggable targets OG5_126583	All targets in OG5_126583
Trichomonas vaginalis	aldo-keto reductase, putative	Get druggable targets OG5_126583	All targets in OG5_126583
Schistosoma japonicum	IPR001395,Aldo/keto reductase,domain-containing	Get druggable targets OG5_126583	All targets in OG5_126583
Leishmania donovani	aldehyde reductase, putative	Get druggable targets OG5_126583	All targets in OG5_126583
Echinococcus multilocularis	aldo keto reductase	Get druggable targets OG5_126583	All targets in OG5_126583
Echinococcus multilocularis	aldo keto reductase	Get druggable targets OG5_126583	All targets in OG5_126583
Candida albicans	similar to mammalian aldo/keto reductases	Get druggable targets OG5_126583	All targets in OG5_126583
Mycobacterium ulcerans	oxidoreductase	Get druggable targets OG5_126583	All targets in OG5_126583
Trichomonas vaginalis	aldo-keto reductase, putative	Get druggable targets OG5_126583	All targets in OG5_126583
Echinococcus granulosus	aldo keto reductase family 1 member B4	Get druggable targets OG5_126583	All targets in OG5_126583
Leishmania major	prostaglandin f2-alpha synthase/D-arabinose dehydrogenase	Get druggable targets OG5_126583	All targets in OG5_126583
Echinococcus granulosus	hypothetical protein	Get druggable targets OG5_126583	All targets in OG5_126583
Echinococcus multilocularis	aldo keto reductase	Get druggable targets OG5_126583	All targets in OG5_126583
Leishmania infantum	aldehyde reductase, putative,oxidoreductase, putative	Get druggable targets OG5_126583	All targets in OG5_126583
Mycobacterium tuberculosis	Probable oxidoreductase	Get druggable targets OG5_126583	All targets in OG5_126583
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	Get druggable targets OG5_126583	All targets in OG5_126583
Onchocerca volvulus		Get druggable targets OG5_126583	All targets in OG5_126583
Echinococcus granulosus	aldo keto reductase family 1 member B4	Get druggable targets OG5_126583	All targets in OG5_126583
Candida albicans	see also nonallelic CaP19.2244	Get druggable targets OG5_126583	All targets in OG5_126583
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	Get druggable targets OG5_126583	All targets in OG5_126583
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	Get druggable targets OG5_126583	All targets in OG5_126583
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	Get druggable targets OG5_126583	All targets in OG5_126583
Trichomonas vaginalis	aldo-keto reductase, putative	Get druggable targets OG5_126583	All targets in OG5_126583
Candida albicans	Aldose reductase	Get druggable targets OG5_126583	All targets in OG5_126583
Candida albicans	Aldose reductase	Get druggable targets OG5_126583	All targets in OG5_126583
Echinococcus granulosus	aldehyde reductase	Get druggable targets OG5_126583	All targets in OG5_126583
Entamoeba histolytica	aldose reductase, putative	Get druggable targets OG5_126583	All targets in OG5_126583
Trichomonas vaginalis	dihydrodiol dehydrogenase, putative	Get druggable targets OG5_126583	All targets in OG5_126583
Echinococcus multilocularis	aldo keto reductase family 1, member B4	Get druggable targets OG5_126583	All targets in OG5_126583
Leishmania infantum	prostaglandin f synthase, putative	Get druggable targets OG5_126583	All targets in OG5_126583
Trypanosoma cruzi	aldo/keto reductase, putative	Get druggable targets OG5_126583	All targets in OG5_126583
Echinococcus granulosus	aldo keto reductase family 1 member B4	Get druggable targets OG5_126583	All targets in OG5_126583
Trichomonas vaginalis	aldo-keto reductase, putative	Get druggable targets OG5_126583	All targets in OG5_126583
Candida albicans	similar to mammalian aldo/keto reductases	Get druggable targets OG5_126583	All targets in OG5_126583
Trichomonas vaginalis	dihydrodiol dehydrogenase, putative	Get druggable targets OG5_126583	All targets in OG5_126583
Schistosoma mansoni	aldo-keto reductase	Get druggable targets OG5_126583	All targets in OG5_126583
Candida albicans	similar to mammalian aldo/keto reductases	Get druggable targets OG5_126583	All targets in OG5_126583
Echinococcus granulosus	aldo keto reductase family 1 member B4	Get druggable targets OG5_126583	All targets in OG5_126583
Trypanosoma congolense	aldo-keto reductase, putative	Get druggable targets OG5_126583	All targets in OG5_126583
Echinococcus multilocularis	aldo keto reductase family 1, member B4	Get druggable targets OG5_126583	All targets in OG5_126583
Leishmania donovani	prostaglandin f synthase, putative	Get druggable targets OG5_126583	All targets in OG5_126583
Echinococcus granulosus	aldo keto reductase family 1 member B4	Get druggable targets OG5_126583	All targets in OG5_126583
Trypanosoma brucei gambiense	prostaglandin f synthase. putative	Get druggable targets OG5_126583	All targets in OG5_126583
Leishmania braziliensis	aldo-keto reductase-like protein	Get druggable targets OG5_126583	All targets in OG5_126583
Echinococcus granulosus	aldo keto reductase	Get druggable targets OG5_126583	All targets in OG5_126583
Echinococcus granulosus	aldo keto reductase family 1 member B4	Get druggable targets OG5_126583	All targets in OG5_126583
Leishmania major	prostaglandin f synthase, putative	Get druggable targets OG5_126583	All targets in OG5_126583
Trichomonas vaginalis	aldo-keto reductase, putative	Get druggable targets OG5_126583	All targets in OG5_126583
Leishmania donovani	aldo-keto reductase-like protein	Get druggable targets OG5_126583	All targets in OG5_126583
Echinococcus multilocularis	aldo keto reductase family 1, member B4	Get druggable targets OG5_126583	All targets in OG5_126583
Echinococcus multilocularis	aldo keto reductase	Get druggable targets OG5_126583	All targets in OG5_126583
Echinococcus multilocularis	aldo keto reductase family 1, member B4	Get druggable targets OG5_126583	All targets in OG5_126583
Echinococcus granulosus	aldo keto reductase family 1 member B4	Get druggable targets OG5_126583	All targets in OG5_126583
Schistosoma mansoni	aldo-keto reductase	Get druggable targets OG5_126583	All targets in OG5_126583
Leishmania mexicana	prostaglandin f synthase, putative	Get druggable targets OG5_126583	All targets in OG5_126583
Echinococcus multilocularis	aldo keto reductase family 1, member B4	Get druggable targets OG5_126583	All targets in OG5_126583
Trichomonas vaginalis	aldo-keto reductase, putative	Get druggable targets OG5_126583	All targets in OG5_126583
Candida albicans	similar to mammalian aldo/keto reductases	Get druggable targets OG5_126583	All targets in OG5_126583
Loa Loa (eye worm)	oxidoreductase	Get druggable targets OG5_126583	All targets in OG5_126583
Schistosoma japonicum	ko:K00011 aldehyde reductase [EC1.1.1.21], putative	Get druggable targets OG5_126583	All targets in OG5_126583
Onchocerca volvulus		Get druggable targets OG5_126583	All targets in OG5_126583
Leishmania braziliensis	prostaglandin f synthase, putative	Get druggable targets OG5_126583	All targets in OG5_126583
Leishmania infantum	prostaglandin f2-alpha synthase/D-arabinose dehydrogenase	Get druggable targets OG5_126583	All targets in OG5_126583
Trichomonas vaginalis	aldo/keto reductase, putative	Get druggable targets OG5_126583	All targets in OG5_126583
Leishmania major	aldehyde reductase, putative,oxidoreductase, putative	Get druggable targets OG5_126583	All targets in OG5_126583
Trypanosoma congolense	prostaglandin f synthase, putative	Get druggable targets OG5_126583	All targets in OG5_126583
Echinococcus multilocularis	aldo keto reductase family 1, member B4	Get druggable targets OG5_126583	All targets in OG5_126583
Leishmania mexicana	prostaglandin f2-alpha synthase	Get druggable targets OG5_126583	All targets in OG5_126583
Trichomonas vaginalis	aldo/keto reductase, putative	Get druggable targets OG5_126583	All targets in OG5_126583
Leishmania braziliensis	aldehyde reductase, putative,oxidoreductase, putative	Get druggable targets OG5_126583	All targets in OG5_126583
Echinococcus multilocularis	aldo keto reductase family 1, member B4	Get druggable targets OG5_126583	All targets in OG5_126583
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126583	All targets in OG5_126583
Echinococcus multilocularis	aldo keto reductase family 1, member B4	Get druggable targets OG5_126583	All targets in OG5_126583
Echinococcus multilocularis	aldo keto reductase family 1, member B4	Get druggable targets OG5_126583	All targets in OG5_126583
Trichomonas vaginalis	dihydrodiol dehydrogenase, putative	Get druggable targets OG5_126583	All targets in OG5_126583
Neospora caninum	Oxidoreductase, aldo/keto reductase family, related	Get druggable targets OG5_126583	All targets in OG5_126583
Candida albicans	see also nonallelic CaP19.2244	Get druggable targets OG5_126583	All targets in OG5_126583
Toxoplasma gondii	aldose reductase, putative	Get druggable targets OG5_126583	All targets in OG5_126583
Onchocerca volvulus		Get druggable targets OG5_126583	All targets in OG5_126583
Echinococcus granulosus	aldo keto reductase family 1 member B4	Get druggable targets OG5_126583	All targets in OG5_126583
Leishmania mexicana	aldehyde reductase, putative,oxidoreductase, putative	Get druggable targets OG5_126583	All targets in OG5_126583
Loa Loa (eye worm)	oxidoreductase	Get druggable targets OG5_126583	All targets in OG5_126583
Trypanosoma brucei	aldo-keto reductase, putative	Get druggable targets OG5_126583	All targets in OG5_126583
Trichomonas vaginalis	aldo-keto reductase, putative	Get druggable targets OG5_126583	All targets in OG5_126583
Mycobacterium leprae	PROBABLE OXIDOREDUCTASE	Get druggable targets OG5_126583	All targets in OG5_126583
Trichomonas vaginalis	aldo-keto reductase, putative	Get druggable targets OG5_126583	All targets in OG5_126583
Entamoeba histolytica	aldose reductase, putative	Get druggable targets OG5_126583	All targets in OG5_126583
Loa Loa (eye worm)	oxidoreductase	Get druggable targets OG5_126583	All targets in OG5_126583
Trichomonas vaginalis	aldo-keto reductase, putative	Get druggable targets OG5_126583	All targets in OG5_126583
Echinococcus multilocularis	aldo keto reductase family 1, member B4	Get druggable targets OG5_126583	All targets in OG5_126583
Trichomonas vaginalis	aldo-keto reductase, putative	Get druggable targets OG5_126583	All targets in OG5_126583
Leishmania donovani	prostaglandin f2-alpha synthase	Get druggable targets OG5_126583	All targets in OG5_126583
Echinococcus granulosus	aldo keto reductase	Get druggable targets OG5_126583	All targets in OG5_126583
Echinococcus multilocularis	aldo keto reductase family 1, member B4	Get druggable targets OG5_126583	All targets in OG5_126583
Trichomonas vaginalis	aldo/keto reductase, putative	Get druggable targets OG5_126583	All targets in OG5_126583
Onchocerca volvulus		Get druggable targets OG5_126583	All targets in OG5_126583
Trypanosoma cruzi	aldo-keto reductase	Get druggable targets OG5_126583	All targets in OG5_126583
Mycobacterium leprae	Conserved hypothetical protein	Get druggable targets OG5_126583	All targets in OG5_126583

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Onchocerca volvulus	Multiple coagulation factor deficiency protein 2 homolog	Aldose reductase	316 aa	320 aa	40.3 %
Mycobacterium tuberculosis	Conserved protein	Aldose reductase	316 aa	335 aa	24.2 %
Candida albicans	putative aryl alcohol dehydrogenase	Aldose reductase	316 aa	329 aa	19.8 %
Onchocerca volvulus		Aldose reductase	316 aa	321 aa	40.2 %
Candida albicans	aryl alcohol dehydrogenase	Aldose reductase	316 aa	320 aa	19.4 %
Candida albicans	see also nonallelic CaP19.6816	Aldose reductase	316 aa	281 aa	29.2 %
Candida albicans	aryl alcohol dehydrogenase	Aldose reductase	316 aa	330 aa	18.8 %
Neospora caninum	aldo/keto reductase family oxidoreductase, putative	Aldose reductase	316 aa	295 aa	21.4 %
Candida albicans	aryl alcohol dehydrogenase	Aldose reductase	316 aa	320 aa	19.4 %
Candida albicans	putative aryl alcohol dehydrogenase	Aldose reductase	316 aa	320 aa	19.4 %
Mycobacterium ulcerans	hypothetical protein	Aldose reductase	316 aa	334 aa	24.3 %
Leishmania braziliensis	aldo/keto reductase, putative,aldo/keto reductase family-like protein	Aldose reductase	316 aa	267 aa	27.3 %
Candida albicans	see also nonallelic CaP19.6816	Aldose reductase	316 aa	281 aa	29.2 %
Candida albicans	similar to putative aryl alcohol dehydrogenase family	Aldose reductase	316 aa	320 aa	19.7 %
Trypanosoma cruzi	aldo/keto reductase, putative	Aldose reductase	316 aa	309 aa	26.9 %
Candida albicans	aryl alcohol dehydrogenase	Aldose reductase	316 aa	330 aa	18.8 %
Onchocerca volvulus		Aldose reductase	316 aa	314 aa	37.3 %
Candida albicans	D-arabinose dehydrogenase, NADP-dependent	Aldose reductase	316 aa	277 aa	37.2 %
Candida albicans	D-arabinose dehydrogenase, NADP-dependent	Aldose reductase	316 aa	277 aa	37.2 %
Toxoplasma gondii	aldo/keto reductase family oxidoreductase	Aldose reductase	316 aa	296 aa	26.7 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0102	0.2826	1
Echinococcus granulosus	cysteine protease	0.0032	0.019	0.019
Onchocerca volvulus		0.0054	0.1034	1
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0458	0.0041
Echinococcus granulosus	aldo keto reductase	0.0038	0.0419	0.0419
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0038	0.0419	0.0234
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0038	0.0419	0.0419
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0038	0.0419	0.0419
Echinococcus multilocularis	cathepsin L	0.0032	0.019	0.019
Leishmania major	cathepsin L-like protease	0.0054	0.1034	0.2553
Giardia lamblia	Cathepsin B precursor	0.0102	0.2826	1
Leishmania major	cathepsin L-like protease	0.0054	0.1034	0.2553
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0054	0.1034	0.1034
Onchocerca volvulus	Cathepsin L homolog	0.0054	0.1034	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0054	0.1034	0.0641
Schistosoma mansoni	cathepsin F (C01 family)	0.0054	0.1034	0.086
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0054	0.1034	0.3201
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0054	0.1034	0.3201
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0054	0.1034	0.3201
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0054	0.1034	1
Loa Loa (eye worm)	fibroinase	0.0054	0.1034	0.0641
Trichomonas vaginalis	aldo-keto reductase, putative	0.0038	0.0419	0.087
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0039	0.0458	0.0274
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0038	0.0419	0.0419
Trichomonas vaginalis	aldo-keto reductase, putative	0.0038	0.0419	0.087
Trypanosoma cruzi	aldo/keto reductase, putative	0.0038	0.0419	0.0234
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0054	0.1034	0.3201
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0054	0.1034	0.3201
Schistosoma mansoni	cathepsin F (C01 family)	0.0039	0.0458	0.0274
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0054	0.1034	0.3201
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0054	0.1034	0.3201
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0054	0.1034	0.3201
Echinococcus granulosus	cathepsin l1	0.0054	0.1034	0.1034
Brugia malayi	cathepsin L-like precursor	0.0039	0.0458	0.0274
Onchocerca volvulus		0.0039	0.0458	0.0637
Schistosoma mansoni	cathepsin F (C01 family)	0.0054	0.1034	0.086
Brugia malayi	Cathepsin L-like precursor	0.0054	0.1034	0.086
Trichomonas vaginalis	aldo-keto reductase, putative	0.0038	0.0419	0.087
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0054	0.1034	0.3201
Trypanosoma cruzi	cysteine peptidase, putative	0.0054	0.1034	0.086
Brugia malayi	Cathepsin L-like precursor	0.0054	0.1034	0.086
Echinococcus multilocularis	cathepsin L cysteine protease	0.0054	0.1034	0.1034
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0054	0.1034	0.0641
Echinococcus granulosus	aldo keto reductase	0.0038	0.0419	0.0419
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0054	0.1034	0.1034
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0038	0.0419	0.0419
Onchocerca volvulus		0.0054	0.1034	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0054	0.1034	0.3201
Leishmania major	cathepsin L-like protease	0.0054	0.1034	0.2553
Echinococcus multilocularis	cysteine protease	0.0054	0.1034	0.1034
Leishmania major	cysteine peptidase A (CPA)	0.0054	0.1034	0.2553
Brugia malayi	Cathepsin L-like precursor	0.0039	0.0458	0.0274
Trypanosoma brucei	aldo-keto reductase, putative	0.0038	0.0419	0.087
Trichomonas vaginalis	aldo-keto reductase, putative	0.0038	0.0419	0.087
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0054	0.1034	0.3201
Schistosoma mansoni	aldo-keto reductase	0.0038	0.0419	0.0234
Echinococcus granulosus	cathepsin L	0.0032	0.019	0.019
Mycobacterium ulcerans	oxidoreductase	0.0038	0.0419	0.5
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0038	0.0419	0.0419
Leishmania major	cathepsin L-like protease	0.0054	0.1034	0.2553
Giardia lamblia	Cathepsin B precursor	0.0102	0.2826	1
Brugia malayi	Cathepsin L-like precursor	0.0039	0.0458	0.0274
Onchocerca volvulus	Cathepsin L homolog	0.0054	0.1034	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0054	0.1034	0.3201
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0054	0.1034	0.3201
Brugia malayi	Cathepsin L-like precursor	0.0054	0.1034	0.086
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0038	0.0419	0.0419
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0054	0.1034	0.3201
Trichomonas vaginalis	aldo-keto reductase, putative	0.0038	0.0419	0.087
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0038	0.0419	0.0419
Entamoeba histolytica	cysteine proteinase, putative	0.0054	0.1034	1
Loa Loa (eye worm)	cathepsin B	0.0102	0.2826	0.2513
Trichomonas vaginalis	dihydrodiol dehydrogenase, putative	0.0038	0.0419	0.087
Trichomonas vaginalis	aldo-keto reductase, putative	0.0038	0.0419	0.087
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0039	0.0458	0.1018
Echinococcus multilocularis	aldo keto reductase	0.0038	0.0419	0.0419
Plasmodium vivax	vivapain-2	0.0054	0.1034	1
Echinococcus multilocularis	cathepsin b	0.0292	1	1
Echinococcus granulosus	cathepsin L cysteine protease	0.0032	0.019	0.019
Leishmania major	cathepsin L-like protease	0.0054	0.1034	0.2553
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0292	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0054	0.1034	0.3201
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0292	1	1
Trypanosoma brucei	prostaglandin f synthase	0.0038	0.0419	0.087
Echinococcus multilocularis	cathepsin b	0.0292	1	1
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0038	0.0419	0.0419
Echinococcus granulosus	cathepsin l1	0.0039	0.0458	0.0458
Trichomonas vaginalis	aldo-keto reductase, putative	0.0038	0.0419	0.087
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0038	0.0419	0.0419
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0054	0.1034	0.3201
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0054	0.1034	0.1034
Trypanosoma cruzi	cysteine peptidase, putative	0.0054	0.1034	0.086
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0038	0.0419	0.0419
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0054	0.1034	0.3201
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0038	0.0419	0.0419
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0038	0.0419	0.0419
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0054	0.1034	0.3201
Giardia lamblia	Cathepsin B precursor	0.0102	0.2826	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0054	0.1034	0.3201
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0458	0.0041
Entamoeba histolytica	cysteine proteinase, putative	0.0039	0.0458	0.3182
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0102	0.2826	1
Leishmania major	cathepsin L-like protease	0.0054	0.1034	0.2553
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0054	0.1034	1
Onchocerca volvulus		0.0054	0.1034	1
Entamoeba histolytica	aldose reductase, putative	0.0038	0.0419	0.2718
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0054	0.1034	0.3201
Echinococcus multilocularis	aldo keto reductase	0.0038	0.0419	0.0419
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0054	0.1034	0.3201
Toxoplasma gondii	cathepsin B	0.0102	0.2826	1
Entamoeba histolytica	aldose reductase, putative	0.0038	0.0419	0.2718
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0054	0.1034	0.3201
Entamoeba histolytica	aldose reductase, putative	0.0038	0.0419	0.2718
Onchocerca volvulus	Cathepsin F homolog	0.0054	0.1034	1
Entamoeba histolytica	cysteine protease, putative	0.0054	0.1034	1
Echinococcus granulosus	aldo keto reductase	0.0038	0.0419	0.0419
Mycobacterium tuberculosis	Probable oxidoreductase	0.0038	0.0419	0.5
Echinococcus granulosus	cathepsin b	0.0292	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0054	0.1034	0.3201
Trypanosoma cruzi	cysteine peptidase, putative	0.0054	0.1034	0.086
Trichomonas vaginalis	aldo/keto reductase, putative	0.0038	0.0419	0.087
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0054	0.1034	0.1034
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0054	0.1034	0.3201
Toxoplasma gondii	cathepsin CPL	0.0054	0.1034	0.2553
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0054	0.1034	0.3201
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0054	0.1034	0.3201
Echinococcus multilocularis	cathepsin L cysteine protease	0.0054	0.1034	0.1034
Trichomonas vaginalis	aldo-keto reductase, putative	0.0038	0.0419	0.087
Schistosoma mansoni	pol-related	0.0038	0.0419	0.0234
Schistosoma mansoni	aldo-keto reductase	0.0038	0.0419	0.0234
Echinococcus granulosus	hypothetical protein	0.0038	0.0419	0.0419
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0458	0.0041
Trypanosoma cruzi	cysteine peptidase, putative	0.0054	0.1034	0.086
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0102	0.2826	1
Trichomonas vaginalis	aldo-keto reductase, putative	0.0038	0.0419	0.087
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0038	0.0419	0.0419
Trichomonas vaginalis	dihydrodiol dehydrogenase, putative	0.0038	0.0419	0.087
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0054	0.1034	0.3201
Brugia malayi	Cathepsin L-like precursor	0.0054	0.1034	0.086
Trichomonas vaginalis	aldo-keto reductase, putative	0.0038	0.0419	0.087
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0054	0.1034	0.3201
Onchocerca volvulus		0.0054	0.1034	1
Trichomonas vaginalis	aldo/keto reductase, putative	0.0038	0.0419	0.087
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0102	0.2826	0.2688
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0038	0.0419	0.0234
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0054	0.1034	0.3201
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0038	0.0419	0.0419
Echinococcus multilocularis	aldo keto reductase	0.0038	0.0419	0.0419
Leishmania major	cathepsin L-like protease	0.0054	0.1034	0.2553
Brugia malayi	Cathepsin L-like precursor	0.0054	0.1034	0.086
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0039	0.0458	0.1018
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0054	0.1034	0.3201
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0054	0.1034	0.3201
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0054	0.1034	1
Loa Loa (eye worm)	cysteine protease	0.0054	0.1034	0.0641
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0038	0.0419	0.0419
Loa Loa (eye worm)	ctsf protein	0.0054	0.1034	0.0641
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0038	0.0419	0.0234
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0038	0.0419	0.0419
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0102	0.2826	0.2688
Echinococcus multilocularis	cysteine protease	0.0054	0.1034	0.1034
Onchocerca volvulus		0.0054	0.1034	1
Brugia malayi	Papain family cysteine protease containing protein	0.0054	0.1034	0.086
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0038	0.0419	0.0419
Onchocerca volvulus		0.0054	0.1034	1
Trypanosoma cruzi	aldo-keto reductase	0.0038	0.0419	0.0234
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0054	0.1034	0.3201
Leishmania major	cathepsin L-like protease	0.0054	0.1034	0.2553
Onchocerca volvulus		0.0054	0.1034	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0054	0.1034	0.3201
Brugia malayi	Cathepsin L-like precursor	0.0054	0.1034	0.086
Loa Loa (eye worm)	hypothetical protein	0.0292	1	1
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0039	0.0458	0.0274
Entamoeba histolytica	cysteine proteinase, putative	0.0054	0.1034	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0054	0.1034	0.3201
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0038	0.0419	0.0419
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0054	0.1034	0.3201
Mycobacterium leprae	PROBABLE OXIDOREDUCTASE	0.0038	0.0419	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0054	0.1034	0.3201
Echinococcus multilocularis	aldo keto reductase	0.0038	0.0419	0.0419
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0292	1	1
Trichomonas vaginalis	aldo/keto reductase, putative	0.0038	0.0419	0.087
Echinococcus granulosus	cathepsin b	0.0292	1	1
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0038	0.0419	0.0419
Plasmodium vivax	vivapain-2	0.0054	0.1034	1
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0292	1	1
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0038	0.0419	0.0419
Loa Loa (eye worm)	hypothetical protein	0.0054	0.1034	0.0641
Trichomonas vaginalis	aldo-keto reductase, putative	0.0038	0.0419	0.087
Trypanosoma cruzi	cruzipain precursor, putative	0.0054	0.1034	0.086
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0038	0.0419	0.0234
Trichomonas vaginalis	dihydrodiol dehydrogenase, putative	0.0038	0.0419	0.087
Trichomonas vaginalis	aldo-keto reductase, putative	0.0038	0.0419	0.087
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0292	1	1

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 14 uM	Inhibition of aldose reductase in rat lens homogenate	ChEMBL.	14510595

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL452498

Bibliographic References

No literature references available for this target.

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Detailed information for compound 951882