TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 363.817 | Formula: C17H19ClFN5O
H donors: 1 H acceptors: 3 LogP: 1.53 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: N#C[C@@H]1C[C@@H](CN1C(=O)CN[C@@H]1[C@@H]2[C@H]1CN(C2)c1ccc(cn1)Cl)F
InChi: 1S/C17H19ClFN5O/c18-10-1-2-15(21-5-10)23-8-13-14(9-23)17(13)22-6-16(25)24-7-11(19)3-12(24)4-20/h1-2,5,11-14,17,22H,3,6-9H2/t11-,12-,13-,14+,17+/m0/s1
InChiKey: UGAJFBJKPIYEMY-CKENWRIRSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	dipeptidyl-peptidase 7	Starlite/ChEMBL	References
Homo sapiens	dipeptidyl-peptidase 8	Starlite/ChEMBL	References
Homo sapiens	dipeptidyl-peptidase 4	Starlite/ChEMBL	References
Homo sapiens	prolyl endopeptidase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus multilocularis	dipeptidyl aminopeptidaseprotein	Get druggable targets OG5_128614	All targets in OG5_128614
Echinococcus multilocularis	Dipeptidyl peptidase 9	Get druggable targets OG5_129743	All targets in OG5_129743
Schistosoma mansoni	prolyl oligopeptidase (S09 family)	Get druggable targets OG5_129295	All targets in OG5_129295
Schistosoma japonicum	ko:K01322 prolyl oligopeptidase [EC3.4.21.26], putative	Get druggable targets OG5_129295	All targets in OG5_129295
Brugia malayi	prolyl oligopeptidase family protein	Get druggable targets OG5_128614	All targets in OG5_128614
Trypanosoma cruzi	serine peptidase, Clan SC, Family S9B	Get druggable targets OG5_129743	All targets in OG5_129743
Candida albicans	dipeptidyl aminopeptidase B	Get druggable targets OG5_128614	All targets in OG5_128614
Schistosoma mansoni	prolyl oligopeptidase (S09 family)	Get druggable targets OG5_129295	All targets in OG5_129295
Candida albicans	dipeptidyl aminopeptidase B	Get druggable targets OG5_128614	All targets in OG5_128614
Leishmania donovani	serine peptidase, Clan SC, Family S9B	Get druggable targets OG5_129743	All targets in OG5_129743
Echinococcus granulosus	prolyl endopeptidase	Get druggable targets OG5_129295	All targets in OG5_129295
Brugia malayi	prolyl oligopeptidase family protein	Get druggable targets OG5_129743	All targets in OG5_129743
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_129295	All targets in OG5_129295
Trypanosoma cruzi	dipeptidyl-peptidase 8-like serine peptidase	Get druggable targets OG5_129743	All targets in OG5_129743
Trypanosoma cruzi	prolyl endopeptidase	Get druggable targets OG5_129295	All targets in OG5_129295
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_129743	All targets in OG5_129743
Schistosoma mansoni	subfamily S9B unassigned peptidase (S09 family)	Get druggable targets OG5_128614	All targets in OG5_128614
Echinococcus granulosus	Lysosomal Pro X carboxypeptidase	Get druggable targets OG5_139351	All targets in OG5_139351
Mycobacterium tuberculosis	Probable protease II PtrBa [first part] (oligopeptidase B)	Get druggable targets OG5_129295	All targets in OG5_129295
Trypanosoma brucei	serine peptidase, Clan SC, Family S9B	Get druggable targets OG5_129743	All targets in OG5_129743
Neospora caninum	Prolyl oligopeptidase (EC 3.4.21.26) (Precursor), related	Get druggable targets OG5_129295	All targets in OG5_129295
Trypanosoma brucei	prolyl endopeptidase	Get druggable targets OG5_129295	All targets in OG5_129295
Schistosoma japonicum	Prolyl endopeptidase, putative	Get druggable targets OG5_129295	All targets in OG5_129295
Schistosoma japonicum	ko:K01276 dipeptidyl-peptidase II [EC3.4.14.2], putative	Get druggable targets OG5_139351	All targets in OG5_139351
Brugia malayi	prolyl oligopeptidase family protein	Get druggable targets OG5_129295	All targets in OG5_129295
Leishmania mexicana	dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B	Get druggable targets OG5_129743	All targets in OG5_129743
Leishmania braziliensis	dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B	Get druggable targets OG5_129743	All targets in OG5_129743
Echinococcus multilocularis	Lysosomal Pro X carboxypeptidase	Get druggable targets OG5_139351	All targets in OG5_139351
Leishmania infantum	prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative	Get druggable targets OG5_129295	All targets in OG5_129295
Echinococcus granulosus	dipeptidyl aminopeptidaseprotein	Get druggable targets OG5_128614	All targets in OG5_128614
Leishmania infantum	dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B	Get druggable targets OG5_129743	All targets in OG5_129743
Leishmania major	prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative	Get druggable targets OG5_129295	All targets in OG5_129295
Schistosoma japonicum	ko:K01278 dipeptidyl-peptidase 4, putative	Get druggable targets OG5_128614	All targets in OG5_128614
Trypanosoma brucei gambiense	prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative	Get druggable targets OG5_129295	All targets in OG5_129295
Loa Loa (eye worm)	prolyl oligopeptidase	Get druggable targets OG5_128614	All targets in OG5_128614
Leishmania donovani	prolyl endopeptidase	Get druggable targets OG5_129295	All targets in OG5_129295
Leishmania mexicana	prolyl oligopeptidase, putative	Get druggable targets OG5_129295	All targets in OG5_129295
Trypanosoma congolense	prolyl endopeptidase	Get druggable targets OG5_129295	All targets in OG5_129295
Trypanosoma brucei gambiense	dipeptidyl-peptidase 8-like serine protease	Get druggable targets OG5_129743	All targets in OG5_129743
Schistosoma japonicum	ko:K08656 dipeptidyl-peptidase 9, putative	Get druggable targets OG5_129743	All targets in OG5_129743
Echinococcus multilocularis	prolyl endopeptidase	Get druggable targets OG5_129295	All targets in OG5_129295
Toxoplasma gondii	prolyl endopeptidase	Get druggable targets OG5_129295	All targets in OG5_129295
Trypanosoma brucei	Dipeptidyl-peptidase 8-like, putative	Get druggable targets OG5_129743	All targets in OG5_129743
Echinococcus granulosus	Dipeptidyl peptidase 9	Get druggable targets OG5_129743	All targets in OG5_129743
Onchocerca volvulus	Dipeptidyl peptidase family member 1 homolog	Get druggable targets OG5_128614	All targets in OG5_128614
Schistosoma mansoni	family S28 unassigned peptidase (S28 family)	Get druggable targets OG5_139351	All targets in OG5_139351
Onchocerca volvulus	Prolyl endopeptidase homolog	Get druggable targets OG5_129295	All targets in OG5_129295
Leishmania major	dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B	Get druggable targets OG5_129743	All targets in OG5_129743
Schistosoma mansoni	dipeptidyl-peptidase 9 (S09 family)	Get druggable targets OG5_129743	All targets in OG5_129743

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Trypanosoma brucei	oligopeptidase b	prolyl endopeptidase	710 aa	630 aa	27.0 %
Trypanosoma cruzi	serine carboxypeptidase S28, putative	dipeptidyl-peptidase 7	492 aa	471 aa	25.7 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	rhodopsin orphan GPCR	0.021	0.1514	0.148
Loa Loa (eye worm)	G-protein coupled receptor	0.021	0.1514	0.1514
Mycobacterium leprae	PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B)	0.0096	0.0549	0.5
Echinococcus multilocularis	g protein coupled receptor	0.021	0.1514	0.148
Loa Loa (eye worm)	hypothetical protein	0.0205	0.1472	0.1472
Loa Loa (eye worm)	hypothetical protein	0.021	0.1514	0.1514
Trypanosoma brucei	serine peptidase, Clan SC, Family S9B	0.0224	0.1633	1
Echinococcus multilocularis	acetylcholinesterase	0.1216	1	1
Brugia malayi	neuropeptide F receptor	0.021	0.1514	0.148
Brugia malayi	Carboxylesterase family protein	0.0205	0.1472	0.1438
Trypanosoma cruzi	oligopeptidase B-like protein, putative	0.0096	0.0549	0.2649
Echinococcus multilocularis	acylamino acid releasing enzyme	0.005	0.0158	0.0119
Brugia malayi	hypothetical protein	0.021	0.1514	0.148
Echinococcus multilocularis	acetylcholinesterase	0.1216	1	1
Onchocerca volvulus		0.021	0.1514	0.1819
Trypanosoma brucei	prolyl endopeptidase	0.0191	0.1353	0.8099
Brugia malayi	hypothetical protein	0.0108	0.0646	0.0609
Loa Loa (eye worm)	acetylcholinesterase 1	0.1216	1	1
Onchocerca volvulus		0.021	0.1514	0.1819
Brugia malayi	Carboxylesterase family protein	0.0205	0.1472	0.1438
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0205	0.1472	1
Loa Loa (eye worm)	hypothetical protein	0.021	0.1514	0.1514
Toxoplasma gondii	dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein	0.0157	0.1066	0.7597
Echinococcus multilocularis	para nitrobenzyl esterase	0.0205	0.1472	0.1438
Echinococcus multilocularis	prolyl endopeptidase	0.0191	0.1353	0.1318
Echinococcus granulosus	prolyl endopeptidase	0.0191	0.1353	0.1318
Trypanosoma cruzi	serine peptidase, clan SC, family S9A-like protein, putative	0.0096	0.0549	0.2649
Echinococcus granulosus	tachykinin peptides receptor 99D	0.021	0.1514	0.148
Schistosoma mansoni	neuropeptide f receptor 76f	0.021	0.1514	0.1456
Loa Loa (eye worm)	hypothetical protein	0.021	0.1514	0.1514
Schistosoma mansoni	subfamily S9B unassigned peptidase (S09 family)	0.0296	0.2238	0.2185
Echinococcus multilocularis	somatostatin receptor	0.021	0.1514	0.148
Echinococcus multilocularis	neuropeptide s receptor	0.021	0.1514	0.148
Schistosoma mansoni	neuropeptide receptor	0.021	0.1514	0.1456
Schistosoma mansoni	neuropeptide receptor	0.021	0.1514	0.1456
Brugia malayi	prolyl oligopeptidase family protein	0.0296	0.2238	0.2207
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.021	0.1514	0.148
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.021	0.1514	0.1456
Echinococcus multilocularis	rhodopsin orphan GPCR	0.021	0.1514	0.148
Echinococcus granulosus	neuropeptide Y receptor	0.021	0.1514	0.148
Echinococcus multilocularis	Lysosomal Pro X carboxypeptidase	0.0456	0.3591	0.3565
Onchocerca volvulus	Neuropeptide F receptor homolog	0.021	0.1514	0.1819
Trichomonas vaginalis	carboxylesterase domain containing protein, putative	0.0205	0.1472	1
Loa Loa (eye worm)	hypothetical protein	0.021	0.1514	0.1514
Trypanosoma brucei	serine peptidase, clan SC, family S9A-like protein	0.0096	0.0549	0.2649
Brugia malayi	hypothetical protein	0.021	0.1514	0.148
Entamoeba histolytica	prolyl oligopeptidase family protein	0.005	0.0158	0.5
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.021	0.1514	0.148
Loa Loa (eye worm)	hypothetical protein	0.021	0.1514	0.1514
Echinococcus granulosus	rhodopsin orphan GPCR	0.021	0.1514	0.148
Schistosoma mansoni	histamine h1 receptor	0.021	0.1514	0.1456
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.021	0.1514	0.1456
Echinococcus multilocularis	dipeptidyl aminopeptidaseprotein	0.0296	0.2238	0.2207
Onchocerca volvulus	Dipeptidyl peptidase family member 1 homolog	0.0296	0.2238	1
Brugia malayi	Tachykinin-like peptides receptor 99D	0.021	0.1514	0.148
Echinococcus granulosus	serotonin receptor	0.021	0.1514	0.148
Echinococcus granulosus	neuropeptides capa receptor	0.021	0.1514	0.148
Echinococcus granulosus	small conductance calcium activated potassium	0.0486	0.3837	0.3813
Loa Loa (eye worm)	hypothetical protein	0.021	0.1514	0.1514
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.021	0.1514	0.1456
Brugia malayi	hypothetical protein	0.021	0.1514	0.148
Echinococcus granulosus	rhodopsin orphan GPCR	0.021	0.1514	0.148
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.021	0.1514	0.148
Entamoeba histolytica	prolyl oligopeptidase family protein	0.005	0.0158	0.5
Schistosoma mansoni	hypothetical protein	0.021	0.1514	0.1456
Loa Loa (eye worm)	hypothetical protein	0.021	0.1514	0.1514
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.021	0.1514	0.1514
Loa Loa (eye worm)	neuropeptide F receptor	0.021	0.1514	0.1514
Echinococcus granulosus	7tm_1 domain containing protein	0.021	0.1514	0.148
Brugia malayi	hypothetical protein	0.021	0.1514	0.148
Echinococcus granulosus	dro:myosuppressin receptor	0.021	0.1514	0.148
Toxoplasma gondii	phosphotransferase enzyme family protein	0.0081	0.0425	0.2233
Echinococcus granulosus	neuropeptide receptor A26	0.021	0.1514	0.148
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0205	0.1472	0.1414
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.021	0.1514	0.1456
Brugia malayi	Serotonin receptor	0.021	0.1514	0.148
Loa Loa (eye worm)	neuropeptide F receptor	0.021	0.1514	0.1514
Loa Loa (eye worm)	prolyl oligopeptidase	0.005	0.0158	0.0158
Loa Loa (eye worm)	hypothetical protein	0.021	0.1514	0.1514
Echinococcus granulosus	neuropeptide Y receptor	0.021	0.1514	0.148
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.021	0.1514	0.1514
Trypanosoma cruzi	serine peptidase, Clan SC, Family S9B	0.0224	0.1633	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.021	0.1514	0.148
Loa Loa (eye worm)	hypothetical protein	0.021	0.1514	0.1514
Echinococcus granulosus	7TM GPCR rhodopsin	0.021	0.1514	0.148
Echinococcus multilocularis	neuroligin	0.0205	0.1472	0.1438
Echinococcus granulosus	neuropeptides capa receptor	0.021	0.1514	0.148
Echinococcus granulosus	para nitrobenzyl esterase	0.0205	0.1472	0.1438
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.021	0.1514	0.1456
Onchocerca volvulus		0.0205	0.1472	0.1349
Echinococcus multilocularis	neuropeptide receptor A26	0.021	0.1514	0.148
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.021	0.1514	0.148
Loa Loa (eye worm)	hypothetical protein	0.021	0.1514	0.1514
Loa Loa (eye worm)	hypothetical protein	0.021	0.1514	0.1514
Brugia malayi	Dopamine receptor protein 2	0.021	0.1514	0.148
Schistosoma mansoni	biogenic amine (5HT) receptor	0.021	0.1514	0.1456
Schistosoma mansoni	hypothetical protein	0.021	0.1514	0.1456
Brugia malayi	putative neuropeptide receptor NPR1	0.021	0.1514	0.148
Loa Loa (eye worm)	hypothetical protein	0.021	0.1514	0.1514
Loa Loa (eye worm)	hypothetical protein	0.021	0.1514	0.1514
Loa Loa (eye worm)	hypothetical protein	0.021	0.1514	0.1514
Loa Loa (eye worm)	carboxylesterase	0.0205	0.1472	0.1472
Loa Loa (eye worm)	carboxylesterase	0.0205	0.1472	0.1472
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.021	0.1514	0.1456
Loa Loa (eye worm)	choline/ethanolamine kinase	0.0081	0.0425	0.0425
Echinococcus multilocularis	neuropeptide receptor	0.021	0.1514	0.148
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.021	0.1514	0.148
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.021	0.1514	0.148
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0205	0.1472	0.1414
Echinococcus multilocularis	rhodopsin orphan GPCR	0.021	0.1514	0.148
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.021	0.1514	0.148
Schistosoma mansoni	dipeptidyl-peptidase 9 (S09 family)	0.0224	0.1633	0.1576
Loa Loa (eye worm)	prolyl oligopeptidase	0.0296	0.2238	0.2238
Onchocerca volvulus		0.021	0.1514	0.1819
Loa Loa (eye worm)	hypothetical protein	0.021	0.1514	0.1514
Echinococcus granulosus	rhodopsin orphan GPCR	0.021	0.1514	0.148
Onchocerca volvulus		0.021	0.1514	0.1819
Echinococcus multilocularis	Dipeptidyl peptidase 9	0.0224	0.1633	0.16
Loa Loa (eye worm)	hypothetical protein	0.021	0.1514	0.1514
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.1216	1	1
Leishmania major	prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative	0.0191	0.1353	0.7414
Echinococcus granulosus	tm gpcr rhodopsin	0.021	0.1514	0.148
Echinococcus granulosus	tm gpcr rhodopsin	0.021	0.1514	0.148
Echinococcus granulosus	neuropeptide FF receptor 2	0.021	0.1514	0.148
Loa Loa (eye worm)	hypothetical protein	0.0108	0.0646	0.0646
Echinococcus multilocularis	neuropeptide receptor	0.021	0.1514	0.148
Echinococcus granulosus	rhodopsin orphan GPCR	0.021	0.1514	0.148
Loa Loa (eye worm)	hypothetical protein	0.0191	0.1353	0.1353
Brugia malayi	neuropeptide F receptor	0.021	0.1514	0.148
Schistosoma mansoni	neuropeptide receptor	0.021	0.1514	0.1456
Onchocerca volvulus		0.0205	0.1472	0.1349
Echinococcus granulosus	sex peptide receptor	0.021	0.1514	0.148
Schistosoma mansoni	amine GPCR	0.021	0.1514	0.1456
Echinococcus multilocularis	rhodopsin orphan GPCR	0.021	0.1514	0.148
Brugia malayi	GnHR receptor homolog	0.021	0.1514	0.148
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.021	0.1514	0.148
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0205	0.1472	0.1414
Onchocerca volvulus		0.021	0.1514	0.1819
Echinococcus granulosus	g protein coupled receptor	0.021	0.1514	0.148
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.021	0.1514	0.148
Loa Loa (eye worm)	hypothetical protein	0.0205	0.1472	0.1472
Echinococcus multilocularis	family S9 non peptidase ue (S09 family)	0.0205	0.1472	0.1438
Brugia malayi	G-protein coupled receptor	0.021	0.1514	0.148
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0057	0.022	0.0468
Brugia malayi	sulfakinin receptor protein	0.021	0.1514	0.148
Schistosoma mansoni	hypothetical protein	0.021	0.1514	0.1456
Brugia malayi	Carboxylesterase family protein	0.0205	0.1472	0.1438
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.021	0.1514	0.148
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.021	0.1514	0.1456
Schistosoma mansoni	calcium-activated potassium channel	0.0486	0.3837	0.3795
Echinococcus granulosus	neuroligin	0.0205	0.1472	0.1438
Echinococcus multilocularis	allatostatin A receptor	0.021	0.1514	0.148
Brugia malayi	Dopamine receptor protein 1	0.021	0.1514	0.148
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.021	0.1514	0.1456
Loa Loa (eye worm)	hypothetical protein	0.0205	0.1472	0.1472
Echinococcus multilocularis	fmrfamide receptor	0.021	0.1514	0.148
Schistosoma mansoni	prolyl oligopeptidase (S09 family)	0.0191	0.1353	0.1294
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.021	0.1514	0.148
Echinococcus multilocularis	neuropeptide FF receptor 2	0.021	0.1514	0.148
Echinococcus granulosus	g-protein coupled receptor	0.021	0.1514	0.148
Brugia malayi	Carboxylesterase family protein	0.1216	1	1
Loa Loa (eye worm)	hypothetical protein	0.021	0.1514	0.1514
Trypanosoma cruzi	prolyl endopeptidase	0.0191	0.1353	0.8099
Schistosoma mansoni	neuropeptide F-like receptor	0.021	0.1514	0.1456
Echinococcus multilocularis	G protein coupled receptor 139	0.021	0.1514	0.148
Echinococcus multilocularis	rhodopsin orphan GPCR	0.021	0.1514	0.148
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.021	0.1514	0.148
Echinococcus granulosus	Dipeptidyl peptidase 9	0.0224	0.1633	0.16
Schistosoma mansoni	prolyl oligopeptidase (S09 family)	0.005	0.0158	0.0091
Trypanosoma brucei	Dipeptidyl-peptidase 8-like, putative	0.0224	0.1633	1
Plasmodium falciparum	choline kinase	0.0081	0.0425	1
Echinococcus multilocularis	g protein coupled receptor	0.021	0.1514	0.148
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.021	0.1514	0.148
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.021	0.1514	0.1456
Entamoeba histolytica	dipeptidyl-peptidase, putative	0.005	0.0158	0.5
Loa Loa (eye worm)	hypothetical protein	0.021	0.1514	0.1514
Loa Loa (eye worm)	hypothetical protein	0.021	0.1514	0.1514
Echinococcus granulosus	family S9 non peptidase ue S09 family	0.0205	0.1472	0.1438
Onchocerca volvulus		0.021	0.1514	0.1819
Loa Loa (eye worm)	hypothetical protein	0.021	0.1514	0.1514
Schistosoma mansoni	myosin xvIII	0.021	0.1514	0.1456
Onchocerca volvulus		0.0205	0.1472	0.1349
Loa Loa (eye worm)	hypothetical protein	0.021	0.1514	0.1514
Echinococcus granulosus	allatostatin A receptor	0.021	0.1514	0.148
Loa Loa (eye worm)	hypothetical protein	0.021	0.1514	0.1514
Echinococcus multilocularis	fmrfamide receptor	0.021	0.1514	0.148
Trypanosoma cruzi	oligopeptidase b	0.0096	0.0549	0.2649
Loa Loa (eye worm)	hypothetical protein	0.0205	0.1472	0.1472
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.021	0.1514	0.148
Brugia malayi	hypothetical protein	0.0205	0.1472	0.1438
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.021	0.1514	0.1456
Echinococcus granulosus	peptide allatostatin:somatostatin	0.021	0.1514	0.148
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.021	0.1514	0.148
Brugia malayi	prolyl oligopeptidase family protein	0.005	0.0158	0.0119
Onchocerca volvulus		0.021	0.1514	0.1819
Loa Loa (eye worm)	hypothetical protein	0.021	0.1514	0.1514
Entamoeba histolytica	dipeptidyl-peptidase, putative	0.005	0.0158	0.5
Brugia malayi	AKH receptor	0.021	0.1514	0.148
Echinococcus granulosus	neuropeptide s receptor	0.021	0.1514	0.148
Onchocerca volvulus		0.021	0.1514	0.1819
Echinococcus granulosus	dipeptidyl aminopeptidaseprotein	0.0296	0.2238	0.2207
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.021	0.1514	0.148
Brugia malayi	hypothetical protein	0.021	0.1514	0.148
Echinococcus multilocularis	rhodopsin orphan GPCR	0.021	0.1514	0.148
Echinococcus granulosus	rhodopsin orphan GPCR	0.021	0.1514	0.148
Schistosoma mansoni	biogenic amine receptor	0.021	0.1514	0.1456
Plasmodium vivax	choline kinase, putative	0.0081	0.0425	1
Loa Loa (eye worm)	hypothetical protein	0.021	0.1514	0.1514
Onchocerca volvulus		0.021	0.1514	0.1819
Schistosoma mansoni	growth hormone secretagogue receptor	0.021	0.1514	0.1456
Onchocerca volvulus		0.021	0.1514	0.1819
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.021	0.1514	0.1456
Echinococcus granulosus	neuropeptide receptor	0.021	0.1514	0.148
Echinococcus granulosus	acetylcholinesterase	0.1216	1	1
Brugia malayi	G protein-coupled receptor F59B2.13	0.021	0.1514	0.148
Echinococcus multilocularis	serotonin receptor	0.021	0.1514	0.148
Loa Loa (eye worm)	hypothetical protein	0.021	0.1514	0.1514
Trichomonas vaginalis	spcc417.12 protein, putative	0.0205	0.1472	1
Onchocerca volvulus		0.021	0.1514	0.1819
Loa Loa (eye worm)	hypothetical protein	0.0243	0.1793	0.1793
Schistosoma mansoni	acetylcholinesterase	0.0205	0.1472	0.1414
Schistosoma mansoni	hypothetical protein	0.021	0.1514	0.1456
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.021	0.1514	0.1456
Loa Loa (eye worm)	hypothetical protein	0.021	0.1514	0.1514
Brugia malayi	follicle stimulating hormone receptor	0.021	0.1514	0.148
Brugia malayi	prolyl oligopeptidase family protein	0.0191	0.1353	0.1318
Loa Loa (eye worm)	hypothetical protein	0.021	0.1514	0.1514
Echinococcus granulosus	carboxylesterase 5A	0.1216	1	1
Echinococcus multilocularis	sex peptide receptor	0.021	0.1514	0.148
Schistosoma mansoni	amine GPCR	0.021	0.1514	0.1456
Schistosoma mansoni	opsin-like receptor	0.021	0.1514	0.1456
Schistosoma mansoni	neuroligin 3 (S09 family)	0.0205	0.1472	0.1414
Brugia malayi	hypothetical protein	0.021	0.1514	0.148
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.021	0.1514	0.1456
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.021	0.1514	0.148
Brugia malayi	Serotonin receptor	0.021	0.1514	0.148
Mycobacterium tuberculosis	Probable protease II PtrBa [first part] (oligopeptidase B)	0.0142	0.0933	0.4158
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.021	0.1514	0.1819
Schistosoma mansoni	biogenic amine receptor	0.021	0.1514	0.1456
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.021	0.1514	0.1456
Brugia malayi	larval opioid receptor	0.021	0.1514	0.148
Echinococcus granulosus	Lysosomal Pro X carboxypeptidase	0.0456	0.3591	0.3565
Echinococcus multilocularis	choline:ethanolamine kinase	0.0081	0.0425	0.0387
Echinococcus multilocularis	dro:myosuppressin receptor	0.021	0.1514	0.148
Loa Loa (eye worm)	hypothetical protein	0.021	0.1514	0.1514
Loa Loa (eye worm)	hypothetical protein	0.021	0.1514	0.1514
Loa Loa (eye worm)	hypothetical protein	0.021	0.1514	0.1514
Schistosoma mansoni	BC026374 protein (S09 family)	0.0205	0.1472	0.1414
Schistosoma mansoni	neuropeptide F-like receptor	0.021	0.1514	0.1456
Brugia malayi	hypothetical protein	0.021	0.1514	0.148
Brugia malayi	Melatonin receptor type 1A	0.021	0.1514	0.148
Loa Loa (eye worm)	hypothetical protein	0.0205	0.1472	0.1472
Echinococcus granulosus	rhodopsin orphan GPCR	0.021	0.1514	0.148
Brugia malayi	Dopamine receptor	0.021	0.1514	0.148
Loa Loa (eye worm)	hypothetical protein	0.021	0.1514	0.1514
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.021	0.1514	0.148
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.021	0.1514	0.148
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.021	0.1514	0.148
Loa Loa (eye worm)	hypothetical protein	0.021	0.1514	0.1514
Echinococcus multilocularis	serotonin receptor	0.021	0.1514	0.148
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.021	0.1514	0.148
Brugia malayi	Choline/ethanolamine kinase family protein	0.0081	0.0425	0.0387
Brugia malayi	G protein-coupled receptor	0.021	0.1514	0.148
Echinococcus multilocularis	rhodopsin orphan GPCR	0.021	0.1514	0.148
Echinococcus multilocularis	BC026374 protein (S09 family)	0.0205	0.1472	0.1438
Entamoeba histolytica	hypothetical protein, conserved	0.005	0.0158	0.5
Entamoeba histolytica	prolyl oligopeptidase family protein	0.005	0.0158	0.5
Schistosoma mansoni	acylaminoacyl-peptidase (S09 family)	0.005	0.0158	0.0091
Onchocerca volvulus		0.021	0.1514	0.1819
Loa Loa (eye worm)	hypothetical protein	0.0218	0.1583	0.1583
Echinococcus multilocularis	rhodopsin orphan GPCR	0.021	0.1514	0.148
Schistosoma mansoni	family S28 unassigned peptidase (S28 family)	0.0456	0.3591	0.3547
Mycobacterium ulcerans	carboxylesterase, LipT	0.0205	0.1472	1
Schistosoma mansoni	amine GPCR	0.021	0.1514	0.1456
Schistosoma mansoni	opsin-like receptor	0.021	0.1514	0.1456
Loa Loa (eye worm)	TYRA-2 protein	0.021	0.1514	0.1514
Schistosoma mansoni	adenoreceptor	0.021	0.1514	0.1456
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.021	0.1514	0.1456
Brugia malayi	hypothetical protein	0.021	0.1514	0.148
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.021	0.1514	0.1456
Onchocerca volvulus		0.021	0.1514	0.1819
Schistosoma mansoni	alpha-1 adrenergic receptor	0.021	0.1514	0.1456
Echinococcus multilocularis	neuropeptides capa receptor	0.021	0.1514	0.148
Echinococcus granulosus	somatostatin receptor	0.021	0.1514	0.148
Loa Loa (eye worm)	hypothetical protein	0.021	0.1514	0.1514
Schistosoma mansoni	hypothetical protein	0.0486	0.3837	0.3795
Loa Loa (eye worm)	carboxylesterase	0.1216	1	1
Loa Loa (eye worm)	hypothetical protein	0.021	0.1514	0.1514
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.021	0.1514	0.1514
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.021	0.1514	0.148
Schistosoma mansoni	amine GPCR	0.021	0.1514	0.1456
Mycobacterium tuberculosis	Carboxylesterase LipT	0.0205	0.1472	1
Brugia malayi	ORL1-like opioid receptor	0.021	0.1514	0.148
Loa Loa (eye worm)	hypothetical protein	0.0486	0.3837	0.3837
Brugia malayi	RE15519p	0.021	0.1514	0.148
Trypanosoma brucei	oligopeptidase b	0.0096	0.0549	0.2649
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.021	0.1514	0.1456
Schistosoma mansoni	opsin-like receptor	0.021	0.1514	0.1456
Echinococcus multilocularis	neuropeptide Y receptor	0.021	0.1514	0.148
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0205	0.1472	1
Echinococcus granulosus	acetylcholinesterase	0.1216	1	1
Loa Loa (eye worm)	hypothetical protein	0.0117	0.0726	0.0726
Loa Loa (eye worm)	hypothetical protein	0.021	0.1514	0.1514
Brugia malayi	G-protein coupled receptor	0.021	0.1514	0.148
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.021	0.1514	0.1456
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.021	0.1514	0.1456
Echinococcus granulosus	g protein coupled receptor	0.021	0.1514	0.148
Loa Loa (eye worm)	hypothetical protein	0.1216	1	1
Loa Loa (eye worm)	hypothetical protein	0.021	0.1514	0.1514
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0057	0.022	0.0468
Echinococcus granulosus	biogenic amine 5HT receptor	0.021	0.1514	0.148
Schistosoma mansoni	neuropeptide receptor	0.021	0.1514	0.1456
Echinococcus granulosus	fmrfamide receptor	0.021	0.1514	0.148
Echinococcus granulosus	hypothetical protein	0.021	0.1514	0.148
Loa Loa (eye worm)	hypothetical protein	0.021	0.1514	0.1514
Schistosoma mansoni	amine GPCR	0.021	0.1514	0.1456
Loa Loa (eye worm)	hypothetical protein	0.0205	0.1472	0.1472
Echinococcus multilocularis	g protein coupled receptor	0.021	0.1514	0.148
Echinococcus granulosus	choline:ethanolamine kinase	0.0081	0.0425	0.0387
Toxoplasma gondii	prolyl endopeptidase	0.0191	0.1353	1
Onchocerca volvulus		0.021	0.1514	0.1819
Onchocerca volvulus		0.021	0.1514	0.1819
Echinococcus multilocularis	orexin receptor type 2	0.021	0.1514	0.148
Echinococcus multilocularis	G-protein coupled receptor, putative	0.021	0.1514	0.148
Brugia malayi	Carboxylesterase family protein	0.0205	0.1472	0.1438
Echinococcus multilocularis	small conductance calcium activated potassium	0.0486	0.3837	0.3813
Echinococcus granulosus	neuropeptide receptor	0.021	0.1514	0.148
Loa Loa (eye worm)	hypothetical protein	0.021	0.1514	0.1514
Echinococcus multilocularis	neuropeptide Y receptor	0.021	0.1514	0.148
Schistosoma mansoni	calcium-activated potassium channel	0.0462	0.3637	0.3594
Echinococcus multilocularis	g-protein coupled receptor	0.021	0.1514	0.148
Onchocerca volvulus		0.021	0.1514	0.1819
Loa Loa (eye worm)	G-protein coupled receptor	0.021	0.1514	0.1514
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.021	0.1514	0.1514
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.021	0.1514	0.1456
Giardia lamblia	Alanyl dipeptidyl peptidase	0.005	0.0158	0.5
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.021	0.1514	0.148
Loa Loa (eye worm)	hypothetical protein	0.1216	1	1
Schistosoma mansoni	biogenic amine receptor	0.021	0.1514	0.1456
Schistosoma mansoni	prolyl oligopeptidase (S09 family)	0.0191	0.1353	0.1294
Trypanosoma cruzi	dipeptidyl-peptidase 8-like serine peptidase	0.0224	0.1633	1
Echinococcus granulosus	g protein coupled receptor	0.021	0.1514	0.148
Trypanosoma cruzi	oligopeptidase b	0.0096	0.0549	0.2649
Giardia lamblia	Alanyl dipeptidyl peptidase	0.005	0.0158	0.5
Loa Loa (eye worm)	hypothetical protein	0.021	0.1514	0.1514
Echinococcus granulosus	orexin receptor type 2	0.021	0.1514	0.148
Echinococcus granulosus	biogenic amine 5HT receptor	0.021	0.1514	0.148
Brugia malayi	prolyl oligopeptidase family protein	0.005	0.0158	0.0119
Brugia malayi	prolyl oligopeptidase family protein	0.0224	0.1633	0.16
Echinococcus granulosus	tm gpcr rhodopsin	0.021	0.1514	0.148
Loa Loa (eye worm)	hypothetical protein	0.021	0.1514	0.1514
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.021	0.1514	0.148
Echinococcus granulosus	BC026374 protein S09 family	0.0205	0.1472	0.1438
Brugia malayi	hypothetical protein	0.021	0.1514	0.148
Onchocerca volvulus		0.0205	0.1472	0.1349
Schistosoma mansoni	biogenic amine (5HT) receptor	0.021	0.1514	0.1456
Brugia malayi	hypothetical protein	0.021	0.1514	0.148
Trypanosoma brucei	prolyl oligopeptidase, putative	0.0096	0.0549	0.2649
Loa Loa (eye worm)	melatonin receptor type 1A	0.021	0.1514	0.1514
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.021	0.1514	0.1456
Brugia malayi	putative neuropeptide receptor	0.021	0.1514	0.148
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.021	0.1514	0.1514
Schistosoma mansoni	gliotactin	0.0205	0.1472	0.1414
Echinococcus granulosus	G protein coupled receptor 139	0.021	0.1514	0.148
Echinococcus granulosus	acylamino acid releasing enzyme	0.005	0.0158	0.0119
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0036	0.004	0.004
Loa Loa (eye worm)	hypothetical protein	0.005	0.0158	0.0158
Loa Loa (eye worm)	hypothetical protein	0.021	0.1514	0.1514
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.021	0.1514	0.1456
Echinococcus granulosus	alpha 1A adrenergic receptor	0.021	0.1514	0.148
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.021	0.1514	0.148
Onchocerca volvulus		0.0205	0.1472	0.1349
Loa Loa (eye worm)	hypothetical protein	0.021	0.1514	0.1514
Loa Loa (eye worm)	hypothetical protein	0.0205	0.1472	0.1472
Echinococcus multilocularis	carboxylesterase 5A	0.1216	1	1
Leishmania major	dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B	0.0224	0.1633	1
Echinococcus multilocularis	neuropeptides capa receptor	0.021	0.1514	0.148
Loa Loa (eye worm)	hypothetical protein	0.021	0.1514	0.1514
Loa Loa (eye worm)	hypothetical protein	0.021	0.1514	0.1514
Loa Loa (eye worm)	hypothetical protein	0.021	0.1514	0.1514
Onchocerca volvulus		0.021	0.1514	0.1819

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (binding)		Inhibition of DPP9	ChEMBL.	18602260
IC50 (binding)	= 49 nM	Inhibition of human plasma DPP4	ChEMBL.	18602260
IC50 (binding)	= 2375 nM	Inhibition of DPP8	ChEMBL.	18602260
IC50 (binding)	= 8750 nM	Inhibition of DPP2	ChEMBL.	18602260
IC50 (binding)	= 9044 nM	Inhibition of PPCE	ChEMBL.	18602260

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL471956

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 972412