TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 448.474 | Formula: C24H21N2O3PS
H donors: 2 H acceptors: 2 LogP: 4.04 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: COP(=O)(c1ccccc1)c1ccc(cc1)C(=O)Nc1cc(ccc1N)c1cccs1
InChi: 1S/C24H21N2O3PS/c1-29-30(28,19-6-3-2-4-7-19)20-12-9-17(10-13-20)24(27)26-22-16-18(11-14-21(22)25)23-8-5-15-31-23/h2-16H,25H2,1H3,(H,26,27)
InChiKey: KDDZFAMHBWRFCE-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	histone deacetylase 1	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma mansoni	histone deacetylase	Get druggable targets OG5_126742	All targets in OG5_126742
Leishmania mexicana	histone deacetylase, putative	Get druggable targets OG5_126742	All targets in OG5_126742
Candida albicans	one of two distinct genes with strong similarity to S. cerevisiae RPD3 (YNL330C) SIN3 histone deacetylase complex component	Get druggable targets OG5_126742	All targets in OG5_126742
Theileria parva	histone deacetylase, putative	Get druggable targets OG5_126742	All targets in OG5_126742
Echinococcus granulosus	histone deacetylase 1	Get druggable targets OG5_126742	All targets in OG5_126742
Loa Loa (eye worm)	histone deacetylase 3	Get druggable targets OG5_126742	All targets in OG5_126742
Plasmodium knowlesi	histone deacetylase 1, putative	Get druggable targets OG5_126742	All targets in OG5_126742
Plasmodium berghei	histone deacetylase 1, putative	Get druggable targets OG5_126742	All targets in OG5_126742
Trichomonas vaginalis	histone deacetylase 1, 2 ,3, putative	Get druggable targets OG5_126742	All targets in OG5_126742
Leishmania donovani	histone deacetylase, putative	Get druggable targets OG5_126742	All targets in OG5_126742
Plasmodium yoelii	histone deacetylase	Get druggable targets OG5_126742	All targets in OG5_126742
Trypanosoma brucei	histone deacetylase 1	Get druggable targets OG5_126742	All targets in OG5_126742
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126742	All targets in OG5_126742
Trichomonas vaginalis	histone deacetylase 1, 2 ,3, putative	Get druggable targets OG5_126742	All targets in OG5_126742
Candida albicans	one of two distinct genes with strong similarity to S. cerevisiae RPD3 (YNL330C) SIN3 histone deacetylase complex component	Get druggable targets OG5_126742	All targets in OG5_126742
Babesia bovis	histone deacetylase	Get druggable targets OG5_126742	All targets in OG5_126742
Trypanosoma brucei gambiense	histone deacetylase 1,histone deacetylase-like 1 protein, putative	Get druggable targets OG5_126742	All targets in OG5_126742
Cryptosporidium hominis	histone deacetylase	Get druggable targets OG5_126742	All targets in OG5_126742
Loa Loa (eye worm)	histone deacetylase 1	Get druggable targets OG5_126742	All targets in OG5_126742
Trypanosoma congolense	histone deacetylase-like 1 protein, putative	Get druggable targets OG5_126742	All targets in OG5_126742
Echinococcus granulosus	histone deacetylase 3	Get druggable targets OG5_126742	All targets in OG5_126742
Giardia lamblia	Histone deacetylase	Get druggable targets OG5_126742	All targets in OG5_126742
Trichomonas vaginalis	histone deacetylase, putative	Get druggable targets OG5_126742	All targets in OG5_126742
Neospora caninum	histone deacetylase, putative	Get druggable targets OG5_126742	All targets in OG5_126742
Leishmania donovani	histone deacetylase, putative	Get druggable targets OG5_126742	All targets in OG5_126742
Trichomonas vaginalis	histone deacetylase 1, 2 ,3, putative	Get druggable targets OG5_126742	All targets in OG5_126742
Trichomonas vaginalis	histone deacetylase, putative	Get druggable targets OG5_126742	All targets in OG5_126742
Leishmania braziliensis	histone deacetylase, putative	Get druggable targets OG5_126742	All targets in OG5_126742
Trypanosoma cruzi	histone deacetylase 1, putative	Get druggable targets OG5_126742	All targets in OG5_126742
Leishmania infantum	histone deacetylase, putative	Get druggable targets OG5_126742	All targets in OG5_126742
Toxoplasma gondii	histone deacetylase HDAC2	Get druggable targets OG5_126742	All targets in OG5_126742
Entamoeba histolytica	histone deacetylase, putative	Get druggable targets OG5_126742	All targets in OG5_126742
Plasmodium vivax	histone deacetylase 1, putative	Get druggable targets OG5_126742	All targets in OG5_126742
Brugia malayi	histone deacetylase 1 (HD1)	Get druggable targets OG5_126742	All targets in OG5_126742
Echinococcus multilocularis	histone deacetylase 1	Get druggable targets OG5_126742	All targets in OG5_126742
Trypanosoma cruzi	histone deacetylase 1, putative	Get druggable targets OG5_126742	All targets in OG5_126742
Schistosoma japonicum	ko:K06067 histone deacetylase 1/2, putative	Get druggable targets OG5_126742	All targets in OG5_126742
Leishmania major	histone deacetylase, putative	Get druggable targets OG5_126742	All targets in OG5_126742
Candida albicans	one of two distinct genes with strong similarity to S. cerevisiae RPD3 (YNL330C) SIN3 histone deacetylase complex component	Get druggable targets OG5_126742	All targets in OG5_126742
Neospora caninum	hypothetical protein	Get druggable targets OG5_126742	All targets in OG5_126742
Schistosoma japonicum	ko:K01463 Hdac3 [EC:3.5.1.-], putative	Get druggable targets OG5_126742	All targets in OG5_126742
Trichomonas vaginalis	histone deacetylase, putative	Get druggable targets OG5_126742	All targets in OG5_126742
Candida albicans	one of two distinct genes with strong similarity to S. cerevisiae RPD3 (YNL330C) SIN3 histone deacetylase complex component	Get druggable targets OG5_126742	All targets in OG5_126742
Cryptosporidium parvum	RPD3/HD1 histone deacetylase	Get druggable targets OG5_126742	All targets in OG5_126742
Brugia malayi	histone deacetylase 3 (HD3)	Get druggable targets OG5_126742	All targets in OG5_126742
Leishmania braziliensis	histone deacetylase, putative	Get druggable targets OG5_126742	All targets in OG5_126742
Cryptosporidium parvum	histone deacetylase HDA2/Rpd3p	Get druggable targets OG5_126742	All targets in OG5_126742
Leishmania mexicana	histone deacetylase, putative	Get druggable targets OG5_126742	All targets in OG5_126742
Leishmania major	histone deacetylase, putative	Get druggable targets OG5_126742	All targets in OG5_126742
Leishmania infantum	histone deacetylase, putative	Get druggable targets OG5_126742	All targets in OG5_126742
Brugia malayi	Histone deacetylase 1	Get druggable targets OG5_126742	All targets in OG5_126742
Plasmodium falciparum	histone deacetylase 1	Get druggable targets OG5_126742	All targets in OG5_126742
Trichomonas vaginalis	histone deacetylase, putative	Get druggable targets OG5_126742	All targets in OG5_126742
Toxoplasma gondii	histone deacetylase HDAC3	Get druggable targets OG5_126742	All targets in OG5_126742
Schistosoma mansoni	histone deacetylase	Get druggable targets OG5_126742	All targets in OG5_126742
Cryptosporidium hominis	histone deacetylase	Get druggable targets OG5_126742	All targets in OG5_126742
Trichomonas vaginalis	histone deacetylase, putative	Get druggable targets OG5_126742	All targets in OG5_126742
Echinococcus multilocularis	histone deacetylase 3	Get druggable targets OG5_126742	All targets in OG5_126742
Trichomonas vaginalis	histone deacetylase, putative	Get druggable targets OG5_126742	All targets in OG5_126742

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	Xaa-Pro dipeptidase (M24 family)	0.016	0.0561	0.0699
Echinococcus multilocularis	xaa Pro dipeptidase	0.016	0.0561	0.0561
Trypanosoma brucei	Metallopeptidase family M24, putative	0.016	0.0561	0.0561
Trypanosoma brucei	methionine aminopeptidase 2, putative	0.016	0.0561	0.0561
Trichomonas vaginalis	Clan MG, familly M24, aminopeptidase P-like metallopeptidase	0.016	0.0561	1
Chlamydia trachomatis	methionine aminopeptidase	0.1267	0.8025	1
Loa Loa (eye worm)	DNA-binding protein	0.016	0.0561	0.0561
Echinococcus multilocularis	xaa pro aminopeptidase	0.016	0.0561	0.0561
Leishmania major	aminopeptidase P1, putative,metallo-peptidase, Clan MG, Family M24	0.016	0.0561	0.0561
Trichomonas vaginalis	Clan MG, familly M24, aminopeptidase P-like metallopeptidase	0.016	0.0561	1
Plasmodium falciparum	proliferation-associated protein 2g4, putative	0.016	0.0561	0.0561
Echinococcus multilocularis	methionine aminopeptidase, type I	0.016	0.0561	0.0561
Toxoplasma gondii	peptidase D, putative	0.016	0.0561	0.0561
Echinococcus granulosus	Proliferation associated protein 2G4	0.016	0.0561	0.0561
Schistosoma mansoni	proliferation-associated protein 2G4 38kDa (M24 family)	0.016	0.0561	0.0699
Plasmodium falciparum	aminopeptidase P	0.016	0.0561	0.0561
Brugia malayi	metallopeptidase family M24 containing protein	0.016	0.0561	0.0561
Giardia lamblia	Methionine aminopeptidase	0.016	0.0561	1
Toxoplasma gondii	proliferation-associated protein 2G4, putative	0.016	0.0561	0.0561
Trichomonas vaginalis	Clan MG, familly M24, aminopeptidase P-like metallopeptidase	0.016	0.0561	1
Plasmodium falciparum	HP12 protein homolog, putative	0.0293	0.1457	0.1457
Brugia malayi	metallopeptidase family M24 containing protein	0.016	0.0561	0.0561
Trichomonas vaginalis	Clan MG, familly M24, aminopeptidase P-like metallopeptidase	0.016	0.0561	1
Echinococcus granulosus	Xaa Pro aminopeptidase 3	0.016	0.0561	0.0561
Trypanosoma brucei	methionine aminopeptidase, type I, putative	0.1561	1	1
Plasmodium vivax	peptidase, putative	0.016	0.0561	0.0561
Echinococcus multilocularis	Proliferation associated protein 2G4	0.016	0.0561	0.0561
Leishmania major	methionine aminopeptidase 2, putative	0.016	0.0561	0.0561
Trypanosoma cruzi	metallo-peptidase, Clan MG, Family M24	0.016	0.0561	0.0561
Giardia lamblia	Xaa-Pro dipeptidase	0.016	0.0561	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0293	0.1457	0.1457
Trypanosoma brucei	metallo-peptidase, Clan MG, Family M24	0.016	0.0561	0.0561
Trypanosoma brucei	Xaa-Pro aminopeptidase, putative	0.016	0.0561	0.0561
Mycobacterium tuberculosis	Methionine aminopeptidase MapB (map) (peptidase M)	0.1267	0.8025	1
Echinococcus multilocularis	xaa Pro dipeptidase	0.016	0.0561	0.0561
Plasmodium vivax	FACT complex subunit SPT16, putative	0.016	0.0561	0.0561
Trypanosoma cruzi	Metallopeptidase family M24, putative	0.016	0.0561	0.0561
Leishmania major	hypothetical protein, conserved	0.0293	0.1457	0.1457
Loa Loa (eye worm)	hypothetical protein	0.016	0.0561	0.0561
Toxoplasma gondii	methionine aminopeptidase	0.1267	0.8025	0.8025
Loa Loa (eye worm)	methionine aminopeptidase type I	0.1561	1	1
Trypanosoma cruzi	Metallopeptidase family M24, putative	0.016	0.0561	0.0561
Trichomonas vaginalis	Clan MG, familly M24, aminopeptidase P-like metallopeptidase	0.016	0.0561	1
Echinococcus granulosus	FACT complex subunit SPT16	0.016	0.0561	0.0561
Toxoplasma gondii	hypothetical protein	0.0293	0.1457	0.1457
Trypanosoma cruzi	aminopeptidase P1, putative	0.016	0.0561	0.0561
Leishmania major	transcription factor-like protein	0.016	0.0561	0.0561
Trypanosoma cruzi	metallo-peptidase, Clan MG, Family M24, putative	0.016	0.0561	0.0561
Schistosoma mansoni	methionyl aminopeptidase 2 (M24 family)	0.016	0.0561	0.0699
Trypanosoma cruzi	metallo-peptidase, Clan MG, Family M24	0.016	0.0561	0.0561
Trypanosoma cruzi	aminopeptidase P, putative	0.016	0.0561	0.0561
Trichomonas vaginalis	Clan MG, familly M24, aminopeptidase P-like metallopeptidase	0.016	0.0561	1
Trypanosoma cruzi	metallo- peptidase, Clan MG, Family M24	0.1561	1	1
Toxoplasma gondii	methionine aminopeptidase	0.1561	1	1
Trichomonas vaginalis	Clan MG, familly M24, aminopeptidase P-like metallopeptidase	0.016	0.0561	1
Mycobacterium leprae	PROBABLE METHIONINE AMINOPEPTIDASE MAPB (MAP) (PEPTIDASE M)	0.1267	0.8025	1
Leishmania major	aminopeptidase P1, putative,metallo-peptidase, Clan MG, Family M24	0.016	0.0561	0.0561
Schistosoma mansoni	peptidase	0.016	0.0561	0.0699
Echinococcus granulosus	xaa Pro dipeptidase	0.016	0.0561	0.0561
Brugia malayi	metallopeptidase family M24 containing protein	0.016	0.0561	0.0561
Loa Loa (eye worm)	initiation factor 2-associated protein	0.016	0.0561	0.0561
Plasmodium falciparum	methionine aminopeptidase 1c, putative	0.016	0.0561	0.0561
Toxoplasma gondii	transcriptional elongation factor FACT140	0.016	0.0561	0.0561
Entamoeba histolytica	Xaa-Pro dipeptidase, putative	0.016	0.0561	1
Treponema pallidum	methionine aminopeptidase (map)	0.1267	0.8025	1
Trichomonas vaginalis	Clan MG, familly M24, aminopeptidase P-like metallopeptidase	0.016	0.0561	1
Loa Loa (eye worm)	hypothetical protein	0.016	0.0561	0.0561
Plasmodium falciparum	FACT complex subunit SPT16, putative	0.016	0.0561	0.0561
Leishmania major	methionine aminopeptidase, putative,metallo-peptidase, Clan MG, Family M24	0.1561	1	1
Schistosoma mansoni	aminopeptidase P1 (M24 family)	0.016	0.0561	0.0699
Trypanosoma cruzi	metallo- peptidase, Clan MG, Family M24	0.1561	1	1
Trypanosoma brucei	hypothetical protein, conserved	0.0293	0.1457	0.1457
Echinococcus granulosus	xaa Pro dipeptidase	0.016	0.0561	0.0561
Plasmodium vivax	proliferation-associated protein 2g4, putative	0.016	0.0561	0.0561
Plasmodium falciparum	methionine aminopeptidase 2	0.016	0.0561	0.0561
Onchocerca volvulus	Dipeptidase C homolog	0.016	0.0561	0.5
Plasmodium vivax	methionine aminopeptidase 2, putative	0.016	0.0561	0.0561
Plasmodium vivax	methionine aminopeptidase 1a, putative	0.1267	0.8025	0.8025
Schistosoma mansoni	aminopeptidase P homologue (M24 family)	0.016	0.0561	0.0699
Schistosoma mansoni	chromatin-specific transcription elongation factor 140 kDa subunit (M24 family)	0.016	0.0561	0.0699
Trypanosoma brucei	metallo-peptidase, Clan MG, Family M24	0.016	0.0561	0.0561
Entamoeba histolytica	peptidase, putative	0.016	0.0561	1
Trypanosoma cruzi	metallo-peptidase, Clan MG, Family M24	0.016	0.0561	0.0561
Giardia lamblia	Xaa-Pro dipeptidase	0.016	0.0561	1
Entamoeba histolytica	aminopeptidase, putative	0.016	0.0561	1
Mycobacterium ulcerans	methionine aminopeptidase MapB	0.1267	0.8025	1
Brugia malayi	DNA-binding protein, 42 kDa containing protein	0.016	0.0561	0.0561
Entamoeba histolytica	methionine aminopeptidase, putative	0.016	0.0561	1
Onchocerca volvulus	Methionine aminopeptidase 2 homolog	0.016	0.0561	0.5
Brugia malayi	initiation factor 2-associated protein.	0.016	0.0561	0.0561
Plasmodium falciparum	methionine aminopeptidase 1a, putative	0.1267	0.8025	0.8025
Plasmodium falciparum	methionine aminopeptidase 1b, putative	0.1561	1	1
Echinococcus granulosus	xaa pro aminopeptidase	0.016	0.0561	0.0561
Echinococcus granulosus	methionyl aminopeptidase 1 M24 family	0.1561	1	1
Schistosoma mansoni	methionyl aminopeptidase 1 (M24 family)	0.1267	0.8025	1
Mycobacterium leprae	PROBABLE METHIONINE AMINOPEPTIDASE MAPA (MAP) (PEPTIDASE M) (MetAP)	0.1267	0.8025	1
Wolbachia endosymbiont of Brugia malayi	methionine aminopeptidase	0.1267	0.8025	1
Loa Loa (eye worm)	hypothetical protein	0.016	0.0561	0.0561
Trypanosoma brucei	metallo- peptidase, Clan MG, Family M24	0.1561	1	1
Trichomonas vaginalis	Clan MG, familly M24, aminopeptidase P-like metallopeptidase	0.016	0.0561	1
Leishmania major	hypothetical protein, conserved	0.016	0.0561	0.0561
Trichomonas vaginalis	Clan MG, familly M24, aminopeptidase P-like metallopeptidase	0.016	0.0561	1
Trypanosoma cruzi	metallo-peptidase, Clan MG, Family M24, putative	0.016	0.0561	0.0561
Toxoplasma gondii	creatinase domain-containing protein	0.016	0.0561	0.0561
Echinococcus multilocularis	methionyl aminopeptidase 1 (M24 family)	0.1267	0.8025	0.8025
Leishmania major	aminopeptidase P1, putative,metallo-peptidase, Clan MG, Family M24	0.016	0.0561	0.0561
Schistosoma mansoni	methionyl aminopeptidase 1 (M24 family)	0.1267	0.8025	1
Trypanosoma cruzi	metallo-peptidase, Clan MG, Family M24	0.016	0.0561	0.0561
Plasmodium vivax	methionine aminopeptidase 1b, putative	0.1561	1	1
Echinococcus multilocularis	FACT complex subunit SPT16	0.016	0.0561	0.0561
Leishmania major	aminopeptidase, putative,metallo-peptidase, Clan MG, Family M24	0.016	0.0561	0.0561
Toxoplasma gondii	methionine aminopeptidase, type i, putative	0.1267	0.8025	0.8025
Plasmodium vivax	methionine aminopeptidase 1c, putative	0.016	0.0561	0.0561
Trypanosoma cruzi	hypothetical protein, conserved	0.0293	0.1457	0.1457
Trypanosoma brucei	metallo-peptidase, Clan MG, Family M24	0.016	0.0561	0.0561
Onchocerca volvulus	FACT complex subunit SPT16 homolog	0.016	0.0561	0.5
Onchocerca volvulus		0.016	0.0561	0.5
Loa Loa (eye worm)	metallopeptidase family M24 containing protein	0.016	0.0561	0.0561
Leishmania major	aminopeptidase P, putative,metallo-peptidase, Clan MG, Family M24	0.016	0.0561	0.0561
Echinococcus granulosus	methionyl aminopeptidase 2	0.016	0.0561	0.0561
Echinococcus multilocularis	methionyl aminopeptidase 2	0.016	0.0561	0.0561
Entamoeba histolytica	hypothetical protein, conserved	0.016	0.0561	1
Toxoplasma gondii	methionine aminopeptidase 2, putative	0.016	0.0561	0.0561
Schistosoma mansoni	proliferation-associated protein 2G4 38kDa (M24 family)	0.016	0.0561	0.0699
Trypanosoma cruzi	Metallopeptidase family M24/FACT complex subunit (SPT16/CDC68)/Histone chaperone Rttp106-like, putative	0.016	0.0561	0.0561
Plasmodium vivax	hypothetical protein, conserved	0.0293	0.1457	0.1457
Echinococcus multilocularis	methionyl aminopeptidase 1 (M24 family)	0.1561	1	1
Echinococcus multilocularis	Xaa Pro aminopeptidase 3	0.016	0.0561	0.0561
Trypanosoma brucei	methionine aminopeptidase, putative	0.1561	1	1
Trichomonas vaginalis	Clan MG, familly M24, aminopeptidase P-like metallopeptidase	0.016	0.0561	1
Trichomonas vaginalis	Clan MG, familly M24, aminopeptidase P-like metallopeptidase	0.016	0.0561	1
Mycobacterium tuberculosis	Methionine aminopeptidase MapA (map) (peptidase M) (MetAP)	0.1267	0.8025	1
Trypanosoma brucei	Facilitates chromatin transcription complex subunit spt16	0.016	0.0561	0.0561
Trichomonas vaginalis	Clan MG, familly M24, aminopeptidase P-like metallopeptidase	0.016	0.0561	1
Mycobacterium ulcerans	methionine aminopeptidase	0.1267	0.8025	1
Echinococcus granulosus	methionine aminopeptidase type I	0.016	0.0561	0.0561

Activities

Activity type	Activity value	Assay description	Source	Reference
AUC (ADMET)	= 12 uM.hr	AUC in mouse at 150 mg/kg, po	ChEMBL.	19268585
Cmax (ADMET)	= 11 uM	Cmax in mouse at 150 mg/kg, po	ChEMBL.	19268585
GI50 (functional)	= 0.38 uM	Antiproliferative activity against human HCT116 cells after 72 hrs	ChEMBL.	19268585
IC50 (binding)	= 29 nM	Inhibition of HDAC1	ChEMBL.	19268585

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL471868

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 976710