Detailed information for compound 980895

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 514.524 | Formula: C26H30N2O9
  • H donors: 3 H acceptors: 5 LogP: 1.63 Rotable bonds: 15
    Rule of 5 violations (Lipinski): 2
  • SMILES: COCCOCOc1ccc2c(c1)[C@H](NC(=O)OCC=C)[C@H]([C@@H](N2C(=O)c1ccccc1)CC(=O)O)O
  • InChi: 1S/C26H30N2O9/c1-3-11-36-26(33)27-23-19-14-18(37-16-35-13-12-34-2)9-10-20(19)28(21(24(23)31)15-22(29)30)25(32)17-7-5-4-6-8-17/h3-10,14,21,23-24,31H,1,11-13,15-16H2,2H3,(H,27,33)(H,29,30)/t21-,23-,24-/m0/s1
  • InChiKey: DNPRTPSKGAQMRC-XWGVYQGASA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus Glucosylceramidase homolog 0.0165 0.6368 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0154 0.0154
Loa Loa (eye worm) hypothetical protein 0.0085 0.3005 0.3005
Entamoeba histolytica aminopeptidase, putative 0.0035 0.0926 1
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0035 0.0926 0.1932
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0154 0.0154
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0154 0.1663
Echinococcus multilocularis aminopeptidase N 0.0121 0.4493 0.9373
Echinococcus granulosus cathepsin l1 0.0017 0.0154 0.0321
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0154 0.0154
Trypanosoma cruzi cysteine peptidase, putative 0.0065 0.2165 0.4517
Toxoplasma gondii cathepsin CPL 0.0017 0.0154 0.0321
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0051 0.1568 0.3271
Trypanosoma brucei prolyl oligopeptidase, putative 0.0051 0.1568 0.3271
Loa Loa (eye worm) hypothetical protein 0.0023 0.0403 0.0403
Leishmania major cathepsin L-like protease 0.0017 0.0154 0.0321
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0119 0.0249
Echinococcus granulosus cathepsin l cysteine peptidase 0.0017 0.0154 0.0321
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0154 0.0321
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0035 0.0926 0.0926
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0051 0.1568 0.3271
Plasmodium vivax glutathione reductase, putative 0.0047 0.1403 1
Brugia malayi Cathepsin L-like precursor 0.0017 0.0154 0.0154
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0154 0.0154
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.4321 0.4321
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.0051 0.1568 0.3369
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0035 0.0926 0.1932
Leishmania major cysteine peptidase A (CPA) 0.0017 0.0154 0.0321
Leishmania major trypanothione reductase 0.0047 0.1403 0.2927
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0017 0.0154 0.1098
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0154 0.0154
Trypanosoma cruzi oligopeptidase b 0.0051 0.1568 0.3271
Mycobacterium tuberculosis Probable protease II PtrBa [first part] (oligopeptidase B) 0.0114 0.4232 0.9563
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0154 0.0154
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0016 0.0119 0.0849
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0051 0.1568 0.3271
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0016 0.0119 0.0249
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0017 0.0154 0.0154
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0119 0.442 1
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0119 0.0119
Trypanosoma cruzi aminopeptidase, putative 0.0035 0.0926 0.1932
Echinococcus multilocularis cysteine protease 0.0017 0.0154 0.0321
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0154 0.0154
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0107 0.3919 0.8837
Trypanosoma brucei oligopeptidase b 0.0051 0.1568 0.3271
Leishmania major cathepsin L-like protease 0.0065 0.2165 0.4517
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0016 0.0119 0.0849
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0154 0.0154
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0016 0.0119 0.0249
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0035 0.0926 0.1932
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0154 0.1663
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.6368 0.6368
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0252 1 1
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0119 0.0249
Trypanosoma brucei Aminopeptidase M1, putative 0.0035 0.0926 0.1932
Plasmodium falciparum glutathione reductase 0.0016 0.0119 0.0849
Loa Loa (eye worm) ctsf protein 0.0017 0.0154 0.0154
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0016 0.0119 0.5
Trypanosoma cruzi cruzipain precursor, putative 0.0065 0.2165 0.4517
Onchocerca volvulus Cathepsin F homolog 0.0017 0.0154 0.0242
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0016 0.0119 0.0249
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.0154 0.0154
Brugia malayi Cathepsin L-like precursor 0.0017 0.0154 0.0154
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.6368 0.6368
Schistosoma mansoni family M1 non-peptidase homologue (M01 family) 0.0023 0.0403 0.0707
Onchocerca volvulus 0.0017 0.0154 0.0242
Loa Loa (eye worm) hypothetical protein 0.0108 0.397 0.397
Trypanosoma cruzi trypanothione reductase, putative 0.0047 0.1403 0.2927
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0035 0.0926 0.0926
Brugia malayi glutathione reductase 0.0047 0.1403 0.1403
Loa Loa (eye worm) hypothetical protein 0.0017 0.0154 0.0154
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0035 0.0926 0.1932
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0154 0.0154
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.4321 0.4321
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0035 0.0926 0.1624
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0119 0.0249
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.2165 0.4517
Toxoplasma gondii thioredoxin reductase 0.0047 0.1403 0.2927
Onchocerca volvulus 0.0017 0.0154 0.0242
Trypanosoma cruzi oligopeptidase b 0.0051 0.1568 0.3271
Leishmania major cathepsin L-like protease 0.0017 0.0154 0.0321
Echinococcus multilocularis prolyl endopeptidase 0.0128 0.4793 1
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0035 0.0926 0.1932
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0154 0.0154
Trypanosoma cruzi cysteine peptidase, putative 0.0017 0.0154 0.0321
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0035 0.0926 0.1932
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.6368 0.6368
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0154 0.0154
Brugia malayi Peptidase family M1 containing protein 0.0035 0.0926 0.0926
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0017 0.0154 0.0154
Leishmania major oligopeptidase b 0.0051 0.1568 0.3271
Leishmania major cathepsin L-like protease 0.0017 0.0154 0.0321
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.0154 0.0154
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0154 0.0154
Onchocerca volvulus Cathepsin L homolog 0.0017 0.0154 0.0242
Trypanosoma cruzi cysteine peptidase, putative 0.0065 0.2165 0.4517
Leishmania major cathepsin L-like protease 0.0017 0.0154 0.0321
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0035 0.0926 0.1932
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0016 0.0119 0.0849
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0154 0.0154
Onchocerca volvulus 0.0017 0.0154 0.0242
Trichomonas vaginalis glutathione reductase, putative 0.0016 0.0119 0.0119
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.0154 0.0154
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0051 0.1568 1
Brugia malayi Cathepsin L-like precursor 0.0017 0.0154 0.0154
Plasmodium falciparum glutathione reductase 0.0047 0.1403 1
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.6368 0.6368
Echinococcus granulosus thioredoxin glutathione reductase 0.0047 0.1403 0.2927
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.2165 0.4517
Onchocerca volvulus 0.0121 0.4493 0.7055
Trypanosoma cruzi Aminopeptidase M1, putative 0.0035 0.0926 0.1932
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0119 0.0249
Trypanosoma brucei prolyl endopeptidase 0.0128 0.4793 1
Plasmodium falciparum thioredoxin reductase 0.0047 0.1403 1
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.6368 0.6368
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0035 0.0926 0.1932
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0023 0.0403 0.0841
Mycobacterium ulcerans aminopeptidase N PepN 0.0035 0.0926 0.5571
Echinococcus multilocularis cysteine protease 0.0017 0.0154 0.0321
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.6741 0.6741
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0035 0.0926 0.1932
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0119 0.0249
Plasmodium vivax vivapain-2 0.0017 0.0154 0.1098
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.6368 0.6368
Trichomonas vaginalis glucosylceramidase, putative 0.0252 1 1
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.6741 0.6741
Trichomonas vaginalis glucosylceramidase, putative 0.0252 1 1
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.0119 0.0249
Plasmodium falciparum cysteine proteinase falcipain 3 0.0017 0.0154 0.1098
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.2165 0.4517
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0016 0.0119 0.0249
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0035 0.0926 0.1932
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0154 0.0154
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.2165 0.4517
Loa Loa (eye worm) cysteine protease 0.0017 0.0154 0.0154
Plasmodium vivax thioredoxin reductase, putative 0.0047 0.1403 1
Onchocerca volvulus 0.0017 0.0154 0.0242
Echinococcus granulosus aminopeptidase N 0.0121 0.4493 0.9373
Loa Loa (eye worm) thioredoxin reductase 0.0047 0.1403 0.1403
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0128 0.4793 0.8404
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0119 0.442 1
Trichomonas vaginalis glucosylceramidase, putative 0.0252 1 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0107 0.3919 0.8837
Trichomonas vaginalis glucosylceramidase, putative 0.0252 1 1
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0119 0.442 1
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0107 0.3919 0.8246
Echinococcus multilocularis thioredoxin glutathione reductase 0.0047 0.1403 0.2927
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0154 0.0154
Leishmania major cathepsin L-like protease 0.0065 0.2165 0.4517
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0016 0.0119 0.5
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0035 0.0926 0.1932
Entamoeba histolytica cysteine protease, putative 0.0017 0.0154 0.1663
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0154 0.0321
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.6368 0.6368
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0119 0.0249
Onchocerca volvulus Prolyl endopeptidase homolog 0.0128 0.4793 0.7527
Plasmodium falciparum thioredoxin reductase 0.0016 0.0119 0.0849
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.0128 0.4793 1
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0154 0.027
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0128 0.4793 0.8404
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0154 0.0154
Loa Loa (eye worm) glutathione reductase 0.0047 0.1403 0.1403
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0154 0.0154
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0051 0.1568 0.3271
Loa Loa (eye worm) peptidase family M1 containing protein 0.0098 0.3528 0.3528
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0119 0.0249
Onchocerca volvulus 0.0017 0.0154 0.0242
Onchocerca volvulus 0.0035 0.0926 0.1454
Trypanosoma brucei Aminopeptidase M1, putative 0.0035 0.0926 0.1932
Plasmodium vivax vivapain-2 0.0017 0.0154 0.1098
Onchocerca volvulus 0.0017 0.0154 0.0242
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0016 0.0119 0.0849
Onchocerca volvulus Cathepsin L homolog 0.0017 0.0154 0.0242
Brugia malayi Cathepsin L-like precursor 0.0017 0.0154 0.0154
Trypanosoma cruzi trypanothione reductase, putative 0.0016 0.0119 0.0249
Trypanosoma cruzi cysteine peptidase, putative 0.0065 0.2165 0.4517
Toxoplasma gondii prolyl endopeptidase 0.0128 0.4793 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0154 0.0154
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0047 0.1403 0.2985
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0119 0.0249
Echinococcus granulosus cathepsin L cysteine proteinase 0.0017 0.0154 0.0321
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0154 0.0154
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0035 0.0926 0.1932
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.2165 0.4517
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.0119 0.0249
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.2165 0.4517
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.2165 0.4517
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.2165 0.4517
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0023 0.0403 0.0841
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0154 0.0321
Trichomonas vaginalis glucosylceramidase, putative 0.0252 1 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0119 0.0249
Loa Loa (eye worm) fibroinase 0.0017 0.0154 0.0154
Brugia malayi Cathepsin L-like precursor 0.0017 0.0154 0.0154
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0154 0.0154
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.2165 0.4517
Trichomonas vaginalis glucosylceramidase, putative 0.0252 1 1
Leishmania major cathepsin L-like protease 0.0017 0.0154 0.0321
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.2165 0.4517
Brugia malayi MH2 domain containing protein 0.0116 0.4321 0.4321
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0016 0.0119 0.5
Trypanosoma cruzi prolyl endopeptidase 0.0128 0.4793 1
Brugia malayi prolyl oligopeptidase family protein 0.0128 0.4793 0.4793
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0107 0.3919 0.8837
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.0119 0.0209
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0154 0.0321
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0016 0.0119 0.0249
Leishmania major cathepsin L-like protease 0.0065 0.2165 0.4517
Mycobacterium tuberculosis Probable reductase 0.0107 0.3919 0.8837
Echinococcus granulosus prolyl endopeptidase 0.0128 0.4793 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.2165 0.4517
Loa Loa (eye worm) hypothetical protein 0.0128 0.4793 0.4793
Toxoplasma gondii NADPH-glutathione reductase 0.0016 0.0119 0.0249
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0154 0.027
Brugia malayi Cathepsin L-like precursor 0.0017 0.0154 0.0154
Mycobacterium tuberculosis Probable dehydrogenase 0.0107 0.3919 0.8837
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0107 0.3919 0.8837
Trypanosoma brucei trypanothione reductase 0.0047 0.1403 0.2927
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0154 0.0154
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0154 0.0154
Mycobacterium tuberculosis Probable peptidase 0.0051 0.1568 0.3369
Giardia lamblia NADH oxidase lateral transfer candidate 0.0016 0.0119 1
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0035 0.0926 0.1932
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0119 0.0249
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0035 0.0926 0.1624
Onchocerca volvulus 0.0017 0.0154 0.0242
Brugia malayi Peptidase family M1 containing protein 0.0121 0.4493 0.4493
Brugia malayi Thioredoxin reductase 0.0047 0.1403 0.1403
Loa Loa (eye worm) aminopeptidase N 0.0035 0.0926 0.0926
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0035 0.0926 0.1932
Mycobacterium tuberculosis Probable oxidoreductase 0.0119 0.442 1
Trichomonas vaginalis mercuric reductase, putative 0.0016 0.0119 0.0119
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0119 0.0249
Trypanosoma cruzi major cysteine proteinase, putative 0.0051 0.1582 0.33
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0059 0.1929 0.4024
Treponema pallidum NADH oxidase 0.0016 0.0119 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0154 0.0154
Brugia malayi hypothetical protein 0.0035 0.0926 0.0926
Loa Loa (eye worm) hypothetical protein 0.0023 0.0403 0.0403
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0119 0.0249
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0017 0.0154 0.1098

Activities

Activity type Activity value Assay description Source Reference
Kd (binding) Binding affinity to mouse Mcl-1 expressed in Escherichia coli BL21 cells ChEMBL. 18603434
Kd (binding) = 4000 uM Binding affinity to mouse Bcl-XL expressed in Escherichia coli BL21 cells ChEMBL. 18603434

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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