TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 372.461 | Formula: C20H28N4O3
H donors: 2 H acceptors: 4 LogP: 3.39 Rotable bonds: 10
Rule of 5 violations (Lipinski): 1
SMILES: CCCCC[C@@H](C(=O)N1CCC[C@H]1c1nc2c([nH]1)cccc2)CN(C=O)O
InChi: 1S/C20H28N4O3/c1-2-3-4-8-15(13-23(27)14-25)20(26)24-12-7-11-18(24)19-21-16-9-5-6-10-17(16)22-19/h5-6,9-10,14-15,18,27H,2-4,7-8,11-13H2,1H3,(H,21,22)/t15-,18+/m1/s1
InChiKey: RVDPUENQQQYFQZ-QAPCUYQASA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Mycobacterium tuberculosis	Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase)	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Mycobacterium tuberculosis	Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase)	Get druggable targets OG5_128237	All targets in OG5_128237
Plasmodium vivax	peptide deformylase, putative	Get druggable targets OG5_128237	All targets in OG5_128237
Chlamydia trachomatis	peptide deformylase	Get druggable targets OG5_128237	All targets in OG5_128237
Treponema pallidum	polypeptide deformylase (def)	Get druggable targets OG5_128237	All targets in OG5_128237
Wolbachia endosymbiont of Brugia malayi	peptide deformylase	Get druggable targets OG5_128237	All targets in OG5_128237
Plasmodium yoelii	polypeptide deformylase, putative	Get druggable targets OG5_128237	All targets in OG5_128237
Toxoplasma gondii	hypothetical protein	Get druggable targets OG5_128237	All targets in OG5_128237
Plasmodium falciparum	peptide deformylase	Get druggable targets OG5_128237	All targets in OG5_128237
Mycobacterium ulcerans	peptide deformylase	Get druggable targets OG5_128237	All targets in OG5_128237
Plasmodium berghei	peptide deformylase, putative	Get druggable targets OG5_128237	All targets in OG5_128237
Neospora caninum	Peptide deformylase, related	Get druggable targets OG5_128237	All targets in OG5_128237
Mycobacterium leprae	PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE)	Get druggable targets OG5_128237	All targets in OG5_128237
Plasmodium knowlesi	peptide deformylase, putative	Get druggable targets OG5_128237	All targets in OG5_128237

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Trypanosoma cruzi	surface protease GP63, putative	Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase)	197 aa	171 aa	25.1 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0053	0.0279	0.0276
Giardia lamblia	Aurora kinase	0.0059	0.0345	0.5
Schistosoma mansoni	hypothetical protein	0.0193	0.1798	0.1798
Brugia malayi	PXA domain containing protein	0.0154	0.1375	0.1373
Brugia malayi	hypothetical protein	0.0154	0.1375	0.1373
Entamoeba histolytica	hypothetical protein	0.0065	0.0406	0.0599
Onchocerca volvulus		0.0148	0.1303	0.3835
Echinococcus granulosus	twitchin	0.0035	0.0081	0.0098
Trichomonas vaginalis	conserved hypothetical protein	0.0154	0.1375	1
Echinococcus granulosus	transcription factor collier	0.0065	0.0406	0.0488
Echinococcus multilocularis	transcription factor collier	0.0065	0.0406	0.0488
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0053	0.0279	0.0276
Trichomonas vaginalis	conserved hypothetical protein	0.0154	0.1375	1
Trichomonas vaginalis	regulator of G protein signaling 5, rgs5, putative	0.0154	0.1375	1
Entamoeba histolytica	hypothetical protein	0.0065	0.0406	0.0599
Schistosoma mansoni	vesicular amine transporter	0.0033	0.0063	0.0063
Loa Loa (eye worm)	hypothetical protein	0.0148	0.1303	0.1301
Echinococcus multilocularis	basement membrane specific heparan sulfate	0.003	0.0036	0.0044
Brugia malayi	serine/threonine-protein kinase 6	0.0059	0.0345	0.0342
Treponema pallidum	polypeptide deformylase (def)	0.0279	0.2722	0.5
Echinococcus multilocularis	hypothetical protein	0.0148	0.1303	0.1564
Echinococcus multilocularis	Regulator of G protein signaling 20	0.0154	0.1375	0.1651
Loa Loa (eye worm)	plexin A	0.0406	0.4093	0.4092
Trichomonas vaginalis	conserved hypothetical protein	0.0065	0.0406	0.2455
Echinococcus granulosus	regulator of G protein signaling 3	0.0154	0.1375	0.1651
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0038	0.0118	0.0115
Schistosoma mansoni	hypothetical protein	0.0065	0.0406	0.0406
Echinococcus multilocularis	plexin a4	0.0406	0.4093	0.4913
Loa Loa (eye worm)	hypothetical protein	0.0148	0.1303	0.1301
Echinococcus granulosus	Immunoglobulin	0.003	0.0036	0.0044
Loa Loa (eye worm)	hypothetical protein	0.0148	0.1303	0.1301
Loa Loa (eye worm)	hypothetical protein	0.003	0.0036	0.0034
Loa Loa (eye worm)	AGC/GRK/GRK protein kinase	0.0797	0.8332	0.8331
Echinococcus multilocularis	regulator of G protein signaling 7	0.0154	0.1375	0.1651
Echinococcus multilocularis	regulator of G protein signaling	0.0154	0.1375	0.1651
Echinococcus multilocularis	axis inhibition protein axin	0.0154	0.1375	0.1651
Schistosoma mansoni	defective proboscis extension response (dpr)-related	0.003	0.0036	0.0036
Loa Loa (eye worm)	hypothetical protein	0.003	0.0036	0.0034
Trichomonas vaginalis	Clan MA, family M8, leishmanolysin-like metallopeptidase	0.0065	0.0406	0.2455
Loa Loa (eye worm)	TK/ALK protein kinase	0.0251	0.2419	0.2417
Brugia malayi	Regulator of G protein signaling domain containing protein	0.0154	0.1375	0.1373
Schistosoma mansoni	hypothetical protein	0.0065	0.0406	0.0406
Brugia malayi	Sema domain containing protein	0.0148	0.1303	0.1301
Trichomonas vaginalis	Clan MA, family M8, leishmanolysin-like metallopeptidase	0.0065	0.0406	0.2455
Echinococcus multilocularis	axis inhibition protein axin	0.0154	0.1375	0.1651
Schistosoma mansoni	nephrin	0.0035	0.0087	0.0087
Echinococcus multilocularis	A kinase anchor protein 10, mitochondrial	0.0154	0.1375	0.1651
Schistosoma mansoni	axis inhibition protein axin	0.0154	0.1375	0.1375
Brugia malayi	Sema domain containing protein	0.0148	0.1303	0.1301
Schistosoma mansoni	regulator of G protein signaling	0.0154	0.1375	0.1375
Trichomonas vaginalis	AGC family protein kinase	0.0059	0.0345	0.1974
Echinococcus granulosus	exocyst complex component 2	0.0065	0.0406	0.0488
Brugia malayi	Probable exocyst complex component Sec5	0.0065	0.0406	0.0404
Echinococcus multilocularis	beta adrenergic receptor kinase	0.073	0.7598	0.9119
Echinococcus granulosus	semaphorin 1A	0.0148	0.1303	0.1564
Trichomonas vaginalis	conserved hypothetical protein	0.0065	0.0406	0.2455
Trypanosoma brucei	Polypeptide deformylase 1	0.0106	0.0858	1
Loa Loa (eye worm)	hypothetical protein	0.0148	0.1303	0.1301
Echinococcus multilocularis	roundabout 2	0.0035	0.0087	0.0104
Loa Loa (eye worm)	hypothetical protein	0.003	0.0036	0.0034
Echinococcus multilocularis	regulator of G protein signaling 7	0.0154	0.1375	0.1651
Schistosoma mansoni	hypothetical protein	0.0027	0.0003	0.0003
Brugia malayi	PXA domain containing protein	0.0154	0.1375	0.1373
Entamoeba histolytica	hypothetical protein	0.0065	0.0406	0.0599
Plasmodium vivax	peptide deformylase, putative	0.0279	0.2722	1
Brugia malayi	A-kinase anchor protein 10, precursor	0.0154	0.1375	0.1373
Loa Loa (eye worm)	AUR protein kinase	0.0059	0.0345	0.0342
Trichomonas vaginalis	Clan MA, family M8, leishmanolysin-like metallopeptidase	0.0065	0.0406	0.2455
Entamoeba histolytica	protein kinase domain containing protein	0.0087	0.0649	0.2955
Echinococcus multilocularis	regulator of G protein signaling 3	0.0154	0.1375	0.1651
Schistosoma mansoni	hypothetical protein	0.0148	0.1303	0.1303
Entamoeba histolytica	cell surface protease gp63, putative	0.0065	0.0406	0.0599
Echinococcus multilocularis	semaphorin 5B	0.0148	0.1303	0.1564
Schistosoma mansoni	regulator of G protein signaling	0.0154	0.1375	0.1375
Loa Loa (eye worm)	AUR protein kinase	0.0059	0.0345	0.0342
Echinococcus multilocularis	expressed protein	0.0154	0.1375	0.1651
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.0154	0.1375	0.1375
Schistosoma mansoni	cell adhesion molecule	0.0035	0.0087	0.0087
Echinococcus multilocularis	exocyst complex component 2	0.0065	0.0406	0.0488
Echinococcus multilocularis	G protein coupled receptor kinase 1	0.0575	0.5929	0.7117
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0038	0.0118	0.0142
Echinococcus granulosus	G protein coupled receptor kinase 1	0.0575	0.5929	0.7117
Loa Loa (eye worm)	sema domain-containing protein	0.0148	0.1303	0.1301
Toxoplasma gondii	hypothetical protein	0.0279	0.2722	1
Loa Loa (eye worm)	sema domain-containing protein	0.0148	0.1303	0.1301
Trichomonas vaginalis	conserved hypothetical protein	0.0065	0.0406	0.2455
Brugia malayi	Protein kinase domain containing protein	0.0251	0.242	0.2418
Brugia malayi	hypothetical protein	0.0148	0.1303	0.1301
Loa Loa (eye worm)	hypothetical protein	0.003	0.0036	0.0034
Loa Loa (eye worm)	RGS-3 protein	0.0154	0.1375	0.1373
Schistosoma mansoni	voltage-gated potassium channel	0.0042	0.0156	0.0156
Brugia malayi	regulator of G-protein signaling rgs-7	0.0154	0.1375	0.1373
Schistosoma mansoni	Neurotrimin precursor (hNT)	0.003	0.0036	0.0036
Schistosoma mansoni	regulator of G protein signaling	0.0154	0.1375	0.1375
Schistosoma mansoni	serine/threonine protein kinase	0.073	0.7598	0.7598
Brugia malayi	hypothetical protein	0.0154	0.1375	0.1373
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0035	0.0087	0.0084
Echinococcus granulosus	semaphorin 5B	0.0148	0.1303	0.1564
Schistosoma mansoni	fibrocystin l	0.0065	0.0406	0.0406
Echinococcus multilocularis	Immunoglobulin	0.003	0.0036	0.0044
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0087	0.0084
Echinococcus multilocularis	neuroglian	0.003	0.0036	0.0044
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0038	0.0118	0.0142
Echinococcus granulosus	roundabout 2	0.0035	0.0087	0.0104
Entamoeba histolytica	hypothetical protein	0.0065	0.0406	0.0599
Entamoeba histolytica	hypothetical protein	0.0154	0.1375	1
Trichomonas vaginalis	conserved hypothetical protein	0.0154	0.1375	1
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0087	0.0084
Loa Loa (eye worm)	hypothetical protein	0.0148	0.1303	0.1301
Loa Loa (eye worm)	hypothetical protein	0.0154	0.1375	0.1373
Echinococcus granulosus	[G-protein-coupledreceptor] kinase	0.0797	0.8332	1
Echinococcus granulosus	regulator of G protein signaling 3	0.0154	0.1375	0.1651
Loa Loa (eye worm)	hypothetical protein	0.0193	0.1798	0.1796
Schistosoma mansoni	regulator of G protein signaling	0.0154	0.1375	0.1375
Echinococcus multilocularis	G protein coupled receptor kinase 6	0.0797	0.8332	1
Mycobacterium leprae	PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE)	0.0279	0.2722	0.5
Schistosoma mansoni	regulator of G protein signaling	0.0154	0.1375	0.1375
Schistosoma mansoni	plexin	0.0193	0.1798	0.1798
Echinococcus granulosus	A kinase anchor protein 10 mitochondrial	0.0154	0.1375	0.1651
Echinococcus multilocularis	regulator of G protein signaling 3	0.0154	0.1375	0.1651
Schistosoma mansoni	serine/threonine protein kinase	0.0059	0.0345	0.0345
Echinococcus multilocularis	serine:threonine protein kinase 12 B	0.0059	0.0345	0.0414
Mycobacterium ulcerans	peptide deformylase	0.0279	0.2722	0.5
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.0154	0.1375	0.1375
Echinococcus multilocularis	Immunoglobulin	0.003	0.0036	0.0044
Trichomonas vaginalis	conserved hypothetical protein	0.0065	0.0406	0.2455
Trypanosoma cruzi	Peptide deformylase 2, putative	0.0106	0.0858	1
Loa Loa (eye worm)	AGC/GRK/BARK protein kinase	0.073	0.7598	0.7597
Schistosoma mansoni	serine/threonine protein kinase	0.0952	1	1
Brugia malayi	Probable G protein-coupled receptor kinase F19C6.1, putative	0.0797	0.8332	0.8331
Trichomonas vaginalis	AGC family protein kinase	0.0059	0.0345	0.1974
Echinococcus granulosus	neuroglian	0.003	0.0036	0.0044
Loa Loa (eye worm)	hypothetical protein	0.0154	0.1375	0.1373
Brugia malayi	plexin A	0.0406	0.4093	0.4092
Echinococcus multilocularis	aurora kinase A	0.0059	0.0345	0.0414
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0406	0.0404
Trypanosoma cruzi	polypeptide deformylase-like protein, putative	0.0106	0.0858	1
Schistosoma mansoni	serine/threonine protein kinase	0.073	0.7598	0.7598
Schistosoma mansoni	hypothetical protein	0.0148	0.1303	0.1303
Schistosoma mansoni	regulator of G protein signaling 3 rgs3	0.0154	0.1375	0.1375
Loa Loa (eye worm)	hypothetical protein	0.003	0.0036	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0064	0.0061
Echinococcus granulosus	regulator of G protein signaling 7	0.0154	0.1375	0.1651
Trichomonas vaginalis	AGC family protein kinase	0.0059	0.0345	0.1974
Echinococcus granulosus	serine:threonine protein kinase 12 B	0.0059	0.0345	0.0414
Mycobacterium tuberculosis	Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase)	0.0279	0.2722	0.5
Brugia malayi	Fibronectin type III domain containing protein	0.0035	0.0087	0.0084
Brugia malayi	serine/threonine protein kinase 6	0.0059	0.0345	0.0342
Trypanosoma cruzi	polypeptide deformylase-like protein, putative	0.0106	0.0858	1
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0406	0.0404
Brugia malayi	hypothetical protein	0.0035	0.0087	0.0084
Echinococcus granulosus	MAM	0.0027	0.0003	0.0003
Loa Loa (eye worm)	hypothetical protein	0.003	0.0036	0.0034
Echinococcus granulosus	Regulator of G protein signaling 20	0.0154	0.1375	0.1651
Schistosoma mansoni	axis inhibition protein axin	0.0154	0.1375	0.1375
Brugia malayi	DNA-binding protein LAG-1	0.0065	0.0406	0.0404
Echinococcus granulosus	aurora kinase A	0.0059	0.0345	0.0414
Schistosoma mansoni	z-protein (S1r protein)	0.0154	0.1375	0.1375
Brugia malayi	Plexin repeat family protein	0.0341	0.3394	0.3392
Echinococcus granulosus	plexin a4	0.0406	0.4093	0.4913
Trichomonas vaginalis	AGC family protein kinase	0.0059	0.0345	0.1974
Trichomonas vaginalis	conserved hypothetical protein	0.0065	0.0406	0.2455
Echinococcus granulosus	defective proboscis extension response	0.003	0.0036	0.0044
Echinococcus granulosus	beta-adrenergic receptor kinase	0.073	0.7598	0.9119
Plasmodium falciparum	peptide deformylase	0.0279	0.2722	1
Wolbachia endosymbiont of Brugia malayi	peptide deformylase	0.0279	0.2722	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0154	0.1375	1
Echinococcus granulosus	axis inhibition protein axin	0.0154	0.1375	0.1651
Brugia malayi	serine/threonine kinase 12	0.0059	0.0345	0.0342
Echinococcus granulosus	expressed protein	0.0154	0.1375	0.1651
Trichomonas vaginalis	conserved hypothetical protein	0.0065	0.0406	0.2455
Onchocerca volvulus		0.0341	0.3394	1
Loa Loa (eye worm)	hypothetical protein	0.0154	0.1375	0.1373
Echinococcus granulosus	axis inhibition protein axin	0.0154	0.1375	0.1651
Entamoeba histolytica	hypothetical protein	0.0154	0.1375	1
Schistosoma mansoni	plexin	0.0341	0.3394	0.3394
Entamoeba histolytica	hypothetical protein	0.0154	0.1375	1
Loa Loa (eye worm)	hypothetical protein	0.0341	0.3394	0.3392
Trichomonas vaginalis	conserved hypothetical protein	0.0065	0.0406	0.2455
Echinococcus multilocularis	MAM	0.0027	0.0003	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0154	0.1375	0.1373
Loa Loa (eye worm)	AUR protein kinase	0.0059	0.0345	0.0342
Loa Loa (eye worm)	AGC/GRK/GRK protein kinase	0.0952	1	1
Trichomonas vaginalis	Clan MA, family M8, leishmanolysin-like metallopeptidase	0.0065	0.0406	0.2455
Trichomonas vaginalis	Clan MA, family M8, leishmanolysin-like metallopeptidase	0.0065	0.0406	0.2455
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0038	0.0118	0.0115
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0406	0.0404
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0406	0.0404
Loa Loa (eye worm)	G protein-coupled receptor kinase 1	0.0797	0.8332	0.8331
Loa Loa (eye worm)	PXA domain-containing protein	0.0154	0.1375	0.1373
Loa Loa (eye worm)	G protein signaling regulator EGL-10	0.0154	0.1375	0.1373
Schistosoma mansoni	hypothetical protein	0.0027	0.0003	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0154	0.1375	0.1373
Entamoeba histolytica	tyrosin kinase, putative	0.0087	0.0649	0.2955
Trichomonas vaginalis	conserved hypothetical protein	0.0154	0.1375	1
Echinococcus granulosus	neurotracting:lsamp:neurotrimin:obcam	0.003	0.0036	0.0044
Brugia malayi	IPT/TIG domain containing protein	0.0065	0.0406	0.0404
Brugia malayi	Regulator of G protein signaling domain containing protein	0.0154	0.1375	0.1373
Trichomonas vaginalis	conserved hypothetical protein	0.0154	0.1375	1
Trypanosoma brucei	Peptide deformylase 2	0.0106	0.0858	1
Schistosoma mansoni	protein kinase	0.0059	0.0345	0.0345
Loa Loa (eye worm)	hypothetical protein	0.0201	0.1881	0.1878
Schistosoma mansoni	semaphorin 5-related	0.0148	0.1303	0.1303
Leishmania major	polypeptide deformylase-like protein, putative	0.0106	0.0858	1
Brugia malayi	hypothetical protein	0.0148	0.1303	0.1301
Chlamydia trachomatis	peptide deformylase	0.0279	0.2722	0.5
Schistosoma mansoni	voltage-gated potassium channel	0.0042	0.0156	0.0156
Brugia malayi	regulator of G-protein signaling egl-10	0.0154	0.1375	0.1373
Trypanosoma cruzi	Peptide deformylase 2, putative	0.0106	0.0858	1
Loa Loa (eye worm)	hypothetical protein	0.0148	0.1303	0.1301
Loa Loa (eye worm)	hypothetical protein	0.0154	0.1375	0.1373
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0087	0.0084
Onchocerca volvulus		0.0032	0.0053	0.0148
Echinococcus granulosus	regulator of G protein signaling 7	0.0154	0.1375	0.1651

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.015 uM	Inhibition of Mycobacterium tuberculosis peptide deformylase expressed in Escherichia coli M15(pREp4) by microplate assay	ChEMBL.	19008098

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL482180

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 982322