TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 385.412 | Formula: C24H19NO4
H donors: 0 H acceptors: 2 LogP: 5 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: COc1cc2nccc(c2cc1OC)Oc1ccccc1C(=O)c1ccccc1
InChi: 1S/C24H19NO4/c1-27-22-14-18-19(15-23(22)28-2)25-13-12-21(18)29-20-11-7-6-10-17(20)24(26)16-8-4-3-5-9-16/h3-15H,1-2H3
InChiKey: IKWYJDFTNMSTAW-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	SRC proto-oncogene, non-receptor tyrosine kinase	Starlite/ChEMBL	References
Homo sapiens	activin A receptor, type IB	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus granulosus	tyrosine kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	Proto-oncogene tyrosine-protein kinase FGR, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Blk	Get druggable targets OG5_127750	All targets in OG5_127750
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	Get druggable targets OG5_129709	All targets in OG5_129709
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Brugia malayi	bone morphogenetic protein type 1 receptor	Get druggable targets OG5_129709	All targets in OG5_129709
Echinococcus multilocularis	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	TGF-beta receptor type-1	Get druggable targets OG5_129709	All targets in OG5_129709
Echinococcus granulosus	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Src42A	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	ko:K05703 proto-oncogene tyrosine-protein kinase Fyn, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma mansoni	protein kinase	Get druggable targets OG5_129709	All targets in OG5_129709
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Src42A	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	ko:K08892 fyn-related kinase, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Blk	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Src64B	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Src64B	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Fgr	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Loa Loa (eye worm)	TK protein kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Loa Loa (eye worm)	SRC-1	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	TGF beta receptor type 1	Get druggable targets OG5_129709	All targets in OG5_129709
Echinococcus multilocularis	tyrosine protein kinase Src42A	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	Proto-oncogene tyrosine-protein kinase Yrk, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Entamoeba histolytica	protein kinase, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	Proto-oncogene tyrosine-protein kinase FYN, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase HCK	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	TGF beta receptor type 1	Get druggable targets OG5_129709	All targets in OG5_129709
Brugia malayi	protein-tyrosine kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Loa Loa (eye worm)	TK protein kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	Proto-oncogene tyrosine-protein kinase FYN, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Brugia malayi	SRC-1	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	ko:K04674 transforming growth factor, beta receptor I, putative	Get druggable targets OG5_129709	All targets in OG5_129709
Echinococcus multilocularis	tyrosine protein kinase HCK	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Src42A	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Srms	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Lyn	Get druggable targets OG5_127750	All targets in OG5_127750

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	protein kinase	0.0191	0.5419	0.5419
Leishmania major	heat shock protein 83-1	0.0047	0.0846	0.6096
Plasmodium falciparum	endoplasmin, putative	0.0034	0.0441	0.0542
Onchocerca volvulus		0.0029	0.0293	0.0582
Schistosoma mansoni	protein kinase	0.0087	0.2134	0.2134
Entamoeba histolytica	protein kinase, putative	0.0036	0.0523	0.3472
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0051	0.0995	0.0995
Brugia malayi	bone morphogenetic protein type 1 receptor	0.0192	0.5451	0.5792
Trichomonas vaginalis	aldehyde oxidase, putative	0.0171	0.4765	1
Loa Loa (eye worm)	TK protein kinase	0.0047	0.0855	0.0909
Treponema pallidum	hypothetical protein	0.0028	0.0247	0.2333
Echinococcus granulosus	endoplasmin	0.0044	0.0755	0.0755
Brugia malayi	heat shock protein 90	0.0047	0.0846	0.0899
Echinococcus granulosus	TGF-beta receptor type-1	0.0191	0.5419	0.5419
Onchocerca volvulus	Putative organic anion transporter	0.0029	0.0293	0.0582
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0468	0.0497
Loa Loa (eye worm)	TK protein kinase	0.0036	0.0523	0.0555
Plasmodium vivax	endoplasmin, putative	0.0047	0.0846	0.1389
Brugia malayi	Protein kinase domain containing protein	0.0074	0.1702	0.1808
Trichomonas vaginalis	heat shock protein, putative	0.0044	0.0755	0.1162
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0052	0.1004	0.1004
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0051	0.0995	0.0995
Schistosoma mansoni	hypothetical protein	0.0037	0.0529	0.0529
Trypanosoma brucei	heat shock protein, putative	0.0047	0.0846	0.6096
Giardia lamblia	Heat shock protein HSP 90-alpha	0.0047	0.0846	1
Toxoplasma gondii	LsmAD domain-containing protein	0.0026	0.0182	0.0304
Leishmania major	heat shock protein 83-1	0.0047	0.0846	0.6096
Trypanosoma brucei	heat shock protein, putative	0.0047	0.0846	0.6096
Loa Loa (eye worm)	SRC-1	0.0051	0.0995	0.1057
Trypanosoma brucei	heat shock protein, putative	0.0047	0.0846	0.6096
Echinococcus multilocularis	heat shock protein 90	0.004	0.0633	0.0633
Trypanosoma brucei	heat shock protein, putative	0.0047	0.0846	0.6096
Giardia lamblia	Grp94/Hsp90	0.0044	0.0755	0.5748
Plasmodium vivax	heat shock protein 86, putative	0.0047	0.0846	0.1389
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0036	0.0523	0.0523
Echinococcus granulosus	TGF beta receptor type 1	0.0191	0.5419	0.5419
Leishmania major	heat shock protein 83-1	0.0047	0.0846	0.6096
Echinococcus multilocularis	Dipeptidyl peptidase 9	0.006	0.1271	0.1271
Leishmania major	heat shock protein 83-1	0.0047	0.0846	0.6096
Trypanosoma cruzi	MFS transporter, putative	0.0029	0.0293	0.1016
Echinococcus multilocularis	heat shock protein 75 kDa, mitochondrial	0.0031	0.0351	0.0351
Trichomonas vaginalis	xanthine dehydrogenase, putative	0.0171	0.4765	1
Onchocerca volvulus	Dipeptidyl peptidase family member 1 homolog	0.0179	0.5025	1
Leishmania major	heat shock protein 83-1	0.0047	0.0846	0.6096
Entamoeba histolytica	hypothetical protein	0.0037	0.0529	0.36
Trypanosoma cruzi	heat shock protein 85, putative	0.004	0.0633	0.4139
Schistosoma mansoni	tyrosine kinase	0.0051	0.0995	0.0995
Trichomonas vaginalis	heat shock protein, putative	0.0044	0.0755	0.1162
Leishmania major	heat shock protein 83-1	0.0047	0.0846	0.6096
Schistosoma mansoni	endoplasmin	0.0047	0.0846	0.0846
Leishmania major	heat shock protein 83-1	0.0047	0.0846	0.6096
Mycobacterium ulcerans	carbon monoxyde dehydrogenase large chain CoxL	0.0051	0.0969	0.2678
Trypanosoma cruzi	heat shock protein 85, putative	0.0047	0.0846	0.6096
Trypanosoma cruzi	heat shock protein 85, putative	0.0047	0.0846	0.6096
Loa Loa (eye worm)	sodium-independent organic anion transporter	0.0029	0.0293	0.0311
Brugia malayi	hypothetical protein	0.0026	0.0182	0.0193
Mycobacterium ulcerans	heat shock protein 90	0.0044	0.0755	0.1886
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0051	0.0995	0.0995
Leishmania major	heat shock protein 83-1	0.0047	0.0846	0.6096
Trypanosoma brucei	Heat shock protein 83, putative	0.0047	0.0846	0.6096
Echinococcus multilocularis	organic anion transporting polypeptide 30B	0.0029	0.0293	0.0293
Trypanosoma brucei	heat shock protein 84, putative	0.0031	0.0351	0.1548
Echinococcus multilocularis	heat shock protein 90	0.0047	0.0846	0.0846
Loa Loa (eye worm)	endoplasmin	0.0047	0.0846	0.0899
Onchocerca volvulus	Putative organic anion transporter	0.0029	0.0293	0.0582
Toxoplasma gondii	1,3-beta-glucan synthase component protein	0.0209	0.5982	1
Schistosoma mansoni	dipeptidyl-peptidase 9 (S09 family)	0.006	0.1271	0.1271
Brugia malayi	Endoplasmin precursor	0.0047	0.0846	0.0899
Brugia malayi	protein C17H12.11	0.0074	0.1693	0.1799
Loa Loa (eye worm)	STAT protein	0.0318	0.9411	1
Echinococcus multilocularis	heat shock protein	0.0047	0.0846	0.0846
Echinococcus granulosus	heat shock protein 90	0.004	0.0633	0.0633
Brugia malayi	sodium-independent organic anion transporter family protein	0.0029	0.0293	0.0311
Mycobacterium ulcerans	carbon monoxyde dehydrogenase medium chain CoxM	0.0058	0.1191	0.3502
Echinococcus multilocularis	geminin	0.0336	1	1
Leishmania major	heat shock protein 83-1	0.0047	0.0846	0.6096
Mycobacterium tuberculosis	Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G)	0.0044	0.0755	0.2349
Trypanosoma brucei	heat shock protein, putative	0.0047	0.0846	0.6096
Trichomonas vaginalis	endoplasmin, putative	0.0034	0.0441	0.047
Trichomonas vaginalis	xanthine dehydrogenase, putative	0.0171	0.4765	1
Loa Loa (eye worm)	hypothetical protein	0.0154	0.4238	0.4503
Brugia malayi	hypothetical protein	0.0154	0.4238	0.4503
Leishmania major	heat shock protein 83-1	0.0047	0.0846	0.6096
Brugia malayi	hypothetical protein	0.0074	0.1693	0.1799
Leishmania major	heat shock protein 83-1	0.0047	0.0846	0.6096
Onchocerca volvulus	Heat shock protein 75 kDa, mitochondrial homolog	0.0031	0.0351	0.0698
Trypanosoma brucei	Dipeptidyl-peptidase 8-like, putative	0.006	0.1271	1
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0051	0.0976	0.1037
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0051	0.0995	0.0995
Loa Loa (eye worm)	prolyl oligopeptidase	0.0179	0.5025	0.534
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0293	0.0311
Schistosoma mansoni	heat shock protein	0.0047	0.0846	0.0846
Plasmodium falciparum	heat shock protein 90, putative	0.0177	0.4964	1
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0976	0.1037
Mycobacterium tuberculosis	Probable carbon monoxyde dehydrogenase (large chain)	0.0081	0.1913	1
Brugia malayi	latrophilin 2 splice variant baaae	0.0035	0.0468	0.0497
Echinococcus granulosus	Solute carrier organic anion transporter family	0.0029	0.0293	0.0293
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0047	0.0855	0.0855
Toxoplasma gondii	transporter, major facilitator family protein	0.0029	0.0293	0.0489
Schistosoma mansoni	organic anion transporter	0.0029	0.0293	0.0293
Mycobacterium ulcerans	aerobic-type carbon monoxide dehydrogenase subunit CoxM_2	0.0058	0.1191	0.3502
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0182	0.0193
Plasmodium falciparum	heat shock protein 90, putative	0.0027	0.0228	0.0096
Trypanosoma brucei	heat shock protein, putative	0.0047	0.0846	0.6096
Brugia malayi	sodium-independent organic anion transporter family protein	0.0029	0.0293	0.0311
Plasmodium vivax	heat shock protein 90, putative	0.0031	0.0351	0.0353
Trypanosoma brucei	heat shock protein, putative	0.0047	0.0846	0.6096
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0293	0.0311
Mycobacterium tuberculosis	Probable carbon monoxyde dehydrogenase (medium chain)	0.0058	0.1191	0.5229
Plasmodium falciparum	heat shock protein 90	0.0047	0.0846	0.1389
Trypanosoma brucei	heat shock protein 90, putative	0.0047	0.0846	0.6096
Leishmania major	dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B	0.006	0.1271	1
Toxoplasma gondii	heat shock protein 90, putative	0.0047	0.0846	0.1414
Treponema pallidum	heat shock protein 90	0.0044	0.0755	1
Echinococcus granulosus	tyrosine protein kinase Blk	0.0047	0.0855	0.0855
Loa Loa (eye worm)	TKL/STKR/TYPE2 protein kinase	0.0074	0.1702	0.1808
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0293	0.0311
Leishmania major	heat shock protein 83-1	0.0047	0.0846	0.6096
Onchocerca volvulus		0.0029	0.0293	0.0582
Leishmania major	heat shock protein 83-1	0.0047	0.0846	0.6096
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0051	0.0976	0.1037
Echinococcus multilocularis	activin receptor type	0.0088	0.2142	0.2142
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0047	0.0855	0.0855
Brugia malayi	MH2 domain containing protein	0.0122	0.3216	0.3417
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0293	0.0311
Treponema pallidum	quinoline 2-oxidoreductase	0.0027	0.0227	0.2026
Brugia malayi	hypothetical protein	0.0046	0.0823	0.0875
Schistosoma mansoni	hypothetical protein	0.0336	1	1
Echinococcus granulosus	tyrosine protein kinase HCK	0.0036	0.0523	0.0523
Mycobacterium ulcerans	aerobic-type carbon monoxide dehydrogenase subunit CoxL_2	0.0081	0.1913	0.618
Onchocerca volvulus		0.0029	0.0293	0.0582
Echinococcus granulosus	Dipeptidyl peptidase 9	0.006	0.1271	0.1271
Brugia malayi	protein-tyrosine kinase	0.0047	0.0855	0.0909
Trichomonas vaginalis	heat shock protein, putative	0.004	0.0633	0.0892
Leishmania major	heat shock protein, putative	0.0031	0.0351	0.1548
Loa Loa (eye worm)	heat shock protein 90	0.0047	0.0846	0.0899
Brugia malayi	hypothetical protein	0.0037	0.0529	0.0562
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.0074	0.1702	0.1808
Trypanosoma cruzi	heat shock protein 85, putative	0.0047	0.0846	0.6096
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0823	0.0875
Trypanosoma cruzi	dipeptidyl-peptidase 8-like serine peptidase	0.006	0.1271	1
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0046	0.0815	0.0815
Entamoeba histolytica	hypothetical protein	0.0037	0.0529	0.36
Schistosoma mansoni	hypothetical protein	0.0336	1	1
Echinococcus multilocularis	TGF beta receptor type 1	0.0191	0.5419	0.5419
Schistosoma mansoni	subfamily S9B unassigned peptidase (S09 family)	0.0179	0.5025	0.5025
Wolbachia endosymbiont of Brugia malayi	heat shock protein 90	0.0044	0.0755	0.5
Toxoplasma gondii	heat shock protein 75, putative	0.0031	0.0351	0.0586
Echinococcus multilocularis	endoplasmin	0.0044	0.0755	0.0755
Mycobacterium ulcerans	carbon monoxide dehydrogenase	0.0113	0.2943	1
Onchocerca volvulus		0.0029	0.0293	0.0582
Onchocerca volvulus	Putative organic anion transporter	0.0029	0.0293	0.0582
Trypanosoma brucei	heat shock protein 90, putative	0.0047	0.0846	0.6096
Leishmania major	heat shock protein 83-1	0.0047	0.0846	0.6096
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0047	0.0855	0.0855
Mycobacterium leprae	PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G)	0.0044	0.0755	0.5
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0051	0.0995	0.0995
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0051	0.0995	0.0995
Schistosoma mansoni	hypothetical protein	0.0035	0.0468	0.0468
Echinococcus granulosus	heat shock protein 90	0.0047	0.0846	0.0846
Echinococcus granulosus	heat shock protein 75 kDa mitochondrial	0.0031	0.0351	0.0351
Onchocerca volvulus		0.0154	0.4238	0.8433
Plasmodium vivax	heat shock protein, putative	0.0177	0.4964	1
Trypanosoma cruzi	heat shock protein, putative	0.0031	0.0351	0.1548
Onchocerca volvulus		0.0029	0.0293	0.0582
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0051	0.0995	0.0995
Schistosoma mansoni	heat shock protein	0.0031	0.0351	0.0351
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0293	0.0311
Leishmania major	heat shock protein 83-1	0.0047	0.0846	0.6096
Brugia malayi	prolyl oligopeptidase family protein	0.006	0.1271	0.1351
Loa Loa (eye worm)	hypothetical protein	0.0074	0.1693	0.1799
Echinococcus multilocularis	Solute carrier organic anion transporter family	0.0029	0.0293	0.0293
Echinococcus multilocularis	dipeptidyl aminopeptidaseprotein	0.0179	0.5025	0.5025
Brugia malayi	hypothetical protein	0.0029	0.0293	0.0311
Schistosoma mansoni	organic anion transporter	0.0029	0.0293	0.0293
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0051	0.0995	0.0995
Trichomonas vaginalis	heat shock protein, putative	0.0047	0.0846	0.1362
Mycobacterium ulcerans	carbon monoxyde dehydrogenase small chain CoxS	0.0033	0.04	0.0568
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0051	0.0995	0.0995
Toxoplasma gondii	Hsp90 domain-containing protein	0.0177	0.4964	0.8298
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0037	0.0529	0.0529
Loa Loa (eye worm)	transcription factor SMAD2	0.0122	0.3216	0.3417
Brugia malayi	prostaglandin transporter	0.0029	0.0293	0.0311
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0051	0.0995	0.0995
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0046	0.0815	0.0815
Entamoeba histolytica	heat shock protein 90, putative	0.0047	0.0846	1
Echinococcus granulosus	heat shock protein heat shock protein 90 alpha	0.004	0.0633	0.0633
Echinococcus granulosus	heat shock protein	0.0047	0.0846	0.0846
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0051	0.0995	0.0995
Toxoplasma gondii	heat shock protein HSP90	0.0047	0.0846	0.1414
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0037	0.0529	0.0529
Leishmania major	heat shock protein 83-1	0.0047	0.0846	0.6096
Schistosoma mansoni	endoplasmin	0.0047	0.0846	0.0846
Schistosoma mansoni	transcription factor LCR-F1	0.0037	0.0529	0.0529
Echinococcus granulosus	activin receptor type	0.0088	0.2142	0.2142
Trypanosoma cruzi	heat shock protein 90, putative	0.004	0.0633	0.4139
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.0192	0.5451	0.5792
Entamoeba histolytica	hypothetical protein	0.0037	0.0529	0.36
Trypanosoma cruzi	serine peptidase, Clan SC, Family S9B	0.006	0.1271	1
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0293	0.0311
Brugia malayi	sodium-independent organic anion transporter family protein	0.0029	0.0293	0.0311
Loa Loa (eye worm)	heat shock protein 75	0.0031	0.0351	0.0373
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0051	0.0995	0.0995
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0293	0.0311
Trypanosoma cruzi	Heat shock protein 83, putative	0.0047	0.0846	0.6096
Brugia malayi	STAT protein, DNA binding domain containing protein	0.0318	0.9411	1
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0051	0.0995	0.0995
Trypanosoma brucei	heat shock protein, putative	0.0047	0.0846	0.6096
Schistosoma mansoni	heat shock protein	0.0047	0.0846	0.0846
Echinococcus granulosus	dipeptidyl aminopeptidaseprotein	0.0179	0.5025	0.5025
Entamoeba histolytica	hypothetical protein	0.0037	0.0529	0.36
Leishmania major	lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative	0.0044	0.0755	0.5264
Trypanosoma brucei	serine peptidase, Clan SC, Family S9B	0.006	0.1271	1
Brugia malayi	Hsp90 protein	0.0031	0.0351	0.0373
Mycobacterium ulcerans	carbon monoxyde dehydrogenase small chain CoxS	0.0033	0.04	0.0568
Echinococcus granulosus	organic anion transporting polypeptide 30B	0.0029	0.0293	0.0293
Echinococcus multilocularis	serine:threonine protein kinase receptor R3	0.0086	0.2102	0.2102
Mycobacterium ulcerans	carbon monoxyde dehydrogenase large chain CoxL	0.0081	0.1913	0.618
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0051	0.0995	0.0995
Leishmania major	heat shock protein 83-1	0.0047	0.0846	0.6096
Echinococcus granulosus	tyrosine kinase	0.0047	0.0855	0.0855
Toxoplasma gondii	dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein	0.006	0.1271	0.2125
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0051	0.0976	0.1037
Loa Loa (eye worm)	MH2 domain-containing protein	0.0122	0.3216	0.3417
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0047	0.0855	0.0855
Trypanosoma cruzi	heat shock protein 90, putative	0.0047	0.0846	0.6096
Entamoeba histolytica	heat shock protein 90, putative	0.0047	0.0846	1
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0051	0.0995	0.0995
Brugia malayi	prolyl oligopeptidase family protein	0.0179	0.5025	0.534
Brugia malayi	hypothetical protein	0.0029	0.0293	0.0311
Schistosoma mansoni	tyrosine kinase	0.0051	0.0995	0.0995
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0051	0.0995	0.0995
Brugia malayi	SRC-1	0.0051	0.0995	0.1057
Trichomonas vaginalis	heat shock protein, putative	0.0034	0.0441	0.047

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 4.5 uM	Inhibition of c-Src	ChEMBL.	18479116
IC50 (binding)	= 16 uM	Inhibition of ALK5 by filter binding assay	ChEMBL.	18479116

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL482728

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 985287