Detailed information for compound 985329

Basic information

Technical information
  • TDR Targets ID: 985329
  • Name: (4Z,7E)-1,11-di(furan-3-yl)-4,8-dimethylundec a-4,7-dien-6-one
  • MW: 326.429 | Formula: C21H26O3
  • H donors: 0 H acceptors: 1 LogP: 5.76 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: C/C(=C/C(=O)/C=C(/CCCc1cocc1)\C)/CCCc1cocc1
  • InChi: 1S/C21H26O3/c1-17(5-3-7-19-9-11-23-15-19)13-21(22)14-18(2)6-4-8-20-10-12-24-16-20/h9-16H,3-8H2,1-2H3/b17-13-,18-14+
  • InChiKey: LMNQNJRZKZYBMX-SIJTWYJSSA-N  

Network

Hover on a compound node to display the structore

Synonyms

  • (4Z,7E)-1,11-bis(3-furyl)-4,8-dimethyl-undeca-4,7-dien-6-one
  • (4Z,7E)-1,11-bis(3-furyl)-4,8-dimethylundeca-4,7-dien-6-one
  • (4Z,7E)-1,11-di(furan-3-yl)-4,8-dimethyl-undeca-4,7-dien-6-one

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Brugia malayi RNA, U transporter 1 0.0089 0.013 0.1073
Echinococcus multilocularis serine:threonine protein kinase N2 0.0334 0.0661 0.5621
Loa Loa (eye worm) hypothetical protein 0.4545 0.9787 0.9787
Schistosoma mansoni serine/threonine protein kinase 0.0334 0.0661 0.5621
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.0044 0.0341
Loa Loa (eye worm) hypothetical protein 0.0236 0.0448 0.0444
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0085 0.0121 0.0996
Brugia malayi MAP kinase sur-1 0.0066 0.0078 0.0634
Onchocerca volvulus 0.0236 0.0448 0.0461
Schistosoma mansoni atypical protein kinase C 0.057 0.1172 1
Echinococcus multilocularis serine:threonine protein kinase N2 0.0334 0.0661 0.5621
Echinococcus granulosus beta LACTamase domain containing family member 0.0039 0.0021 0.0145
Toxoplasma gondii diacylglycerol kinase, putative 0.0236 0.0448 0.6777
Loa Loa (eye worm) hypothetical protein 0.431 0.9276 0.9275
Trichomonas vaginalis AGC family protein kinase 0.0334 0.0661 1
Brugia malayi RhoGAP domain containing protein 0.0236 0.0448 0.3797
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.005 0.0044 0.0341
Loa Loa (eye worm) hypothetical protein 0.0236 0.0448 0.0444
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0236 0.0448 0.3797
Trichomonas vaginalis AGC family protein kinase 0.0334 0.0661 1
Brugia malayi RhoGEF domain containing protein 0.0236 0.0448 0.3797
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0085 0.0121 0.5
Schistosoma mansoni protein kinase C mu 0.0236 0.0448 0.3797
Loa Loa (eye worm) AGC/NDR protein kinase 0.0334 0.0661 0.0657
Echinococcus granulosus myotubularin protein 13 0.0236 0.0448 0.3797
Schistosoma mansoni diacylglycerol kinase theta 0.0236 0.0448 0.3797
Echinococcus granulosus C2 calcium dependent membrane targeting 0.0236 0.0448 0.3797
Trichomonas vaginalis CMGC family protein kinase 0.0066 0.0078 0.0893
Echinococcus granulosus protein kinase c eta type 0.0236 0.0448 0.3797
Echinococcus multilocularis serine:threonine protein kinase 38 0.0334 0.0661 0.5621
Loa Loa (eye worm) hypothetical protein 0.0236 0.0448 0.0444
Echinococcus multilocularis protein kinase c eta type 0.0236 0.0448 0.3797
Onchocerca volvulus 0.0236 0.0448 0.0461
Loa Loa (eye worm) hypothetical protein 0.0039 0.0021 0.0017
Echinococcus multilocularis Rac GTPase activating protein 1 0.0236 0.0448 0.3797
Trypanosoma brucei rac serine-threonine kinase, putative 0.0334 0.0661 1
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0085 0.0121 1
Brugia malayi beta-lactamase 0.0039 0.0021 0.0145
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0334 0.0661 0.5621
Echinococcus multilocularis peptidase Clp (S14 family) 0.0056 0.0057 0.0453
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0334 0.0661 0.5621
Schistosoma mansoni hypothetical protein 0.0236 0.0448 0.3797
Brugia malayi beta-lactamase family protein 0.0039 0.0021 0.0145
Schistosoma mansoni hypothetical protein 0.0335 0.0662 0.563
Brugia malayi C1-like domain containing protein 0.0244 0.0465 0.394
Brugia malayi Protein kinase domain containing protein 0.0244 0.0465 0.394
Brugia malayi protein kinase C3,putative 0.0244 0.0465 0.394
Brugia malayi Protein kinase domain containing protein 0.0334 0.0661 0.5621
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0021 0.0145
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0085 0.0121 1
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.057 0.1172 0.1168
Trichomonas vaginalis AGC family protein kinase 0.0334 0.0661 1
Echinococcus multilocularis N chimaerin 0.0236 0.0448 0.3797
Trichomonas vaginalis AGC family protein kinase 0.0334 0.0661 1
Entamoeba histolytica protein kinase, putative 0.0334 0.0661 1
Loa Loa (eye worm) RasGEF domain-containing protein 0.0236 0.0448 0.0444
Brugia malayi p70 ribosomal S6 kinase beta 0.0334 0.0661 0.5621
Brugia malayi Hr1 repeat family protein 0.0334 0.0661 0.5621
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0085 0.0121 1
Trichomonas vaginalis AGC family protein kinase 0.0334 0.0661 1
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0236 0.0448 0.3797
Brugia malayi beta-lactamase family protein 0.0039 0.0021 0.0145
Schistosoma mansoni serine/threonine protein kinase 0.057 0.1172 1
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0056 0.0057 0.0786
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0056 0.0057 0.0786
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.0236 0.0448 0.3797
Echinococcus multilocularis protein kinase c epsilon type 0.057 0.1172 1
Echinococcus granulosus serine:threonine protein kinase N2 0.0334 0.0661 0.5621
Schistosoma mansoni serine/threonine protein kinase 0.0236 0.0448 0.3797
Echinococcus multilocularis mitogen activated protein kinase 3 0.0066 0.0078 0.0634
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0334 0.0661 0.0657
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0066 0.0078 0.0074
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.005 0.0044 0.004
Brugia malayi Variant SH3 domain containing protein 0.0236 0.0448 0.3797
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0334 0.0661 0.5621
Mycobacterium leprae Probable lipase LipE 0.0039 0.0021 0.1768
Echinococcus granulosus Protein kinase C brain isozyme 0.057 0.1172 1
Echinococcus multilocularis mitogen activated protein kinase 0.0066 0.0078 0.0634
Mycobacterium tuberculosis Possible penicillin-binding protein 0.025 0.0479 1
Schistosoma mansoni protein kinase C 0.0236 0.0448 0.3797
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0066 0.0078 1
Trypanosoma brucei hypothetical protein, conserved 0.0039 0.0021 0.0257
Trichomonas vaginalis AGC family protein kinase 0.0334 0.0661 1
Echinococcus multilocularis protein kinase c iota type 0.057 0.1172 1
Schistosoma mansoni unc-13 (munc13) 0.0236 0.0448 0.3797
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0334 0.0661 0.0657
Trichomonas vaginalis CMGC family protein kinase 0.0066 0.0078 0.0893
Schistosoma mansoni vav2 0.0236 0.0448 0.3797
Echinococcus multilocularis unc 13 (munc13) 0.0236 0.0448 0.3797
Schistosoma mansoni serine/threonine protein kinase 0.057 0.1172 1
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0236 0.0448 0.0444
Schistosoma mansoni serine/threonine protein kinase 0.0244 0.0465 0.394
Loa Loa (eye worm) hypothetical protein 0.0236 0.0448 0.0444
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0236 0.0448 0.3797
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0066 0.0078 1
Brugia malayi RhoGAP domain containing protein 0.0236 0.0448 0.3797
Echinococcus granulosus mitogen activated protein kinase 0.0066 0.0078 0.0634
Trichomonas vaginalis CMGC family protein kinase 0.0066 0.0078 0.0893
Echinococcus granulosus Rac GTPase activating protein 1 0.0236 0.0448 0.3797
Loa Loa (eye worm) Ras association domain family 1 isoform A 0.0236 0.0448 0.0444
Echinococcus granulosus raf serine:threonine protein kinase 0.0236 0.0448 0.3797
Echinococcus granulosus N chimaerin 0.0236 0.0448 0.3797
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0066 0.0078 1
Echinococcus granulosus protein kinase c iota type 0.057 0.1172 1
Giardia lamblia Kinase, CMGC MAPK 0.0066 0.0078 0.5
Trichomonas vaginalis CMGC family protein kinase 0.0066 0.0078 0.0893
Schistosoma mansoni serine/threonine protein kinase 0.0334 0.0661 0.5621
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0334 0.0661 0.5621
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0244 0.0465 0.046
Loa Loa (eye worm) hypothetical protein 0.0236 0.0448 0.0444
Echinococcus multilocularis myotubularin protein 13 0.0236 0.0448 0.3797
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0066 0.0078 1
Schistosoma mansoni protein kinase C mu 0.0244 0.0465 0.394
Trichomonas vaginalis AGC family protein kinase 0.0334 0.0661 1
Schistosoma mansoni serine/threonine protein kinase 0.0066 0.0078 0.0634
Loa Loa (eye worm) hypothetical protein 0.0236 0.0448 0.0444
Brugia malayi Probable ClpP-like protease 0.0085 0.0121 0.0996
Brugia malayi Protein kinase c protein 2 0.0244 0.0465 0.394
Echinococcus granulosus mitogen activated protein kinase 3 0.0066 0.0078 0.0634
Echinococcus granulosus snurportin 1 0.0335 0.0662 0.563
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0334 0.0661 0.0657
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.0044 0.0341
Loa Loa (eye worm) raf kinase 0.0236 0.0448 0.0444
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0021 0.0145
Loa Loa (eye worm) beta-lactamase 0.0039 0.0021 0.0017
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0039 0.0021 0.0017
Schistosoma mansoni serine/threonine protein kinase 0.057 0.1172 1
Echinococcus granulosus Diacylglycerol kinase theta 0.0236 0.0448 0.3797
Entamoeba histolytica protein kinase, putative 0.0334 0.0661 1
Brugia malayi Protein kinase domain containing protein 0.0334 0.0661 0.5621
Echinococcus multilocularis beta LACTamase domain containing family member 0.0039 0.0021 0.0145
Trichomonas vaginalis AGC family protein kinase 0.0334 0.0661 1
Echinococcus granulosus peptidase Clp S14 family 0.0056 0.0057 0.0453
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0244 0.0465 0.394
Loa Loa (eye worm) AGC/AKT protein kinase 0.0334 0.0661 0.0657
Brugia malayi protein kinase C II. 0.057 0.1172 1
Loa Loa (eye worm) hypothetical protein 0.0236 0.0448 0.0444
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.0244 0.0465 0.046
Toxoplasma gondii HEAT repeat-containing protein 0.0031 0.0004 0.0067
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0334 0.0661 0.5621
Loa Loa (eye worm) hypothetical protein 0.0236 0.0448 0.0444
Onchocerca volvulus 0.0236 0.0448 0.0461
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0236 0.0448 0.3797
Trichomonas vaginalis AGC family protein kinase 0.0334 0.0661 1
Brugia malayi Ras association domain family 1 isoform A 0.0236 0.0448 0.3797
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0244 0.0465 0.394
Schistosoma mansoni serine/threonine kinase 0.0334 0.0661 0.5621
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0244 0.0465 0.394
Loa Loa (eye worm) hypothetical protein 0.0039 0.0021 0.0017
Schistosoma mansoni serine/threonine protein kinase 0.0334 0.0661 0.5621
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0085 0.0121 0.5
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0044 0.0341
Plasmodium vivax hypothetical protein, conserved 0.0039 0.0021 0.1768
Loa Loa (eye worm) AGC/PKN protein kinase 0.0334 0.0661 0.0657
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0066 0.0078 1
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0085 0.0121 0.0996
Echinococcus granulosus protein kinase c epsilon type 0.057 0.1172 1
Plasmodium falciparum importin beta, putative 0.0031 0.0004 0.0369
Schistosoma mansoni rac gtpase activating protein 0.0236 0.0448 0.3797
Loa Loa (eye worm) hypothetical protein 0.0085 0.0121 0.0116
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0334 0.0661 0.5621
Onchocerca volvulus 0.431 0.9276 1
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0326 0.0644 0.9738
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.0044 0.0341
Loa Loa (eye worm) hypothetical protein 0.0039 0.0021 0.0017
Echinococcus granulosus protein kinase C gamma type 0.0334 0.0661 0.5621
Loa Loa (eye worm) hypothetical protein 0.0039 0.0021 0.0017
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0066 0.0078 0.1188
Loa Loa (eye worm) hypothetical protein 0.431 0.9276 0.9275
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0085 0.0121 1
Brugia malayi diacylglycerol kinase 0.0236 0.0448 0.3797
Entamoeba histolytica protein kinase, putative 0.0334 0.0661 1
Trichomonas vaginalis AGC family protein kinase 0.0334 0.0661 1
Loa Loa (eye worm) hypothetical protein 0.0236 0.0448 0.0444
Echinococcus granulosus unc 13 munc13 0.0236 0.0448 0.3797
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0039 0.0021 0.0145
Echinococcus multilocularis raf serine:threonine protein kinase 0.0236 0.0448 0.3797
Echinococcus granulosus NDR protein kinase 0.0334 0.0661 0.5621
Plasmodium vivax importin-beta 2, putative 0.0031 0.0004 0.0369
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0085 0.0121 0.1828
Brugia malayi Pleckstrin Homology Domain 0.0236 0.0448 0.3797
Loa Loa (eye worm) hypothetical protein 0.0236 0.0448 0.0444
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0056 0.0057 0.4744
Brugia malayi Protein kinase domain containing protein 0.0334 0.0661 0.5621
Schistosoma mansoni serine/threonine protein kinase 0.0244 0.0465 0.394
Trichomonas vaginalis AGC family protein kinase 0.0334 0.0661 1
Mycobacterium leprae conserved hypothetical protein 0.0039 0.0021 0.1768
Toxoplasma gondii AGC kinase 0.0334 0.0661 1
Toxoplasma gondii ABC1 family protein 0.0039 0.0021 0.0323
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.0044 0.0341
Echinococcus multilocularis snurportin 1 0.0335 0.0662 0.563
Echinococcus multilocularis Diacylglycerol kinase theta 0.0236 0.0448 0.3797
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0085 0.0121 1
Schistosoma mansoni unc-13 (munc13) 0.0236 0.0448 0.3797
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0236 0.0448 0.0444
Loa Loa (eye worm) hypothetical protein 0.0039 0.0021 0.0017
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0085 0.0121 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0044 0.0341
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0085 0.0121 0.1828
Schistosoma mansoni serine/threonine protein kinase 0.0334 0.0661 0.5621
Loa Loa (eye worm) hypothetical protein 0.0039 0.0021 0.0017
Echinococcus multilocularis Protein kinase C, brain isozyme 0.057 0.1172 1
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0335 0.0662 0.0658
Schistosoma mansoni peptidase Clp (S14 family) 0.0085 0.0121 0.0996
Echinococcus multilocularis serine threonine protein kinase 0.0334 0.0661 0.5621
Trypanosoma brucei protein kinase, putative 0.0066 0.0078 0.1128
Loa Loa (eye worm) hypothetical protein 0.431 0.9276 0.9275
Entamoeba histolytica protein kinase, putative 0.0334 0.0661 1
Schistosoma mansoni diacylglycerol kinase theta 0.0236 0.0448 0.3797
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0085 0.0121 0.5
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0044 0.0341
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0066 0.0078 0.1128
Loa Loa (eye worm) hypothetical protein 0.0236 0.0448 0.0444
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0334 0.0661 0.0657
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0066 0.0078 1
Brugia malayi diacylglycerol kinase 0.0236 0.0448 0.3797

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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