Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Anandamide amidohydrolase | Starlite/ChEMBL | References |
Homo sapiens | diacylglycerol lipase, alpha | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma japonicum | Fatty-acid amide hydrolase 1, putative | Anandamide amidohydrolase | 579 aa | 499 aa | 24.6 % |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | Anandamide amidohydrolase | 579 aa | 470 aa | 28.3 % |
Echinococcus granulosus | fatty acid amide hydrolase 1 | Anandamide amidohydrolase | 579 aa | 470 aa | 28.7 % |
Onchocerca volvulus | Anandamide amidohydrolase | 579 aa | 539 aa | 34.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | suppression of tumorigenicity 18 protein | 0.0052 | 0.1405 | 0.2237 |
Trypanosoma brucei | lipase domain protein, putative | 0.0173 | 0.5983 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0173 | 0.5983 | 1 |
Echinococcus granulosus | histone acetyltransferase MYST2 | 0.0052 | 0.1405 | 0.2237 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0033 | 0.0668 | 0.1116 |
Schistosoma mansoni | fatty-acid amide hydrolase | 0.0123 | 0.4098 | 0.4098 |
Echinococcus granulosus | sn1 specific diacylglycerol lipase beta | 0.0173 | 0.5983 | 0.9527 |
Brugia malayi | C2-HC type zinc finger protein C.e-MyT1 | 0.0052 | 0.1405 | 0.2348 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0024 | 0.0344 | 0.5 |
Schistosoma mansoni | scm-relatedprotein containing 4 mbt domains (sfmbt) | 0.0046 | 0.1164 | 0.1164 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0046 | 0.1164 | 0.1164 |
Brugia malayi | hypothetical protein | 0.0024 | 0.0344 | 0.0575 |
Echinococcus multilocularis | polycomb protein SCMH1 | 0.0046 | 0.1164 | 0.1854 |
Leishmania major | hypothetical protein, conserved | 0.0173 | 0.5983 | 1 |
Echinococcus granulosus | SAM and MBT domain containing protein | 0.0046 | 0.1164 | 0.1854 |
Loa Loa (eye worm) | mbt repeat family protein | 0.0046 | 0.1164 | 0.1946 |
Brugia malayi | hypothetical protein | 0.0016 | 0.0018 | 0.003 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0024 | 0.0344 | 0.5 |
Echinococcus multilocularis | geminin | 0.0163 | 0.5605 | 0.8925 |
Brugia malayi | MH2 domain containing protein | 0.0115 | 0.3779 | 0.6316 |
Echinococcus granulosus | endonuclease exonuclease phosphatase | 0.0181 | 0.628 | 1 |
Echinococcus granulosus | suppression of tumorigenicity 18 protein | 0.0052 | 0.1405 | 0.2237 |
Brugia malayi | Lipase family protein | 0.0173 | 0.5983 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0123 | 0.4098 | 0.6849 |
Echinococcus multilocularis | endonuclease exonuclease phosphatase | 0.0181 | 0.628 | 1 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.0123 | 0.4098 | 0.6526 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.1243 | 0.2077 |
Trichomonas vaginalis | lipase containing protein, putative | 0.0173 | 0.5983 | 0.5 |
Schistosoma mansoni | myelin transcription factor 1 myt1 | 0.0052 | 0.1405 | 0.1405 |
Brugia malayi | amidase | 0.0123 | 0.4098 | 0.6849 |
Schistosoma mansoni | hypothetical protein | 0.0163 | 0.5605 | 0.5605 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.1164 | 0.1946 |
Loa Loa (eye worm) | lipase | 0.0173 | 0.5983 | 1 |
Trypanosoma brucei | lipase domain protein, putative | 0.0173 | 0.5983 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0048 | 0.1243 | 0.2077 |
Echinococcus granulosus | geminin | 0.0163 | 0.5605 | 0.8925 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0046 | 0.1164 | 0.1164 |
Brugia malayi | mbt repeat family protein | 0.0046 | 0.1164 | 0.1946 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0115 | 0.3779 | 0.6316 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0344 | 0.0575 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.1405 | 0.2348 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0048 | 0.1243 | 0.2077 |
Schistosoma mansoni | amidase | 0.0123 | 0.4098 | 0.4098 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0668 | 0.0668 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0115 | 0.3779 | 0.6316 |
Echinococcus multilocularis | sn1 specific diacylglycerol lipase beta | 0.0173 | 0.5983 | 0.9527 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0173 | 0.5983 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0668 | 0.1116 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.0123 | 0.4098 | 0.6526 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0024 | 0.0344 | 0.5 |
Onchocerca volvulus | 0.0173 | 0.5983 | 1 | |
Brugia malayi | mbt repeat family protein | 0.0046 | 0.1164 | 0.1946 |
Echinococcus granulosus | polycomb protein SCMH1 | 0.0046 | 0.1164 | 0.1854 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.0123 | 0.4098 | 0.6526 |
Echinococcus multilocularis | SAM and MBT domain containing protein | 0.0046 | 0.1164 | 0.1854 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.0123 | 0.4098 | 0.6526 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0024 | 0.0344 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0048 | 0.1243 | 0.2077 |
Echinococcus multilocularis | histone acetyltransferase MYST2 | 0.0052 | 0.1405 | 0.2237 |
Trichomonas vaginalis | lipase containing protein, putative | 0.0173 | 0.5983 | 0.5 |
Loa Loa (eye worm) | MBCTL1 | 0.0052 | 0.1405 | 0.2348 |
Schistosoma mansoni | hypothetical protein | 0.0163 | 0.5605 | 0.5605 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.023 uM | Inhibition of FAAH mediated [14C]anandamide hydrolysis in rat brain after 30 mins | ChEMBL. | 17452063 |
IC50 (binding) | = 0.13 uM | Inhibition of human recombinant DAGLalpha mediated sn-1-[14C]oleoyl-2-arachidonoyl-glycerol hydrolysis to 2-AG overexpressed in COS cells after 20 mins | ChEMBL. | 17452063 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.