Detailed information for compound 990585

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 329.827 | Formula: C17H20ClN5
  • H donors: 0 H acceptors: 2 LogP: 1.83 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccccc1CN(CCn1cncc1)CCn1cncc1
  • InChi: 1S/C17H20ClN5/c18-17-4-2-1-3-16(17)13-21(9-11-22-7-5-19-14-22)10-12-23-8-6-20-15-23/h1-8,14-15H,9-13H2
  • InChiKey: OCLIBHOFHUPFRD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0502 0.0753
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0134 0.0214
Brugia malayi RNA recognition motif domain containing protein 0.0067 0.0836 0.1377
Schistosoma mansoni DNA polymerase eta 0.0019 0.0134 0.0143
Leishmania major DNA polymerase kappa, putative 0.0019 0.0134 0.0214
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.0502 0.0696
Loa Loa (eye worm) carboxylesterase 0.0431 0.6068 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0134 0.0214
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0196 0.0367
Giardia lamblia DINP protein human, muc B family 0.0019 0.0134 0.4786
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0134 0.0179
Toxoplasma gondii hypothetical protein 0.0047 0.0543 0.0497
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0502 0.0753
Schistosoma mansoni hypothetical protein 0.0033 0.034 0.0484
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0041 0.0456 0.1016
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0836 0.1308
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0502 0.0753
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0134 0.0214
Echinococcus multilocularis acetylcholinesterase 0.0431 0.6068 1
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0134 0.0143
Echinococcus multilocularis muscleblind protein 1 0.0144 0.1941 0.3144
Brugia malayi RNA binding protein 0.0067 0.0836 0.1377
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0073 0.0914 0.1438
Leishmania major mitochondrial DNA polymerase beta 0.0292 0.4061 1
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0134 0.0143
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0099 0.0105
Trypanosoma cruzi trypanothione reductase, putative 0.0037 0.0392 0.0856
Loa Loa (eye worm) glutathione reductase 0.0037 0.0392 0.0512
Mycobacterium leprae Chorismate synthase AroF (5-enolpyruvylshikimate-3-phosphate phospholyase). 0.0348 0.4863 1
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0013 0.0048 0.5
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0134 0.0214
Onchocerca volvulus 0.0073 0.0914 0.3299
Loa Loa (eye worm) hypothetical protein 0.0017 0.0112 0.0045
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0134 0.0143
Loa Loa (eye worm) hypothetical protein 0.0017 0.0112 0.0045
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0134 0.0214
Brugia malayi N-terminal motif family protein 0.0174 0.2374 0.3911
Schistosoma mansoni gliotactin 0.0073 0.0914 0.1438
Echinococcus granulosus dna polymerase kappa 0.0019 0.0134 0.0143
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0196 0.2168
Brugia malayi Carboxylesterase family protein 0.0073 0.0914 0.1507
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.0112 0.0133
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0196 0.0322
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0134 0.0179
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0196 0.0148
Onchocerca volvulus 0.0073 0.0914 0.3299
Brugia malayi Flap endonuclease-1 0.0025 0.0228 0.0376
Plasmodium vivax acyl-CoA synthetase, putative 0.0017 0.0112 0.0064
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0138 0.1851 0.4494
Loa Loa (eye worm) acetylcholinesterase 1 0.0431 0.6068 1
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0134 0.0221
Echinococcus granulosus acetylcholinesterase 0.0431 0.6068 1
Loa Loa (eye worm) hypothetical protein 0.0073 0.0914 0.1385
Echinococcus granulosus BC026374 protein S09 family 0.0073 0.0914 0.1438
Plasmodium vivax glutathione reductase, putative 0.0037 0.0392 0.0345
Loa Loa (eye worm) hypothetical protein 0.0073 0.0914 0.1385
Echinococcus granulosus carboxylesterase 5A 0.0431 0.6068 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0099 0.0105
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0292 0.4061 1
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0196 0.2168
Entamoeba histolytica hypothetical protein 0.0038 0.0417 1
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0093 0.1198 0.2389
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0073 0.0914 1
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0041 0.0456 0.1016
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.0417 0.0612
Echinococcus multilocularis acetylcholinesterase 0.0431 0.6068 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0154 0.2076 0.421
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0017 0.0112 0.0064
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0292 0.4061 1
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0196 0.0306
Leishmania major DNA polymerase eta, putative 0.0019 0.0134 0.0214
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.0559 0.0921
Brugia malayi hypothetical protein 0.0073 0.0914 0.1507
Loa Loa (eye worm) carboxylesterase 0.0073 0.0914 0.1385
Echinococcus multilocularis neuroligin 0.0073 0.0914 0.1438
Loa Loa (eye worm) hypothetical protein 0.0023 0.0196 0.0184
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0134 0.0214
Plasmodium falciparum flap endonuclease 1 0.0025 0.0228 0.018
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0836 0.1308
Loa Loa (eye worm) hypothetical protein 0.0174 0.2374 0.3825
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0134 0.0214
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0083 0.1065 0.2111
Echinococcus multilocularis muscleblind protein 0.0144 0.1941 0.3144
Echinococcus granulosus GPCR family 2 0.0015 0.0085 0.0061
Echinococcus multilocularis para nitrobenzyl esterase 0.0073 0.0914 0.1438
Mycobacterium ulcerans hypothetical protein 0.0154 0.2076 0.2037
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0051 0.0007
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0502 0.0753
Schistosoma mansoni acetylcholinesterase 0.0073 0.0914 0.1438
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0456 0.1016
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0073 0.0914 0.1798
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0134 0.0214
Trichomonas vaginalis spcc417.12 protein, putative 0.0073 0.0914 1
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0083 0.1065 0.2111
Echinococcus granulosus flap endonuclease 1 0.0025 0.0228 0.0298
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0134 0.0143
Brugia malayi Carboxylesterase family protein 0.0431 0.6068 1
Toxoplasma gondii thioredoxin reductase 0.0037 0.0392 0.0345
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0134 0.0214
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0051 0.0007
Loa Loa (eye worm) hypothetical protein 0.0017 0.0112 0.0045
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0134 0.0214
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0502 0.0753
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0134 0.0086
Brugia malayi Carboxylesterase family protein 0.0431 0.6068 1
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.0417 0.0612
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0836 0.1308
Schistosoma mansoni hypothetical protein 0.0015 0.0085 0.0061
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.0559 0.0791
Mycobacterium ulcerans hypothetical protein 0.0023 0.0196 0.0148
Loa Loa (eye worm) hypothetical protein 0.0073 0.0914 0.1385
Echinococcus multilocularis carboxylesterase 5A 0.0431 0.6068 1
Trypanosoma brucei unspecified product 0.0013 0.0051 0.0007
Plasmodium falciparum thioredoxin reductase 0.0037 0.0392 0.0345
Loa Loa (eye worm) hypothetical protein 0.0073 0.0914 0.1385
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0836 0.1308
Plasmodium falciparum chorismate synthase 0.0705 1 1
Loa Loa (eye worm) hypothetical protein 0.0073 0.0914 0.1385
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0073 0.0914 0.1438
Giardia lamblia Flap structure-specific endonuclease 0.0025 0.0228 1
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0196 0.0148
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0502 0.0753
Trypanosoma brucei unspecified product 0.0019 0.0134 0.0214
Echinococcus multilocularis GPCR, family 2 0.0015 0.0085 0.0061
Loa Loa (eye worm) hypothetical protein 0.0144 0.1941 0.3102
Trichomonas vaginalis flap endonuclease-1, putative 0.0025 0.0228 0.2075
Echinococcus multilocularis dna polymerase eta 0.0019 0.0134 0.0143
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0431 0.6068 1
Brugia malayi Carboxylesterase family protein 0.0073 0.0914 0.1507
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0196 0.0148
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0073 0.0914 0.1438
Brugia malayi Muscleblind-like protein 0.0144 0.1941 0.3199
Loa Loa (eye worm) hypothetical protein 0.0431 0.6068 1
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0073 0.0914 0.1438
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0292 0.4061 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0112 0.0045
Schistosoma mansoni hypothetical protein 0.0015 0.0085 0.0061
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0093 0.1198 0.2389
Loa Loa (eye worm) hypothetical protein 0.0073 0.0914 0.1385
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0134 0.0214
Loa Loa (eye worm) hypothetical protein 0.0019 0.0134 0.0082
Loa Loa (eye worm) TAR-binding protein 0.0067 0.0836 0.1254
Brugia malayi Thioredoxin reductase 0.0037 0.0392 0.0645
Entamoeba histolytica hypothetical protein 0.0038 0.0417 1
Echinococcus granulosus para nitrobenzyl esterase 0.0073 0.0914 0.1438
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0025 0.0228 0.0448
Loa Loa (eye worm) hypothetical protein 0.0144 0.1941 0.3102
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0017 0.0112 0.0064
Onchocerca volvulus 0.0073 0.0914 0.3299
Echinococcus multilocularis tar DNA binding protein 0.0067 0.0836 0.1308
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0085 0.0141
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0085 0.0061
Leishmania major trypanothione reductase 0.0037 0.0392 0.0856
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0037 0.0392 0.0713
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0085 0.0061
Mycobacterium tuberculosis Carboxylesterase LipT 0.0073 0.0914 0.1798
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0134 0.0214
Loa Loa (eye worm) hypothetical protein 0.0023 0.0196 0.0184
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0836 0.1308
Brugia malayi hypothetical protein 0.0038 0.0417 0.0687
Plasmodium vivax thioredoxin reductase, putative 0.0037 0.0392 0.0345
Loa Loa (eye worm) RNA binding protein 0.0067 0.0836 0.1254
Echinococcus granulosus tar DNA binding protein 0.0067 0.0836 0.1308
Echinococcus multilocularis thioredoxin glutathione reductase 0.0037 0.0399 0.0582
Loa Loa (eye worm) carboxylesterase 0.0073 0.0914 0.1385
Brugia malayi Carboxylesterase family protein 0.0073 0.0914 0.1507
Onchocerca volvulus 0.0073 0.0914 0.3299
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0083 0.1065 0.1862
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0134 0.0214
Loa Loa (eye worm) hypothetical protein 0.0017 0.0112 0.0045
Echinococcus granulosus acetylcholinesterase 0.0431 0.6068 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0085 0.0061
Echinococcus granulosus muscleblind protein 0.0144 0.1941 0.3144
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0196 0.0306
Entamoeba histolytica hypothetical protein 0.0038 0.0417 1
Mycobacterium tuberculosis Probable reductase 0.0083 0.1065 0.2111
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0025 0.0228 0.0448
Plasmodium falciparum glutathione reductase 0.0037 0.0392 0.0345
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0134 0.0214
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.0502 0.0827
Mycobacterium ulcerans carboxylesterase, LipT 0.0073 0.0914 0.087
Onchocerca volvulus 0.0073 0.0914 0.3299
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0134 0.0143
Schistosoma mansoni hypothetical protein 0.0015 0.0085 0.0061
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0025 0.0228 0.0448
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0174 0.2374 1
Loa Loa (eye worm) hypothetical protein 0.0073 0.0914 0.1385
Schistosoma mansoni hypothetical protein 0.0038 0.0417 0.0612
Mycobacterium tuberculosis Probable chorismate synthase AroF (5-enolpyruvylshikimate-3-phosphate phospholyase) 0.0348 0.4863 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.0417 0.0612
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0134 0.0214
Loa Loa (eye worm) thioredoxin reductase 0.0037 0.0392 0.0512
Trypanosoma brucei unspecified product 0.0013 0.0051 0.0007
Loa Loa (eye worm) hypothetical protein 0.0033 0.034 0.0425
Schistosoma mansoni flap endonuclease-1 0.0023 0.0193 0.0241
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0134 0.0221
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0134 0.0214
Loa Loa (eye worm) hypothetical protein 0.0048 0.0559 0.0791
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0099 0.0105
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0134 0.0086
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0093 0.1198 0.2149
Echinococcus multilocularis BC026374 protein (S09 family) 0.0073 0.0914 0.1438
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0196 0.0148
Echinococcus multilocularis flap endonuclease 1 0.0025 0.0228 0.0298
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0196 0.0322
Echinococcus granulosus dna polymerase eta 0.0019 0.0134 0.0143
Schistosoma mansoni hypothetical protein 0.0015 0.0085 0.0061
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0099 0.0105
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0134 0.0082
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0502 0.0753
Loa Loa (eye worm) hypothetical protein 0.0431 0.6068 1
Loa Loa (eye worm) flap endonuclease-1 0.0025 0.0228 0.0238
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0456 0.1016
Echinococcus granulosus thioredoxin glutathione reductase 0.0037 0.0399 0.0582
Plasmodium vivax flap endonuclease 1, putative 0.0025 0.0228 0.018
Entamoeba histolytica hypothetical protein 0.0038 0.0417 1
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0073 0.0914 0.1438
Mycobacterium ulcerans chorismate synthase 0.0705 1 1
Schistosoma mansoni BC026374 protein (S09 family) 0.0073 0.0914 0.1438
Echinococcus granulosus neuroligin 0.0073 0.0914 0.1438
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0196 0.0148
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0085 0.0061
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0138 0.1851 0.4494
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0083 0.1065 0.2111
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0134 0.0993
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0067 0.0836 0.1254
Entamoeba histolytica Flap nuclease, putative 0.0025 0.0228 0.3315
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0085 0.0141
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.034 0.056
Brugia malayi Carboxylesterase family protein 0.0073 0.0914 0.1507
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0134 0.0214
Toxoplasma gondii chorismate synthase, putative 0.0705 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0051 0.0007
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0073 0.0914 0.1798
Plasmodium falciparum acyl-CoA synthetase 0.0017 0.0112 0.0064
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.0559 0.0921
Plasmodium vivax chorismate synthase 0.0705 1 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0196 0.0184
Schistosoma mansoni neuroligin 3 (S09 family) 0.0073 0.0914 0.1438
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0134 0.0214
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0196 0.0148
Trypanosoma brucei trypanothione reductase 0.0037 0.0392 0.0856
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0083 0.1065 0.2111
Mycobacterium tuberculosis Probable oxidoreductase 0.0093 0.1198 0.2389
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0134 0.0214
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0196 0.0367
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0025 0.0228 0.018
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.005 0.0585 0.1338
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0196 0.0148
Brugia malayi glutathione reductase 0.0037 0.0392 0.0645
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0196 0.0367
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0134 0.0993
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0196 0.2168
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0134 0.0214
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0196 0.0322
Brugia malayi TAR-binding protein 0.0067 0.0836 0.1377
Mycobacterium tuberculosis Probable dehydrogenase 0.0083 0.1065 0.2111
Treponema pallidum NADH oxidase 0.0013 0.0048 0.5
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0138 0.1851 0.4494
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0013 0.0048 0.5
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0013 0.0048 0.008

Activities

Activity type Activity value Assay description Source Reference
MIC (functional) = 16 ug ml-1 Antibacterial activity against Escherichia coli ATCC 25922 after 24 hrs by micro-broth dilution method ChEMBL. 20598399
MIC (functional) > 256 ug ml-1 Antifungal activity against Candida albicans ATCC 76615 after 24 hrs by micro-broth dilution method ChEMBL. 20598399

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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