Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | bile acid beta-glucosidase-related | 0.0212 | 0.3349 | 0.3794 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0082 | 0.0526 | 0.0489 |
Onchocerca volvulus | 0.0083 | 0.0548 | 0.0653 | |
Trichomonas vaginalis | Clan AA, family A1, cathepsin D-like aspartic peptidase | 0.0076 | 0.0385 | 0.0348 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.034 | 0.6127 | 0.6112 |
Schistosoma mansoni | beta-galactosidase | 0.0161 | 0.2234 | 0.2531 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0082 | 0.0526 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.034 | 0.6127 | 0.6112 |
Echinococcus granulosus | ceramide glucosyltransferase | 0.0243 | 0.4023 | 0.4319 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0082 | 0.0526 | 0.0526 |
Loa Loa (eye worm) | O-glycosyl hydrolase family 30 protein | 0.0519 | 1 | 1 |
Echinococcus multilocularis | non lysosomal glucosylceramidase | 0.0212 | 0.3349 | 0.3596 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.034 | 0.6127 | 0.6112 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0082 | 0.0526 | 1 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0487 | 0.9314 | 1 |
Schistosoma mansoni | aminoadipate-semialdehyde dehydrogenase | 0.0083 | 0.0548 | 0.0621 |
Trypanosoma cruzi | lysosomal alpha-mannosidase precursor, putative | 0.0083 | 0.0547 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.034 | 0.6127 | 0.6112 |
Leishmania major | alpha glucosidase II subunit, putative | 0.0082 | 0.0526 | 1 |
Echinococcus multilocularis | neutral alpha glucosidase AB | 0.0082 | 0.0526 | 0.0564 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0082 | 0.0526 | 0.9586 |
Echinococcus multilocularis | lysosomal alpha mannosidase | 0.0083 | 0.0547 | 0.0587 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0039 | 0.0039 |
Loa Loa (eye worm) | hypothetical protein | 0.0161 | 0.2234 | 0.2234 |
Schistosoma mansoni | alpha-glucosidase | 0.0465 | 0.8827 | 1 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0082 | 0.0526 | 0.0489 |
Schistosoma mansoni | cathepsin D (A01 family) | 0.0076 | 0.0385 | 0.0436 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0519 | 1 | 1 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0082 | 0.0526 | 0.0526 |
Echinococcus multilocularis | bile acid beta glucosidase | 0.0212 | 0.3349 | 0.3596 |
Plasmodium falciparum | plasmepsin VI | 0.0076 | 0.0385 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.0385 | 0.0385 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0487 | 0.9314 | 1 |
Trypanosoma brucei | lysosomal alpha-mannosidase precursor, putative | 0.007 | 0.0248 | 0.4111 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.006 | 0.0039 | 0.0039 |
Schistosoma mansoni | alpha-glucosidase | 0.0465 | 0.8827 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0272 | 0.4654 | 0.4654 |
Onchocerca volvulus | Ceramide glucosyltransferase homolog | 0.0243 | 0.4023 | 0.5106 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0082 | 0.0526 | 0.0489 |
Schistosoma mansoni | alpha glucosidase | 0.0082 | 0.0526 | 0.0595 |
Echinococcus granulosus | lysosomal alpha mannosidase | 0.0083 | 0.0547 | 0.0587 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0082 | 0.0526 | 0.0489 |
Echinococcus granulosus | beta galactosidase | 0.0161 | 0.2234 | 0.2399 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0082 | 0.0526 | 0.0489 |
Schistosoma mansoni | ceramide glucosyltransferase | 0.0243 | 0.4023 | 0.4557 |
Plasmodium falciparum | plasmepsin I | 0.0076 | 0.0385 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0519 | 1 | 1 |
Echinococcus granulosus | bile acid beta glucosidase | 0.0212 | 0.3349 | 0.3596 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.034 | 0.6127 | 0.6112 |
Plasmodium vivax | plasmepsin IV, putative | 0.0076 | 0.0385 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0143 | 0.1851 | 0.1851 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0082 | 0.0526 | 0.0489 |
Echinococcus granulosus | neutral alpha glucosidase AB | 0.0082 | 0.0526 | 0.0564 |
Toxoplasma gondii | glycosyl hydrolase, family 31 protein | 0.0082 | 0.0526 | 1 |
Loa Loa (eye worm) | ceramide glucosyltransferase | 0.0243 | 0.4023 | 0.4023 |
Plasmodium vivax | aspartyl proteinase, putative | 0.0076 | 0.0385 | 1 |
Trypanosoma brucei | glucosidase, putative | 0.0082 | 0.0526 | 0.9586 |
Echinococcus granulosus | non lysosomal glucosylceramidase | 0.0212 | 0.3349 | 0.3596 |
Schistosoma mansoni | bile acid beta-glucosidase-related | 0.0212 | 0.3349 | 0.3794 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0076 | 0.0385 | 0.0436 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0519 | 1 | 1 |
Giardia lamblia | Ceramide glucosyltransferase | 0.011 | 0.1134 | 0.5 |
Plasmodium falciparum | plasmepsin IV | 0.0076 | 0.0385 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0359 | 0.6525 | 0.6512 |
Schistosoma mansoni | ceramide glucosyltransferase | 0.0243 | 0.4023 | 0.4557 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.0548 | 0.0548 |
Onchocerca volvulus | 0.0419 | 0.784 | 1 | |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0487 | 0.9314 | 0.9314 |
Trichomonas vaginalis | sucrase-isomaltase, putative | 0.0082 | 0.0526 | 0.0489 |
Trypanosoma brucei | lysosomal alpha-mannosidase precursor, putative | 0.0083 | 0.0547 | 1 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0487 | 0.9314 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0519 | 1 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0082 | 0.0526 | 0.9586 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0519 | 1 | 1 |
Echinococcus granulosus | L aminoadipate semialdehyde | 0.0083 | 0.0548 | 0.0588 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0082 | 0.0526 | 0.0489 |
Schistosoma mansoni | lysosomal alpha-mannosidase (mannosidase alpha class 2b member 1) | 0.0083 | 0.0547 | 0.0619 |
Echinococcus multilocularis | ceramide glucosyltransferase | 0.0243 | 0.4023 | 0.4319 |
Plasmodium falciparum | plasmepsin II | 0.0076 | 0.0385 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0187 | 0.0187 |
Brugia malayi | aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase | 0.0083 | 0.0548 | 0.0548 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0359 | 0.6525 | 0.6512 |
Trypanosoma cruzi | lysosomal alpha-mannosidase precursor, putative | 0.0083 | 0.0547 | 1 |
Onchocerca volvulus | Glucosylceramidase homolog | 0.034 | 0.6127 | 0.7804 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0519 | 1 | 1 |
Echinococcus multilocularis | cathepsin d (lysosomal aspartyl protease) | 0.0076 | 0.0385 | 0.0414 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.034 | 0.6127 | 0.6112 |
Loa Loa (eye worm) | aspartic protease BmAsp-2 | 0.0076 | 0.0385 | 0.0385 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0487 | 0.9314 | 0.9314 |
Brugia malayi | Ceramide glucosyltransferase | 0.0243 | 0.4023 | 0.4023 |
Echinococcus granulosus | cathepsin d lysosomal aspartyl protease | 0.0076 | 0.0385 | 0.0414 |
Echinococcus multilocularis | L aminoadipate semialdehyde | 0.0083 | 0.0548 | 0.0588 |
Trichomonas vaginalis | maltase-glucoamylase, putative | 0.0082 | 0.0526 | 0.0489 |
Schistosoma mansoni | cathepsin D (A01 family) | 0.0076 | 0.0385 | 0.0436 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.034 | 0.6127 | 0.6112 |
Echinococcus multilocularis | beta galactosidase | 0.0161 | 0.2234 | 0.2399 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.