Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | coagulation factor II (thrombin) receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | fatty acid desaturase, putative | 0.1485 | 1 | 1 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.1346 | 0.905 | 0.905 |
Onchocerca volvulus | 0.1485 | 1 | 1 | |
Mycobacterium tuberculosis | Probable transmembrane alkane 1-monooxygenase AlkB (alkane 1-hydroxylase) (lauric acid omega-hydroxylase) (omega-hydroxylase) (f | 0.0139 | 0.0789 | 0.5 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.1346 | 0.905 | 0.905 |
Echinococcus multilocularis | Peptidase M, neutral zinc metallopeptidases, zinc binding site | 0.0139 | 0.0789 | 0.5 |
Leishmania major | fatty acid desaturase, putative | 0.0139 | 0.0789 | 0.0789 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0054 | 0.0206 | 0.0228 |
Echinococcus granulosus | Sphingolipid delta4 desaturase DES1 | 0.0139 | 0.0789 | 0.5 |
Echinococcus multilocularis | Fatty acid desaturase, type 1 | 0.0139 | 0.0789 | 0.5 |
Brugia malayi | acyl-CoA desaturase | 0.1346 | 0.905 | 1 |
Trypanosoma brucei | cytochrome b5-dependent oleate desaturase | 0.0139 | 0.0789 | 0.0789 |
Mycobacterium tuberculosis | Probable conserved membrane protein | 0.0139 | 0.0789 | 0.5 |
Schistosoma mansoni | fatty acid desaturase | 0.0139 | 0.0789 | 0.5 |
Leishmania major | fatty acid desaturase, putative,sphingolipid delta 4 desaturase, putative | 0.0139 | 0.0789 | 0.0789 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.0139 | 0.0789 | 0.0789 |
Brugia malayi | Delta5 fatty acid desaturase | 0.0139 | 0.0789 | 0.0872 |
Mycobacterium tuberculosis | Possible electron transfer protein FdxB | 0.0139 | 0.0789 | 0.5 |
Loa Loa (eye worm) | acyl-CoA desaturase | 0.1346 | 0.905 | 1 |
Leishmania major | fatty-acid desaturase, putative | 0.1485 | 1 | 1 |
Leishmania major | fatty acid desaturase, putative | 0.0139 | 0.0789 | 0.0789 |
Trypanosoma cruzi | cytochrome b5-dependent oleate desaturase | 0.0139 | 0.0789 | 0.0789 |
Mycobacterium ulcerans | electron transfer protein FdxB | 0.0139 | 0.0789 | 1 |
Trypanosoma brucei | delta-6 fatty acid desaturase, putative | 0.0139 | 0.0789 | 0.0789 |
Loa Loa (eye worm) | hypothetical protein | 0.0139 | 0.0789 | 0.0872 |
Loa Loa (eye worm) | fatty acid desaturase | 0.0139 | 0.0789 | 0.0872 |
Leishmania major | delta-5 fatty acid desaturase | 0.0139 | 0.0789 | 0.0789 |
Trypanosoma cruzi | delta-4 fatty acid desaturase, putative | 0.0139 | 0.0789 | 0.0789 |
Leishmania major | delta-6 fatty acid desaturase | 0.0139 | 0.0789 | 0.0789 |
Leishmania major | delta-4 fatty acid desaturase | 0.0139 | 0.0789 | 0.0789 |
Leishmania major | fatty acid desaturase, putative,sphingolipid delta 4 desaturase, putative | 0.0139 | 0.0789 | 0.0789 |
Onchocerca volvulus | 0.1485 | 1 | 1 | |
Leishmania major | fatty acid desaturase, putative,sphingolipid delta 4 desaturase, putative | 0.0139 | 0.0789 | 0.0789 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.1485 | 1 | 1 |
Echinococcus multilocularis | Peptidase M, neutral zinc metallopeptidases, zinc binding site | 0.0139 | 0.0789 | 0.5 |
Brugia malayi | Fatty acid desaturase family protein | 0.0139 | 0.0789 | 0.0872 |
Loa Loa (eye worm) | FAT-3 protein | 0.0139 | 0.0789 | 0.0872 |
Leishmania major | delta-12 fatty acid desaturase | 0.0139 | 0.0789 | 0.0789 |
Mycobacterium ulcerans | linoleoyl-CoA desaturase, DesA3 | 0.0139 | 0.0789 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0054 | 0.0206 | 0.0228 |
Trypanosoma brucei | delta-4 fatty acid desaturase | 0.0139 | 0.0789 | 0.0789 |
Trypanosoma brucei | sphingolipid delta 4 desaturase, putative | 0.0139 | 0.0789 | 0.0789 |
Plasmodium vivax | stearoyl-CoA desaturase (acyl-CoA desaturase, faty acid desaturase), putative | 0.1346 | 0.905 | 0.5 |
Mycobacterium ulcerans | transmembrane alkane 1-monooxygenase AlkB | 0.0139 | 0.0789 | 1 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.0139 | 0.0789 | 0.0789 |
Mycobacterium ulcerans | hypothetical protein | 0.0139 | 0.0789 | 1 |
Loa Loa (eye worm) | fatty acid desaturase | 0.0139 | 0.0789 | 0.0872 |
Plasmodium falciparum | stearoyl-CoA desaturase | 0.1346 | 0.905 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0139 | 0.0789 | 1 |
Echinococcus granulosus | Fatty acid desaturase type 1 | 0.0139 | 0.0789 | 0.5 |
Trypanosoma cruzi | sphingolipid delta 4 desaturase, putative | 0.0139 | 0.0789 | 0.0789 |
Mycobacterium ulcerans | linoleoyl-CoA desaturase, DesA3 | 0.0139 | 0.0789 | 1 |
Brugia malayi | Fatty acid desaturase family protein | 0.0139 | 0.0789 | 0.0872 |
Leishmania major | fatty acid desaturase, putative,sphingolipid delta 4 desaturase, putative | 0.0139 | 0.0789 | 0.0789 |
Trypanosoma cruzi | delta-4 fatty acid desaturase, putative | 0.0139 | 0.0789 | 0.0789 |
Mycobacterium ulcerans | linoleoyl-CoA desaturase, DesA3_2 | 0.0139 | 0.0789 | 1 |
Toxoplasma gondii | sphingolipid delta 4 desaturase/c-4 hydroxylase protein des2 family protein | 0.0139 | 0.0789 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 6.2 nM | Displacement of [3H]haTRAP from PAR1 in human platelets | ChEMBL. | 18447380 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.