Detailed information for compound 2071820

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 332.464 | Formula: C17H24N4OS
  • H donors: 1 H acceptors: 2 LogP: 2.29 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccsc1CNC1CCCN(C1)Cc1noc(n1)C1CC1
  • InChi: 1S/C17H24N4OS/c1-12-6-8-23-15(12)9-18-14-3-2-7-21(10-14)11-16-19-17(22-20-16)13-4-5-13/h6,8,13-14,18H,2-5,7,9-11H2,1H3
  • InChiKey: ZTECCZUJHPLSPC-UHFFFAOYSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni polycystin 1-related 0.0024 0.0112 0.0338
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0208 0.0195
Trichomonas vaginalis glutathione reductase, putative 0.002 0.0041 0.0028
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.0266 0.0266
Loa Loa (eye worm) hypothetical protein 0.0036 0.0328 0.0328
Schistosoma mansoni lamin 0.0033 0.0266 0.0806
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.002 0.0041 0.0116
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.008 0.1098 0.1098
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0354 0.1007
Brugia malayi LBP / BPI / CETP family, N-terminal domain containing protein 0.0041 0.0409 0.0409
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.01 0.0087
Trichomonas vaginalis glycoside hydrolase, putative 0.0204 0.3286 0.3277
Loa Loa (eye worm) hypothetical protein 0.0033 0.0266 0.0266
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0045 0.0128
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0145 0.2247 0.7619
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0453 0.0441
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0036 0.033 0.1121
Schistosoma mansoni regulator of G protein signaling 0.0023 0.01 0.0303
Brugia malayi glutathione reductase 0.0057 0.0699 0.0699
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0043 0.0454 0.1292
Echinococcus multilocularis Ankyrin repeat domain containing protein 0.0109 0.1607 0.2101
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.002 0.0041 0.0116
Trypanosoma cruzi sterol C-24 reductase, putative 0.0031 0.0244 0.0694
Leishmania major cathepsin L-like protease 0.002 0.0048 0.0138
Echinococcus granulosus cathepsin L cysteine proteinase 0.002 0.0048 0.0063
Loa Loa (eye worm) ICD-1 protein 0.0042 0.0437 0.0437
Brugia malayi Cathepsin L-like precursor 0.002 0.0048 0.0048
Schistosoma mansoni survival motor neuron protein 0.0035 0.0302 0.0915
Onchocerca volvulus 0.0122 0.185 0.1983
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0038 0.0364 0.1234
Brugia malayi hypothetical protein 0.0023 0.0103 0.0103
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0028 0.008
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0364 0.0352
Entamoeba histolytica cysteine proteinase, putative 0.002 0.0048 0.0164
Schistosoma mansoni jumonji/arid domain-containing protein 0.0062 0.0786 0.2378
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1042 0.3153
Toxoplasma gondii hypothetical protein 0.0035 0.0308 0.369
Leishmania major dihydrolipoamide dehydrogenase, putative 0.002 0.0041 0.0116
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0048 0.0036
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0172 0.2722 0.2722
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1051 0.2991
Trichomonas vaginalis glucosylceramidase, putative 0.0584 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0045 0.0128
Schistosoma mansoni regulator of G protein signaling 0.0023 0.01 0.0303
Brugia malayi intermediate filament protein 0.0033 0.0266 0.0266
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0019 0.0028 0.0037
Loa Loa (eye worm) glycosyl hydrolase family 2 0.0106 0.156 0.156
Mycobacterium ulcerans hypothetical protein 0.0185 0.2949 1
Echinococcus granulosus thioredoxin glutathione reductase 0.0057 0.0699 0.0914
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0023 0.01 0.0303
Brugia malayi Beta-glucuronidase precursor 0.0098 0.1417 0.1417
Plasmodium falciparum glutathione reductase 0.002 0.0041 0.0165
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0043 0.0454 0.1292
Loa Loa (eye worm) TAR-binding protein 0.0076 0.1042 0.1042
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0328 0.0429
Brugia malayi M-phase phosphoprotein, mpp8 0.0122 0.185 0.185
Trypanosoma cruzi DNA polymerase kappa, putative 0.005 0.0567 0.1612
Trypanosoma brucei C-14 sterol reductase, putative 0.0031 0.0244 0.0694
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0052 0.0608 0.7641
Plasmodium vivax glutathione reductase, putative 0.0057 0.0699 0.8847
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.008 0.1098 0.3125
Onchocerca volvulus 0.0099 0.1444 0.1537
Echinococcus multilocularis lipoxygenase domain containing protein 0.0024 0.0112 0.0146
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.002 0.0041 0.0053
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0217 0.3515 1
Loa Loa (eye worm) hypothetical protein 0.0185 0.2949 0.2949
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0019 0.0028 0.008
Onchocerca volvulus 0.0041 0.0409 0.0397
Echinococcus granulosus regulator of G protein signaling 7 0.0023 0.01 0.0131
Echinococcus multilocularis isocitrate dehydrogenase 0.0019 0.0028 0.0037
Schistosoma mansoni loxhd1 0.0024 0.0112 0.0338
Echinococcus granulosus cathepsin l cysteine peptidase 0.002 0.0048 0.0063
Echinococcus granulosus lysine specific demethylase 5A 0.0062 0.0786 0.1027
Entamoeba histolytica hypothetical protein 0.0052 0.0608 0.2061
Loa Loa (eye worm) ctsf protein 0.002 0.0048 0.0048
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0026 0.0144 0.0488
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.002 0.0041 0.0116
Trichomonas vaginalis ap endonuclease, putative 0.0036 0.033 0.0318
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0048 0.0036
Mycobacterium tuberculosis Conserved hypothetical protein 0.0114 0.1705 0.5783
Loa Loa (eye worm) hypothetical protein 0.0023 0.0103 0.0103
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0048 0.0036
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0048 0.0036
Loa Loa (eye worm) hypothetical protein 0.0038 0.0354 0.0354
Trypanosoma cruzi DNA polymerase kappa, putative 0.005 0.0567 0.1612
Loa Loa (eye worm) hypothetical protein 0.0023 0.01 0.01
Trypanosoma brucei DNA polymerase kappa, putative 0.005 0.0567 0.1612
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.013 0.199 0.675
Loa Loa (eye worm) PXA domain-containing protein 0.0023 0.01 0.01
Brugia malayi Isocitrate dehydrogenase 0.0019 0.0028 0.0028
Schistosoma mansoni sphingoid long chain base kinase 0.0185 0.2949 0.8928
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0048 0.0036
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0258 0.0246
Brugia malayi polk-prov protein 0.0038 0.0354 0.0354
Loa Loa (eye worm) hypothetical protein 0.0027 0.0175 0.0175
Brugia malayi Kringle domain containing protein 0.0062 0.0787 0.0787
Trichomonas vaginalis glucosylceramidase, putative 0.0383 0.6455 0.6451
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0054 0.0649 0.1847
Brugia malayi Regulator of G protein signaling domain containing protein 0.0023 0.01 0.01
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0048 0.0036
Brugia malayi exodeoxyribonuclease III family protein 0.0036 0.033 0.033
Brugia malayi hypothetical protein 0.0024 0.0112 0.0112
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1042 0.3153
Loa Loa (eye worm) hypothetical protein 0.0122 0.185 0.185
Onchocerca volvulus 0.0023 0.0103 0.006
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1051 0.2991
Loa Loa (eye worm) hypothetical protein 0.0023 0.0103 0.0103
Trichomonas vaginalis glucosylceramidase, putative 0.0404 0.6819 0.6815
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.007 0.0933 0.2655
Entamoeba histolytica transcription factor BTF3, putative 0.0042 0.0437 0.1481
Plasmodium falciparum basic transcription factor 3b, putative 0.0042 0.0437 0.5385
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0018 0.0013 0.0036
Loa Loa (eye worm) thioredoxin reductase 0.0057 0.0699 0.0699
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0364 0.1036
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0036 0.033 0.094
Plasmodium vivax hypothetical protein, conserved 0.0039 0.0387 0.4724
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.01 0.0087
Echinococcus granulosus lamin 0.0033 0.0266 0.0348
Schistosoma mansoni Lamin B receptor (ERG24) 0.0031 0.0244 0.0738
Loa Loa (eye worm) hypothetical protein 0.0129 0.1966 0.1966
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0041 0.0116
Loa Loa (eye worm) phosphatidylinositol 3 0.0054 0.0649 0.0649
Trichomonas vaginalis glucosylceramidase, putative 0.0383 0.6455 0.6451
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0018 0.0013 0.0036
Schistosoma mansoni rab6-interacting 0.0024 0.0112 0.0338
Entamoeba histolytica hypothetical protein 0.0023 0.01 0.0339
Loa Loa (eye worm) hypothetical protein 0.0041 0.0409 0.0409
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0048 0.0036
Loa Loa (eye worm) hypothetical protein 0.0535 0.9132 0.9132
Brugia malayi Ubiquitin conjugating enzyme protein 13 0.0046 0.0505 0.0505
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0018 0.0013 0.0036
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.1042 0.1042
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.008 0.1098 0.1436
Trypanosoma brucei glucosidase, putative 0.0038 0.0364 0.1036
Loa Loa (eye worm) acetylcholinesterase 1 0.0096 0.1388 0.1388
Leishmania major hypothetical protein, conserved 0.0062 0.0787 0.2238
Echinococcus granulosus axis inhibition protein axin 0.0023 0.01 0.0131
Schistosoma mansoni hypothetical protein 0.0062 0.0787 0.2382
Mycobacterium tuberculosis Probable reductase 0.013 0.199 0.675
Echinococcus granulosus tissue type plasminogen activator 0.0062 0.0787 0.1029
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.003 0.0229 0.0652
Plasmodium falciparum cysteine repeat modular protein 1 0.0062 0.0787 1
Schistosoma mansoni alpha-glucosidase 0.0148 0.23 0.6963
Schistosoma mansoni hypothetical protein 0.0106 0.156 0.4724
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0046 0.0505 0.0492
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.01 0.0087
Plasmodium falciparum glutathione reductase 0.0057 0.0699 0.8847
Brugia malayi Disco-interacting protein 2 homolog 0.0027 0.0175 0.0175
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0103 0.1501 0.427
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0264 0.0251
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0048 0.0036
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0036 0.033 0.3984
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0048 0.0036
Brugia malayi hypothetical protein 0.0023 0.0103 0.0103
Brugia malayi LBP / BPI / CETP family, C-terminal domain containing protein 0.0041 0.0409 0.0409
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0027 0.0175 0.0461
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0048 0.0036
Plasmodium vivax ubiquitin-conjugating enzyme E2 N, putative 0.0046 0.0505 0.6279
Leishmania major cathepsin L-like protease 0.0077 0.1051 0.2991
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0453 0.0441
Leishmania major phosphopantetheinyl transferase-like protein 0.0052 0.0608 0.1729
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0028 0.008
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0404 0.0392
Schistosoma mansoni intermediate filament proteins 0.0033 0.0266 0.0806
Onchocerca volvulus 0.0041 0.0409 0.0397
Loa Loa (eye worm) manba-prov protein 0.0071 0.0938 0.0938
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0264 0.0251
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0052 0.0608 1
Echinococcus granulosus transcription factor btf3 0.0042 0.0437 0.0571
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0027 0.0175 0.0147
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0437 0.0425
Brugia malayi Doublecortin family protein 0.0024 0.0112 0.0112
Loa Loa (eye worm) hypothetical protein 0.017 0.2685 0.2685
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1051 0.2991
Schistosoma mansoni lozenge 0.0067 0.0876 0.2651
Brugia malayi Cathepsin L-like precursor 0.002 0.0048 0.0048
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1051 0.2991
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.002 0.0041 0.0165
Echinococcus multilocularis transcription factor Dp 1 0.0046 0.0506 0.0662
Echinococcus granulosus ubiquitin conjugating enzyme E2 N 0.0046 0.0505 0.066
Trichomonas vaginalis glucosylceramidase, putative 0.0584 1 1
Schistosoma mansoni ap endonuclease 0.0036 0.033 0.1
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0023 0.01 0.01
Echinococcus granulosus regulator of G protein signaling 3 0.0023 0.01 0.0131
Plasmodium falciparum ubiquitin-conjugating enzyme E2 N, putative 0.0046 0.0505 0.6279
Trypanosoma brucei DNA polymerase kappa, putative 0.005 0.0567 0.1612
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0027 0.0175 0.0593
Echinococcus granulosus lysosomal alpha glucosidase 0.0172 0.2722 0.356
Plasmodium falciparum thioredoxin reductase 0.002 0.0041 0.0165
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0036 0.033 0.0996
Echinococcus multilocularis lamin dm0 0.0033 0.0266 0.0348
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.002 0.0041 0.0116
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0584 1 1
Trichomonas vaginalis maltase-glucoamylase, putative 0.0038 0.0364 0.0352
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0023 0.01 0.01
Mycobacterium ulcerans putative fatty-acid--CoA ligase 0.0027 0.0175 0.0461
Echinococcus granulosus lipoxygenase domain containing protein 0.0024 0.0112 0.0146
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.0046 0.0505 0.0505
Echinococcus multilocularis survival motor neuron protein 1 0.017 0.2685 0.3511
Trichomonas vaginalis beta-mannosidase, putative 0.0071 0.0938 0.0927
Echinococcus granulosus geminin 0.0205 0.3303 0.4319
Trypanosoma cruzi cruzipain precursor, putative 0.0077 0.1051 0.2991
Echinococcus multilocularis tar DNA binding protein 0.0076 0.1042 0.1362
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.008 0.1098 0.3725
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0038 0.0364 0.1234
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1042 0.3153
Echinococcus multilocularis regulator of G protein signaling 3 0.0023 0.01 0.0131
Mycobacterium tuberculosis Putative ferredoxin reductase 0.013 0.199 0.675
Echinococcus granulosus sphingosine kinase 1 0.0185 0.2949 0.3856
Mycobacterium tuberculosis Probable dehydrogenase 0.013 0.199 0.675
Trypanosoma cruzi hypothetical protein, conserved 0.0062 0.0787 0.2238
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.0046 0.0505 0.1435
Leishmania major ubiquitin-conjugating enzyme e2, putative 0.0046 0.0505 0.1435
Echinococcus granulosus lamin b receptor 0.0031 0.0244 0.0319
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0048 0.0036
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.002 0.0041 0.0123
Trypanosoma brucei DNA polymerase kappa, putative 0.005 0.0567 0.1612
Schistosoma mansoni sphingosine kinase A B 0.0185 0.2949 0.8928
Loa Loa (eye worm) TK/ROR protein kinase 0.0062 0.0787 0.0787
Trypanosoma brucei ubiquitin-protein ligase, putative 0.0046 0.0505 0.1435
Echinococcus multilocularis axis inhibition protein axin 0.0023 0.01 0.0131
Echinococcus granulosus cathepsin l1 0.002 0.0048 0.0063
Loa Loa (eye worm) LBP/BPI/CETP family domain-containing protein 0.0023 0.0103 0.0103
Trichomonas vaginalis glucosylceramidase, putative 0.0383 0.6455 0.6451
Echinococcus granulosus neutral alpha glucosidase AB 0.0038 0.0364 0.0476
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1051 0.2991
Schistosoma mansoni beta-galactosidase 0.0129 0.1966 0.5953
Echinococcus multilocularis beta galactosidase 0.0129 0.1966 0.2571
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0054 0.0649 0.0849
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0048 0.0036
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1051 0.2991
Brugia malayi Regulator of G protein signaling domain containing protein 0.0023 0.01 0.01
Trypanosoma brucei trypanothione reductase 0.0057 0.0699 0.199
Toxoplasma gondii cathepsin CPL 0.002 0.0048 0.0265
Trypanosoma cruzi DNA polymerase kappa, putative 0.005 0.0567 0.1612
Schistosoma mansoni hypothetical protein 0.0024 0.0112 0.0338
Entamoeba histolytica hypothetical protein 0.0023 0.01 0.0339
Leishmania major cathepsin L-like protease 0.002 0.0048 0.0138
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0023 0.0089 0.0254
Trichomonas vaginalis set domain proteins, putative 0.0286 0.474 0.4734
Brugia malayi hypothetical protein 0.0024 0.0112 0.0112
Schistosoma mansoni alpha-glucosidase 0.0148 0.23 0.6963
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.002 0.0048 0.0036
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0185 0.295 0.295
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1051 0.2991
Loa Loa (eye worm) carboxylesterase 0.0096 0.1388 0.1388
Loa Loa (eye worm) hypothetical protein 0.0185 0.295 0.295
Schistosoma mansoni z-protein (S1r protein) 0.0023 0.01 0.0303
Trypanosoma brucei DNA polymerase kappa, putative 0.005 0.0567 0.1612
Schistosoma mansoni lamin 0.0033 0.0266 0.0806
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0028 0.0037
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0209 0.0196
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0328 0.0992
Brugia malayi Papain family cysteine protease containing protein 0.002 0.0048 0.0048
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.002 0.0041 0.0116
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.1098 0.3125
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.1098 0.3125
Loa Loa (eye worm) hypothetical protein 0.0023 0.01 0.01
Brugia malayi Cathepsin L-like precursor 0.002 0.0048 0.0048
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0364 0.0352
Brugia malayi Glycosyl hydrolases family 31 protein 0.0172 0.2722 0.2722
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.0649 0.0637
Echinococcus multilocularis thioredoxin glutathione reductase 0.0057 0.0699 0.0914
Trypanosoma brucei DNA polymerase kappa, putative 0.005 0.0567 0.1612
Plasmodium vivax basic transcription factor 3b, putative 0.0042 0.0437 0.5385
Plasmodium falciparum thioredoxin reductase 0.0057 0.0699 0.8847
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0025 0.0141 0.0477
Trypanosoma cruzi DNA polymerase kappa, putative 0.005 0.0567 0.1612
Schistosoma mansoni axis inhibition protein axin 0.0023 0.01 0.0303
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0145 0.2247 0.7619
Loa Loa (eye worm) hypothetical protein 0.0023 0.0103 0.0103
Onchocerca volvulus 0.0035 0.0302 0.0279
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0019 0.0028 0.0037
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0052 0.0608 0.195
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0019 0.0028 0.008
Loa Loa (eye worm) fibroinase 0.002 0.0048 0.0048
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0036 0.033 0.5108
Brugia malayi A-kinase anchor protein 10, precursor 0.0023 0.01 0.01
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0062 0.0787 1
Trypanosoma brucei DNA polymerase IV, putative 0.005 0.0567 0.1612
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0057 0.0699 0.2371
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0217 0.3515 1
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1042 0.3153
Onchocerca volvulus 0.0286 0.474 0.5165
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.002 0.0048 0.0036
Schistosoma mansoni disco-interacting protein 2 (dip2) 0.0027 0.0175 0.0529
Trichomonas vaginalis ap endonuclease, putative 0.0036 0.033 0.0318
Echinococcus granulosus lipoxygenase domain containing protein 0.0024 0.0112 0.0146
Leishmania major cathepsin L-like protease 0.0077 0.1051 0.2991
Echinococcus granulosus tar DNA binding protein 0.0076 0.1042 0.1362
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0175 0.0461
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.003 0.0229 0.0652
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0054 0.0649 0.1847
Brugia malayi Thioredoxin reductase 0.0057 0.0699 0.0699
Schistosoma mansoni hypothetical protein 0.0205 0.3303 1
Echinococcus multilocularis geminin 0.0205 0.3303 0.4319
Brugia malayi MH2 domain containing protein 0.0144 0.2236 0.2236
Echinococcus granulosus regulator of G protein signaling 3 0.0023 0.01 0.0131
Loa Loa (eye worm) beta-glucuronidase 0.0098 0.1417 0.1417
Brugia malayi isocitrate dehydrogenase 0.0019 0.0028 0.0028
Loa Loa (eye worm) jmjC domain-containing protein 0.0062 0.0786 0.0786
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0023 0.01 0.0303
Brugia malayi hypothetical protein 0.0122 0.185 0.185
Toxoplasma gondii NAC domain-containing protein 0.0042 0.0437 0.5385
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0145 0.2247 1
Brugia malayi ubiquitin conjugating enzyme protein 13 0.0046 0.0505 0.0505
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0023 0.01 0.01
Brugia malayi hypothetical protein 0.0535 0.9132 0.9132
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0041 0.0116
Echinococcus granulosus beta-adrenergic receptor kinase 0.0023 0.01 0.0131
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0209 0.0196
Leishmania major basic transcription factor 3a, putative 0.0042 0.0437 0.1242
Loa Loa (eye worm) hypothetical protein 0.0305 0.5067 0.5067
Trypanosoma cruzi cysteine peptidase, putative 0.002 0.0048 0.0138
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0045 0.0128
Onchocerca volvulus 0.0062 0.0787 0.0813
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0025 0.0141 0.04
Schistosoma mansoni transcription factor btf3 0.0042 0.0437 0.1322
Echinococcus multilocularis lamin b receptor 0.0031 0.0244 0.0319
Loa Loa (eye worm) hypothetical protein 0.0062 0.0787 0.0787
Brugia malayi Carboxylesterase family protein 0.0096 0.1388 0.1388
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0023 0.01 0.0131
Echinococcus granulosus expressed conserved protein 0.0051 0.0586 0.0766
Echinococcus multilocularis acetylcholinesterase 0.0096 0.1388 0.1815
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0054 0.0649 0.1847
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.013 0.199 0.675
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.1051 0.2991
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0041 0.0116
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0039 0.0387 0.4724
Onchocerca volvulus 0.0041 0.0409 0.0397
Loa Loa (eye worm) hypothetical protein 0.0122 0.185 0.185
Echinococcus granulosus beta mannosidase 0.0071 0.0938 0.1227
Brugia malayi LBP / BPI / CETP family, C-terminal domain containing protein 0.0023 0.0103 0.0103
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0018 0.0013 0.0039
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0027 0.0175 0.0593
Brugia malayi LBP / BPI / CETP family, C-terminal domain containing protein 0.0023 0.0103 0.0103
Echinococcus multilocularis Regulator of G protein signaling 20 0.0023 0.01 0.0131
Leishmania major C-14 sterol reductase, putative 0.0031 0.0244 0.0694
Loa Loa (eye worm) papain family cysteine protease containing protein 0.002 0.0048 0.0048
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0404 0.0392
Echinococcus multilocularis cysteine protease 0.002 0.0048 0.0063
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.01 0.0087
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0036 0.033 0.094
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0328 0.0992
Mycobacterium ulcerans hypothetical protein 0.0114 0.1705 0.5724
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0209 0.0196
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0028 0.008
Echinococcus multilocularis carboxylesterase 5A 0.0096 0.1388 0.1815
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.0328 0.0429
Trypanosoma brucei DNA polymerase IV, putative 0.005 0.0567 0.1612
Leishmania major cathepsin L-like protease 0.002 0.0048 0.0138
Plasmodium falciparum cysteine proteinase falcipain 2a 0.002 0.0048 0.0265
Trypanosoma brucei unspecified product 0.0042 0.0426 0.1212
Loa Loa (eye worm) hypothetical protein 0.0023 0.01 0.01
Entamoeba histolytica hypothetical protein 0.0023 0.01 0.0339
Schistosoma mansoni ubiquitin conjugating enzyme 13 0.0046 0.0505 0.1528
Echinococcus granulosus transcription factor Dp 1 0.0046 0.0506 0.0662
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0142 0.2205 0.2884
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0018 0.0013 0.0017
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.0328 0.0429
Onchocerca volvulus 0.0041 0.0409 0.0397
Brugia malayi Cathepsin L-like precursor 0.002 0.0048 0.0048
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0453 0.0441
Plasmodium vivax SET domain protein, putative 0.0036 0.0328 0.3948
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. 0.0027 0.0175 0.0593
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0054 0.0649 0.2202
Entamoeba histolytica ubiquitin-conjugating enzyme family protein 0.0046 0.0505 0.1711
Echinococcus granulosus carboxylesterase 5A 0.0096 0.1388 0.1815
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0041 0.0116
Echinococcus multilocularis dna polymerase kappa 0.005 0.0567 0.0741
Plasmodium falciparum LCCL domain-containing protein 0.0024 0.0112 0.1101
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.2236 0.2236
Brugia malayi Glycosyl hydrolases family 2, sugar binding domain containing protein 0.0106 0.156 0.156
Echinococcus granulosus L aminoadipate semialdehyde 0.0185 0.295 0.3857
Entamoeba histolytica beta-galactosidase, putative 0.0106 0.156 0.5291
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0251 0.4127 0.4127
Schistosoma mansoni lipoxygenase 0.0142 0.2205 0.6676
Toxoplasma gondii NADPH-glutathione reductase 0.002 0.0041 0.0165
Leishmania major cathepsin L-like protease 0.0077 0.1051 0.2991
Trichomonas vaginalis glucosylceramidase, putative 0.0383 0.6455 0.6451
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0036 0.033 0.476
Loa Loa (eye worm) glutathione reductase 0.0057 0.0699 0.0699
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0038 0.0364 0.0364
Giardia lamblia GTOR 0.0054 0.0649 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0013 0.0013
Leishmania major cathepsin L-like protease 0.002 0.0048 0.0138
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1051 0.2991
Echinococcus granulosus Polycystic kidney disease protein 0.0024 0.0112 0.0146
Trichomonas vaginalis glucosylceramidase, putative 0.0383 0.6455 0.6451
Loa Loa (eye worm) hypothetical protein 0.0023 0.0103 0.0103
Giardia lamblia DINP protein human, muc B family 0.0025 0.0141 0.1641
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.1051 0.2991
Echinococcus multilocularis musashi 0.0033 0.0266 0.0348
Echinococcus multilocularis beta mannosidase 0.0071 0.0938 0.1227
Loa Loa (eye worm) hypothetical protein 0.002 0.0048 0.0048
Onchocerca volvulus 0.0041 0.0409 0.0397
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0018 0.0013 0.0036
Echinococcus granulosus acetylcholinesterase 0.0096 0.1388 0.1815
Brugia malayi TAR-binding protein 0.0076 0.1042 0.1042
Schistosoma mansoni serine/threonine protein kinase 0.0023 0.01 0.0303
Brugia malayi Carboxylesterase family protein 0.0096 0.1388 0.1388
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0052 0.0608 0.7641
Brugia malayi regulator of G-protein signaling rgs-7 0.0023 0.01 0.01
Echinococcus multilocularis beta adrenergic receptor kinase 0.0023 0.01 0.0131
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0054 0.0649 0.2202
Echinococcus multilocularis L aminoadipate semialdehyde 0.0185 0.295 0.3857
Schistosoma mansoni jumonji/arid domain-containing protein 0.0062 0.0786 0.2378
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.008 0.1098 0.3326
Echinococcus granulosus Regulator of G protein signaling 20 0.0023 0.01 0.0131
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0036 0.033 0.1121
Trichomonas vaginalis sucrase-isomaltase, putative 0.0038 0.0364 0.0352
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0109 0.1607 0.4865
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0328 0.0992
Trichomonas vaginalis conserved hypothetical protein 0.0204 0.3286 0.3277
Loa Loa (eye worm) hypothetical protein 0.0032 0.0256 0.0256
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.005 0.0571 0.1728
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0019 0.0028 0.0086
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) 0.0027 0.0175 0.0593
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0062 0.0786 0.1027
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0052 0.0608 0.7641
Trypanosoma cruzi transcription factor btf3, putative 0.0042 0.0437 0.1242
Leishmania major trypanothione reductase 0.0057 0.0699 0.199
Trichomonas vaginalis glucosylceramidase, putative 0.0404 0.6819 0.6815
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0404 0.0392
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0103 0.1501 0.427
Echinococcus granulosus beta galactosidase 0.0129 0.1966 0.2571
Brugia malayi Cathepsin L-like precursor 0.002 0.0048 0.0048
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.013 0.199 0.878
Echinococcus multilocularis lysosomal alpha glucosidase 0.0172 0.2722 0.356
Loa Loa (eye worm) hypothetical protein 0.0023 0.01 0.01
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.013 0.199 0.675
Trichomonas vaginalis glucosylceramidase, putative 0.0584 1 1
Treponema pallidum exodeoxyribonuclease (exoA) 0.0036 0.033 0.5108
Loa Loa (eye worm) RGS-3 protein 0.0023 0.01 0.01
Trypanosoma brucei DNA polymerase IV, putative 0.0042 0.0426 0.1212
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0036 0.033 0.3984
Toxoplasma gondii ubiquitin-conjugating enzyme subfamily protein 0.0046 0.0505 0.6279
Brugia malayi jmjC domain containing protein 0.0062 0.0786 0.0786
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0048 0.0036
Mycobacterium tuberculosis Probable oxidoreductase 0.0145 0.2247 0.7619
Onchocerca volvulus 0.0024 0.0112 0.007
Loa Loa (eye worm) LBP/BPI/CETP family domain-containing protein 0.0023 0.0103 0.0103
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0036 0.033 0.094
Onchocerca volvulus 0.0041 0.0409 0.0397
Loa Loa (eye worm) hypothetical protein 0.0096 0.1388 0.1388
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.0649 0.0637
Brugia malayi RNA binding protein 0.0076 0.1042 0.1042
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0048 0.0063
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0027 0.0175 0.0593
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.002 0.0041 0.0165
Mycobacterium leprae conserved hypothetical protein 0.0052 0.0608 0.2206
Onchocerca volvulus 0.005 0.0571 0.0575
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.0046 0.0505 0.0505
Brugia malayi hypothetical protein 0.017 0.2685 0.2685
Echinococcus multilocularis regulator of G protein signaling 0.0023 0.01 0.0131
Onchocerca volvulus 0.0033 0.0266 0.024
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0052 0.0608 1
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0027 0.0175 0.0593
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0109 0.1607 0.4865
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0038 0.0364 0.0352
Echinococcus granulosus axis inhibition protein axin 0.0023 0.01 0.0131
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0142 0.2205 0.2884
Leishmania major cysteine peptidase A (CPA) 0.002 0.0048 0.0138
Echinococcus multilocularis RUN 0.0024 0.0112 0.0146
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0313 0.0301
Onchocerca volvulus 0.0041 0.0409 0.0397
Echinococcus multilocularis expressed conserved protein 0.0051 0.0586 0.0766
Brugia malayi hypothetical protein 0.0023 0.01 0.01
Brugia malayi LBP / BPI / CETP family, N-terminal domain containing protein 0.0041 0.0409 0.0409
Echinococcus multilocularis sphingosine kinase 1 0.0185 0.2949 0.3856
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0048 0.0063
Schistosoma mansoni hypothetical protein 0.0205 0.3303 1
Echinococcus multilocularis axis inhibition protein axin 0.0023 0.01 0.0131
Echinococcus multilocularis cysteine protease 0.002 0.0048 0.0063
Mycobacterium tuberculosis Conserved protein 0.0185 0.2949 1
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.1051 0.2991
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0027 0.0175 0.0147
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0019 0.0028 0.0096
Leishmania major cathepsin L-like protease 0.002 0.0048 0.0138
Loa Loa (eye worm) hypothetical protein 0.0023 0.0103 0.0103
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.002 0.0041 0.0165
Brugia malayi Pre-SET motif family protein 0.0251 0.4127 0.4127
Echinococcus granulosus intermediate filament protein 0.0033 0.0266 0.0348
Echinococcus granulosus dna polymerase kappa 0.005 0.0567 0.0741
Trichomonas vaginalis DNA polymerase eta, putative 0.005 0.0567 0.0555
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0023 0.01 0.01
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0048 0.0036
Schistosoma mansoni jumonji domain containing protein 0.0062 0.0786 0.2378
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0023 0.01 0.0303
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0027 0.0175 0.0147
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0036 0.033 0.033
Echinococcus multilocularis transcription factor btf3 0.0042 0.0437 0.0571
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.0013 0.0013
Echinococcus multilocularis neutral alpha glucosidase AB 0.0038 0.0364 0.0476
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0054 0.0649 0.1966
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0364 0.0352
Echinococcus multilocularis expressed protein 0.0451 0.7647 1
Plasmodium vivax multidomain scavenger receptor, putative 0.0024 0.0112 0.1101
Loa Loa (eye worm) hypothetical protein 0.0027 0.0175 0.0175
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0027 0.0175 0.0461
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0027 0.0175 0.0593
Trypanosoma brucei DNA polymerase kappa, putative 0.005 0.0567 0.1612
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0304 0.0398
Schistosoma mansoni rab6-interacting 0.0024 0.0112 0.0338
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0048 0.0146
Entamoeba histolytica hypothetical protein 0.0042 0.0437 0.1481
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0404 0.0392
Brugia malayi Glycosyl hydrolases family 31 protein 0.0038 0.0364 0.0364
Onchocerca volvulus 0.0023 0.0103 0.006
Schistosoma mansoni hypothetical protein 0.0035 0.0302 0.0915
Echinococcus multilocularis ubiquitin conjugating enzyme E2 N 0.0046 0.0505 0.066
Schistosoma mansoni beta-mannosidase 0.0071 0.0938 0.2841
Echinococcus multilocularis disco interacting protein 2 0.0027 0.0175 0.0229
Loa Loa (eye worm) hypothetical protein 0.0535 0.9132 0.9132
Trypanosoma cruzi major cysteine proteinase, putative 0.0061 0.076 0.2163
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0038 0.0364 0.4426
Plasmodium falciparum cysteine proteinase falcipain 3 0.002 0.0048 0.0265
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0054 0.0649 0.1847
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.002 0.0041 0.0165
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0453 0.0441
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.0328 0.3948
Trypanosoma brucei DNA polymerase beta thumb, putative 0.003 0.0229 0.0652
Brugia malayi PXA domain containing protein 0.0023 0.01 0.01
Loa Loa (eye worm) hypothetical protein 0.0024 0.0112 0.0112
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.002 0.0041 0.0138
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0054 0.0649 0.1847
Loa Loa (eye worm) LBP/BPI/CETP family domain-containing protein 0.0041 0.0409 0.0409
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1051 0.2991
Brugia malayi manba-prov protein 0.0168 0.2664 0.2664
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0048 0.0036
Echinococcus granulosus expressed protein 0.0451 0.7647 1
Echinococcus granulosus Ankyrin repeat domain containing protein 0.0109 0.1607 0.2101
Echinococcus multilocularis Polycystic kidney disease protein 0.0024 0.0112 0.0146
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.002 0.0041 0.0041
Echinococcus granulosus lamin dm0 0.0033 0.0266 0.0348
Trichomonas vaginalis mercuric reductase, putative 0.002 0.0041 0.0028
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0404 0.0392
Brugia malayi Pre-SET motif family protein 0.0036 0.0328 0.0328
Mycobacterium ulcerans DNA polymerase IV 0.005 0.0567 0.1809
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0185 0.295 0.893
Entamoeba histolytica cysteine protease, putative 0.002 0.0048 0.0164
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0175 0.0461
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0028 0.0037
Trypanosoma cruzi C-14 sterol reductase, putative 0.0031 0.0244 0.0694
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.1098 0.3125
Loa Loa (eye worm) isocitrate dehydrogenase 0.0019 0.0028 0.0028
Trichomonas vaginalis glucosylceramidase, putative 0.0584 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0209 0.0196
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.008 0.1098 0.1436
Leishmania major DNA polymerase kappa, putative 0.0025 0.0141 0.04
Onchocerca volvulus 0.0033 0.0266 0.024
Trypanosoma brucei DNA polymerase kappa, putative 0.005 0.0567 0.1612
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0048 0.0036
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0035 0.0302 0.0302
Leishmania major acetoin dehydrogenase e3 component-like protein 0.002 0.0041 0.0116
Toxoplasma gondii thioredoxin reductase 0.0057 0.0699 0.8847
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0036 0.033 0.0432
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1051 0.2991
Toxoplasma gondii target of rapamycin (TOR), putative 0.004 0.0404 0.4952
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0026 0.0144 0.0488
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0208 0.0195
Brugia malayi Cathepsin L-like precursor 0.002 0.0048 0.0048
Trypanosoma cruzi trypanothione reductase, putative 0.0057 0.0699 0.199
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.1042 0.1042
Trypanosoma brucei hypothetical protein, conserved 0.0052 0.0608 0.1729
Echinococcus multilocularis regulator of G protein signaling 7 0.0023 0.01 0.0131
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0048 0.0036
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0437 0.0425
Trichomonas vaginalis glucosylceramidase, putative 0.0584 1 1
Trypanosoma cruzi sterol C-24 reductase, putative 0.0031 0.0244 0.0694
Echinococcus multilocularis regulator of G protein signaling 7 0.0023 0.01 0.0131
Echinococcus multilocularis Protein lozenge 0.0067 0.0876 0.1145
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.008 0.1098 0.1098
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0046 0.0505 0.0492
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0023 0.01 0.0131
Echinococcus granulosus survival motor neuron protein 1 0.017 0.2685 0.3511
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0048 0.0063
Entamoeba histolytica cysteine proteinase, putative 0.002 0.0048 0.0164
Echinococcus granulosus disco interacting protein 2 0.0027 0.0175 0.0229
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0364 0.1036
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0048 0.0036
Echinococcus multilocularis lipoxygenase domain containing protein 0.0024 0.0112 0.0146
Trypanosoma brucei DNA polymerase kappa, putative 0.005 0.0567 0.1612
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0096 0.1388 0.4203
Onchocerca volvulus Glucosylceramidase homolog 0.0383 0.6455 0.7053
Schistosoma mansoni regulator of G protein signaling 0.0023 0.01 0.0303
Loa Loa (eye worm) intermediate filament protein 0.0033 0.0266 0.0266
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1051 0.2991
Brugia malayi beta-NAC-like protein 0.0042 0.0437 0.0437
Echinococcus granulosus regulator of G protein signaling 7 0.0023 0.01 0.0131
Trypanosoma cruzi C-14 sterol reductase, putative 0.0031 0.0244 0.0694
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.0649 0.0637
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0404 0.0392
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.005 0.0567 0.0555
Trichomonas vaginalis glucosylceramidase, putative 0.0383 0.6455 0.6451
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0062 0.0786 0.1027
Brugia malayi jmjC domain containing protein 0.0062 0.0786 0.0786
Loa Loa (eye worm) hypothetical protein 0.0096 0.1388 0.1388
Schistosoma mansoni axis inhibition protein axin 0.0023 0.01 0.0303
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.01 0.0087
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0023 0.01 0.0087
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1042 0.3153
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.002 0.0041 0.0165
Echinococcus multilocularis regulator of G protein signaling 3 0.0023 0.01 0.0131
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.0046 0.0505 0.1435
Echinococcus multilocularis lamin 0.0033 0.0266 0.0348
Mycobacterium ulcerans DNA polymerase IV 0.005 0.0567 0.1809
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0052 0.0608 0.2061
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0048 0.0036
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0052 0.0608 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0048 0.0036
Schistosoma mansoni serine/threonine protein kinase 0.0023 0.01 0.0303
Trichomonas vaginalis glucosylceramidase, putative 0.0584 1 1
Trypanosoma cruzi transcription factor btf3, putative 0.0042 0.0437 0.1242
Plasmodium vivax thioredoxin reductase, putative 0.0057 0.0699 0.8847
Leishmania major sterol C-24 reductase, putative 0.0031 0.0244 0.0694
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0437 0.0425
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0036 0.033 0.094
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.002 0.0048 0.0048
Leishmania major dihydrolipoamide dehydrogenase, putative 0.002 0.0041 0.0116
Echinococcus granulosus acetylcholinesterase 0.0096 0.1388 0.1815
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0264 0.0251
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0364 0.0352
Trichomonas vaginalis glucosylceramidase, putative 0.0383 0.6455 0.6451
Brugia malayi PXA domain containing protein 0.0023 0.01 0.01
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0041 0.0116
Loa Loa (eye worm) doublecortin family protein 0.0024 0.0112 0.0112
Trichomonas vaginalis beta-galactosidase, putative 0.0204 0.3286 0.3277
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0048 0.0036
Loa Loa (eye worm) cysteine protease 0.002 0.0048 0.0048
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0052 0.0608 0.195
Echinococcus multilocularis acetylcholinesterase 0.0096 0.1388 0.1815
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0048 0.0036
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0028 0.0037
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.003 0.0229 0.0652
Schistosoma mansoni lipoxygenase 0.01 0.1449 0.4386
Onchocerca volvulus 0.0535 0.9132 1
Plasmodium vivax vivapain-2 0.002 0.0048 0.0265
Toxoplasma gondii exonuclease III APE 0.0036 0.033 0.3984
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0018 0.0013 0.0017
Leishmania major mitochondrial DNA polymerase beta 0.0217 0.3515 1
Schistosoma mansoni regulator of G protein signaling 0.0023 0.01 0.0303
Brugia malayi regulator of G-protein signaling egl-10 0.0023 0.01 0.01
Loa Loa (eye worm) hypothetical protein 0.0024 0.0112 0.0112
Schistosoma mansoni alpha glucosidase 0.0038 0.0364 0.1102
Toxoplasma gondii kringle domain-containing protein 0.0062 0.0787 1
Trypanosoma cruzi target of rapamycin kinase 3 0.0043 0.0454 0.1292
Schistosoma mansoni regulator of G protein signaling 0.0023 0.01 0.0303
Echinococcus granulosus RUN 0.0024 0.0112 0.0146
Onchocerca volvulus 0.0024 0.0112 0.007
Brugia malayi Protein kinase domain containing protein 0.0062 0.0787 0.0787
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0175 0.0461
Brugia malayi LBP / BPI / CETP family, C-terminal domain containing protein 0.0023 0.0103 0.0103
Schistosoma mansoni ap endonuclease 0.0036 0.033 0.1
Leishmania major alpha glucosidase II subunit, putative 0.0038 0.0364 0.1036
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0048 0.0146
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0036 0.033 0.0432
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.002 0.0041 0.0116
Onchocerca volvulus 0.0122 0.185 0.1983
Loa Loa (eye worm) runx1 0.0067 0.0876 0.0876
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.002 0.0041 0.0053
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0175 0.0461
Echinococcus multilocularis tissue type plasminogen activator 0.0062 0.0787 0.1029
Plasmodium vivax vivapain-2 0.002 0.0048 0.0265
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0364 0.0352
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0354 0.1007
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0054 0.0649 0.0649
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0038 0.0364 0.0352
Schistosoma mansoni serine/threonine protein kinase 0.0023 0.01 0.0303
Brugia malayi hypothetical protein 0.0023 0.01 0.01
Loa Loa (eye worm) hypothetical protein 0.0129 0.1966 0.1966
Echinococcus multilocularis lysosomal alpha glucosidase 0.0172 0.2722 0.356
Loa Loa (eye worm) hypothetical protein 0.0023 0.01 0.01
Onchocerca volvulus 0.0041 0.0409 0.0397
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0054 0.0649 0.1847
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0018 0.0013 0.0036
Onchocerca volvulus 0.0185 0.295 0.3194
Echinococcus multilocularis lysine specific demethylase 5A 0.0062 0.0786 0.1027
Trypanosoma brucei transcription factor BTF3, putative 0.0042 0.0437 0.1242
Entamoeba histolytica hypothetical protein, conserved 0.0185 0.2949 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0208 0.0195
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0334 0.0322
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0258 0.0246
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0103 0.1501 0.427
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.01 0.0087
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0217 0.3515 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0048 0.0063
Trypanosoma brucei DNA polymerase kappa, putative 0.005 0.0567 0.1612
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.002 0.0041 0.0116
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0027 0.0175 0.0147
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0404 0.0392
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0054 0.0649 0.0849
Trypanosoma cruzi trypanothione reductase, putative 0.002 0.0041 0.0116
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0453 0.0441
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0026 0.0144 0.0411
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.0509 0.0497
Plasmodium falciparum cysteine proteinase falcipain 2b 0.002 0.0048 0.0265
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0041 0.0116
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.2236 0.2236
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.0266 0.0266
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0037 0.0347 0.0986
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0052 0.0608 0.7641
Leishmania major phosphatidylinositol 3-kinase, putative 0.0018 0.0013 0.0036
Loa Loa (eye worm) hypothetical protein 0.0023 0.01 0.01
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0048 0.0036
Trypanosoma brucei DNA polymerase kappa, putative 0.0025 0.0141 0.04
Loa Loa (eye worm) RNA binding protein 0.0076 0.1042 0.1042

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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