TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 259.304 | Formula: C14H17N3O2
H donors: 1 H acceptors: 3 LogP: 1.27 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: OCc1nnn(c1)CC1Cc2c(O1)c(C)ccc2C
InChi: 1S/C14H17N3O2/c1-9-3-4-10(2)14-13(9)5-12(19-14)7-17-6-11(8-18)15-16-17/h3-4,6,12,18H,5,7-8H2,1-2H3
InChiKey: ORCBKJJWJJCLTG-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma cruzi	cysteine peptidase, putative	0.0062	0.233	0.2506
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0054	0.1945	0.1745
Trichomonas vaginalis	CAMK family protein kinase	0.02	0.8566	0.8566
Plasmodium vivax	dihydrolipoyl dehydrogenase, mitochondrial, putative	0.0019	0.0349	0.0612
Trypanosoma cruzi	polo-like protein kinase, putative	0.02	0.8566	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0245	0.0245
Onchocerca volvulus		0.0016	0.0245	0.0245
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0245	0.0246
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0245	0.0245
Echinococcus multilocularis	serine:threonine protein kinase PLK1	0.02	0.8566	0.8546
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0054	0.1945	0.2985
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0019	0.0349	0.5
Toxoplasma gondii	NADPH-glutathione reductase	0.0019	0.0349	0.0612
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0052	0.1865	0.2177
Schistosoma mansoni	serine/threonine protein kinase	0.02	0.8566	1
Plasmodium vivax	glutathione reductase, putative	0.0054	0.1945	1
Schistosoma mansoni	hypothetical protein	0.0041	0.1361	0.1589
Plasmodium falciparum	glutathione reductase	0.0054	0.1945	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0245	0.0245
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0052	0.1865	0.1663
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.231	0.2697
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.233	0.2411
Brugia malayi	serine/threonine-protein kinase plk-2	0.02	0.8566	0.8581
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.231	0.2697
Onchocerca volvulus	Cathepsin L homolog	0.0016	0.0245	0.0245
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0029	0.0826	0.3418
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.0826	0.0964
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0041	0.1361	0.1363
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0028	0.0777	0.0779
Trichomonas vaginalis	CAMK family protein kinase	0.02	0.8566	0.8566
Trichomonas vaginalis	CAMK family protein kinase	0.02	0.8566	0.8566
Loa Loa (eye worm)	fibroinase	0.0016	0.0245	0.0246
Entamoeba histolytica	serine/threonine protein kinase, putative	0.02	0.8566	1
Brugia malayi	Papain family cysteine protease containing protein	0.0016	0.0245	0.0246
Giardia lamblia	Kinase, PLK	0.02	0.8566	1
Echinococcus multilocularis	survival motor neuron protein 1	0.0231	0.9982	1
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0019	0.0349	0.5
Leishmania major	cathepsin L-like protease	0.0062	0.233	0.2506
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0019	0.0349	0.0125
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0062	0.231	0.2315
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.233	0.2411
Trypanosoma cruzi	cysteine peptidase, putative	0.0062	0.233	0.2506
Schistosoma mansoni	hypothetical protein	0.0047	0.1641	0.1915
Chlamydia trachomatis	dihydrolipoyl dehydrogenase	0.0019	0.0349	0.5
Onchocerca volvulus		0.0016	0.0245	0.0245
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0123	0.5072	0.8837
Onchocerca volvulus		0.0029	0.0826	0.0826
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0245	0.0245
Leishmania major	protein kinase, putative,polo-like protein kinase, putative	0.02	0.8566	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0245	0.0245
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0016	0.0245	0.0246
Plasmodium falciparum	glutathione reductase	0.0019	0.0349	0.0612
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0245	0.0245
Toxoplasma gondii	pyruvate dehydrogenase complex subunit PDH-E3II	0.0019	0.0349	0.0612
Leishmania major	cathepsin L-like protease	0.0062	0.233	0.2506
Onchocerca volvulus		0.0016	0.0245	0.0245
Brugia malayi	Thioredoxin reductase	0.0054	0.1945	0.1948
Trypanosoma cruzi	cysteine peptidase, putative	0.0062	0.233	0.2506
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.233	0.2411
Brugia malayi	Pre-SET motif family protein	0.0203	0.8726	0.8742
Schistosoma mansoni	survival motor neuron protein	0.0047	0.1641	0.1915
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0245	0.0245
Brugia malayi	hypothetical protein	0.0231	0.9982	1
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0016	0.0245	0.0246
Brugia malayi	Pre-SET motif family protein	0.0029	0.0826	0.0828
Schistosoma mansoni	dihydrolipoamide dehydrogenase	0.0019	0.0349	0.0408
Leishmania major	2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein	0.0019	0.0349	0.0125
Echinococcus granulosus	serine:threonine protein kinase PLK1	0.02	0.8566	0.8581
Trichomonas vaginalis	CAMK family protein kinase	0.0099	0.399	0.399
Brugia malayi	Cathepsin L-like precursor	0.0016	0.0245	0.0246
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0245	0.0245
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0137	0.5694	1
Loa Loa (eye worm)	TAR-binding protein	0.0062	0.231	0.2315
Trichomonas vaginalis	CAMK family protein kinase	0.0099	0.399	0.399
Loa Loa (eye worm)	hypothetical protein	0.0231	0.9982	1
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.231	0.2697
Loa Loa (eye worm)	PLK/PLK1 protein kinase	0.02	0.8566	0.8581
Onchocerca volvulus		0.0016	0.0245	0.0245
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0245	0.0245
Brugia malayi	hypothetical protein	0.0041	0.1361	0.1363
Leishmania major	cathepsin L-like protease	0.0062	0.233	0.2506
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.0826	0.0964
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0052	0.1865	0.2177
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0245	0.0245
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0245	0.0245
Brugia malayi	RNA binding protein	0.0062	0.231	0.2315
Plasmodium vivax	dihydrolipoyl dehydrogenase, apicoplast, putative	0.0019	0.0349	0.0612
Brugia malayi	Cathepsin L-like precursor	0.0016	0.0245	0.0246
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0245	0.0245
Treponema pallidum	NADH oxidase	0.0019	0.0349	0.5
Plasmodium falciparum	dihydrolipoyl dehydrogenase, apicoplast	0.0019	0.0349	0.0612
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0123	0.5072	0.8837
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.233	0.2411
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0203	0.8726	0.8742
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0016	0.0245	0.0245
Onchocerca volvulus	Cathepsin F homolog	0.0016	0.0245	0.0245
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase, LpdB	0.0019	0.0349	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0245	0.0245
Echinococcus multilocularis	tar DNA binding protein	0.0062	0.231	0.2121
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0245	0.0245
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0047	0.1641	0.1644
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0245	0.0245
Trypanosoma cruzi	cruzipain precursor, putative	0.0062	0.233	0.2506
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.233	0.2411
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.231	0.2697
Entamoeba histolytica	cysteine proteinase, putative	0.0016	0.0245	0.0286
Trichomonas vaginalis	CAMK family protein kinase	0.02	0.8566	0.8566
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0245	0.0245
Entamoeba histolytica	cysteine protease, putative	0.0016	0.0245	0.0286
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0016	0.0245	0.0246
Onchocerca volvulus		0.0016	0.0245	0.0245
Trichomonas vaginalis	CAMK family protein kinase	0.02	0.8566	0.8566
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.233	0.2411
Schistosoma mansoni	transcription factor LCR-F1	0.0041	0.1361	0.1589
Brugia malayi	Cathepsin L-like precursor	0.0016	0.0245	0.0246
Entamoeba histolytica	hypothetical protein	0.0041	0.1361	0.1589
Echinococcus granulosus	thioredoxin glutathione reductase	0.0054	0.1945	0.1948
Echinococcus granulosus	cathepsin l1	0.0016	0.0245	0.0246
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0019	0.0349	0.0125
Brugia malayi	Cathepsin L-like precursor	0.0016	0.0245	0.0246
Mycobacterium tuberculosis	Probable reductase	0.0123	0.5072	0.8837
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0052	0.1865	0.1868
Brugia malayi	alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase	0.0014	0.0125	0.0125
Echinococcus granulosus	tar DNA binding protein	0.0062	0.231	0.2315
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.233	0.2411
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0019	0.0349	0.0125
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0052	0.1865	0.1868
Schistosoma mansoni	cathepsin F (C01 family)	0.0016	0.0245	0.0286
Brugia malayi	Cathepsin L-like precursor	0.0016	0.0245	0.0246
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.233	0.2411
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0019	0.0349	0.0125
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0019	0.0349	0.0125
Entamoeba histolytica	hypothetical protein	0.0041	0.1361	0.1589
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0123	0.5072	0.8837
Onchocerca volvulus	Serine\/threonine kinase homolog	0.02	0.8566	0.8566
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0041	0.1361	0.1146
Mycobacterium ulcerans	flavoprotein disulfide reductase	0.0019	0.0349	0.5
Trypanosoma brucei	polo-like protein kinase	0.02	0.8566	1
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0019	0.0349	0.0125
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0245	0.0245
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0019	0.0349	0.0125
Plasmodium falciparum	thioredoxin reductase	0.0019	0.0349	0.0612
Schistosoma mansoni	cathepsin F (C01 family)	0.0016	0.0245	0.0286
Brugia malayi	TAR-binding protein	0.0062	0.231	0.2315
Plasmodium vivax	thioredoxin reductase, putative	0.0054	0.1945	1
Trichomonas vaginalis	glutathione reductase, putative	0.0019	0.0349	0.0349
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0019	0.0349	0.0125
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0019	0.0349	0.0125
Schistosoma mansoni	kinase	0.0102	0.4109	0.4797
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0029	0.0826	0.0597
Loa Loa (eye worm)	cysteine protease	0.0016	0.0245	0.0246
Onchocerca volvulus	Cathepsin L homolog	0.0016	0.0245	0.0245
Mycobacterium tuberculosis	Probable oxidoreductase	0.0137	0.5694	1
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.231	0.2697
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.0019	0.0349	0.0107
Brugia malayi	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein	0.0014	0.0125	0.0125
Onchocerca volvulus		0.0016	0.0245	0.0245
Plasmodium falciparum	thioredoxin reductase	0.0054	0.1945	1
Trypanosoma cruzi	polo-like protein kinase, putative	0.02	0.8566	1
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0057	0.2085	0.2211
Brugia malayi	Cathepsin L-like precursor	0.0016	0.0245	0.0246
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0245	0.0245
Trypanosoma cruzi	trypanothione reductase, putative	0.0054	0.1945	0.2042
Plasmodium vivax	SET domain protein, putative	0.0029	0.0826	0.3418
Entamoeba histolytica	hypothetical protein	0.0041	0.1361	0.1589
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.233	0.2411
Brugia malayi	glutathione reductase	0.0054	0.1945	0.1948
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.233	0.2411
Echinococcus granulosus	histone lysine methyltransferase setb	0.0029	0.0826	0.0828
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0019	0.0349	0.0125
Onchocerca volvulus		0.0047	0.1641	0.1641
Leishmania major	trypanothione reductase	0.0054	0.1945	0.2042
Loa Loa (eye worm)	thioredoxin reductase	0.0054	0.1945	0.1948
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.233	0.2411
Onchocerca volvulus		0.0016	0.0245	0.0245
Loa Loa (eye worm)	ctsf protein	0.0016	0.0245	0.0246
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0029	0.0826	0.0964
Entamoeba histolytica	hypothetical protein	0.0041	0.1361	0.1589
Trypanosoma cruzi	trypanothione reductase, putative	0.0019	0.0349	0.0125
Entamoeba histolytica	cysteine proteinase, putative	0.0016	0.0245	0.0286
Loa Loa (eye worm)	RNA binding protein	0.0062	0.231	0.2315
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0052	0.1865	0.1868
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0123	0.5072	0.8837
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase	0.0019	0.0349	0.5
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0052	0.1865	0.1868
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.0826	0.0964
Leishmania major	acetoin dehydrogenase e3 component-like protein	0.0019	0.0349	0.0125
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0826	0.0828
Trypanosoma cruzi	major cysteine proteinase, putative	0.0049	0.1725	0.1779
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0029	0.0826	0.0597
Echinococcus granulosus	survival motor neuron protein 1	0.0231	0.9982	1
Trichomonas vaginalis	CAMK family protein kinase	0.02	0.8566	0.8566
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0137	0.5694	1
Toxoplasma gondii	thioredoxin reductase	0.0054	0.1945	1
Brugia malayi	RNA recognition motif domain containing protein	0.0062	0.231	0.2315
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0245	0.0245
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0245	0.0245
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0016	0.0245	0.0245
Loa Loa (eye worm)	glutathione reductase	0.0054	0.1945	0.1948
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0137	0.5694	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0052	0.1865	0.1663
Trichomonas vaginalis	CAMK family protein kinase	0.02	0.8566	0.8566
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0019	0.0349	0.035
Trypanosoma brucei	trypanothione reductase	0.0054	0.1945	0.1942
Trichomonas vaginalis	mercuric reductase, putative	0.0019	0.0349	0.0349
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.0019	0.0349	0.035
Mycobacterium tuberculosis	Probable dehydrogenase	0.0123	0.5072	0.8837
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0052	0.1865	0.2177
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0245	0.0245
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0245	0.0245
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0016	0.0245	0.0246
Plasmodium falciparum	dihydrolipoyl dehydrogenase, mitochondrial	0.0019	0.0349	0.0612
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0245	0.0245

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL572790

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1073334